CN102415374B - Trinexapacethyl water dispersible granule preparation and preparation method thereof - Google Patents
Trinexapacethyl water dispersible granule preparation and preparation method thereof Download PDFInfo
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- CN102415374B CN102415374B CN 201110320956 CN201110320956A CN102415374B CN 102415374 B CN102415374 B CN 102415374B CN 201110320956 CN201110320956 CN 201110320956 CN 201110320956 A CN201110320956 A CN 201110320956A CN 102415374 B CN102415374 B CN 102415374B
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Abstract
The invention discloses a trinexapacethyl water dispersible granule preparation, which consists of 10 to 30 percent of trinexapacethyl raw medicine, 1 to 10 percent of wetting agents, 1 to 15 percent of dispersing agents, 1 to 10 percent of disintegrating agents, 30 to 60 percent of absorbing agents and 1 to 50 percent of inert carriers. The trinexapacethyl water dispersible granule preparation is produced by adopting a circular disc granulation mode, the kneading and the granulation are integrated into one step, and work procedures are reduced. Obtained products are spherical granules, the appearance is attractive, the flowability is good, the disintegration is fast, the heat generation is avoided in the granulation process, and the method is suitable for the production of low-melting-point raw medicine.
Description
Technical field
The present invention relates to a kind of anti-water dispersible granules of falling the ester and preparation method thereof.
Background technology
Anti-ester belongs to the cyclohexane-carboxylic acid plant growth regulator, regulates the prosperous length of plant by the biosynthesis that suppresses gibberellin.Be used for cereal crop and winter rape, can prevent lodging and improve results efficient; Be used for the lawn and can reduce the pruning number of times; Be used for sugarcane and can promote maturation.Because anti-the former medicine fusing point of ester is lower, has only 36 ℃, at present main formulation is missible oil and microemulsion, and not seeing has the water dispersible granules product to emerge.Use in the missible oil a large amount of environmental toxicities big contain the phenyl ring kind solvent, also contain polar solvent and a large amount of macromolecule emulsifier of more difficult degraded in the microemulsion, bigger to environment and human body harm.
Comply with more environmental protection of the formulations of pesticide, safer developing direction, the present invention will resist down ester to be processed into water dispersible granules.Water dispersible granules is disintegration fast in water, and dispersiveness and suspension are good, good drug efficacy; No dust from flying, safety is good; Can make the product of high concentration, reduce the storing cost.So water dispersible granules has just obtained development rapidly once coming out, it is one of best formulation of combination property in the various formulations.
The processing method of domestic water dispersible granule is generally the extruder grain mode at present, and its process is more loaded down with trivial details, and operation is more, heating easily in the granulation process, difficult control during production low melting point agricultural chemicals, because the extruding dynamics is bigger, it is more tight and disintegrative is relatively poor to produce product.
Summary of the invention
The object of the present invention is to provide a kind of good fluidity, disintegration is quick, athermic anti-water dispersible granules of falling the ester of granulation process and preparation method thereof.
Technical solution of the present invention is:
A kind of anti-water dispersible granules of falling the ester is characterized in that: is made up of following component in percentage by weight: the inert carrier that resists the former medicine 10～30% of ester, wetting agent 1～10%, dispersant 1～15%, disintegrant 1～10%, adsorbent 30～60% and 1～50%.
Described wetting agent is selected from
One or more of LZ/B, Tea Saponin, Morwet-EFW.
Described dispersant is selected from one or more among Morwet D-425, Reax 88A, the PVP K-30.
Described disintegrant is selected from one or more in urea, sodium chloride, the white granulated sugar.
Described adsorbent is white carbon; Described inert carrier is selected from one or more in atlapulgite, diatomite, the kaolin.
A kind of preparation method of the anti-water dispersible granules of falling the ester is characterized in that: comprise the following steps:
(1) will resist down the former medicine heating and melting of ester earlier, anti-after adopting the twin-screw cone-type mixer with fusion falls the former medicine of ester and is sprayed in the adsorbent white carbon and adsorbs; Add wetting agent, dispersant, disintegrant, inert carrier then, continue to mix;
(2) mixed material is crushed to average grain diameter below 5 microns with fluidized bed air flow crusher;
(3) material after the pulverizing is binding agent with water, adopts granulating disc to carry out granulation;
(4) adopting horizontal type fluidized-bed drier to be dried to the moisture percentage by weight after the granulation is below 2.0%;
(5) get 10 orders～120 purpose particles with concussion sieve sieve, namely get product.
The present invention has following characteristics:
1. the prepared pesticide water dispersible granules of the present invention is compared and existing product missible oil, has avoided the use to environment, organic solvent that the human injury is big, and is environmentally friendly.
2. granulating disc involved in the present invention collects kneading, granulation in a step, the reduction operation; And dispose the sprayer unit of adjustable flow and fogging degree, adjusting process flexibly; Dispose scraper, cutter, discharging opening, to realize automatic crushing large particle, self-emptying is produced continuously, improves yield and production efficiency.
3. the prepared pesticide water dispersible granules of the present invention is spherical in shape, and good fluidity is easy to metering and packing.
4. the prepared water dispersible granules disintegration rate in water of the present invention is fast, disintegration time in 30S, during use configuration convenient, suspensibility is greater than 90%, the drug effect height.
The present invention for the former medicine of low melting point, the former medicine of liquid is processed into solid pharmaceutical preparation provides a kind of convenience feasible method.
The invention will be further described below in conjunction with embodiment.
Embodiment
Embodiment 1
In 1000L twin-screw cone blender, drop into the white carbon 120 kg, stir down anti-31.25 kilograms of the former medicines of ester of falling that add fusion by sprayer unit, stirring and adsorbing is made female powder, add 10 kilograms of Morwet-EFW then successively, Morwet D-42512.5 kilogram, 2.5 kilograms of white granulated sugars, 73.75 kilograms of kaolin.Mix by airslide disintegrating mill and be crushed to average grain diameter below 5 microns; In granulating disc, be bed material, be that binding agent carries out the disk granulation with water with above-mentioned pulverizing gained material then; the gained particle is dried to moisture below 2.0% with horizontal type fluidized-bed drier; get 10 orders～120 purpose particles by concussion sieve sieve, namely get product after qualified after testing.
Embodiment 2
Drop into 135 kilograms of white carbons in the 1000L twin-screw cone blender, stir down anti-62.5 kilograms of the former medicines of ester of falling that add fusion by sprayer unit, stirring and adsorbing is all made female powder, adds successively then
10 kilograms of LZ/B, 15 kilograms of Reax 88A, 2.5 kilograms in urea, 25 kilograms in diatomite.Mix by airslide disintegrating mill and be crushed to average grain diameter below 5 microns; In granulating disc, be bed material, be that binding agent carries out the disk granulation with water with above-mentioned pulverizing gained material then; the gained particle is dried to moisture below 2.0% with horizontal type fluidized-bed drier; get 10 orders～120 purpose particles by concussion sieve sieve, namely get product after qualified after testing.
Embodiment 3
Drop into 150 kilograms of white carbons in the 1000L twin-screw cone blender, stir down anti-70 kilograms of the former medicines of ester of falling that add fusion by sprayer unit, stirring and adsorbing is all made female powder, add 10 kilograms of Tea Saponins then successively, 15 kilograms of PVP K-30,2.5 kilograms in sodium chloride, 2.5 kilograms of atlapulgites.Mix by airslide disintegrating mill and be crushed to average grain diameter below 5 microns; In granulating disc, be bed material, be that binding agent carries out the disk granulation with water with above-mentioned pulverizing gained material then; the gained particle is dried to moisture below 2.0% with horizontal type fluidized-bed drier; get 10 orders～120 purpose particles by concussion sieve sieve, namely get product after qualified after testing.
The adsorption plant that above-described embodiment adopts is the twin-screw cone-type mixer of band heating jacket and sprayer unit.The granulating disc that adopts disposes the sprayer unit of adjustable flow and fogging degree, with flexible adjusting process.The granulating disc that adopts disposes scraper, cutter, discharging opening, and to realize automatic crushing large particle, self-emptying is produced continuously, improves yield and production efficiency.
Above-mentioned three embodiment products obtained therefroms are as follows to wheat effect resistant to lodging:
With products obtained therefrom convert water dilution back with the amount of every mu 5 gram active ingredient to the processing of spraying of wheat later stage, the results are shown in following table
As seen, the anti-water dispersible granules of falling the ester that this patent is invented, the drug effect height, (every mu 5 gram active ingredient) has extraordinary effect resistant to lodging under low consumption.
Claims (2)
1. anti-water dispersible granules of falling the ester is characterized in that: is made up of following component in percentage by weight: the inert carrier that resists the former medicine 10～30% of ester, wetting agent 1～10%, dispersant 1～15%, disintegrant 1～10%, adsorbent 30～60% and 1 ~ 50%; Described wetting agent is Morwet-EFW; Described dispersant is selected from one or more among Morwet D-425, the PVP K-30; Described disintegrant is selected from one or more in urea, sodium chloride, the white granulated sugar; Described adsorbent is white carbon; Described inert carrier is selected from one or more in atlapulgite, diatomite, the kaolin.
2. the preparation method of the described anti-water dispersible granules of falling the ester of claim 1 is characterized in that: comprise the following steps:
(1) will resist down the former medicine heating and melting of ester earlier, anti-after adopting the twin-screw cone-type mixer with fusion falls the former medicine of ester and is sprayed in the adsorbent white carbon and adsorbs; Add wetting agent, dispersant, disintegrant, inert carrier then, continue to mix;
(2) mixed material is crushed to average grain diameter below 5 microns with fluidized bed air flow crusher;
(3) material after the pulverizing is binding agent with water, adopts granulating disc to carry out granulation;
(4) adopting horizontal type fluidized-bed drier to be dried to the moisture percentage by weight after the granulation is below 2.0%;
Get 10 orders～120 purpose particles with concussion sieve sieve, namely get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110320956 CN102415374B (en) | 2011-10-20 | 2011-10-20 | Trinexapacethyl water dispersible granule preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110320956 CN102415374B (en) | 2011-10-20 | 2011-10-20 | Trinexapacethyl water dispersible granule preparation and preparation method thereof |
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| CN102415374A CN102415374A (en) | 2012-04-18 |
| CN102415374B true CN102415374B (en) | 2013-10-09 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102696584A (en) * | 2012-05-09 | 2012-10-03 | 安徽华星化工股份有限公司 | Method for preparing pesticide granules |
| WO2014086854A1 (en) * | 2012-12-04 | 2014-06-12 | Basf Agro B.V., Arnhem (Nl) | Compositions comprising a quillay extract and a plant growth regulator |
| CN103027071A (en) * | 2013-01-04 | 2013-04-10 | 福建农林大学 | Spinosad and chlopyrifos compound microsphere suspending agent and preparation method thereof |
| CN104585166B (en) * | 2015-02-09 | 2017-01-04 | 四川国光农化股份有限公司 | Improve heat storage suspensibility and the triazolone water dispersible granules of stability, production method |
| CN105145555A (en) * | 2015-09-28 | 2015-12-16 | 江苏省农用激素工程技术研究中心有限公司 | Butroxydim water dispersible granule and preparation method thereof |
| CN106472506A (en) * | 2016-08-29 | 2017-03-08 | 四川国光农化股份有限公司 | A kind of compositionss of coordinate plant growth, preparation and its application |
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| JPH06128102A (en) * | 1992-09-01 | 1994-05-10 | Takeda Chem Ind Ltd | Granular wettable powder composition for agriculture and it production |
| CN1268290A (en) * | 2000-04-25 | 2000-10-04 | 江苏省农药研究所 | Granulating method of pesticide water-dispersing granules preparation |
| CN100466904C (en) * | 2006-10-20 | 2009-03-11 | 新沂市中港农用化工有限公司 | Water dispersion granules of pesticide, and preparation method |
| CN101278680B (en) * | 2007-04-06 | 2011-06-08 | 中国科学院动物研究所 | Insect baculovirus pesticides in dosage form of water dispersible granule and preparation |
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