CN102399039B - Method for eliminating albendazole residue from aquaculture water - Google Patents
Method for eliminating albendazole residue from aquaculture water Download PDFInfo
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- CN102399039B CN102399039B CN 201110443354 CN201110443354A CN102399039B CN 102399039 B CN102399039 B CN 102399039B CN 201110443354 CN201110443354 CN 201110443354 CN 201110443354 A CN201110443354 A CN 201110443354A CN 102399039 B CN102399039 B CN 102399039B
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- albendazole
- water
- hydrogen peroxide
- formic acid
- residue
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Abstract
The invention discloses a method for eliminating albendazole residue from aquaculture water. The method comprises the following steps of: adding hydrogen peroxide in an amount which is 1 to 3 percent volume of a water sample into the water sample; adding formic acid in an amount which is 0.5 to 1.5 percent volume of the water sample, stirring uniformly, and reacting at the temperature of between 15 and 35DEG C for 2 to 6 hours; and regulating the pH to be neutral by using a 5mol/L sodium hydroxide solution, wherein the mass concentration of the hydrogen peroxide is 30 percent and the mass concentration of formic acid is 0.5-1 percent. Through chemical degradation reaction, the albendazole residue is eliminated from the water through chemical degradation, so that the aims of removing the albendazole residue and purifying the water are fulfilled.
Description
Technical field
The invention belongs to environmental science, be specifically related to a kind of chemical removing method of albendazole in the aquaculture water.
Background technology
Albendazole is a kind of benzimidazoles medicine, and its chemical name is 5-rosickyite base benzimidazole-2-Urethylane.Albendazole is usually used in the animal repelling Enterozoa as the cultivation medication at home, the parasitic diseases such as the tapeworm for the treatment of aquaculture fish, capillaria, acanthocephala.Some toxicologic studies show that albendazole has teratogenesis to the animal and human in recent years.After albendazole used in cultivation, it existed certain residual in water body, can cause the residual contamination of aquaculture water and water surrounding.The technology relevant with albendazole mainly concentrates on its preparation, purposes aspect at present, proposed a kind of preparation method of albendazole such as the CN101270091A patent of invention, patent of invention (CN101664405) has proposed a kind of albendazole in a kind of new purposes of aquaculture.Because how the correlation technique that does not have at present the albendazole drug residue to eliminate removes the albendazole drug residue in the water body, it is the problem that at present cultivation and environment protection face.Along with the application of albendazole in aquaculture is more and more extensive, albendazole residual eliminating technology has important using value in the exploitation water body.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, the residual removing method of albendazole in a kind of aquaculture water is provided.
The inventive method is specifically: the hydrogen peroxide that adds volume of water sample 1%～3% in water body example, the formic acid that adds again volume of water sample 0.5%～1.5%, under 15～35 ℃ of conditions, reacted 2～6 hours behind the stirring and evenly mixing, transfer pH to neutral with 5 mol/L sodium hydroxide solutions at last; Described hydrogen peroxide mass concentration is 30%, and the formic acid mass concentration is 0.5%～1%.
Say further hydrogen peroxide Analysis about Selection pure reagent or chemically pure reagent.
Say further formic acid Analysis about Selection pure reagent, chromatographically pure reagent or chemically pure reagent.
Can be eliminated by reaction by the Albendazole in the said process aquaculture water is residual, eliminate efficient greater than 98%.Chemical equation of the present invention is as follows:
Beneficial effect of the present invention is:
(1) use the chemical degradation reaction to eliminate the albendazole drug residue in the water body, its chemical degradation is eliminated, thereby it is residual to reach the removal albendazole, the purpose of purifying water body.
(2) two kinds of reagent using of present method are all simple, cheap, and formic acid is in last basic solution and remove, and do not have residual; Hydrogen peroxide is water and oxygen at the nature degradable, can not cause environmental pollution.
(3) elimination process is simple, can finish by once adding two kinds of chemical reagent, and it is shorter to eliminate process time, and elimination factor can reach more than 98%, and is workable.
Description of drawings
Fig. 1 is the mass spectrum ion flow graph that contains 100 μ g/L albendazoles in the water body example;
Fig. 2 is the albendazole mass spectrum ion flow graph of aquaculture water sample after the inventive method is processed.
Embodiment
The invention will be further described below in conjunction with embodiment.
Get 1L the residual grass carp culture experiment water body of albendazole is arranged, behind suction filtration, put into reaction tank, add 10 mL reaction reagent 1(30% hydrogen peroxide), add again 5 mL reagent 2(analytical pure formic acid, mass concentration is 0.5%～1%), 15 ℃ of lower reactions 4 hours behind the stirring and evenly mixing, adding at last 3 mL concentration is that 5 mol/L sodium hydroxide transfer pH to neutral.Water sample through above-mentioned technical finesse is measured residual albendazole with the high performance liquid chromatography-tandem mass method, and it is residual not detect albendazole.Albendazole before the reaction in the water body as shown in Figure 1, the albendazole content after the reaction in the water body as shown in Figure 2, the former medicine of albendazole is residual to be eliminated fully.
Getting 1L has the residual culture pond of albendazole to flow out water body, behind suction filtration, put into reaction tank, add 20 mL reaction reagent 1(30% hydrogen peroxide), add again 10 mL reagent 2(analytical pure formic acid, mass concentration is 0.5%～1%), 20 ℃ of lower reactions 2 hours behind the stirring and evenly mixing, adding at last 6 mL concentration is that 5 mol/L sodium hydroxide transfer pH to neutral.Measure with the high performance liquid chromatography-tandem mass method through the water sample of above-mentioned technical finesse, albendazole is residual to be 0.74 μ g/L, and the albendazole elimination factor that disappears is 99.3%.
Getting 1L has the residual culture pond of albendazole to flow out water body, behind suction filtration, put into reaction tank, add 30 mL reaction reagent 1(30% hydrogen peroxide), add again 15 mL reagent 2(chromatographically pure formic acid, mass concentration is 0.5%～1%), 35 ℃ of lower reactions 6 hours behind the stirring and evenly mixing, adding at last 9 mL concentration is that 4mol/L sodium hydroxide transfers pH to neutral.Water sample through above-mentioned technical finesse is measured with the high performance liquid chromatography-tandem mass method, and it is residual not detect albendazole.
Claims (3)
1. the residual removing method of albendazole in the aquaculture water, it is characterized in that: the hydrogen peroxide that in water body example, adds volume of water sample 1%～3%, the formic acid that adds again volume of water sample 0.5%～1.5%, under 15～35 ℃ of conditions, reacted 2～6 hours behind the stirring and evenly mixing, transfer pH to neutral with 5 mol/L sodium hydroxide solutions at last; Described hydrogen peroxide mass concentration is 30%, and the formic acid mass concentration is 0.5%～1%.
2. removing method according to claim 1 is characterized in that: described hydrogen peroxide Analysis about Selection pure reagent or chemically pure reagent.
3. removing method according to claim 1 is characterized in that: described formic acid Analysis about Selection pure reagent, chromatographically pure reagent or chemically pure reagent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110443354 CN102399039B (en) | 2011-12-27 | 2011-12-27 | Method for eliminating albendazole residue from aquaculture water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110443354 CN102399039B (en) | 2011-12-27 | 2011-12-27 | Method for eliminating albendazole residue from aquaculture water |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102399039A CN102399039A (en) | 2012-04-04 |
| CN102399039B true CN102399039B (en) | 2013-01-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201110443354 Expired - Fee Related CN102399039B (en) | 2011-12-27 | 2011-12-27 | Method for eliminating albendazole residue from aquaculture water |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105948309B (en) * | 2016-05-19 | 2019-02-01 | 河南慧锦药业有限公司 | A kind of comprehensive pretreatment method of novel albendazole high strength sulfide-bearing wastewater |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374931A (en) * | 1999-09-18 | 2002-10-16 | 泰特拉股份有限公司 | Process for improving culture water quality of tank system |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374931A (en) * | 1999-09-18 | 2002-10-16 | 泰特拉股份有限公司 | Process for improving culture water quality of tank system |
Non-Patent Citations (5)
| Title |
|---|
| 张小军等.淡水鱼制品中阿苯达唑亚砜、阿苯达唑砜和阿苯达唑_2_氨基砜的测定研究.《中国渔业质量与标准》.2011,第1卷(第1期),第60-63页. |
| 张小军等.超高效液相色谱_串联质谱法测定草鱼肉中阿苯达唑及其代谢物残留.《分析化学》.2011,第39卷(第6期),第815-820页. |
| 淡水鱼制品中阿苯达唑亚砜、阿苯达唑砜和阿苯达唑_2_氨基砜的测定研究;张小军等;《中国渔业质量与标准》;20110630;第1卷(第1期);第60-63页 * |
| 超高效液相色谱_串联质谱法测定草鱼肉中阿苯达唑及其代谢物残留;张小军等;《分析化学》;20110630;第39卷(第6期);第815-820页 * |
| 颜朝国.有机化学.《有机化学》.郑州大学出版社,2007,第397-400页. * |
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| CN102399039A (en) | 2012-04-04 |
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