CN102860302A - Brassinolide water-dispersible effervescent tablets and preparation method thereof - Google Patents
Brassinolide water-dispersible effervescent tablets and preparation method thereof Download PDFInfo
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- CN102860302A CN102860302A CN2012103556763A CN201210355676A CN102860302A CN 102860302 A CN102860302 A CN 102860302A CN 2012103556763 A CN2012103556763 A CN 2012103556763A CN 201210355676 A CN201210355676 A CN 201210355676A CN 102860302 A CN102860302 A CN 102860302A
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- brassin lactones
- acid
- aqueous dispersion
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- effervescent tablet
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Abstract
The invention discloses brassinolide water-dispersible effervescent tablets. The brassinolide water-dispersible effervescent tablets are mainly made with brassinolide, acid source, gas source, surfactant, filler, binder, flow aid, inertial filler and the like. The invention further discloses a preparation method of the brassinolide water-dispersible effervescent tablets. The preparation method mainly includes mixing the brassinolide water-dispersible effervescent tablets with the acid source, the surfactant, the filler and the binder, performing jet milling under more than 500 mesh, performing extruding granulation, straightening and screening, and tabletting with the gas source and the flow aid. The brassinolide water-dispersible effervescent tablets with certain appearance are accurate in single weight and free of flying dust, also have the characteristics of foaming, ebullition, fast disintegration and dissolution, and belong to a novel environment-friendly pesticide. The production process is simple. The use is convenient. The brassinolide water-dispersible effervescent tablets can be directly scattered to paddy fields and autonomously disintegrate and spread, and can also be fed into a sprayer for spraying to target crops after disintegration and spreading.
Description
Technical field
The present invention relates to a plant growth regulators, be specifically related to a kind of brassin lactones aqueous dispersion effervescent tablet and preparation method thereof.
Background technology
It is to contain acidic materials (acid source) and the material of the getting angry (source of getting angry in tablet that pesticide water disperses the basic principle of effervescent tablet, be generally the basic salt that contains carbonate, such as carbonic hydroammonium, sodium carbonate etc.), neutralization reaction occurs with the source of getting angry in acid source after tablet is met water, discharge carbonic acid gas, thereby reach foaming boiling, quickly disintegrated effect, effervescent table as agricultural chemical can directly be shed voluntarily disintegration diffusion in the paddy field in use, also can drop in the sprayer to spray in the crop target after the disintegration dispersion.
Brassin lactones (brassinosteroid) is a kind of up-to-date plant endogenous hormones, be called as the 6th generation plant growth regulator, its main Physiological Function has: promote cell division and elongation, growth; Favourable pollen insemination improves percentage of fertile fruit; Improve chlorophyll content, increase photosynthesis; Strengthen the anti-adversity ability of plant.
This kind is since coming out, its application technology and preparation processing technology have been carried out broad research both at home and abroad, the development and application report of the kinds such as at present existing missible oil (EC), soluble powder (SP`), the characteristic that the present invention is directed to brassin lactones is processed into the aqueous dispersion effervescent tablet, can effectively avoid the shortcoming of the formulations such as missible oil, soluble powder, have environmental protection, be convenient to accumulating, advantage easy to use.
Brassin lactones is because its using dosage extremely low (every mu only needs active ingredient 0.8mg), solvability in solvent is very low, generally be processed into 0.004～0.1% content formulation, as be processed into 0.004% missible oil, its organic solvent such as dimethylbenzene, solvent naphtha content reach more than 80%, equal entered environment is seriously polluted in use; And be processed into 0.1% soluble powder because hygroscopicity is too strong, in packing, use, have dust from flying, be difficult to the shortcomings such as quantitative package control, thereby affect the performance of drug effect, and the aqueous dispersion effervescent tablet since have given configuration, accurately monolithic weight, without dust wave, easy to use, having again simultaneously foaming boiling, fast disintegration, rapidly-soluble characteristic, is a kind of environmentally friendly pesticides new formulation.
Summary of the invention
Goal of the invention: the present invention is that the shortcoming that overcomes the existing preparation of brassin lactones is studied successful a kind of aqueous dispersion effervescent tablet novel form.
The present invention also provides the preparation method of this brassin lactones aqueous dispersion effervescent tablet.
Technical field: a kind of brassin lactones aqueous dispersion effervescent tablet, the component that comprises following mass percent: brassin lactones 0.001～5%, acid source 5～30%, the source 5～30% of getting angry, surfactant 1～8%, binding agent 0.5～3%, free-flow agent 1～5%, surplus are inserts.
As optimization, described acid source is one or more in citric acid or tartaric acid or the fumaric acid.
As optimization, the described source of getting angry is one or more in sodium bicarbonate or carbonic hydroammonium or sodium carbonate or the potash.
As optimization, described surfactant is one or more in penetrating agent BX or sodium lignin sulfonate or lauryl sodium sulfate or PO-EO block polyether or acrylate homopolymer sodium salt or dispersant N or maleic acid-acrylic acid copolymer sodium salt or phenolsulfonic acid condensation product sodium salt or naphthalene sulfonic acid condensate sodium salt or the alkylphenol ethoxylate.
As optimization, described binding agent is one or more among water soluble starch or sodium carboxymethyl starch or polyethylene glycol PEG4000 or the polyethylene glycol PEG6000.
As optimization, described free-flow agent is one or more in white carbon or dolomol or the talcum powder.
As optimization, described inserts is the inertia filler, selects in kaolin or talcum powder or bentonite or sodium sulphate or the ammonium sulfate one or more.
The preparation method of described brassin lactones aqueous dispersion effervescent tablet, its step is as follows:
(1) preparation master batch: the former medicine of the brassin lactones that accurate-metering is good, acid source, surfactant, inert filler mix in mixer, in airslide disintegrating mill, it is crushed to more than 500 orders, powder is collected in another mixer, adding 5～15% aqueous solution that are dissolved with binding agent mediates, obtain wet granular through extruder grain, dry to moisture content and be less than 1%, whole grain sieves again, get 30～60 order particles, stand-by;
(2) compressing tablet: master batch, the source of getting angry, the free-flow agent of the above-mentioned steps that accurate-metering is good (1) preparation mix in mixer, in tablet press machine, be pressed into the tablet of given configuration, diameter is selected between 5～12mm, and thickness is selected between 3～8mm, and monolithic weight is at 0.4～3g.
The invention has the advantages that: having given configuration, accurate monolithic weight, wave without dust, having again the characteristic that foaming is seethed with excitement, quick disintegration is dissolved simultaneously, is a kind of environmentally friendly pesticides new formulation.And production technology is simple, and is easy to use, can directly shed voluntarily disintegration diffusion in the paddy field, also can drop in the sprayer to spray in the crop target after the disintegration dispersion.
Embodiment
Embodiment 1
Content of brassin is the preparation of 0.001% brassin lactones aqueous dispersion effervescent tablet:
(1) preparation 0.00132% brassin lactones master batch: the former medicine 0.00142kg of 90% brassin lactones that accurate-metering is good, surfactant---acrylate homopolymer sodium salt 2kg, naphthalene sulfonate 8kg, acid source---citric acid 17 kg, inert filler---kaolin 20kg, ammonium sulfate 51.6kg mixes in mixer, in airslide disintegrating mill, it is crushed to more than 500 orders, powder is collected in another mixer, adding 14kg and be dissolved with binding agent---the aqueous solution of 10% sodium carboxymethyl starch is mediated, obtain the column wet granular through extruder grain, dry to moisture content and be less than 1%, sieved by the whole grain of pelletizing machine vibratory sieve again, get 30～60 order particles, stand-by;
(2) compressing tablet: above-mentioned (1) that accurate-metering is good preparation master batch 76kg, sodium bicarbonate 22kg, free-flow agent---white carbon 2kg mixes in mixer, in tablet press machine, be pressed into circular tablet, diameter 12mm, thickness 3.8mm, monolithic weight is about 1.5g;
(3) performance test: active ingredient: 0.00102%; Disintegration time: 90s; PH value: the 6.5(1% aqueous solution).Percentage composition in the present embodiment is mass percent.
Embodiment 2
Content of brassin is the preparation of 0.1% brassin lactones aqueous dispersion effervescent tablet:
(1) preparation 0.132% brassin lactones master batch: the former medicine 0.146kg of 90% brassin lactones that accurate-metering is good, surfactant---lauryl sodium sulfate 3kg, phenolsulfonic acid condensation product sodium salt 7kg, acid source---tartaric acid 30 kg, inert filler---sodium sulphate 15kg, bentonite 43.2kg mixes in mixer, it is crushed to more than 150 orders, powder is collected in another mixer, adding 16kg and be dissolved with binding agent---the aqueous solution of 10% water soluble starch (hot water dissolving) is mediated, obtain the column wet granular through extruder grain, dry to moisture content and be less than 1%, sieved by the whole grain of pelletizing machine vibratory sieve again, get 30～60 order particles, stand-by;
(2) compressing tablet: above-mentioned (1) that accurate-metering is good preparation master batch 74kg, sodium carbonate 24kg, free-flow agent---talcum powder 2kg mixes in mixer, in tablet press machine, be pressed into circular tablet, diameter 6mm, thickness 3mm, monolithic weight is about 0.4g;
(3) performance test: active ingredient: 0.104%; Disintegration time: 77s; PH value: the 6.2(1% aqueous solution).Percentage composition in the present embodiment is mass percent.
Embodiment 3
Content of brassin is the preparation of 5% brassin lactones aqueous dispersion effervescent tablet:
(1) preparation 6.62% brassin lactones master batch: the former medicine 7.36kg of 90% brassin lactones that accurate-metering is good, surfactant---lauryl sodium sulfate 3kg, phenolsulfonic acid condensation product sodium salt 7kg, acid source---fumaric acid 13.5 kg, inert filler---sodium sulphate 15kg, bentonite 67.5kg mixes in mixer, it is crushed to more than 150 orders, powder is collected in another mixer, adding 16kg and be dissolved with binding agent---the aqueous solution of 10% PEG6000 is mediated, obtain the column wet granular through extruder grain, dry to moisture content and be less than 1%, sieved by the whole grain of pelletizing machine vibratory sieve again, get 30～60 order particles, stand-by;
(2) compressing tablet: above-mentioned (1) that accurate-metering is good preparation master batch 75.5kg, saleratus 23kg, free-flow agent---dolomol 1.5kg mixes in mixer, in tablet press machine, be pressed into circular tablet, diameter 6mm, thickness 2mm, monolithic weight is about 2.7g;
(3) performance test: active ingredient: 5.06%; Disintegration time: 80s; PH value: the 6.3(1% aqueous solution).Percentage composition in the present embodiment is mass percent.
Present embodiment carries out the living test of indoor promotion Dendranthema Growth to be tested, and the result shows consistent with commercially available aqua effect, sees the following form:
Claims (8)
1. brassin lactones aqueous dispersion effervescent tablet, it is characterized in that: the component that comprises following mass percent: brassin lactones 0.001～5%, acid source 5～30%, the source 5～30% of getting angry, surfactant 1～8%, binding agent 0.5～3%, free-flow agent 1～5%, surplus are inserts.
2. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: described acid source is one or more in citric acid or tartaric acid or the fumaric acid.
3. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: the described source of getting angry is one or more in sodium bicarbonate or carbonic hydroammonium or sodium carbonate or the potash.
4. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: described surfactant is one or more in penetrating agent BX or sodium lignin sulfonate or lauryl sodium sulfate or PO-EO block polyether or acrylate homopolymer sodium salt or dispersant N or maleic acid-acrylic acid copolymer sodium salt or phenolsulfonic acid condensation product sodium salt or naphthalene sulfonic acid condensate sodium salt or the alkylphenol ethoxylate.
5. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: described binding agent is one or more among water soluble starch or sodium carboxymethyl starch or polyethylene glycol PEG4000 or the polyethylene glycol PEG6000.
6. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: described free-flow agent is one or more in white carbon or dolomol or the talcum powder.
7. a kind of brassin lactones aqueous dispersion effervescent tablet according to claim 1, it is characterized in that: described inserts is the inertia filler, selects in kaolin or talcum powder or bentonite or sodium sulphate or the ammonium sulfate one or more.
8. preparation method of brassin lactones aqueous dispersion effervescent tablet as claimed in claim 1, it is characterized in that: step is as follows:
(1) preparation master batch: the former medicine of the brassin lactones that accurate-metering is good, acid source, surfactant, inert filler mix in mixer, in airslide disintegrating mill, it is crushed to more than 500 orders, powder is collected in another mixer, adding 5～15% aqueous solution that are dissolved with binding agent mediates, obtain wet granular through extruder grain, dry to moisture content and be less than 1%, whole grain sieves again, get 30～60 order particles, stand-by;
(2) compressing tablet: master batch, the source of getting angry, the free-flow agent of the above-mentioned steps that accurate-metering is good (1) preparation mix in mixer, in tablet press machine, be pressed into the tablet of given configuration, diameter is selected between 5～12mm, and thickness is selected between 3～8mm, and monolithic weight is at 0.4～3g.
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| CN2012103556763A CN102860302A (en) | 2012-09-24 | 2012-09-24 | Brassinolide water-dispersible effervescent tablets and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301136A (en) * | 2013-05-21 | 2013-09-18 | 成都旗美生物科技有限公司 | Combined medical and health-care medicine of naringenin |
| CN108207947A (en) * | 2017-11-21 | 2018-06-29 | 东南大学 | A kind of diquat dibromide soluble effervescent tablet and preparation method thereof |
| CN113545344A (en) * | 2021-07-23 | 2021-10-26 | 安徽省通源环境节能股份有限公司 | Submerged plant growth-promoting sustained-release tablet and preparation method thereof |
| US11219594B2 (en) | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| CN115119836A (en) * | 2022-07-27 | 2022-09-30 | 北京北农绿亨科技发展有限公司 | Environment-friendly chlorobromoisocyanuric acid soluble powder and preparation method thereof |
| US11576855B2 (en) | 2014-09-17 | 2023-02-14 | Steerlife India Private Limited | Effervescent composition and method of making it |
Citations (2)
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|---|---|---|---|---|
| US4820428A (en) * | 1985-11-21 | 1989-04-11 | Oilfield Speciality Products Manufacturing Ltd., Of Canada | Antimicrobial compositions and methods |
| CN102450263A (en) * | 2011-11-09 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Brassinolide effervescent granules/or effervescent tablets and preparation method thereof |
-
2012
- 2012-09-24 CN CN2012103556763A patent/CN102860302A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820428A (en) * | 1985-11-21 | 1989-04-11 | Oilfield Speciality Products Manufacturing Ltd., Of Canada | Antimicrobial compositions and methods |
| CN102450263A (en) * | 2011-11-09 | 2012-05-16 | 安阳市全丰农药化工有限责任公司 | Brassinolide effervescent granules/or effervescent tablets and preparation method thereof |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301136A (en) * | 2013-05-21 | 2013-09-18 | 成都旗美生物科技有限公司 | Combined medical and health-care medicine of naringenin |
| CN103301136B (en) * | 2013-05-21 | 2015-04-15 | 成都旗美生物科技有限公司 | Combined medical and health-care medicine of naringenin |
| US11576855B2 (en) | 2014-09-17 | 2023-02-14 | Steerlife India Private Limited | Effervescent composition and method of making it |
| US11219594B2 (en) | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| CN108207947A (en) * | 2017-11-21 | 2018-06-29 | 东南大学 | A kind of diquat dibromide soluble effervescent tablet and preparation method thereof |
| CN113545344A (en) * | 2021-07-23 | 2021-10-26 | 安徽省通源环境节能股份有限公司 | Submerged plant growth-promoting sustained-release tablet and preparation method thereof |
| CN113545344B (en) * | 2021-07-23 | 2022-08-09 | 安徽省通源环境节能股份有限公司 | Submerged plant growth-promoting sustained-release tablet and preparation method thereof |
| CN115119836A (en) * | 2022-07-27 | 2022-09-30 | 北京北农绿亨科技发展有限公司 | Environment-friendly chlorobromoisocyanuric acid soluble powder and preparation method thereof |
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Application publication date: 20130109 |