CN102388886A - Brassinolide water soluble granules and preparation process thereof - Google Patents
Brassinolide water soluble granules and preparation process thereof Download PDFInfo
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- CN102388886A CN102388886A CN2011103080517A CN201110308051A CN102388886A CN 102388886 A CN102388886 A CN 102388886A CN 2011103080517 A CN2011103080517 A CN 2011103080517A CN 201110308051 A CN201110308051 A CN 201110308051A CN 102388886 A CN102388886 A CN 102388886A
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- wsgs
- brassin lactones
- powder
- brassinolide
- dispersant
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Abstract
The invention discloses brassinolide water soluble granules (WSGs). The brassinolide WSGs are mainly prepared by mixing butene-fipronil, a wetting agent, a dispersing agent, a disintegrating agent and filler in the ratio and are a plant growth regulator. The invention also discloses a preparation method for the brassinolide WSGs; and the method mainly comprises the following steps of: uniformly mixing the butene-fipronil, the wetting agent, the dispersing agent, the disintegrating agent and the filler, performing ultrafine grinding to obtain granules with the grain diameters of more than 800 meshes (equal to 0.015mm), and performing extruding pelleting or boiling pelleting to prepare WSGs. The process has the advantages that: the brassinolide WSGs prepared by the process do not absorb moisture or contain solvents, 0.05 to 1.0g of the WSGs can be quantificationally filled in each capsule; during use, the WSGs can be put in water and can be quickly disintegrated and dissolved so as to form a stable solution which can be directly sprayed onto farmland; and the efficiency of the WSGs is completely consistent with that of an emulsifiable solution and soluble powder.
Description
Technical field
The present invention relates to a kind of brassin lactones novel form that is applied to plant growth regulation.
Background technology
Soluble granula (WSG) is a kind of pesticides new formulation, in water, can dissolve fast, disperse, and forms the solution system with good action mechanism.
Natural brassin lactones (brassinosteroid) is a kind of up-to-date plant endogenous hormones, be called as the 6th generation plant growth regulator, its major physiological function has:
1, promotes cell division and elongation, growth;
2, favourable pollen insemination improves percentage of fertile fruit;
3, improve chlorophyll content, increase photosynthesis;
4, the anti-adversity ability of enhancement of plant.
This kind is since coming out; Its application technology and preparation processing technology have been carried out broad research both at home and abroad; The development and the application report of at present existing missible oil (EC), soluble powder kinds such as (SP`); The characteristic that the present invention is directed to brassin lactones is processed into soluble granula, can avoid the shortcoming of formulations such as missible oil, soluble powder effectively, has environmental protection, is convenient to accumulating, advantage easy to use.
Brassin lactones is because its using dosage extremely low (every mu only needs active ingredient 0.8mg); Solvability in solvent is very low; Generally be processed into 0.004～0.1% content formulation, as be processed into 0.004% missible oil, its organic solvent such as xylol, solvent naphtha content reach more than 80%; All get into environment in use, seriously polluted; And be processed into 0.1% soluble powder because hygroscopicity is too strong, and in packing, use, have dust from flying, be difficult to shortcomings such as quantitative package control, thereby influence the performance of drug effect.
Summary of the invention
The present invention is that the shortcoming that overcomes the existing preparation of brassin lactones is studied successful a kind of brassin lactones novel form.
The content of its brassin lactones of soluble granula that the present invention processes can be selected arbitrarily between 0.001～1%.
Wetting agent of the present invention can be selected like penetrating agent BX, sodium lignin sulfonate, lauryl sodium sulfate, PO-EO block polyether, acrylate homopolymer sodium salt etc., and its addition is 1～5%.
Dispersant of the present invention can be selected like dispersant N, maleic acid-acrylic acid copolymer sodium salt, phenolsulfonic acid condensation product sodium salt, naphthalene sulfonic acid condensate sodium salt, alkylphenol ethoxylate etc., and its addition is 3～20%.
Disintegrant of the present invention can be selected like polyvinylpyrrolidone, sodium sulphate, carbonic hydroammonium etc., and its addition is 0.5～5%.
Inserts of the present invention can be selected like sucrose, glucose, sodium sulphate etc., and its addition adds according to the preparation surplus.
The present invention also provides a kind of method for preparing the soluble granula of brassin lactones, and it is characterized in that: step is following:
The preparation superfine powder:
Brassin lactones and wetting agent, dispersant, disintegrant and inserts dropped in the mixer by proportioning mix; Through airslide disintegrating mill it is crushed to (particle diameter is equivalent to 0.015mm) more than 800 orders, should it be mixed more than precomminution to 80 order on the common cracker if the former medicine fineness of brassin lactones is excessive, comminution by gas stream again.
Granulation
A) extruder grain
800 orders are dropped in the kneader with the overdraught powder, add entry 10～15%, stirred 10 minutes; Emit wet feed, drop in the squash type comminutor, the wet granular of acquisition places in the baking oven with 80 ℃ of oven dry; Dry product sieves through vibratory sieve, and extracting 10～60 order particles is finished product, and residue on sieve returns crushing system.
What this technology obtained is cylindrical particle.
B) fluidized granulating
800 orders are dropped in the fluidized granulating machine with the overdraught powder, start blower fan, make the air-flow powder be in fluidized state; In comminutor, spray into the atomizing attitude water (about 8～12%), make powder gather a granulating, sprayed water after; In comminutor, blast 80 ℃ of hot blasts, with its oven dry, dry product sieves through vibratory sieve; Extracting suitable size particles as required is finished product, and residue on sieve returns crushing system.
What this technology obtained is the near-spherical irregular particle.
Advantage of the present invention: characteristics of the present invention are that brassin lactones and wetting agent, dispersant, disintegrant and inserts are mixed, more than ultra-fine grinding to 800 order (particle diameter is equivalent to 0.015mm), through extruder grain or fluidized granulating; Process sol particle; Because the significantly reducing of specific surface area is non-hygroscopic, solvent-free, can be implemented in 0.05～1.0g metering can quantitatively in capsule; In use it is dropped in the water; The quick disintegration of ability also is dissolved as uniform and stable solution, directly sprays in the farmland, and its usefulness and missible oil and soluble powder are in full accord.
Embodiment
Embodiment 1:
The former medicine 0.667kg of fineness 100 orders 90% brassin lactones, PO-EO block polyether 6 kg, naphthalene sulfonic acid condensate sodium salt 24 kg, polyvinylpyrrolidone 3 kg, sucrose 266.3 kg are dropped in 1000 liters of mixers; Mix and emitted in 15 minutes, it is crushed to more than 800 orders through airslide disintegrating mill.
Divide 5 batches with 800 orders with the overdraught powder, every crowd of 60kg drops in the 120 type fluidized granulating machines, starts blower fan, makes the air-flow powder be in fluidized state; In comminutor, spray into atomizing attitude water (about 5～6kg), make powder gather a granulating, sprayed water after; In comminutor, blast 80 ℃ of hot blasts, with its oven dry, dry product is emitted; Sieve through vibratory sieve, extracting 50～100 order particles is finished product, and residue on sieve returns crushing system.
The near-spherical irregular particle type 0.2% brassin lactones WSG that this technology obtains, following through the detection technique index:
Embodiment 2:
The former medicine 0.0033kg of fineness 100 orders 90% brassin lactones, acrylate homopolymer sodium salt 4.5 kg, dispersant N 45kg, sodium sulphate 15kg, carbonic hydroammonium 9kg, glucose 226.5 kg are dropped in 1000 liters of mixers; Mix and emitted in 15 minutes, it is crushed to more than 800 orders through airslide disintegrating mill.
800 orders are dropped in 1000 liters of type kneaders with the overdraught powder, add entry 42 kg, stirred 10 minutes; Emit wet feed, drop in the squash type wet granulator, the wet granular of acquisition places in the baking oven in 80 ℃ of oven dry; Took out in 3 hours; Dry product sieves through vibratory sieve, and extracting 10～60 order particles is finished product, and residue on sieve returns crushing system.
This technology obtains cylindrical particle 0.001% brassin lactones WSG, and is following through the detection technique index:
Embodiment 3:
The former medicine 3.33kg of fineness 100 orders 90% brassin lactones, PO-EO block polyether 4.5 kg, maleic acid-acrylic acid copolymer sodium salt 30kg, polyvinylpyrrolidone 3kg, sodium sulphate 259.2 kg are dropped in 1000 liters of mixers; Mix and emitted in 15 minutes, it is crushed to more than 800 orders through airslide disintegrating mill.
Divide 5 batches with 800 orders with the overdraught powder, every crowd of 60kg drops in the 120 type fluidized granulating machines, starts blower fan, makes the air-flow powder be in fluidized state; In comminutor, spray into atomizing attitude water (about 5～6kg), make powder gather a granulating, sprayed water after; In comminutor, blast 80 ℃ of hot blasts, with its oven dry, dry product is emitted; Sieve through vibratory sieve, extracting 50～100 order particles is finished product, and residue on sieve returns crushing system.
The near-spherical irregular particle type 1% brassin lactones WSG that this technology obtains, following through the detection technique index:
。
Effect of the present invention:
Under identical water, fertilizer, illumination condition, two leaf stage paddy rice seedling, two all fresh weights increase experiment, and the present invention and missible oil, soluble powder effect are consistent, see the following form:
That actual application value is relatively arranged is 0.2～1.0%WSG.
Claims (6)
1. the soluble granula of a brassin lactones, it is characterized in that: the content of said brassin lactones is 0.001～1% mass parts, and wetting agent is that 1～5% mass parts, dispersant are that 3～20% mass parts, disintegrant are 0.5～5% mass parts, and inserts is a surplus.
2. the soluble granula of a kind of brassin lactones according to claim 1, it is characterized in that: said wetting agent is any one of penetrating agent BX or sodium lignin sulfonate or lauryl sodium sulfate or PO-EO block polyether or acrylate homopolymer sodium salt class material.
3. the soluble granula of a kind of brassin lactones according to claim 1, it is characterized in that: said dispersant is dispersant N or maleic acid-acrylic acid copolymer sodium salt or phenolsulfonic acid condensation product sodium salt or naphthalene sulfonic acid condensate sodium salt or alkylphenol ethoxylate.
4. the soluble granula of a kind of brassin lactones according to claim 1, it is characterized in that: said disintegrant is any one of polyvinylpyrrolidone or sodium sulphate or carbonic hydroammonium.
5. the soluble granula of a kind of brassin lactones according to claim 1, it is characterized in that: said inserts is any one of sucrose or glucose or sodium sulphate.
6. method for preparing the soluble granula of brassin lactones, it is characterized in that: step is following:
A, preparation superfine powder
Brassin lactones and wetting agent, dispersant, disintegrant and inserts dropped in the mixer by proportioning mix; Through airslide disintegrating mill it is crushed to more than 800 orders, should it be mixed more than precomminution to 80 order on the common cracker if the former medicine fineness of brassin lactones is excessive, comminution by gas stream again;
B, granulation
A) extruder grain
800 orders are dropped in the kneader with the overdraught powder, add entry 10～15%, stirred 10 minutes; Emit wet feed, drop in the squash type comminutor, the wet granular of acquisition places in the baking oven with 80 ℃ of oven dry; Dry product sieves through vibratory sieve, and extracting 10～60 order particles is finished product, and residue on sieve returns crushing system;
What this technology obtained is cylindrical particle;
B) fluidized granulating
800 orders are dropped in the fluidized granulating machine with the overdraught powder, start blower fan, make the air-flow powder be in fluidized state; In comminutor, spray into the atomizing attitude water (about 8～12%), make powder gather a granulating, sprayed water after; In comminutor, blast 80 ℃ of hot blasts, with its oven dry, dry product sieves through vibratory sieve; Extracting suitable size particles as required is finished product, and residue on sieve returns crushing system, acquisition be the near-spherical irregular particle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011103080517A CN102388886A (en) | 2011-10-12 | 2011-10-12 | Brassinolide water soluble granules and preparation process thereof |
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| CN2011103080517A CN102388886A (en) | 2011-10-12 | 2011-10-12 | Brassinolide water soluble granules and preparation process thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238617A (en) * | 2012-07-04 | 2013-08-14 | 河北威远生物化工股份有限公司 | Clothianidin synergia solubility granula and preparation method thereof |
| CN104871954A (en) * | 2014-02-28 | 2015-09-02 | 西昌贝安德林农林科技有限公司 | Red Toona sinensis pollination liquid and red Toona sinensis seed cultivation production method |
| CN104872133A (en) * | 2015-03-28 | 2015-09-02 | 济南天邦化工有限公司 | Paraquat-fluoroglycofen ethyl water-soluble granule and preparation method thereof |
| CN106614756A (en) * | 2016-12-20 | 2017-05-10 | 陕西麦可罗生物科技有限公司 | Preparation method of nikkomycin soluble granules |
| CN111345301A (en) * | 2020-04-13 | 2020-06-30 | 张惠明 | Brassinolide soluble granule and preparation method thereof |
| CN114874048A (en) * | 2022-05-19 | 2022-08-09 | 江苏多农多收技术研究有限公司 | Preparation method of pesticide fertilizer capable of reducing injury of crops caused by late spring coldness |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3706835A (en) * | 1971-06-24 | 1972-12-19 | American Cyanamid Co | Crassin acetate used as an analgesic |
| CN101836632A (en) * | 2010-06-17 | 2010-09-22 | 陕西韦尔奇作物保护有限公司 | Brassinolide-containing plant growth regulator |
-
2011
- 2011-10-12 CN CN2011103080517A patent/CN102388886A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3706835A (en) * | 1971-06-24 | 1972-12-19 | American Cyanamid Co | Crassin acetate used as an analgesic |
| CN101836632A (en) * | 2010-06-17 | 2010-09-22 | 陕西韦尔奇作物保护有限公司 | Brassinolide-containing plant growth regulator |
Non-Patent Citations (1)
| Title |
|---|
| 戴权: "水分散粒剂生产工艺及设备优化", 《农药》 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238617A (en) * | 2012-07-04 | 2013-08-14 | 河北威远生物化工股份有限公司 | Clothianidin synergia solubility granula and preparation method thereof |
| CN103238617B (en) * | 2012-07-04 | 2015-01-28 | 河北威远生化农药有限公司 | Clothianidin synergia solubility granula and preparation method thereof |
| CN104871954A (en) * | 2014-02-28 | 2015-09-02 | 西昌贝安德林农林科技有限公司 | Red Toona sinensis pollination liquid and red Toona sinensis seed cultivation production method |
| CN104871954B (en) * | 2014-02-28 | 2017-06-27 | 卢德莉 | A kind of breezing and producing method of red Chinese toon pollination liquid and red Chinese toon seed |
| CN104872133A (en) * | 2015-03-28 | 2015-09-02 | 济南天邦化工有限公司 | Paraquat-fluoroglycofen ethyl water-soluble granule and preparation method thereof |
| CN106614756A (en) * | 2016-12-20 | 2017-05-10 | 陕西麦可罗生物科技有限公司 | Preparation method of nikkomycin soluble granules |
| CN111345301A (en) * | 2020-04-13 | 2020-06-30 | 张惠明 | Brassinolide soluble granule and preparation method thereof |
| CN114874048A (en) * | 2022-05-19 | 2022-08-09 | 江苏多农多收技术研究有限公司 | Preparation method of pesticide fertilizer capable of reducing injury of crops caused by late spring coldness |
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Application publication date: 20120328 |