CN102397525A - Chinese medicinal composition with function of improving nutritional anemia and preparation method thereof - Google Patents
Chinese medicinal composition with function of improving nutritional anemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition with a function of improving nutritional anemia. The Chinese medicinal composition comprises the following components in percentage by weight: 0.1-40 percent of dangshen, 0.1-40 percent of glossy privet fruit, 0.1-40 percent of white paeony root, 0.1-40 percent of Chinese angelica, 0.1-40 percent of barbary barbary wolfberry fruit fruit, 0.1-40 percent of red date, 0.1-40 percent of dried orange peel, 0.1-40 percent of donkey-hide gelatin, 0.1-40 percent of black-bone chicken oligopeptide (black-bone chicken albumen powder), 0.1-40 percent of ferrous gluconate and 0-50 percent of auxiliary material. In the invention, hemopoietics such as Chinese angelica, glossy privet fruit, white paeony root, donkey-hide gelatin, barbary barbary wolfberry fruit fruit, dangshen and the like which are frequently used in the traditional Chinese medical science and can be used for effectively improving the nutritional anemia, black-bone chicken oligopeptide (black-bone chicken albumen powder) with a hematinic function and ferrous gluconate needed for hemogenesis are compounded scientifically, and synergistic actions are played, so that a Chinese medicinal composition formula with a function of improving the nutritional anemia is obtained.
Description
Technical field
The present invention relates to the field of Chinese medicines, have Chinese medicine composition of improving the nutritional anemia function and preparation method thereof more specifically to a kind of.
Background technology
Nutritional anemia is meant because of the necessary nutrient substance of body hemopoietic; As; Relative or the absolute minimizings of material such as ferrum, folic acid, vitamin D; Make formation or the erythrocytic generation of hemoglobin not enough, so that a kind of disease under the hemopoietic function, the relatively poor patient of absorption of nutrient ingredients due to the infant that is mainly in 6 months to 2 years old, trimester of pregnancy or the diseases such as women breast-feeding their children and gastrointestinal tract.
Modern medicine is divided into two kinds of small cell anemia and macrocytic anemia to primary disease.The former also makes iron deficiency anemia Chinese medicine belong to primary disease categories such as " asthenia ", " blood deficiency ".Think that blood derives from spleen, at all at kidney and relate to the heart, liver two is dirty.If weakness of the spleen and stomach, inability of food and drink to be digested and transported is precise and tiny, and source of generating QI and blood is not enough, produces anemia.The blood deficiency the five internal organs lose supports, and just diseases such as deficiency of heart-blood, both liver and kidney deficiency can occur.Common sympton is that the primary disease onset is slower, and the lighter shows as skin, mucosal pallor or greenish yellow, and is more obvious with positions such as lip, dental bed, eyelid, fingernails.Serious anemia is visible dizzy, malaise, and dysphoria, inappetence etc., infant are often with malnutrition.What have soil block, cinder, wall mud etc. also occur eating.Anemia is of a specified duration excessively, can cause dysplasia.
Summary of the invention:
The objective of the invention is on the basis of existing theory of Chinese medical science; Adopt the traditional Chinese medical science often to use hematonic such as Radix Angelicae Sinensis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Colla Corii Asini, Fructus Lycii, Radix Codonopsis etc. can effectively improve the Chinese medicine of nutritional anemia and Gallus Domesticus oligopeptide (having another name called the dark egg white lead) and hemopoietic desired substance Ferrous gluconate that interpolation has blood nourishing function; The science of carrying out compatibility; Bring into play its mutual synergism, thereby obtain a kind of Chinese medicine composition composition formula that improves the nutritional anemia function that has.
Another object of the present invention is to provide a kind of method for preparing of Chinese medicine preparation.
Chinese medicine composition of the present invention, count by weight percentage and comprise following component:
Radix Codonopsis 0.1%～40%, Fructus Ligustri Lucidi 0.1%～40%, the Radix Paeoniae Alba 0.1%～40%; Radix Angelicae Sinensis 0.1%～40%, Fructus Lycii 0.1%～40%, Fructus Jujubae 0.1%～40%; Pericarpium Citri Reticulatae 0.1%～40%, Colla Corii Asini 0.1%～40%, Gallus Domesticus oligopeptide (having another name called the dark egg white lead) 0.1%～40%; Ferrous gluconate 0.1%～40%, adjuvant 0%～50%.
Above-mentioned Chinese medicine composition; Described adjuvant comprises Fruit powder 0.0%～50%, edible essence 0.0%～50%, sweeting agent 0.0%～50%, acidic flavoring agent 0.0%～50%, filler 0.0%～50%, lubricant 0.0%～50%, antiseptic 0.0%～50%, suspending agent 0.0%～50%, food coloring 0.0%～50%, diluent 0.0%～50%%, plasticizer 0.0%～50%, processes peroral dosage form.
Said Fruit powder is by one or more mixing that are selected from orange powder, Fructus Citri Limoniae powder, cherry powder, Fructus Mali pumilae powder and the coconut palm powder; Said edible essence is by one or more mixing that are selected from orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence and the cocoanut flavour; Said sweeting agent is by one or more mixing that are selected from sucralose, acesulfame potassium, aspartame, mogroside and the neotame; Said acidic flavoring agent is by one or more mixing that are selected from citric acid, malic acid, lactic acid and the citric acid; Described filler is by one or more mixing that are selected from erythritol, fructose, sugar alcohol, sucrose, starch and the dextrin; Said lubricant is by one or more mixing that are selected from Pulvis Talci, magnesium stearate, silicon dioxide and the stearic acid; Said antiseptic is by one or more mixing that are selected from sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben and the P-hydroxybenzoic acid phenyl ester; Said suspending agent is by one or more mixing that are selected from sodium carboxymethyl cellulose, sodium alginate and the Cera Flava; Described food coloring is by one or more mixing that are selected from burnt sugar coloring, Gardenia Yellow, curcumin and the chlorophyll; Said diluent is by one or more mixing that are selected from vegetable oil, propylene glycol and the Polyethylene Glycol; Said plasticizer is by one or more mixing that are selected from glycerol, sodium carboxymethyl cellulose, sorbitol and the oleamide sodium sulfonate.
Above-mentioned Chinese medicine composition, said peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
The method for preparing of above-mentioned Chinese medicine composition; With Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae mixed material feeding, water decocts, and filters; Concentrate; Make concentrated solution, make extract powder and Colla Corii Asini, Ferrous gluconate, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), each adjuvant after the drying and mix and get final product.
The method for preparing of above-mentioned Chinese medicine composition can be directly carried out mixing preparation with extract and Colla Corii Asini, Ferrous gluconate, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), each adjuvant of Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae.
Above-mentioned Chinese medicine composition can acceptable auxiliary be processed various peroral dosage forms on bromatology, like powder, granule, tablet, hard capsule, soft capsule and oral liquid.
Above-mentioned Chinese medicine composition can be processed various dosage forms by acceptable composition on bromatology, like powder, granule, tablet, hard capsule, soft capsule, oral liquid.
Advantage of the present invention is: Chinese medicine belongs to nutritional anemia categories such as " asthenia ", " blood deficiency ".This Chinese medicine composition is according to the traditional Chinese medical science understanding and the corresponding rule of treatment of " asthenia " and " blood deficiency " to be started with; The sweet Wen Zhirun of Radix Angelicae Sinensis, replenishing blood and nourishing liver, regulating menstruation by adjusting the flow of blood, the sweet matter of Radix Paeoniae Alba acid softens, nourishes blood and hold back liver, sweet temperature of Radix Angelicae Sinensis and the cloudy gentle association mutually of the Radix Paeoniae Alba; Nourishing YIN and benefiting blood is monarch drug altogether; Fructus Ligustri Lucidi, the equal sweet in the mouth property of Fructus Lycii are put down, and return liver, kidney channel, nourishing the liver and kidney, and Radix Codonopsis, the flat sweet in the mouth of Fructus Jujubae property, invigorating the spleen and replenishing QI is nourished blood; Colla Corii Asini nourishes blood and enriches blood, and Pericarpium Citri Reticulatae is hot to loose, and regulating functional activities of qi cooperates all medicines, blood is full of does not stagnate; Fructus Ligustri Lucidi, Fructus Lycii, Radix Codonopsis, Fructus Jujubae, Colla Corii Asini, Pericarpium Citri Reticulatae are ministerial drug altogether, help Radix Angelicae Sinensis, the Radix Paeoniae Alba to enrich blood, while nourishing the liver and kidney, beneficial smart hemopoietic; Benefiting QI and nourishing blood, regulating qi-flowing for strengthening spleen adds the Gallus Domesticus oligopeptide (having another name called the dark egg white lead) and the hemopoietic desired substance Ferrous gluconate of enriching blood, all medicine compatibilities; Be association of activity and inertia, coordination of potent and mild therapies, thereby tonify without causing stagnation are truly transferred the good recipe of blood for enriching blood.
Radix Angelicae Sinensis can promote peripheral red blood cells, leukocyte, hemoglobin equal size to increase, and the hemopoietic function of bone marrow that causes because of chemicals, radiation exposure is suppressed, and promotes that hemopoietic function is more remarkable; The key medicine of the Radix Paeoniae Alba for enriching blood, have enrich blood and with the effect of blood vessels.Radix Paeoniae Alba water extract has certain protective role to expeirmental myocardial ischemia, can increase the intake of mouse cardiac muscle to Rb, and mouse cardiac muscle nutrient flow amount is improved; The administration of 8 times of amounts of Radix Codonopsis polysaccharide can significantly increase endogenous spleen tuberosity number, and the prompting Radix Codonopsis polysaccharide has facilitation to the compensatory hemopoietic function of spleen; Fructus Ligustri Lucidi has antiplatelet aggregation, blood sugar lowering, blood fat reducing, protects the liver, the anti-ageing effects such as pharmacological action and leukocyte increasing of waiting for a long time; Fructus Lycii can be improved hemopoietic function, and its decoct has facilitation to the hemopoietic function of normal mouse, can make lymphocytosis; Method with blood-letting causes dog and rabbit hemorrhagic anemia, and hemoglobin and erythrocyte number all obviously reduce, and after the Colla Corii Asini treatment hemogram is obviously improved, and Colla Corii Asini also can make lose blood rabbit leukocyte and platelet count obviously increase; The Fructus Jujubae sweet in the mouth is fragrant and sweet, and unique flavor not only contains rich nutrient contents, but also anemia is had therapeutical effect; The Gallus Domesticus n-hexane extract levels such as empty mouse red blood cell, leukocyte, hemoglobin that can raise have blood tonification effect.Pericarpium Citri Reticulatae is ministerial drug in we, mainly act as regulating functional activities of qi, " qi being the governor of blood ", circulation of qi promoting in numerous tonics, tonify without causing stagnation, motion in quiescence is beneficial to and enriches blood.Ferrum is to constitute hemoglobin, MG Myoglobin HMYO, and the main component of cytochrome and other enzyme systems has important physical nutrition and clinical meaning.Ferrous gluconate is organic ferrous salt, odorless, tasteless, and water-soluble easy absorption does not have zest to stomach, is a kind of comparatively ideal organic iron supplement agent.
Description of drawings
Fig. 1 is the oral liquid preparation technology flow chart of Chinese medicine composition according to the invention;
Fig. 2 is the granule preparation technology flow chart of Chinese medicine composition according to the invention;
Fig. 3 is the hard capsule preparation technology flow chart of Chinese medicine composition according to the invention;
Fig. 4 is the tablet producing technology flow chart of Chinese medicine composition according to the invention;
Fig. 5 is the powder preparation technology flow chart of Chinese medicine composition according to the invention;
Fig. 6 is the soft capsule preparation process chart of Chinese medicine composition according to the invention.
The specific embodiment
Embodiment one: the method for preparing of the oral liquid of Chinese medicine composition according to the invention, and as shown in Figure 1.
Take by weighing each component according to following percentage by weight:
With all raw material decoction pieces after the assay was approved, clean, subsequent use; Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter, obtain concentrated solution, leave standstill; Filter; Add Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, erythritol, Fructus Citri Limoniae essence, malic acid, sodium benzoate, vitamin C, aspartame, purified water mix homogeneously, go up the filling machine fill behind the instantaneous sterilizing, get final product after the sterilization.
Embodiment two: the preparation of the granule of Chinese medicine composition according to the invention, and as shown in Figure 2.
Take by weighing each component according to following percentage by weight:
With all raw material decoction pieces after the assay was approved; Subsequent use; Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter, obtain concentrated solution, add the dextrin spray drying and make extract powder; Adding Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, dextrin, Fructus Mali pumilae powder, citric acid, silicon dioxide, aspartame mix homogeneously are granulated, dry, granulate, get final product after total the mixing.
Embodiment three: the preparation of the hard capsule of Chinese medicine composition according to the invention, and as shown in Figure 3.
Take by weighing each component according to following percentage by weight:
With all raw material decoction pieces after the assay was approved, subsequent use, Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter; Obtain concentrated solution, make total extract powder, add Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, magnesium stearate; Mix, granulate granulate; Fill gets final product.
Embodiment four: the preparation of the tablet of Chinese medicine composition according to the invention, and as shown in Figure 4.
Take by weighing each component according to following percentage by weight:
With all raw material decoction pieces after the assay was approved, subsequent use, Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter, obtain concentrated solution; Make total extractum; Add Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, dextrin, hydroxyl isomaltulose, orange powder, cherry essence, mogroside, magnesium stearate, silicon dioxide mix homogeneously; Last granulator is granulated, drying, granulate; Go up the tablet machine tabletting then, get final product.
Embodiment five: the preparation of the powder of Chinese medicine composition according to the invention, and as shown in Figure 5.
Take by weighing each component according to following percentage by weight:
With all raw material decoction pieces after the assay was approved, subsequent use, Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter, obtain concentrated solution; Add the dextrin spray drying and make extract powder, add Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, erythritol, oligofructose, Fructus Citri Limoniae essence, silicon dioxide, malt extract, aspartame, behind the mix homogeneously, get final product.
Embodiment six: the preparation of soft capsule of Chinese medicine composition according to the invention, and as shown in Figure 6.
Take by weighing each component according to following percentage by weight:
Glue: gelatin 46%, glycerol 16%,
Purified water 37%, burnt sugar coloring 0.8%
Ethylparaben 0.2%
With all raw material decoction pieces after the assay was approved; Subsequent use; Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae are carried out water extraction, concentrate, filter, obtain concentrated solution, add the dextrin spray drying and obtain the cream powder; The Colla Corii Asini, Gallus Domesticus oligopeptide (having another name called the dark egg white lead), Ferrous gluconate, soybean oil, the Cera Flava that take by weighing capacity are processed suspended matter after mixing; With processing rubber behind gelatin, glycerol, purified water, burnt sugar coloring, the ethylparaben mixing, the fill of content suspended matter is pressed into soft capsule, get final product after washing ball, drying.
Get the granule in the embodiment of the invention two, carry out the test of safety toxicological evaluation according to " health food check and assessment technique standard " (2003 editions) pertinent regulations:
Experimental result shows, (1) acute oral toxicity test: the maximum tolerated dose (MTD) of, male mice female to the Kunming kind belongs to nontoxic level greater than 20.00g/kgbw;
(2) three genetic toxicity tests: Salmonella reversion test, PCEMNR micronucleus test result, mouse sperm deformity result of the test are all negative;
Fed the result in (3) 30 days: the ratio with 2.35%, 5.00%, 10.00% is mixed feedstuff with sample and is given rat feeding 30 days; Experimental session; Animal growth is good; Each dose groups body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ weights and internal organs/body weight ratio and matched group compare, no explicitly difference (P＞0.05).Gross anatomy is not seen the obviously abnormal change relevant with sample with tissue pathology checking.Point out this granule to feed in 30 days rat is not seen obvious toxic-side effects;
Toxicological evaluation test explanation: avirulence of the present invention.
Get the granule in the embodiment of the invention two, the evaluation methodology according to " health food check and assessment technique standard " (version in 2003), improve nutritional anemia function animal experiment:
Result of the test shows: under this laboratory condition; Per os gives anemia rat model 1.67g/kgbw;, 3.33g/kgbw, 6.67g/kgbw dosage this sample after, 3.33g/kgbw, 6.67g/kgbw dose groups rat hemoglobin and low ferrum matched group comparing difference have significance (P＜0.05); The evaluation of three dose groups rat hemoglobin rising amplitudes reaches more than the 10g/L; 6.67g/kgbw free protoporphyrin and matched group comparing difference have significance (P＜0.05) in the dose groups erythrocyte.Point out this sample to have the animal nutritional of improvement anemia function.
Get the granule in the embodiment of the invention 2, the evaluation methodology according to " health food check and assessment technique standard " (version in 2003), improve nutritional anemia function human feeding trial:
Result of the test shows: behind the sample of trial edition product, the test group hemoglobin is compared with matched group and before testing, and difference has significance (P＜0.05), and relatively preceding with test, rising value＞10.0g/L; Free protoporphyrin lowering of concentration in test group crowd's erythrocyte and is compared before matched group and the test, and difference has significance (P＜0.05); SF is not seen change (P＞0.05) after the test-meal.According to the judgment criteria of regulation in " health food check and assessment technique standard " (version in 2003), point out this product to have the nutritional anemia of improvement function (adult).
Claims (7)
1. one kind has the Chinese medicine composition that improves the nutritional anemia function, counts by weight percentage to comprise following component:
Radix Codonopsis 0.1%～40%, Fructus Ligustri Lucidi 0.1%～40%, the Radix Paeoniae Alba 0.1%～40%; Radix Angelicae Sinensis 0.1%～40%, Fructus Lycii 0.1%～40%, Fructus Jujubae 0.1%～40%; Pericarpium Citri Reticulatae 0.1%～40%, Colla Corii Asini 0.1%～40%, Gallus Domesticus oligopeptide 0.1%～40%; Ferrous gluconate 0.1%～40%, adjuvant 0%～50%.
2. Chinese medicine composition according to claim 1 is characterized in that: described adjuvant comprises following component by weight percentage:
Fruit powder 0.0%～50%, edible essence 0.0%～50%, sweeting agent 0.0%～50%, acidic flavoring agent 0.0%～50%, filler 0.0%～50%, lubricant 0.0%～50%, antiseptic 0.0%～50%, suspending agent 0.0%～50%, food coloring 0.0%～50%, diluent 0.0%～50%%, plasticizer 0.0%～50%.
3. Chinese medicine composition according to claim 2 is characterized in that: said Fruit powder is by one or more mixing that are selected from orange powder, Fructus Citri Limoniae powder, cherry powder, Fructus Mali pumilae powder and the coconut palm powder; Said edible essence is by one or more mixing that are selected from orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence and the cocoanut flavour; Said sweeting agent is by one or more mixing that are selected from sucralose, acesulfame potassium, aspartame, mogroside and the neotame; Said acidic flavoring agent is by one or more mixing that are selected from citric acid, malic acid, lactic acid and the citric acid; Described filler is by one or more mixing that are selected from fructose, sugar alcohol, sucrose, starch and the dextrin; Said lubricant is by one or more mixing that are selected from Pulvis Talci, magnesium stearate, silicon dioxide and the stearic acid; Said antiseptic is by one or more mixing that are selected from sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben and the P-hydroxybenzoic acid phenyl ester; Said suspending agent is by one or more mixing that are selected from sodium carboxymethyl cellulose, sodium alginate and the Cera Flava; Described food coloring is by one or more mixing that are selected from burnt sugar coloring, Gardenia Yellow, curcumin and the chlorophyll; Said diluent is by one or more mixing that are selected from vegetable oil, propylene glycol and the Polyethylene Glycol; Said plasticizer is by one or more mixing that are selected from glycerol, sodium carboxymethyl cellulose, sorbitol and the oleamide sodium sulfonate.
4. the method for preparing of the described Chinese medicine composition of claim 1; It is characterized in that: choose Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae mixed material feeding, water decocts, and filters; Concentrate; Make concentrated solution, make extract powder and Colla Corii Asini, Ferrous gluconate, Gallus Domesticus oligopeptide and adjuvant mixing after the drying and get final product.
5. the method for preparing of Chinese medicine composition according to claim 1 is characterized in that: directly carry out mixing preparation with extract and Colla Corii Asini, Ferrous gluconate, Gallus Domesticus oligopeptide and the adjuvant of choosing Radix Codonopsis, Fructus Ligustri Lucidi, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Fructus Lycii, Fructus Jujubae, Pericarpium Citri Reticulatae.
6. Chinese medicine composition according to claim 1 is characterized in that: described Chinese medicine composition is prepared to peroral dosage form.
7. Chinese medicine composition according to claim 6 is characterized in that: said peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
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| CN104161896A (en) * | 2014-08-16 | 2014-11-26 | 赵学科 | Medicine composition for treating anemia |
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| CN104397812A (en) * | 2014-11-28 | 2015-03-11 | 哈尔滨墨医生物技术有限公司 | Compound oral liquid for improving alimentary anemia and production method thereof |
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| CN109806382A (en) * | 2019-01-29 | 2019-05-28 | 南昌大学 | A kind of composition of Gallus domesticlus brisson peptide and its application in the health food of preparation prevention and treatment dysmenorrhea and gynaecological imflammation, food, drug |
| CN109806382B (en) * | 2019-01-29 | 2022-06-14 | 南昌大学 | A gallus Domesticus peptide composition and its application in preparing medicines for treating dysmenorrhea |
| CN114129647A (en) * | 2021-12-08 | 2022-03-04 | 江西广恩和药业股份有限公司 | Oral liquid and preparation method thereof |
| CN114129647B (en) * | 2021-12-08 | 2022-11-25 | 江西广恩和药业股份有限公司 | Oral liquid and preparation method thereof |
| CN114431352A (en) * | 2022-03-11 | 2022-05-06 | 聊城大学 | Preparation process of donkey-derived donkey-hide gelatin-containing blood-enriching nutritional paste for pet dogs and cats |
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Effective date of registration: 20170126 Address after: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee after: Perfect (China) Co., Ltd. Patentee after: Perfect (Guangdong) Commodity Co., Ltd. Address before: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee before: Perfect (China) Co., Ltd. |