CN103083528A - Tendril-leaved fritillary bulb loquat dropping pill for treating cough and preparation method - Google Patents
Tendril-leaved fritillary bulb loquat dropping pill for treating cough and preparation method Download PDFInfo
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Abstract
The invention discloses a tendril-leaved fritillary bulb loquat dropping pill for treating cough and a preparation method; the preparation method comprises the following steps: weighing raw materials; (2) decocting loquat leaves with water, filtering, concentrating to obtain clear paste, adding ethanol, stirring fully, standing, taking the supernatant to keep in reserve; (3) crushing fritillary bulb, performing heat reflux extraction with balloonflower roots and fructus perillae by using ethanol, filtering, combining the filtrate with the supernatant obtained in step (2), recovering ethanol, concentrating to obtain clear paste, cooling to room temperature, adding butanone, extracting, recovering butanone, concentration to obtain thick paste; heating and melting a substrate, adding the thick paste, uniformly stirring, adding menthol, well mixing, and dropping to obtain the dropping pill. The dropping pill of the invention has the effects of relieving cough, eliminating phlegm, and relieving asthma, has a high drug content, a small size, and a high dissolution speed, is administrated sublingually, can effectively avoid first pass effect, and has no irritation side effect on gastrointestinal tracts. The dropping pill of the invention does not contain sugar, and has the characteristics of suitability for quantitative administration, and convenience for storage and transport.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine preparation, particularly relate to controlling and cough tendril-leaved fritillary bulb loquat drop pills and preparation method.
Background technology
ZHIKE CHUANBEI PIPA LU is by raw material of Chinese medicine: Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae, Bulbus Fritillariae Uninbracteatae fluid extract and Mentholum are prepared from.Has the relieving cough and expelling phlegm function.Be used for the cough that flu and bronchitis cause.Its formula is: Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis fluid extract 7ml, Mentholum 0.15g, and preparation method is: the above five tastes, get Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae and decoct with water secondary, filter, merging filtrate is concentrated in right amount, adds antiseptic, filter, add sucrose 682g, add successively Bulbus Fritillariae Ussuriensis fluid extract and Mentholum, add water move to 1000ml, shake up, and get final product.
The said extracted method can not be fully with extracts active ingredients out, thereby affect the performance of drug effect, also directly affects therapeutic effect.The deficiency that above-mentioned dosage form exists is: ZHIKE CHUANBEI PIPA LU exists liver first-pass effect after taking, bioavailability is lower, thereby affect the performance of drug effect, also directly affect therapeutic effect, sugary in preparation, be unfavorable for that the high patient of blood glucose takes, patient's taking dose is large, quantitatively unsuitable, and have storage, the demanding deficiency of traffic condition.
Contain Rhizoma pinelliae cordatae in the raw material prescription in addition, Rhizoma pinelliae cordatae has the effect of drying dampness to eliminate phlegm cough-relieving, but Rhizoma pinelliae cordatae is slightly poisonous.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide to control and cough tendril-leaved fritillary bulb loquat drop pills.
Second purpose of the present invention is to provide controls the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills.
Technical scheme of the present invention is summarized as follows:
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 1-3 time, filter, each water add quality be the Folium Eriobotryae quality 1-20 doubly, decocting time is 1-5 hour, merging filtrate, being concentrated into 50-100 ℃ of relative density is 1.00～1.50 clear paste, add described clear paste volume 1-5 ethanol doubly, fully stir standing 4-20 hour, get supernatant, standby;
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 1-3 time with alcohol heat reflux with described Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 3-10 times, and extraction time is 1-3 hour; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 50-100 ℃ of relative density be 1.00～1.50 clear paste, let cool to room temperature, add butanone extraction 1-6 time, each butanone add volume be the clear paste volume that is extracted 1-10 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 thick paste; Quite described thick paste quality 1-20 substrate heating is doubly made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Step (2) is preferably: Folium Eriobotryae is decocted with water 2 times, filter, each water add quality be the Folium Eriobotryae quality 3-8 doubly, decocting time is 2-4 hour, merging filtrate, being concentrated into 60-75 ℃ of relative density is 1.30 clear paste, the ethanol that adds 3 times of described clear paste volumes fully stirs standing 6-10 hour, get supernatant, standby.
Step (3) is preferably: described Bulbus Fritillariae Ussuriensis is pulverized, is extracted 2 times with alcohol heat reflux with Radix Platycodonis and Fructus Perillae, filter, each ethanol add quality be Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 5-7 doubly, extraction time is 2 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 60-75 ℃ of relative density be 1.30 clear paste, let cool to room temperature, add butanone extraction 2-4 time, each butanone add volume be the clear paste volume that is extracted 3-5 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 60-75 ℃ of relative density is 1.30 thick paste; The substrate heating of 10 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Described substrate is that PEG-4000 and PEG-4000 are at least a.
Tendril-leaved fritillary bulb loquat drop pills is coughed in controlling of said method preparation.
Experimental results show that the effect that drop pill of the present invention has antitussive, eliminates the phlegm and relievings asthma.Do not contain the composition of Rhizoma pinelliae cordatae in medicine material.
Cough tendril-leaved fritillary bulb loquat drop pills with controlling of method preparation of the present invention, the medicament contg of drop pill is high, volume is little, dissolution velocity is fast, adopt the mode of sublingual administration, can make effective ingredient directly absorb and enter blood circulation by the Sublingual mucosa without gastrointestinal tract and liver, effectively avoid the first pass effect of existing preparation, produce the side effect that stimulates without gastrointestinal tract.Be integrated and form liquid state due to the active component that makes in advance medicine and substrate melting in addition, make the medicine area greatly increase, that the drop pill that the present invention makes has is rapid-action, take, easy to carry, dosage is little, good effect, the characteristics such as not sugary.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, and following explanation is in order to make those skilled in the art better understand the present invention, but does not limit the present invention in any way.
Embodiment 1
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 2 times, filter, the quality that adds of each water is 6 times of Folium Eriobotryae quality, and decocting time is 3 hours, merging filtrate, being concentrated into 70 ℃ of relative densities is 1.30 clear paste, the ethanol that adds 3 times of described clear paste volumes fully stirs standing 8 hours, get supernatant, standby.
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 6 times, and extraction time is 2 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 70 ℃ of relative densities be 1.30 clear paste, let cool to room temperature, add butanone extraction 3 times, the volume that adds of each butanone is 4 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 70 ℃ of relative densities is 1.30 thick paste; The PEG-4000 heating of 10 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
At the surperficial film coating of the above-mentioned drop pill of making, the material of film-coat is Opadry.
Embodiment 2
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 2 times, filter, the quality that adds of each water is 8 times of Folium Eriobotryae quality, and decocting time is 2 hours, merging filtrate, being concentrated into 60 ℃ of relative densities is 1.30 clear paste, the ethanol that adds 3 times of described clear paste volumes fully stirs standing 10 hours, get supernatant, standby.
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 5 times, and extraction time is 2 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 60 ℃ of relative densities be 1.30 clear paste, let cool to room temperature, add butanone extraction 2 times, the volume that adds of each butanone is 3 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 60 ℃ of relative densities is 1.30 thick paste; The PEG-4000 heating of 10 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Embodiment 3
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 2 times, filter, the quality that adds of each water is 3 times of Folium Eriobotryae quality, and decocting time is 4 hours, merging filtrate, being concentrated into 75 ℃ of relative densities is 1.30 clear paste, the ethanol that adds 3 times of described clear paste volumes fully stirs standing 6 hours, get supernatant, standby.
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 2 times with alcohol heat reflux with Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 7 times, and extraction time is 2 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 75 ℃ of relative densities be 1.30 clear paste, let cool to room temperature, add butanone extraction 4 times, the volume that adds of each butanone is 5 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 75 ℃ of relative densities is 1.30 thick paste; The PEG-4000 heating of 10 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Embodiment 4
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 1 time, filter, the quality that adds of each water is 20 times of Folium Eriobotryae quality, and decocting time is 1 hour, merging filtrate, being concentrated into 50 ℃ of relative densities is 1.00 clear paste, the ethanol that adds 1 times of described clear paste volume fully stirs standing 4 hours, get supernatant, standby;
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 1 time with alcohol heat reflux with described Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 10 times, and extraction time is 1 hour; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 100 ℃ of relative densities be 1.00 clear paste, let cool to room temperature, add butanone extraction 6 times, the volume that adds of each butanone is 10 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 100 ℃ of relative densities is 1.00 thick paste; The PEG-4000 heating of 1 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Embodiment 5
Control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 3 times, filter, the quality that adds of each water is 1 times of Folium Eriobotryae quality, and decocting time is 5 hours, merging filtrate, being concentrated into 100 ℃ of relative densities is 1.50 clear paste, the ethanol that adds 5 times of described clear paste volumes fully stirs standing 20 hours, get supernatant, standby;
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 3 times with alcohol heat reflux with described Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 3 times, and extraction time is 3 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 50 ℃ of relative densities be 1.50 clear paste, let cool to room temperature, add butanone extraction 1 time, the volume that adds of each butanone is 1 times of the clear paste volume that is extracted, combining extraction liquid, and reclaiming butanone and being concentrated into 50 ℃ of relative densities is 1.50 thick paste; Substrate (substrate is: mass ratio is PEG-4000 and the PEG-4000 mixture of 1: the 1) heating of 20 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
Embodiment 6 pharmacodynamic experiments
(1) mice Ammonia Process antitussive experiment:
Get healthy without hindering 75 of mices, male and female half and half, be divided at random five groups, every group 15, establish matched group, ZHIKE CHUANBEI PIPA LU (abbreviation is controlled and coughed dew) 4g crude drug/kg, of the present invention controlling coughed tendril-leaved fritillary bulb loquat drop pills 1g crude drug/kg, 2g crude drug/kg and three dosage groups of 4g crude drug/kg (embodiment 1 preparation).Pressed body weight difference gastric infusion (10ml/kg) continuous five days, once a day, matched group gives the normal saline of equivalent.After the last administration 1 hour, mice is placed in inverted 500ml beaker, after drawing strong aqua ammonia 0.3ml and injecting a cotton balls (nearly weighing 50mg), put into immediately beaker, take out after 1.5 minutes.Observe and record mice after putting into cotton balls cough latent period and from the cough number of times of 3 minutes that begins of cough for the first time, between organizing relatively (t test).See Table 1
Table 1 is controlled and is coughed tendril-leaved fritillary bulb loquat drop pills to the antitussive effect of mice
Compare with matched group:
P＜0.05,
P＜0.01.Reveal relatively with controlling to cough: ▲: P＜0.05, ▲ ▲: P＜0.01.Result shows, controls to cough tendril-leaved fritillary bulb loquat drop pills 1g crude drug/kg, 2g crude drug/kg and three dosage groups of 4g crude drug/kg all can obviously reduce the cough number of times that mice is brought out by ammonia, but high, middle dosage group significant prolongation mouse cough incubation period (P＜0.01) wherein.Control and cough tendril-leaved fritillary bulb loquat drop pills and compare with the ZHIKE CHUANBEI PIPA LU Isodose, the former antitussive effect is better than the latter (P＜0.05 and P＜0.01).See Table 1.
(2) the phenol red method of the mice experiment of eliminating the phlegm:
Get 50 of healthy male mices, be divided at random five groups, every group 10, if (is the pharmaceutical quantities of giving large for matched group, ammonium chloride 1g/kg?), ZHIKE CHUANBEI PIPA LU (abbreviation is controlled and coughed dew) 4g crude drug/kg and controlling coughs tendril-leaved fritillary bulb loquat drop pills 2g crude drug/kg, 4g crude drug/kg group (embodiment 1 preparation), pressed body weight gastric infusion (10ml/kg) continuous five days, once a day, ammonium chloride was administered once in experiment the same day.Water is can't help in experiment fasting the previous day, half an hour after the last administration, mouse peritoneal injection 5% phenol red solution 0.1ml/10gbw.After 30 minutes, disconnected neck is put to death animal, peels off trachea, cuts from thyroid cartilage down to one section trachea of trachea bifurcation, put into the test tube that fills the 2ml normal saline, add 0.1ml (1N) sodium hydroxide, fully vibration is got supernatant and is put the U-1100 type and can show in ultraviolet spectrophotometer again, wavelength 546nm place colorimetric, according to pre-rendered phenol red standard curve, calculate every phenol red excretion of mice trachea, compare between organizing (t check).See Table 2.
Table 2 is controlled and is coughed tendril-leaved fritillary bulb loquat drop pills to the phlegm-dispelling functions of mice
Compare with matched group:
P＜0.05,
P＜0.01.
Result shows, controls and coughs tendril-leaved fritillary bulb loquat drop pills 2g crude drug/kg, 4g crude drug/kg group and compare the equal phenol red excretion effect (P＜0.05 and 0.01) that can promote the mice trachea.Control and cough tendril-leaved fritillary bulb loquat drop pills and the comparison of ZHIKE CHUANBEI PIPA LU Isodose, the former effect is better than the latter, but without significance.
(3) the Cavia porcellus experiment of relievining asthma
Select body weight 150-200g Cavia porcellus, 24, male and female half and half are divided 4 groups, press dosage gastric infusion in table 3, and Cavia porcellus is put into
In sprayer unit, with the 4% quantitative constant voltage of acetyl chloride ammonia choline (53.3-66.6kpa) spraying, after every Cavia porcellus is accepted spraying 5s
Take out immediately, record Cavia porcellus and begin incubation period of falling to the tic of panting property occurring from accepting spraying.With the positive medicine group of aminophylline,
Recording drawing of every Cavia porcellus breathes heavily incubation period.Observe respectively the antiasthmatic effect of drop pill of the present invention when various dose.
Table 3 is controlled and is coughed tendril-leaved fritillary bulb loquat drop pills to the antiasthmatic effect of mice
Embodiment 7 pharmacological experiments
Toxicity test:
Acute toxicological experiment shows controls that to cough tendril-leaved fritillary bulb loquat drop pills its mouse oral approach maximum tolerated dose be 216g crude drug/kg, therefore this medicine crude drug LD50＞216g crude drug/kg is equivalent to 1800 times of clinical Coming-of-Age Day consumption.Long term toxication result: control and cough tendril-leaved fritillary bulb loquat drop pills and show through Oral Administration in Rats administration experimental study in 1 month: have no general appearance toxicity and change, hematological indices and biochemical indicator are showed no obvious impact, the rat Main Organ Coefficients is had no obvious impact, the animal main organs is not found the pathological change relevant with administration, all do not cause obvious histopathology to change to convalescent each internal organs.Experimental results show that drop pill safety of the present invention, reliable.
Through experiment, the pharmacodynamic experiment of the product of controlling the preparation method production of coughing tendril-leaved fritillary bulb loquat drop pills of embodiment 2-embodiment 5 is similar to the experimental result of embodiment 1 with toxicity test.
Embodiment 8 clinical experiments
200 routine cold cough (type of phlegm-heat stagnating in the lung) patients' clinical and experimental study.
Selected ZHIKE CHUANBEI PIPA LU medicine in contrast, method of administration: take embodiment 1 controlling of preparation and cough tendril-leaved fritillary bulb loquat drop pills, each buccal 6 balls take 3 every day.The control group ZHIKE CHUANBEI PIPA LU each serving 20ml, takes 3 times every day.All take 7 days as 1 course for the treatment of.
Result shows: the present invention controls and coughs in tendril-leaved fritillary bulb loquat drop pills (embodiment 1 preparation) treatment group 100 examples, clinical recovery 25 examples, and produce effects 29 examples, effective 32 examples, invalid 14 examples, total effective rate is 86.00%; In matched group 100 examples, clinical recovery 16 examples, produce effects 25 examples, effective 32 examples, invalid 27 examples, total effective rate 63.00%.
Clinical observation shows, the present invention controls and coughs the tendril-leaved fritillary bulb loquat drop pills taking convenience, can containing, absorb rapidly, and onset time is fast, and dose is little, because of not sugary, can be used for the use of diabetics.This medicine is not under observation found untoward reaction and toxic and side effects, and is safe and reliable.
Claims (5)
1. control the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills, it is characterized in that being formed by following step:
(1) take raw material: Folium Eriobotryae 68g, Radix Platycodonis 6g, Fructus Perillae 20g, Bulbus Fritillariae Ussuriensis 7g and Mentholum 0.15g;
(2) Folium Eriobotryae is decocted with water 1-3 time, filter, each water add quality be the Folium Eriobotryae quality 1-20 doubly, decocting time is 1-5 hour, merging filtrate, being concentrated into 50-100 ℃ of relative density is 1.00～1.50 clear paste, add described clear paste volume 1-5 ethanol doubly, fully stir standing 4-20 hour, get supernatant, standby;
(3) described Bulbus Fritillariae Ussuriensis is pulverized, extracted 1-3 time with alcohol heat reflux with described Radix Platycodonis and Fructus Perillae, filter, the quality that adds of each ethanol is Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 3-10 times, and extraction time is 1-3 hour; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 50-100 ℃ of relative density be 1.00～1.50 clear paste, let cool to room temperature, add butanone extraction 1-6 time, each butanone add volume be the clear paste volume that is extracted 1-10 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 50-100 ℃ of relative density is 1.00～1.50 thick paste; Quite described thick paste quality 1-20 substrate heating is doubly made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
2. the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills of controlling according to claim 1, it is characterized in that described step (2) is: Folium Eriobotryae is decocted with water 2 times, filters, each water add quality be the Folium Eriobotryae quality 3-8 doubly, decocting time is 2-4 hour, merging filtrate, being concentrated into 60-75 ℃ of relative density is 1.30 clear paste, adds the ethanol of 3 times of described clear paste volumes, fully stir, standing 6-10 hour, get supernatant, standby.
3. the preparation method of coughing tendril-leaved fritillary bulb loquat drop pills of controlling according to claim 1, it is characterized in that described step (3) is: described Bulbus Fritillariae Ussuriensis is pulverized, extract 2 times with alcohol heat reflux with Radix Platycodonis and Fructus Perillae, filter, each ethanol add quality be Bulbus Fritillariae Ussuriensis, Radix Platycodonis and Fructus Perillae quality 5-7 doubly, extraction time is 2 hours; The supernatant that filtrate and step (2) obtain merges, reclaim ethanol, and to be concentrated into 60-75 ℃ of relative density be 1.30 clear paste, let cool to room temperature, add butanone extraction 2-4 time, each butanone add volume be the clear paste volume that is extracted 3-5 doubly, combining extraction liquid, reclaiming butanone and being concentrated into 60-75 ℃ of relative density is 1.30 thick paste; The substrate heating of 10 times of quite described thick paste quality is made whole fusings, add described thick paste, stir, add the Mentholum mix homogeneously, dripping becomes 1000 balls, and get final product.
4. the according to claim 1 or 3 described preparation methoies of coughing tendril-leaved fritillary bulb loquat drop pills of controlling, is characterized in that described substrate is that PEG-4000 and PEG-4000 are at least a.
5. controlling of the method for one of claim 1-4 preparation coughed tendril-leaved fritillary bulb loquat drop pills.
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| CN103705714A (en) * | 2013-11-30 | 2014-04-09 | 天津中新药业集团股份有限公司第六中药厂 | Application of cough treatment fritillary and loquat dripping pill in preparation of anti-influenza A virus drugs |
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