CN102406764B - 抗骨髓炎片在制备治疗风热感冒药物中的应用 - Google Patents
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Abstract
本发明公开了抗骨髓炎片在制备治疗风热感冒药物中的应用，抗骨髓炎片处方为金银花、蒲公英、地丁、半枝莲、白头翁、白花蛇舌草，为糖衣片，除去糖衣后显棕黑色；味微苦，有引湿性，能散瘀消肿，用于附骨疽及骨髓炎属热毒血瘀者，规格为每素片重0.4g，相当于原药材3克，口服，一次8--10片，一日3次，现发现其能治疗风热感冒。
Description
技术领域
本发明涉及一种中成药的新用途，尤其涉及抗骨髓炎片在制备治疗风热感冒药物中的应用。
背景技术
风热感冒是风热之邪犯表、肺气失和所致。症状表现为发热重、微恶风、头胀痛、有汗、咽喉红肿疼痛、咳嗽、痰粘或黄、鼻塞黄涕、口渴喜饮、舌尖边红、苔薄白微黄。风热感冒多见于夏秋季，外感风热所致。中医认为，风热感冒是感受风热之邪所致的表证。
风热外感，多发生于春季、夏季。春季多风，气候转温，故风与温热之邪多相兼致病；夏季室外闷热，室内又较为凉爽，室内室外温度不定，也易患病。风热感冒系风热之邪侵袭肺卫，致卫表不和，肺失清肃而出现的证候。
风热感冒的治疗，大多数是使用清热解毒药板蓝根颗粒等，但产品效果都不太好，因此急需一种治疗风热感冒的中药。抗骨髓炎片是莱阳市江波制药有限责任公司的独家产品，目前还没有其治疗风热感冒的文献报道。
发明内容
发明目的：本发明的目的在于提供抗骨髓炎片在制备治疗风热感冒药物中的应用。
技术方案：抗骨髓炎片在制备治疗风热感冒药物中的应用。
抗骨髓炎片处方为金银花、蒲公英、地丁、半枝莲、白头翁、白花蛇舌草，为糖衣片，除去糖衣后显棕黑色；味微苦，有引湿性，能散瘀消肿，用于附骨疽及骨髓炎属热毒血瘀者，规格为每素片重0.4g，相当于原药材3克，口服，一次8--10片，一日3次，现发现其能治疗风热感冒。
有益效果：抗骨髓炎片治疗风热感冒，效果良好。
具体实施方式
抗骨髓炎片治疗风热感冒的临床资料
临床药物：抗骨髓炎片，莱阳市江波制药有限责任公司，批号：20100409，口服，一次10片，一日3次。
临床观察60例患者，治疗组30例，对照组30例。全部病历均符合病例选择标准，男36例，女24例，年龄35-48岁，病程最短2天，最长2周，服用抗骨髓炎片一周。
诊断依据：断标准以《中医病症诊断疗效标准》中有关风热感冒证的标准为主，①发热、微恶风寒、鼻塞流涕、喷嚏、头痛、全身不适。②舌淡红或边尖红，台簿黄、脉浮数。③气候异常或起居不慎引起，突然发病。
症状体征积分标准：根据《中医新药临床研究指导原则》中相关积分标准，头痛、身痛、流涕、咽痛、咽部充血、咳嗽的消失、轻度、中度、重度分别积0、1、2、3分。
纳入标准：符合中医风热感冒证诊断标准，体温不超过39℃者，病程在48h之内者，年龄在18～65岁之间。
排除病例标准：已使用过治疗药物者如抗生素、激素或其他感冒药物者或已退热者；合并肺部其他原发性疾病者，如肺结核、肺肿痛者；合并严重心血管、肝、肾和造血系统疾病者；年龄在18岁以下或65岁以上者或为妊娠期、哺乳期妇女，以及体质过敏者。
对照组：抗病毒颗粒(四川光大制药有限公司生产，国药准字：Z51020073)，批号：20100421，每袋12g，2袋/次，3次/d，7d为1疗程。
疗效标准：1主要症状体征疗效判定标准体温下降0.5℃以上为起效，下降到37.4℃为体温恢复正常。其他症状体征积分降低1分为起效，0分为消失。2综合疗效判定标准痊愈：治疗3d以内体温恢复正常，症状和体征全部消失，或症状、体征积分下降90％以上者；显效：治疗3d以内体温正常，大部分症状和体征消失，或症状、体征积分下降75％以上者；有效：治疗3d以内体温较以前降低，主要症状和体征部分消失，或症状、体征积分下降50％以上者；无效：治疗3d以内体温未降或升高，主要症状和体征无改善或改善＜50％。
治疗结果：见表1。
表1.抗骨髓炎片治疗风热感冒病人的疗效观察
说明抗骨髓炎片治疗风热感冒效果好于对照组。
典型病例一
病例：李某某，女性，54岁，发热、恶风6小时，伴有咽干痛，咳嗽，头胀，全身不适，汗出，体温38.5℃，苔薄黄，舌红，脉浮数。体检：心率82次/分钟，心律齐，两肺呼吸音清。血常规、粪常规、肝功能、肾功能、心电图均正常。中医辨证：感冒(风热证)。西医诊断：普通感冒。给予抗骨髓炎片，口服，一次10片，一日3次。
服药后1小时体温开始下降，24小时后体温降至37.3℃，发热、恶风、咳嗽、头胀、汗出、全身不适症状消失，继续服药72小时，体温36.80℃，症状均消失。苔薄黄，舌正，脉平。体检：心率65次/分，心律齐，两肺呼吸音清。复查血常规、粪常规、肝功能、肾功能、心电图均正常。临床疗效判定为痊愈，用药期间无不良反应。
典型病例二
病例：患者，黄某某，女，42岁，发热半天。体温38.8℃，伴恶风、咽痛、轻咳，鼻塞流浊涕，头胀不适，无恶心呕吐，伴周身不适，时有汗出，纳差。既往身体健康。查体：中年女性，神志清，精神不振，咽部充血，可见淋巴滤泡增生，扁桃体轻度肿大。双肺呼吸音清，未闻及干湿性罗音。心率78次/分，律整，各瓣膜无杂音。腹软，无压痛，肝脾肋下未触及。四肢活动正常。实验室检查：白细胞总数4.78×109/L，其中中性粒细胞63％，淋巴细胞占44.4％。肝肾功能、心电图正常。舌质淡，苔薄黄，脉浮。证属风热夹湿感冒。给予抗骨髓炎片，口服，一次10片，一日3次。患者服药第一天后体温渐降至38℃以下，时有波动，咽痛、恶风症状稍改善，余证同前。服药第二天后体温渐降至37.6℃以下，诸证较前好转。服药第三天体温降至正常，仅感恶风、汗出，稍咽痛，周身不适。停药后经调养后诸证消失。三天后查白细胞总数4.7×109/L，中性粒细胞55.2％，淋巴细胞占36.5％，肝肾功能正常。
Claims (1)
1.抗骨髓炎片在制备治疗风热感冒药物中的应用，其中该抗骨髓炎片处方为金银花、蒲公英、地丁、半枝莲、白头翁、白花蛇舌草。
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