CN102406820A - Preparation method of fritillary and loquat dripping pills for treating cough - Google Patents
Preparation method of fritillary and loquat dripping pills for treating cough Download PDFInfo
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Abstract
The invention discloses a preparation method of fritillary and loquat dripping pills for treating cough, comprising the following steps of: (1) weighing raw materials; (2) decocting loquat leaf with water, filtering, concentrating to obtain clear paste, adding ethanol, fully mixing, standing, taking supernatant for later use; and (3) pulverizing fritillary bulb, performing hot reflux extraction with ethanol on the fritillary bulb powder, balloonflower and typhonium flagelliforme, filtering, combining the filtrate with the supernatant obtained in the step (2), recycling the ethanol, concentrating to obtain clear paste, cooling to room temperature, adding butanone for extraction, recycling the butanone and concentrating to obtain thick paste; heating a substrate for melting, adding the thick paste, stirring uniformly, adding menthol and mixing uniformly, and dripping to prepare dripping pills. The dripping pills disclosed by the invention have high drug content, small volume and high dissolution rate, are taken sublingually, can effectively avoid the first pass effect, have no stimulating side effect on gastrointestinal tracts, do not contain sugar, are conductive to quantitative administration and are convenient to store and transport.
Description
Technical field
The present invention relates to a kind of method for preparing of Chinese medicine preparation, particularly relate to a kind of controlling and cough the tendril-leaved fritillary bulb loquat drop pills method for preparing.
Background technology
ZHIKE CHUANBEI PIPA LU is raw material of Chinese medicine: Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae, Bulbus Fritillariae Ussuriensis fluid extract and Mentholum are prepared from.Has the relieving cough and expelling phlegm function.Be used to catch a cold and cough that bronchitis causes.Its prescription is: Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis fluid extract 7ml, Mentholum 0.15g, and method for preparing is: the above five tastes, get Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae decocte with water secondary, filter; Merging filtrate is concentrated in right amount, adds antiseptic; Filter, add sucrose 682g, add Bulbus Fritillariae Ussuriensis fluid extract and Mentholum successively; Add water move to 1000ml, shake up, promptly get.
The said extracted method can not be come out extracts active ingredients fully, thereby influences the performance of drug effect, also directly affects therapeutic effect.The deficiency that above-mentioned dosage form exists is: ZHIKE CHUANBEI PIPA LU exists liver first-pass effect after taking, bioavailability is lower, thereby influences the performance of drug effect; Also directly affect therapeutic effect; Contain sugar in the preparation, be unfavorable for that the high patient of blood glucose takes, patient's taking dose is big; Quantitatively unsuitable, and have storage, the demanding deficiency of traffic condition.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide a kind of controlling to cough the tendril-leaved fritillary bulb loquat drop pills method for preparing.
Technical scheme of the present invention is summarized as follows:
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 1-3 time, filter, the adding quality of each water is 1-20 a times of Folium Eriobotryae quality; Decocting time is 1-5 hour, merging filtrate, and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 clear paste; Add said clear paste volume 1-5 ethanol doubly, fully stir, left standstill 4-20 hour; Get supernatant, subsequent use;
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 1-3 time with alcohol heat reflux with said Radix Platycodonis and Rhizoma pinelliae cordatae, filter, the 3-10 that each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality times, extraction time is 1-3 hour; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 50-100 ℃ of relative density be 1.00～1.50 clear paste, put and be chilled to room temperature; Add butanone extraction 1-6 time; The adding volume of each butanone be the clear paste volume that is extracted 1-10 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 thick paste; Quite said thick paste quality 1-20 substrate heating is doubly made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
Step (2) is preferably: with Folium Eriobotryae decocte with water 2 times, filter, the adding quality of each water be the Folium Eriobotryae quality 3-8 doubly; Decocting time is 2-4 hour, merging filtrate, and being concentrated into 60-75 ℃ of relative density is 1.30 clear paste; The ethanol that adds 3 times of said clear paste volumes fully stirs, and leaves standstill 6-10 hour; Get supernatant, subsequent use.
Step (3) is preferably: said Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Rhizoma pinelliae cordatae, filter, the 5-7 that each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality times, extraction time is 2 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 60-75 ℃ of relative density be 1.30 clear paste, put and be chilled to room temperature; Add butanone extraction 2-4 time; The adding volume of each butanone be the clear paste volume that is extracted 3-5 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 60-75 ℃ of relative density is 1.30 thick paste; The substrate heating of 10 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
Said substrate is that Polyethylene Glycol-4000 and Polyethylene Glycol-6000 are at least a.
Cough tendril-leaved fritillary bulb loquat drop pills with controlling of method preparation of the present invention, overcome the defective of prior art preparation.The medicament contg of the drop pill that the raw material that extracts with method for distilling of the present invention is processed is high; Volume is little; Dissolution velocity is fast, adopts the mode of sublingual administration, and effective ingredient is directly absorbed and the entering blood circulation through the Sublingual mucosa with liver without gastrointestinal tract; Avoided the first pass effect of existing preparation effectively, no gastrointestinal tract produces the side effect that stimulates.In addition owing to make the active component of medicine and substrate fusion be one and form liquid in advance; Make the medicine area increase greatly; Production cost of the present invention is lower; Patient's drug cost is reduced, help improving the ability of seeking medical advice of extensive patients, also help improving the general health level of society.
The drop pill that the raw material that extracts with method for distilling of the present invention is processed, the little content of its drug dose is high, takes, easy to carry, good effect, does not contain sugar, is beneficial to quantitatively and takes, and is beneficial to and stores and transportation.
The specific embodiment
Below in conjunction with specific embodiment the present invention is described further, following explanation is in order to make those skilled in the art better understand the present invention, but does not limit the present invention in any way.
Embodiment 1
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 2 times, filter, the adding quality of each water is 6 times of Folium Eriobotryae quality; Decocting time is 3 hours, merging filtrate, and being concentrated into 70 ℃ of relative densities is 1.30 clear paste; The ethanol that adds 3 times of said clear paste volumes fully stirs, and leaves standstill 8 hours; Get supernatant, subsequent use.
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Rhizoma pinelliae cordatae, filter, each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality 6 times, and extraction time is 2 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 70 ℃ of relative densities be 1.30 clear paste, put and be chilled to room temperature; Add butanone extraction 3 times; The adding volume of each butanone is 4 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 70 ℃ of relative densities is 1.30 thick paste; Polyethylene Glycol-6000 heating of 10 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
The bag film-coat on the surface of the above-mentioned drop pill of processing, the material of film-coat is an Opadry.
Embodiment 2
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 6 8g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 2 times, filter, the adding quality of each water is 8 times of Folium Eriobotryae quality; Decocting time is 2 hours, merging filtrate, and being concentrated into 60 ℃ of relative densities is 1.30 clear paste; The ethanol that adds 3 times of said clear paste volumes fully stirs, and leaves standstill 10 hours; Get supernatant, subsequent use.
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Rhizoma pinelliae cordatae, filter, each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality 5 times, and extraction time is 2 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 60 ℃ of relative densities be 1.30 clear paste, put and be chilled to room temperature; Add butanone extraction 2 times; The adding volume of each butanone is 3 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 60 ℃ of relative densities is 1.30 thick paste; Polyethylene Glycol-4000 heating of 10 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
Embodiment 3
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 6 8g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 2 times, filter, the adding quality of each water is 3 times of Folium Eriobotryae quality; Decocting time is 4 hours, merging filtrate, and being concentrated into 75 ℃ of relative densities is 1.30 clear paste; The ethanol that adds 3 times of said clear paste volumes fully stirs, and leaves standstill 6 hours; Get supernatant, subsequent use.
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Rhizoma pinelliae cordatae, filter, each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality 7 times, and extraction time is 2 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 75 ℃ of relative densities be 1.30 clear paste, put and be chilled to room temperature; Add butanone extraction 4 times; The adding volume of each butanone is 5 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 75 ℃ of relative densities is 1.30 thick paste; Polyethylene Glycol-6000 heating of 10 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
Embodiment 4
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 6 8g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 1 time, filter, the adding quality of each water is 20 times of Folium Eriobotryae quality; Decocting time is 1 hour, merging filtrate, and being concentrated into 50 ℃ of relative densities is 1.00 clear paste; The ethanol that adds 1 times of said clear paste volume fully stirs, and leaves standstill 4 hours; Get supernatant, subsequent use;
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 1 time with alcohol heat reflux with said Radix Platycodonis and Rhizoma pinelliae cordatae, filter, each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality 10 times, and extraction time is 1 hour; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 100 ℃ of relative densities be 1.00 clear paste, put and be chilled to room temperature; Add butanone extraction 6 times; The adding volume of each butanone is 10 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 100 ℃ of relative densities is 1.00 thick paste; Polyethylene Glycol-4000 heating of 1 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
Embodiment 5
A kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, form by following step:
(1) takes by weighing raw material: Folium Eriobotryae 6 8g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 3 times, filter, the adding quality of each water is 1 times of Folium Eriobotryae quality; Decocting time is 5 hours, merging filtrate, and being concentrated into 100 ℃ of relative densities is 1.50 clear paste; The ethanol that adds 5 times of said clear paste volumes fully stirs, and leaves standstill 20 hours; Get supernatant, subsequent use;
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 3 times with alcohol heat reflux with said Radix Platycodonis and Rhizoma pinelliae cordatae, filter, each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality 3 times, and extraction time is 3 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 50 ℃ of relative densities be 1.50 clear paste, put and be chilled to room temperature; Add butanone extraction 1 time; The adding volume of each butanone is 1 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 50 ℃ of relative densities is 1.50 thick paste; Substrate (substrate is: mass ratio is 1: 1 Polyethylene Glycol-4000 and the Polyethylene Glycol-6000 mixture) heating of 20 times of quite said thick paste quality is made whole fusings; Add said thick paste, stir, add the Mentholum mix homogeneously; Drip and process 1000 balls, promptly get.
Embodiment 6 pharmacodynamic experiments
(1) mice ammonia method antitussive experiment:
Get healthy nothing and hinder 75 of mices; Male and female half and half; Be divided into five groups at random, 15 every group, establish matched group, ZHIKE CHUANBEI PIPA LU (abbreviation is controlled and coughed dew) 4g crude drug/kg, of the present invention controlling coughed tendril-leaved fritillary bulb loquat drop pills 1g crude drug/kg, 2g crude drug/kg and three dose groups of 4g crude drug/kg (embodiment 1 preparation).Pressed body weight difference gastric infusion (10ml/kg) continuous five days, once a day, matched group gives the normal saline of equivalent.After the last administration 1 hour, mice is placed in the inverted 500ml beaker, after drawing strong aqua ammonia 0.3ml and injecting a cotton balls (nearly weighing 50mg), put into beaker immediately, take out after 1.5 minutes.The cough latent period that observation and record mice are put into behind the cotton balls certainly reaches from the cough number of times of the 3 minutes beginnings of coughing for the first time, compares between organizing (t test).See table 1
Table 1 is controlled and is coughed the antitussive effect of tendril-leaved fritillary bulb loquat drop pills to mice
Compare with matched group:
P＜0.05,
P＜0.01.Reveal relatively with controlling to cough:
▲: P＜0.05,
▲ ▲: P＜0.01.
The result shows, controls to cough tendril-leaved fritillary bulb loquat drop pills 1g crude drug/kg, 2g crude drug/kg and three dose groups of 4g crude drug/kg and all can obviously reduce the cough number of times that mice is brought out by ammonia, but wherein high, middle dose groups significant prolongation mouse cough incubation period (P＜0.01).Control and cough tendril-leaved fritillary bulb loquat drop pills and compare with the ZHIKE CHUANBEI PIPA LU Isodose, the former antitussive effect is superior to the latter (P＜0.05 and P＜0.01).See table 1.
(2) the phenol red method of the mice experiment of eliminating the phlegm:
Get 50 of healthy male mices; Be divided into five groups at random; Every group 10, establish matched group, ammonium chloride 1g/kg, ZHIKE CHUANBEI PIPA LU (abbreviation is controlled and coughed dew) 4g crude drug/kg and control and cough tendril-leaved fritillary bulb loquat drop pills 2g crude drug/kg, 4g crude drug/kg group (embodiment 1 preparation), by continuous five days of body weight gastric infusion (10ml/kg); Once a day, ammonium chloride was administered once in experiment the same day.Water is can't help in experiment fasting the previous day, and half an hour after the last administration, mouse peritoneal is injected 5% phenol red solution 0.1ml/10gbw.After 30 minutes, disconnected neck is put to death animal, peels off trachea; Cut from thyroid cartilage down to one section trachea of trachea bifurcation, put into the test tube that fills the 2ml normal saline, add 0.1ml (1N) sodium hydroxide again; Fully vibration is got supernatant and is put the U-1100 type and can show in the ultraviolet spectrophotometer wavelength 546nm place colorimetric; According to pre-rendered phenol red standard curve, calculate every phenol red excretion of mice trachea, compare between organizing (t check).See table 2.
Table 2 is controlled and is coughed the phlegm-dispelling functions of tendril-leaved fritillary bulb loquat drop pills to mice
Compare with matched group:
P＜0.05,
P＜0.01.
The result shows, controls and coughs tendril-leaved fritillary bulb loquat drop pills 2g crude drug/kg, 4g crude drug/kg group and compare the equal phenol red excretion effect (P＜0.05 and 0.01) that can promote the mice trachea.Control and cough tendril-leaved fritillary bulb loquat drop pills and the comparison of ZHIKE CHUANBEI PIPA LU Isodose, the former effect is better than the latter, but does not have significance.
Embodiment 7 pharmacological experiments
Toxicity test:
Acute toxicological experiment shows controls that to cough tendril-leaved fritillary bulb loquat drop pills its mouse oral approach maximum tolerated dose be 216g crude drug/kg, so this medicine crude drug LD50＞216g crude drug/kg is equivalent to 1800 times of clinical Coming-of-Age Day consumption.Long term toxication result: control and cough tendril-leaved fritillary bulb loquat drop pills and show: do not see that general appearance toxicity changes through the experimental study in 1 month of rat oral administration; Hematological indices and biochemical indicator are not all seen obvious influence; Rat main organs coefficient is not seen obvious influence; The animal main organs is not found the pathological change relevant with administration, all do not cause tangible histopathology to change convalescent each internal organs.Experiment proof drop pill safety of the present invention, reliable.
Through experiment, it is similar with the experimental result of embodiment 1 with toxicity test that embodiment 2-embodiment 5 a kind of controls the pharmacodynamic experiment of the product that the method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills produces.
Embodiment 8 clinical experiments
200 routine cold cough (type of phlegm-heat stagnating in the lung) patients' clinical and experimental study.
Selected for use ZHIKE CHUANBEI PIPA LU as the contrast medicine, method of administration: take embodiment 1 controlling of preparation and cough tendril-leaved fritillary bulb loquat drop pills, each buccal 6 balls are obeyed 3 every day.The The control group ZHIKE CHUANBEI PIPA LU is obeyed 20ml at every turn, obeys every day 3 times.It was 1 course of treatment all with 7 days.
The result shows: the present invention controls and coughs tendril-leaved fritillary bulb loquat drop pills (embodiment 1 preparation) treatment and organize in 100 examples, clinical recovery 24 examples, and produce effects 31 examples, effective 32 examples, invalid 13 examples, total effective rate is 87.00%; In matched group 100 examples, clinical recovery 16 examples, produce effects 25 examples, effective 32 examples, invalid 27 examples, total effective rate 63.00%.
Clinical observation shows that the present invention controls and coughs the tendril-leaved fritillary bulb loquat drop pills taking convenience, can containing, absorb rapidly, and onset time is fast, and dose is little, because of not containing sugar, can be used for the use of diabetics.This medicine is not under observation found untoward reaction and toxic and side effects, and is safe and reliable.
Claims (4)
1. control the method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills for one kind, it is characterized in that forming by following step:
(1) takes by weighing raw material: Folium Eriobotryae 6 8g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) with Folium Eriobotryae decocte with water 1-3 time, filter, the adding quality of each water is 1-20 a times of Folium Eriobotryae quality; Decocting time is 1-5 hour, merging filtrate, and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 clear paste; Add said clear paste volume 1-5 ethanol doubly, fully stir, left standstill 4-20 hour; Get supernatant, subsequent use;
(3) said Bulbus Fritillariae Ussuriensis is pulverized, extracted 1-3 time with alcohol heat reflux with said Radix Platycodonis and Rhizoma pinelliae cordatae, filter, the 3-10 that each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality times, extraction time is 1-3 hour; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 50-100 ℃ of relative density be 1.00～1.50 clear paste, put and be chilled to room temperature; Add butanone extraction 1-6 time; The adding volume of each butanone be the clear paste volume that is extracted 1-10 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 thick paste; Quite said thick paste quality 1-20 substrate heating is doubly made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
2. a kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling according to claim 1 is characterized in that said step (2) is: with Folium Eriobotryae decocte with water 2 times, filter; The adding quality of each water is 3-8 a times of Folium Eriobotryae quality, and decocting time is 2-4 hour, merging filtrate; Being concentrated into 60-75 ℃ of relative density is 1.30 clear paste, adds the ethanol of 3 times of said clear paste volumes, fully stirs; Left standstill 6-10 hour, and got supernatant, subsequent use.
3. a kind of method for preparing of coughing tendril-leaved fritillary bulb loquat drop pills of controlling according to claim 1; It is characterized in that said step (3) is: said Bulbus Fritillariae Ussuriensis is pulverized; Extract 2 times with alcohol heat reflux with Radix Platycodonis and Rhizoma pinelliae cordatae; Filter, the 5-7 that each alcoholic acid adding quality is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Rhizoma pinelliae cordatae quality times, extraction time is 2 hours; Filtrating merges with the supernatant that step (2) obtains; Reclaim ethanol, and to be concentrated into 60-75 ℃ of relative density be 1.30 clear paste, put and be chilled to room temperature; Add butanone extraction 2-4 time; The adding volume of each butanone be the clear paste volume that is extracted 3-5 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 60-75 ℃ of relative density is 1.30 thick paste; The substrate heating of 10 times of quite said thick paste quality is made whole fusings, add said thick paste, stir, add the Mentholum mix homogeneously, drip and process 1000 balls, promptly get.
4. according to claim 1 or 3 described a kind of method for preparinies of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, it is characterized in that said substrate is that Polyethylene Glycol-4000 and Polyethylene Glycol-6000 are at least a.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626145A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for treating cough |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626145A (en) * | 2003-12-11 | 2005-06-15 | 天津天士力制药股份有限公司 | Medication for treating cough |
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| Title |
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| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部药品标准 中药成方制剂 第九册》", 31 December 1998 * |
| 刘丹: "治咳川贝枇杷滴丸", 《天津药学》 * |
| 国家药典委员会: "《国家食品药品监督管理局国家药品标准 新药转正标准 第63册》", 31 March 2008 * |
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