CN102382004B - Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen - Google Patents
Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen Download PDFInfo
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- CN102382004B CN102382004B CN201110238622.4A CN201110238622A CN102382004B CN 102382004 B CN102382004 B CN 102382004B CN 201110238622 A CN201110238622 A CN 201110238622A CN 102382004 B CN102382004 B CN 102382004B
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- paracetamol
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Abstract
The invention provides a decolorization pre-treatment system of acetaminophen and a decolorization pre-treatment method of the acetaminophen. The decolorization pre-treatment system comprises a material conveying device and a beating tank, wherein crude acetaminophen obtained by centrifugally separating a material obtained by acylation crystallization is conveyed to the beating tank by the material conveying device in a closed environment, and the crude acetaminophen and water are beat by the beating tank; a mixture containing the crude acetaminophen and the water which are beat by the beating tank is conveyed to a subsequent decolorization tank by a closed pipeline to be subjected to decolorization treatment. Through the decolorization pre-treatment system provided by the invention, the requirements of clean production are met, the cross contamination is avoided, and the requirements of the various cGMP (Current Good Manufacture Practices) certification are met; the decolorization effect of decolorization treatment is improved, the production schedule is accelerated, and the product quality is improved.
Description
Technical field
The present invention relates to the treatment system in a kind of paracetamol production process and treatment process, particularly a kind of decolouring preprocessing system and decolouring pre-treating process carrying out the decolouring pre-treatment of paracetamol.
Background technology
In the production process of current paracetamol, the material of acidylate crystallization is after whizzer is separated, and disposing mother liquor recycles, and solid materials all loads in sack placement of weighing, and after calculating weight, then drops into bleacher and decolours.
After leaving whizzer from solid materials, to the one section of process entered bleacher, we are referred to as pre-treatment of decolouring, and the relevant device related in this section of process is commonly referred to as decolouring preprocessing system.
According to current production technique, in this decolouring pretreatment process, above-mentioned scene of weighing is often that stain is heavy, disorderly and unsystematic, paracetamol crude product as solid materials does not carry out relevant technological process in airtight environment, is easily subject to crossed contamination, can not reaches the requirement of cleaner production, be difficult to the requirement meeting various cGMP (abbreviation of Current Good Manufacture Practices, i.e. dynamic Good manufacturing practice) certification.
And the decolorizing effect simply the paracetamol crude product measured input bleacher being carried out desolventing technology is also poor, the consumption, kind etc. of desolventing technology time or adjustment active carbon for decolorization is had to extend in order to improve decolorizing effect, bring corresponding trouble to follow-up technique, cause production schedule poor thus.
Summary of the invention
The object of the invention is to the shortcoming overcoming above-mentioned decolouring pretreatment process, realize the requirement of cleaner production, avoid crossed contamination, meet the requirement of various cGMP certification.
Another object of the present invention is that the improvement by the pre-treating technology that decolours improves the decolorizing effect of desolventing technology, and enhance production progress, improves the quality of products.
For this reason, the invention provides a kind of paracetamol decolouring preprocessing system, this system comprises: material conveyer; With making beating tank; the paracetamol crude product that wherein said material conveyer obtains after the material obtained acidylate crystallization is carried out centrifugation is delivered to described making beating tank under enclosed environment; described paracetamol crude product and water are pulled an oar by described making beating tank, and the mixture containing paracetamol crude product and water after described making beating tank completes making beating is delivered in follow-up bleacher by closed conduct and carries out desolventing technology.
In the present invention as stated above, preferred: described material conveyer is selected from auger, the endless belt conveyor of band seal bootr, the shaker conveyer of band seal bootr, the conveying skewed slot of band seal bootr.
In the present invention as stated above, preferred: also to comprise airtight feed bin (20), the paracetamol crude product obtained after centrifugation first by airtight discharging to described feed bin (20), then through described feed bin (20) by custody transfer to described material conveyer (30).
In the present invention as stated above, preferred: described making beating tank (40) is installed on weight sensor.
In the present invention as stated above, preferred: described water is the water being added to the steam condensate in described making beating tank (40) or being heated to 60 ~ 80 DEG C before described paracetamol crude product is transferred.
In the present invention as stated above, preferred: by inputting pressurized gas in described making beating tank, described mixture to be transported to described bleacher by closed conduit.
The present invention also provides a kind of decolouring pre-treating process of paracetamol, and the method comprises: the paracetamol crude product obtained after the material obtained acidylate crystallization is carried out centrifugation is delivered to the first conveying operation of making beating tank under enclosed environment; Utilize the pulping process that paracetamol crude product and water are pulled an oar by described making beating tank; With by making beating after paracetamol crude product and water mixture by closed conduct be delivered in follow-up bleacher carry out desolventing technology second conveying operation.
In the present invention as stated above, preferred: described first conveying operation carries out the custody transfer of described paracetamol crude product by the arbitrary equipment in the conveying skewed slot of the endless belt conveyor of auger, band seal bootr, the shaker conveyer of band seal bootr and band seal bootr.
In the present invention as stated above, preferably: described first conveying operation also comprises by first airtight for described paracetamol crude product discharging to airtight feed bin, then from described feed bin by the operation of custody transfer to described arbitrary equipment.
In the present invention as stated above, preferred: described making beating tank is installed on sensor for weighing.
In the present invention as stated above, preferred: described water is the water being added to the steam condensate in described making beating tank (40) or being heated to 60 ~ 80 DEG C before described paracetamol crude product is transferred.
In the present invention as stated above, preferred: in described second conveying operation, by inputting pressurized gas in described making beating tank, described mixture to be sent to described bleacher by closed conduit.
Invention effect
Decolouring in preprocessing system and pre-treating process according to paracetamol of the present invention, enclosed workshop can be realized from leaving whizzer to the whole pretreatment process before entering bleacher at solid materials, avoid crossed contamination, and improve decolorizing effect, enhance production progress by the stirring in making beating tank.And all equipment all operates by Automated condtrol, therefore save artificial, reduce the labour intensity of workman.
Accompanying drawing explanation
Fig. 1 is the formation schematic diagram of paracetamol of the present invention decolouring preprocessing system.
Nomenclature:
10 whizzers; 20 feed bins; 30 augers; 40 making beating tanks;
41 solid material inlet; 42 slurry outlets; 43 water inlets; 44 pressurized gas entrances;
21,45 agitators; 50 bleachers; 60 external water sources;
70 external compression gas sources; 1020,2030,3040,4050 connecting tubes.
Embodiment
Illustrate according to acetyl aminophenol decolouring preprocessing system of the present invention and decolouring pre-treating process below in conjunction with accompanying drawing.
First acetyl aminophenol decolouring preprocessing system according to preferred embodiment is described.
Fig. 1 is the signal pie graph of the acetyl aminophenol decolouring preprocessing system according to preferred embodiment.
As shown in Figure 1, paracetamol decolouring preprocessing system according to the present invention comprises: feed bin 20, and the feeding mouth of feed bin 20 is connected to the discharge port of whizzer 10; Auger 30, the feeding mouth of auger 30 is connected to the discharge port of feed bin 20; With making beating tank 40, this making beating tank 40 is provided with the solid material inlet 41 of the making beating tank 40 be connected with the discharge port of auger 30, the slurry outlet 42 of tank 40 of pulling an oar, the water inlet 43 be connected with external water source 60, the pressurized gas entrance 44 that is connected with external compression gas source 70.In addition, the slurry outlet 42 of making beating tank 40 is connected to the pulp inlet of bleacher 50.
In paracetamol decolouring preprocessing system according to the present invention, the volume of feed bin 20 can adjust according to the condition of production, to play the effect of transit warehouse, thus at the solid materials stopping still can receiving after conveying solid material in making beating tank from whizzer 10 output.
In actual production, whether arranging feed bin 20 can according to comparing and determining between the unit time load of whizzer 10 and the capacity of auger 30.Such as, self-stopping technology from auger 30 in making beating tank 40 conveying solid material on once restart from for some time to conveying solid material in making beating tank 40 of auger 30, iff when just can receive the solid materials exported from whizzer 10 during this period of time with auger 30, just can cancel the feed bin 20 as transit warehouse, directly the solid materials from whizzer 10 is delivered in auger 30.
In paracetamol decolouring preprocessing system according to the present invention, in order to make the solid materials in feed bin 20 evenly successfully enter in auger 30 via the discharge port of feed bin 20 and the feeding mouth of auger 30, in feed bin 20, agitator 46 can be installed.
In paracetamol decolouring preprocessing system according to the present invention, auger 30 is used for carrying particle or the even little lumpy material of pulverulent material.But as transporting the device of material, auger 30 can be substituted by the conveying skewed slot of the shaker conveyer of the endless belt conveyor of band seal bootr, band seal bootr, band seal bootr, and now, the device of these convey materials can be referred to as material conveyer.
It should be noted that at this, connecting tube 3040 between the discharge port of the connecting tube 1020 between the discharge port of whizzer 10 and the feeding mouth of feed bin 20, connecting tube 2030 between the discharge port of feed bin 20 and the feeding mouth of auger 30, auger 30 and the solid material inlet of making beating tank 40, connecting tube 4050 between the slurry outlet of making beating tank 40 and the pulp inlet of bleacher 50, all should be closed conduct, to ensure that the logistics corridor that solid materials comes out between bleacher 50 from whizzer 10 is not subject to outside contamination.
In addition, for the ease of controlling the flowing of material, above-mentioned connecting tube 1020, connecting tube 2030, connecting tube 3040, connecting tube 4050 can arrange control valve respectively, to control the break-make of the Flow of Goods and Materials in corresponding pipeline.Certainly, control valve is arranged in the middle of pipeline or pipe end, belongs to the common practise of this area, does not repeat them here.
In addition, the connection of connecting tube 1020 respectively and between the feeding mouth of the discharge port of whizzer 10 and feed bin 20 can be closed, the connection of connecting tube 2030 respectively and between the feeding mouth of the discharge port of feed bin 20 and auger 30 can be closed, the connection of connecting tube 3040 respectively and between the solid material inlet of the discharge port of auger 30 and tank 40 of pulling an oar can be closed, and the connection of connecting tube 4050 respectively and between the slurry outlet of making beating tank 40 and the pulp inlet of bleacher 50 can be closed.
In paracetamol decolouring preprocessing system according to the present invention, making beating tank 40 also can within it arrange agitator 45.
In paracetamol decolouring preprocessing system according to the present invention, external water source can be water source from the beginning.In alternative embodiments, consider that the difference in solubility of paracetamol crude product in hot water and cold water is large, external water source can be thermal water source, and the temperature of the hot water that thermal water source provides such as can be 60 ~ 80 DEG C.In alternative embodiments, external water source can be vapor condensation water source.Steam condensate in vapor condensation water source, refer to the water of condensation (sometimes industrial also claim it to be exhaust steam water) of the tail gas of steam-pipe, because the temperature of steam condensate often can reach 80 DEG C, just without the need to reheating during such use, thus the heat in steam condensate is utilized to reach energy-conservation object.First this water of condensation is collected in a storage tank, is transported in making beating tank time to be used by handling equipments such as pumps.
In addition, before solid materials joins making beating tank, just steam condensate is added to the technology of pulling an oar in tank although have employed in above-mentioned explanation, but in general, solid materials and steam condensate add also passable simultaneously, even first adding solid materials, to add steam condensate more also passable, specifically how to determine according to practical condition, for hot water, even cold water is as the same.
For the ease of weighing, can arrange weight sensor (not shown), weight sensor is positioned at below making beating tank 40, is seated on weight sensor to make making beating tank 40, thus the changes in weight of tank 40 of being pulled an oar by weight sensor sensing, to control the discharging of auger 30.In actual production, making beating tank 40 is generally provided with multiple journal stirrup and such as considers to arrange four (not shown) from the angle of balance in bottom, can arrange a weight sensor at each journal stirrup.Certain layout for weight sensor and quantity can adapt to shape, especially the bottom shape structure of making beating tank 40 and change (when tank 40 of such as pulling an oar is hoisting structures, sensor can be installed to the stressed place of hoisting structure, the effect of measuring the solids doses be transported in making beating tank can be played equally).
Decolouring in pre-treating process according to paracetamol of the present invention, the solid materials entering into making beating tank 40 can measure weight by weight sensor.Certainly consider water that the water inlet 43 be connected with external water source 60 enters can before solid materials enters tank 40 of pulling an oar, among or carry out afterwards, before enter making beating tank 40 at solid materials, water all adds fashionable, and weight sensor can be adopted separately to measure the weight of solid materials; If solid materials enter making beating tank 40 before water all do not add, a gauge being used for metering water quantity can be set between external water source 60 and water inlet 43.The solids doses entering making beating tank so just can be calculated by the take off data of the take off data of weight sensor and gauge.
In addition, all can seal bootr be set for feed bin 20, making beating tank 40, bleacher 50, to be isolated from the outside, avoids the crossed contamination from the external world.
Secondly, with reference to Fig. 1, the paracetamol decolouring pre-treating process of preferred embodiment is illustrated as follows.
In whizzer 10, centrifugation is carried out to the material (i.e. the mixture of mother liquor and paracetamol crude product) of acidylate crystallization; obtain solid materials (i.e. paracetamol crude product) and mother liquor, wherein mother liquor is discharged with recycling.
Above-mentioned solid materials enters into feed bin 20 via connecting tube 1020; Solid materials in feed bin 20 enters into auger 30 via connecting tube 2030; Auger 30 is started working and solid materials is moved to the discharge port of auger 30 in auger 30; Enter in making beating tank 40 from the discharge port solid materials out of auger 30 by connecting tube 3040; When the solid materials entering into making beating tank 40 reaches a certain amount of (deciding in the solubleness of water with reference to paracetamol crude product), stop auger 30 to the feeding of making beating tank 40, the feeding as feed bin 20 pairs of augers 30 can optionally stop or continuing.
Be delivered into making beating tank 40 from solid materials to start, just open the stirring (namely pulling an oar) of the agitator 45 in making beating tank 40, the stirring of making beating tank 40 is utilized the steam condensate be added in making beating tank 40 and solid materials to be mixed, after auger 40 stops feeding, generally stir such as 10 minutes for some time again, until stir into atherosclerotic slurry; After stopping stirring, pressurized gas is passed into via the pressurized gas entrance 44 be connected with external compression gas source, open the connecting tube 4050 between the slurry outlet 42 of making beating tank 40 and the pulp inlet of bleacher 50, via pressurized gas, slurry is sent in bleacher 50 from making beating tank 40.
Decolouring in pre-treating process according to paracetamol of the present invention, the agitator in making beating tank 40 starting in time having solid materials to join in making beating tank 40, also can be restarted when charging joins to a certain degree, specifically depending on the condition of production.
Decolouring in pre-treating process according to paracetamol of the present invention, the water yield joined in making beating tank 40 is account for whole making beating tank volume 25% ~ 33%.In one embodiment, the water yield is 2000-2500L, and solid materials is 1550-1850KG.
Comprehensively above-mentioned, decolouring in preprocessing system and pre-treating process according to paracetamol of the present invention, closed production can be realized from leaving whizzer 10 to the whole pretreatment process entered before bleacher 50 at solid materials, material does not expose in an atmosphere, achieve cleaner production, avoid crossed contamination, meet the requirement of domestic and international various cGMP certification.
Decolouring in preprocessing system and pre-treating process according to paracetamol of the present invention, entering before bleacher carries out desolventing technology, due to paracetamol crude product is stirred into atherosclerotic through making beating tank, so add the contact area of crude product material and active carbon for decolorization in follow-up desolventing technology process, decolorizing effect can be improved thus, enhance production progress.
In addition, decolouring in preprocessing system and pre-treating process according to paracetamol of the present invention, at solid materials from leaving whizzer 10 to the whole pretreatment process entered before bleacher 50, involved equipment all can be operated by Automated condtrol, therefore save artificial, reduce the labour intensity of workman.
Claims (9)
1. a decolouring preprocessing system for paracetamol, is characterized in that, this system comprises:
Material conveyer; With
Making beating tank (40),
Wherein, the paracetamol crude product that described material conveyer obtains after the material obtained acidylate crystallization is carried out centrifugation is delivered to described making beating tank (40) under enclosed environment,
Described paracetamol crude product and water are pulled an oar by described making beating tank,
The mixture containing paracetamol crude product and water after described making beating tank (40) completes making beating is delivered to by closed conduct in follow-up bleacher (50) and carries out desolventing technology,
Described material conveyer is selected from auger, the endless belt conveyor of band seal bootr, the shaker conveyer of band seal bootr, the conveying skewed slot of band seal bootr, is provided with the agitator of making beating in described making beating tank.
2. the decolouring preprocessing system of paracetamol as claimed in claim 1, is characterized in that:
Also comprise airtight feed bin (20), the paracetamol crude product obtained after centrifugation first by airtight discharging to described feed bin (20), then through described feed bin (20) by custody transfer to described material conveyer (30).
3. the decolouring preprocessing system of paracetamol as claimed in claim 1, is characterized in that:
Described making beating tank (40) is installed on weight sensor.
4. the decolouring preprocessing system of paracetamol as claimed in claim 1, is characterized in that:
Described water is the water being added to the steam condensate in described making beating tank (40) or being heated to 60 ~ 80 DEG C before described paracetamol crude product is transferred;
By inputting pressurized gas in described making beating tank, described mixture is sent to described bleacher by closed conduit.
5. a decolouring pre-treating process for paracetamol, it is characterized in that, the method comprises:
The paracetamol crude product obtained after the material obtained acidylate crystallization is carried out centrifugation is delivered to the first conveying operation of making beating tank (40) under enclosed environment;
Utilize the pulping process that paracetamol crude product and water are pulled an oar by described making beating tank (40); With
The mixture of the paracetamol crude product after making beating and water is delivered in follow-up bleacher (50) the second conveying operation of carrying out desolventing technology by closed conduct.
6. the decolouring pre-treating process of paracetamol as claimed in claim 5, is characterized in that:
Described first conveying operation carries out the custody transfer of described paracetamol crude product by the arbitrary equipment in the conveying skewed slot of the endless belt conveyor of auger (30), band seal bootr, the shaker conveyer of band seal bootr and band seal bootr.
7. the decolouring pre-treating process of paracetamol as claimed in claim 6, is characterized in that:
Described first conveying operation also comprises by first airtight for described paracetamol crude product discharging to airtight feed bin (20), then from described feed bin (20) by the operation of custody transfer to described arbitrary equipment.
8. the decolouring pre-treating process of paracetamol as claimed in claim 5, is characterized in that:
Described making beating tank (40) is installed on sensor for weighing.
9. the decolouring pre-treating process of paracetamol as claimed in claim 5, is characterized in that:
Described water is the water being added to the steam condensate in described making beating tank (40) or being heated to 60 ~ 80 DEG C before described paracetamol crude product is transferred,
In described second conveying operation, by inputting pressurized gas in described making beating tank, described mixture is sent to described bleacher by closed conduit.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110238622.4A CN102382004B (en) | 2011-08-19 | 2011-08-19 | Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110238622.4A CN102382004B (en) | 2011-08-19 | 2011-08-19 | Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen |
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| Publication Number | Publication Date |
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| CN102382004A CN102382004A (en) | 2012-03-21 |
| CN102382004B true CN102382004B (en) | 2015-03-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110238622.4A Active CN102382004B (en) | 2011-08-19 | 2011-08-19 | Decolorization pre-treatment system and decolorization pre-treatment method of acetaminophen |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102911076B (en) * | 2012-11-07 | 2015-09-02 | 河北冀衡（集团）药业有限公司 | Treatment unit after acetparaminosalol phenol treating and treatment process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061023A (en) * | 1990-11-01 | 1992-05-13 | 赫希斯特人造丝公司 | Improving one's methods of purification of acetaminophen |
| CN201249051Y (en) * | 2008-08-29 | 2009-06-03 | 安丘市鲁安药业有限责任公司 | Decoloration filtering device in a process for preparing paracetamol |
| CN202148270U (en) * | 2011-08-19 | 2012-02-22 | 河北冀衡（集团）药业有限公司 | Decoloration pretreatment system for paracetamol |
-
2011
- 2011-08-19 CN CN201110238622.4A patent/CN102382004B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061023A (en) * | 1990-11-01 | 1992-05-13 | 赫希斯特人造丝公司 | Improving one's methods of purification of acetaminophen |
| CN201249051Y (en) * | 2008-08-29 | 2009-06-03 | 安丘市鲁安药业有限责任公司 | Decoloration filtering device in a process for preparing paracetamol |
| CN202148270U (en) * | 2011-08-19 | 2012-02-22 | 河北冀衡（集团）药业有限公司 | Decoloration pretreatment system for paracetamol |
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Address after: 053000 No.1, Weiwu street, high tech Zone, Hengshui City, Hebei Province Patentee after: Hebei Jiheng Pharmaceutical Co.,Ltd. Address before: 053000 No.368 Jianshe North Street, Hengshui City, Hebei Province Patentee before: HEBEI JIHENG (Group) PHARMACEUTICAL Co.,Ltd. |
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