CN102393382A - Rapid spectral detection system for frequency-domain optical coherence tissue tomography - Google Patents
Rapid spectral detection system for frequency-domain optical coherence tissue tomography Download PDFInfo
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- CN102393382A CN102393382A CN2011103847302A CN201110384730A CN102393382A CN 102393382 A CN102393382 A CN 102393382A CN 2011103847302 A CN2011103847302 A CN 2011103847302A CN 201110384730 A CN201110384730 A CN 201110384730A CN 102393382 A CN102393382 A CN 102393382A
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Abstract
A rapid spectral detection system for frequency-domain optical coherence tissue tomography comprises a pedestal, and a spectral collimating unit, a spectral separating and adjusting unit, a spectral imaging unit, and a spectral signal acquisition unit which are orderly disposed on the pedestal; the pedestal has a V-shaped structure which comprises a first pedestal and a second pedestal, wherein the first pedestal is shorter than the second pedestal; the spectral collimating unit is disposed at the end part of the first pedestal; the spectral separating and adjusting unit is disposed at the joint of the first pedestal and the second pedestal; the spectral imaging unit is disposed on the second pedestal and is close to the spectral separating and adjusting unit; the spectral signal acquisition unit is disposed at the end part of the second pedestal. The invention can rapidly realize a structural parameter optimization adjustment scheme of spectral detection, allows the output of the spectrometer to reach an optimal state, and thus meets the requirements for precision and sensitivity of the OCT system detection.
Description
Technical field
The present invention relates to a kind of spectral detection system, particularly relating to a kind of is the basis with FD-OCT, can extract the quick spectrum detection system that domain optical coherence is organized tomography that is used for the information-related interference spectrum of tissue depth.
Background technology
OCT (Optical coherence tomography) is the harmless biomedical imaging technology of a kind of high resolving power that grows up the beginning of the nineties in last century; In conjunction with multiple technologies such as low coherence interference technology, confocal microscopy, Digital Image Processing, its along track resolution can reach several microns.Because OCT utilizes harmless infrared light to make light source, do not contact, not damaged can be realized fast imaging and real-time monitoring and other advantages, the application of succeeding in biological tissue tomography field.
Along with the develop rapidly of OCT technology, based on technological because the lag line sweep velocity is limit with the time domain OCT that obtains tissue depth information through lag line scanning, the defective that exists image taking speed to meet clinical needs is replaced by frequency domain OCT technology gradually.Frequency domain OCT is also referred to as Fourier territory OCT, has two kinds of technology types.A kind of SLD wideband light source and frequency spectrograph and CCD camera technique of being based on is called FD-OCT.Another kind has adopted narrow-band frequency-sweeping light source and photodiode technologies, is called Sweep Source OCT (SD-OCT).The sampling rate of FD-OCT is by the data read rate decision of line array CCD, and the image taking speed of SD-OCT is decided by the frequency sweep frequency of light source.Along with development of electronic technology; Adopt the line read rate of the CCD line-scan digital camera of CMOS technology can reach KHz/S up to a hundred at present; Can realize the high speed data transfer of camera and intercomputer prerequisite being provided in conjunction with the image pick-up card that adopts Camera-Link host-host protocol interface for the quick 3D of OCT system forms images.
Summary of the invention
Technical matters to be solved by this invention is, provides a kind of and can make the output of spectrometer reach optimum condition, thereby satisfy the quick spectrum detection system that domain optical coherence is organized tomography that is used for of OCT system accuracy of detection and sensitivity requirement.
The technical scheme that the present invention adopted is: a kind ofly be used for the quick spectrum detection system that domain optical coherence is organized tomography; Include pedestal; Be successively set on spectrum collimation unit, spectral separation adjustment unit, light spectrum image-forming unit and spectral signal collecting unit on the pedestal; The V font structure that described pedestal is made up of first pedestal and second pedestal, wherein, described first pedestal is shorter than second pedestal; Described spectrum collimation unit is arranged on the end of first pedestal; Described spectral separation adjustment unit is arranged on first pedestal and the second pedestal intersection, and described light spectrum image-forming unit is arranged on second pedestal and closes on the spectral separation adjustment unit, and described spectral signal collecting unit is arranged on the end of second pedestal.
The angle of the described V font structure of being made up of first pedestal and second pedestal is 110～130 degree.
Described spectrum collimation unit includes: the collimating mirror tube stent that is fixed on first base ends; Be arranged on the collimation lens barrel on the collimating mirror tube stent; Be arranged on the optical fiber input interface of collimation lens barrel front port, be arranged on collimating mirror group and the collimating mirror trim ring that is used for fixing the collimating mirror group in the collimating mirror tube rear end mouth.
Described spectral separation adjustment unit includes: the grating adjusting gear pedestal that is fixed on first pedestal and the second pedestal intersection; Be arranged on the grating Y axle rotation adjustment axle tray rack on the grating adjusting gear pedestal; Be arranged on grating X axle and Z axle rotary fine adjustment pallet on the grating Y axle rotation adjustment axle tray rack; Be arranged on the grating dish pedestal on grating X axle and the Z axle rotary fine adjustment pallet; Be installed in the grating Z axle rotation adjustment dish on the grating dish pedestal; And being installed in the diffraction grating on the grating Z axle rotation adjustment dish, described grating Y axle rotation is adjusted on the axle tray rack and is positioned at the forward and backward monosymmetric X of the being provided with axle and the Z axle rotary fine adjustment screw of grating X axle and Z axle rotary fine adjustment pallet.
Described X axle and Z axle rotary fine adjustment screw on grating Y axle rotation adjustment axle tray rack symmetry be provided with 3 pairs.
Described light spectrum image-forming unit includes: be fixed on the camera objective lens support on second pedestal; Be fixed on the objective lens focusing drawtube on the camera objective lens support; Be installed in the light spectrum image-forming objective lens on the objective lens focusing drawtube, and be arranged on the object lens trim ring that is used for fixing the light spectrum image-forming objective lens on the objective lens focusing drawtube.
Described spectral signal collecting unit includes the line-scan digital camera support that is fixed on second pedestal, is arranged on second pedestal also through the line-scan digital camera of screw retention on the line-scan digital camera support.
Of the present inventionly be used for the quick spectrum detection system that domain optical coherence is organized tomography; To carry out spectral evolution from the interference modulations spectral signal that has tissue depth information that sample arm and reference arm return and spectral signal will be gathered through the high-speed CCD line-scan digital camera; The spectroscopic data of gathering is realized the high speed data transfer of camera and intercomputer through the image pick-up card that adopts Camera-Link host-host protocol interface, and then realizes organizing fast tomography.Can make things convenient for the structure parameter optimizing adjustment scheme of Rapid Realization spectral detection, make the output of spectrometer reach optimum condition, thereby satisfy OCT system accuracy of detection and sensitivity requirement.
Description of drawings
Fig. 1 is an one-piece construction synoptic diagram of the present invention;
Fig. 2: the output spectrum control curve that input spectrum and spectral detection of the present invention system are detected,
Among the figure, (a) input spectrum; (b) output spectrum.
Wherein:
1: optical fiber input interface 2: the collimation lens barrel
3: collimating mirror tube stent 4: the collimating mirror group
5: collimating mirror trim ring 6: grating adjusting gear pedestal
7: grating Y axle rotation adjustment axle tray rack 8: grating X axle and Z axle rotary fine adjustment pallet
9:X axle and Z axle rotary fine adjustment screw 10: grating dish pedestal
11: grating Z axle rotation adjustment dish 12: diffraction grating
13: camera objective lens support 14: the objective lens focusing drawtube
15: light spectrum image-forming objective lens 16: the object lens trim ring
17: line-scan digital camera support 18: the camera fixing screw
19: line-scan digital camera 20: line array CCD
21: pedestal
Embodiment
Organize the quick spectrum detection system of tomography to make detailed description below in conjunction with embodiment and accompanying drawing to the domain optical coherence that is used for of the present invention.
Of the present inventionly be used for the quick spectrum detection system that domain optical coherence is organized tomography; Be to be the basis with FD-OCT; The spectral detection system of a kind of optical coherent chromatographic imaging of designing is in order to the extraction detection system of the information-related interference spectrum of extraction and tissue depth.The signal output of this system send computing machine to carry out data processing through data collecting card, and then organizes tomography.
As shown in Figure 1; Of the present inventionly be used for the quick spectrum detection system that domain optical coherence is organized tomography; Include pedestal 21; Be successively set on spectrum collimation unit A, spectral separation adjustment unit B, light spectrum image-forming unit C and spectral signal collecting unit D on the pedestal 21, the V font structure that described pedestal 21 is made up of first pedestal 211 and second pedestal 212, the angle of the described V font structure of being made up of first pedestal 211 and second pedestal 212 is 110～130 degree.Wherein, Described first pedestal 211 is shorter than second pedestal 212; Described spectrum collimation unit A is arranged on the end of first pedestal 211; Described spectral separation adjustment unit B is arranged on first pedestal 211 and second pedestal, 212 intersections, and described light spectrum image-forming unit C is arranged on second pedestal 212 and closes on spectral separation adjustment unit B, and described spectral signal collecting unit D is arranged on the end of second pedestal 212.
Described spectrum collimation unit A includes: the collimating mirror tube stent 3 that is fixed on first pedestal, 211 ends; Be arranged on the collimation lens barrel 2 on the collimating mirror tube stent 3; Be arranged on the optical fiber input interface 1 of collimation lens barrel 2 front ports, be arranged on collimating mirror group 4 and the collimating mirror trim ring 5 that is used for fixing collimating mirror group 4 in collimation lens barrel 2 rear ports.
Above-mentioned optical fiber input interface adopts the form of FC/PC or FC/APC to be used for the interference modulations spectral signal that has tissue depth information that returns from sample arm and reference arm is incorporated into the spectral detection system.The collimating mirror group collimates the interference modulations spectral signal that has tissue depth information of optical fiber output, and it is relevant with the imaging scope and the required spectral measurement ranges of selected camera that the focal length of collimating mirror group is chosen.
Described spectral separation adjustment unit B includes: the grating adjusting gear pedestal 6 that is fixed on first pedestal 211 and second pedestal, 212 intersections; Be arranged on the grating Y axle rotation adjustment axle tray rack 7 on the grating adjusting gear pedestal 6; Be arranged on grating X axle and Z axle rotary fine adjustment pallet 8 on the grating Y axle rotation adjustment axle tray rack 7; Be arranged on the grating dish pedestal 10 on grating X axle and the Z axle rotary fine adjustment pallet 8; Be installed in the grating Z axle rotation adjustment dish 11 on the grating dish pedestal 10; And being installed in the diffraction grating 12 on the grating Z axle rotation adjustment dish 11, described grating Y axle rotation is adjusted on the axle tray rack 7 and is positioned at the forward and backward monosymmetric X of the being provided with axle and the Z axle rotary fine adjustment screw 9 of grating X axle and Z axle rotary fine adjustment pallet 8.Described X axle and Z axle rotary fine adjustment screw 9 on grating Y axle rotation adjustment axle tray rack 7 symmetry be provided with 3 pairs.
Above-mentioned grating Y axle is vertical with pedestal 21, grating X axle and pedestal 21 plane parallel and with optical grating diffraction grating 12 planes, grating Z axle and pedestal 21 plane parallel and vertical with diffraction grating 12 planes.
Above-mentioned spectrum collimation unit A will project diffraction grating 12 by certain incident angle through the input signal of collimation, and carry out spectral evolution by certain orientation.
Described light spectrum image-forming unit C includes: be fixed on the camera objective lens support 13 on second pedestal 212; Be fixed on the objective lens focusing drawtube 14 on the camera objective lens support 13; Be installed in the light spectrum image-forming objective lens 15 on the objective lens focusing drawtube 14, and be arranged on the object lens trim ring 16 that is used for fixing light spectrum image-forming objective lens 15 on the objective lens focusing drawtube 14.Described light spectrum image-forming objective lens is used for the spectral signal that launches is focused on the line array CCD of high speed linear array camera.
Described spectral signal collecting unit D includes the line-scan digital camera support 17 that is fixed on second pedestal 212, is arranged on second pedestal 212 and through screw 18 and is fixed on the line-scan digital camera 19 on the line-scan digital camera support 17.Described high-speed CCD line-scan digital camera carries out the spectral signal collection and extracts; Digital signal after extracting is realized the high speed data transfer of camera and intercomputer through the image pick-up card that adopts Camera-Link host-host protocol interface, and then realize organizing fast tomography.
Described spectral separation adjustment unit B, light spectrum image-forming unit C are used for optimizing and revising of spectral detection system.
Of the present inventionly be used for the quick spectrum detection system that domain optical coherence is organized tomography, the course of work is following:
The interference modulations spectral signal that has tissue depth information that returns from sample arm and reference arm is incorporated into spectral detection of the present invention system through optical fiber input interface 1; Collimating mirror group 4 collimates the interference modulations spectral signal that has tissue depth information of optical fiber output; Light beam behind the collimation projects diffraction grating 12 by certain incident angle; Transmission-type diffraction grating 12 will carry out spectral evolution by certain orientation through the input signal of collimation; The spectral signal that launches projects light spectrum image-forming objective lens 15; Light spectrum image-forming objective lens 15 focuses on the spectral signal that launches on the line array CCD 20 of high speed linear array camera 19; High-speed CCD line-scan digital camera 19 carries out the spectral signal collection and extracts, and the digital signal after extracting is realized the high speed data transfer of camera and intercomputer through the image pick-up card that adopts Camera-Link host-host protocol interface, and then realizes organizing fast tomography; Grating Y axle rotation adjustment axle tray rack 7 is used to adjust the incident angle of incoming signal; Grating X axle and Z axle rotary fine adjustment pallet 8 and X axle and Z axle rotary fine adjustment screw (6) 9 are used to finely tune grating along the inclination angle on X axle and the Z-direction; Grating Z axle rotation adjustment dish 11 is used to adjust grid stroke and X, Y axle clamp angle; Objective lens focusing drawtube 14, light spectrum image-forming objective lens 15 are used for spectral signal is focused on line array CCD 20.The output spectrum that input spectrum and camera is gathered through adjustment grating Y axle rotation adjustment axle tray rack 7, grating X axle and Z axle rotary fine adjustment pallet 8, X axle and Z axle rotary fine adjustment screw 9, grating Z axle rotation adjustment dish 11 and objective lens focusing drawtube 14 matches, thereby reaches the optimum detection effect.
The output spectrum control curve that Fig. 2 is detected for input spectrum and spectral detection of the present invention system.
Claims (7)
1. one kind is used for the quick spectrum detection system that domain optical coherence is organized tomography; It is characterized in that; Include pedestal (21); Be successively set on spectrum collimation unit (A), spectral separation adjustment unit (B), light spectrum image-forming unit (C) and spectral signal collecting unit (D) on the pedestal (21); The V font structure that described pedestal (21) is made up of first pedestal (211) and second pedestal (212), wherein, described first pedestal (211) is shorter than second pedestal (212); Described spectrum collimation unit (A) is arranged on the end of first pedestal (211); Described spectral separation adjustment unit (B) is arranged on first pedestal (211) and second pedestal (212) intersection, and described light spectrum image-forming unit (C) is arranged on second pedestal (212) and closes on spectral separation adjustment unit (B), and described spectral signal collecting unit (D) is arranged on the end of second pedestal (212).
2. according to claim 1ly be used for the quick spectrum detection system that domain optical coherence is organized tomography, it is characterized in that, the angle of the described V font structure of being made up of first pedestal (211) and second pedestal (212) is 110～130 degree.
3. according to claim 1ly be used for the quick spectrum detection system that domain optical coherence is organized tomography; It is characterized in that; Described spectrum collimation unit (A) includes: the collimating mirror tube stent (3) that is fixed on first pedestal (211) end; Be arranged on the collimation lens barrel (2) on the collimating mirror tube stent (3); Be arranged on the optical fiber input interface (1) of collimation lens barrel (2) front port, be arranged on the collimating mirror group (4) in collimation lens barrel (2) rear port and be used for fixing the collimating mirror trim ring (5) of collimating mirror group (4).
4. according to claim 1ly be used for the quick spectrum detection system that domain optical coherence is organized tomography; It is characterized in that; Described spectral separation adjustment unit (B) includes: the grating adjusting gear pedestal (6) that is fixed on first pedestal (211) and second pedestal (212) intersection; Be arranged on the grating Y axle rotation adjustment axle tray rack (7) on the grating adjusting gear pedestal (6); Be arranged on grating X axle and Z axle rotary fine adjustment pallet (8) on the grating Y axle rotation adjustment axle tray rack (7); Be arranged on the grating dish pedestal (10) on grating X axle and the Z axle rotary fine adjustment pallet (8); Be installed in the grating Z axle rotation adjustment dish (11) on the grating dish pedestal (10), and be installed in the diffraction grating (12) on the grating Z axle rotation adjustment dish (11), the forward and backward monosymmetric X of the being provided with axle and the Z axle rotary fine adjustment screw (9) of grating X axle and Z axle rotary fine adjustment pallet (8) gone up and be positioned to described grating Y axle rotation adjustment axle tray rack (7).
5. according to claim 4ly be used for the quick spectrum detection system that domain optical coherence is organized tomography, it is characterized in that, described X axle and Z axle rotary fine adjustment screw (9) are provided with 3 pairs what grating Y axle rotation adjustment axle tray rack (7) was gone up symmetry.
6. according to claim 1ly be used for the quick spectrum detection system that domain optical coherence is organized tomography; It is characterized in that; Described light spectrum image-forming unit (C) includes: be fixed on the camera objective lens support (13) on second pedestal (212); Be fixed on the objective lens focusing drawtube (14) on the camera objective lens support (13); Be installed in the light spectrum image-forming objective lens (15) on the objective lens focusing drawtube (14), and be arranged on the object lens trim ring (16) that is used for fixing light spectrum image-forming objective lens (15) on the objective lens focusing drawtube (14).
7. according to claim 1ly be used for the quick spectrum detection system that domain optical coherence is organized tomography; It is characterized in that; Described spectral signal collecting unit (D) includes the line-scan digital camera support (17) that is fixed on second pedestal (212), is arranged on second pedestal (212) and upward and through screw (18) is fixed on the line-scan digital camera (19) on the line-scan digital camera support (17).
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| CN 201110384730 CN102393382B (en) | 2011-11-28 | 2011-11-28 | Rapid spectral detection system for frequency-domain optical coherence tissue tomography |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103954359A (en) * | 2014-05-13 | 2014-07-30 | 哈尔滨工业大学（威海） | Zoom spectrograph with spectral measuring range and resolution ratio adjustable |
| CN107328740A (en) * | 2017-06-06 | 2017-11-07 | 中国科学院上海光学精密机械研究所 | Polarize domain optical coherence tomography spectroscopic calibration method |
| CN111521266A (en) * | 2020-04-23 | 2020-08-11 | 佛山科学技术学院 | Spectrometer light path building device |
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| CN202339324U (en) * | 2011-11-28 | 2012-07-18 | 天津迈达医学科技有限公司 | Fast spectrum detection system for frequency domain optical coherent texture tomography |
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Patent Citations (4)
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| US20010055462A1 (en) * | 2000-06-19 | 2001-12-27 | Seibel Eric J. | Medical imaging, diagnosis, and therapy using a scanning single optical fiber system |
| KR101011556B1 (en) * | 2009-03-02 | 2011-01-27 | 경북대학교 산학협력단 | Optical doppler tomography system and method for detecting Doppler frequency thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103954359A (en) * | 2014-05-13 | 2014-07-30 | 哈尔滨工业大学（威海） | Zoom spectrograph with spectral measuring range and resolution ratio adjustable |
| CN103954359B (en) * | 2014-05-13 | 2015-12-09 | 哈尔滨工业大学（威海） | A kind of spectral measurement ranges and the adjustable zoom spectrometer of resolution |
| CN107328740A (en) * | 2017-06-06 | 2017-11-07 | 中国科学院上海光学精密机械研究所 | Polarize domain optical coherence tomography spectroscopic calibration method |
| CN107328740B (en) * | 2017-06-06 | 2019-10-18 | 中国科学院上海光学精密机械研究所 | Polarize domain optical coherence tomography spectroscopic calibration method |
| CN111521266A (en) * | 2020-04-23 | 2020-08-11 | 佛山科学技术学院 | Spectrometer light path building device |
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