CN102380011B - Traditional Chinese medicine composition for treating polyarteritis nodosa - Google Patents
Traditional Chinese medicine composition for treating polyarteritis nodosa Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating polyarteritis nodosa, which is prepared from cassia twig, radix astragali, radix paeoniae alba, peach kernel, rhizoma atractylodis, green tangerine orange peel, prepared rhizoma cyperi, radix achyranthis bidentatae, lumbricus, scorpion, giant knotweed, pawpaw, centipede, honey-suckle stem and licorice root. The traditional Chinese medicine composition can be used for treating polyarteritis nodosa in clinic.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition for the treatment of polyarteritis nodosa.
Background technology
Polyarteritis nodosa claims again polyarteritis, or periarteritis nodosa, is in a kind of involving, arteriolar necrotizing vasculitis disease.Polyarteritis nodosa can involve any organ of human body, but it is the most common to get involved with skin, joint, peripheral nervous, gastrointestinal tract and kidney.The order of severity interindividual variation of pathological changes is very large.Polyarteritis nodosa can also be incorporated in other diseases such as rheumatoid arthritis, sjogren syndrome etc.According to the involved vessels size, be divided into classic polyarteritis nodosa and miniature multiple arteritis, the former invades medium-sized artery and bifurcation thereof, the latter involves small artery and venule, characteristics are middle arteriolonecrosis, non-granulomatous angiitis, this is because blood vessel injury is not only to involve the arterial wall skin, causes necrotizing arteritis but may involve simultaneously each layer of arterial wall, causes at last Multiple aneurysms, thrombosis or infarction.
Polyarteritis nodosa belongs to traditional Chinese medical science disorders of meridian category, no matter which vascular lesion be phase, always dialectical is the resistance of venation numbness, and dialectical according to different stadium again is the resistance of pyretic toxicity venation numbness, the resistance of stasis of blood expectorant venation numbness, the resistance of deficiency of vital energy venation numbness, the resistance of blood stasis venation numbness, the resistance of deficiency of YIN venation numbness etc.Clinical manifestation mostly is Semen Glycines to Semen Viciae fabae or larger tuberosity, one or morely arranges along skin table shallow artery, sometimes be gathered in brokenly blood vessel near, the normal cerise of color of the leather or lividity, can promote or with the skin adhesion, obvious pain and tenderness are arranged.Primary disease is by the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, in have damp and hotly, accumulate the steaming skin, so that meridians intercept, blood stasis stagnates and forms.
Summary of the invention
The Chinese medicine composition of the treatment polyarteritis nodosa that the object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect.
The object of the present invention is achieved like this, according to Chinese medical theory, utilizes the property of medicine of Chinese medicine uniqueness, adopts Ramulus Cinnamomi, the Radix Astragali, the Radix Paeoniae Alba, Semen Persicae, Rhizoma Atractylodis, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi (processed), Radix Achyranthis Bidentatae, Pheretima, Scorpio, Rhizoma Polygoni Cuspidati, Fructus Chaenomelis, Scolopendra, Caulis Lonicerae, Radix Glycyrrhizae is according to certain compatibility requirement, through being processed into.
Preparing Chinese medicine composition of the present invention is made by following raw material medicaments: Ramulus Cinnamomi 8-12 gram, Radix Astragali 25-35 gram, Radix Paeoniae Alba 8-12 gram, Semen Persicae 8-12 gram, Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram, Radix Achyranthis Bidentatae 7-12 gram, Pheretima 7-12 gram, Scorpio 7-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram, Fructus Chaenomelis 4-8 gram, 2 of Scolopendras, Caulis Lonicerae 25-35 gram, Radix Glycyrrhizae 4-8 gram.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
The pharmacological action of Chinese medicine of the present invention is as follows:
Ramulus Cinnamomi: hot, sweet, warm, GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.Be used for anemofrigid cold, congealing cold with blood stasis, phlegm retention, syndrome of water-retention.
The Radix Astragali: sweet, warm, return lung, spleen channel.Benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Be used for diarrhea due to hypofunction of the spleen, wait the card of all Qi and blood deficiencies.
The Radix Paeoniae Alba: bitter, sour, be slightly cold, return liver, spleen channel.Nourish blood and seek relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly the blood deficiency cold and heat, epigastric pain, it is dizzy to have a headache.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for multiple blood stasis symptom, dryness of the intestine constipation, lung abscess, acute appendicitis.
Rhizoma Atractylodis: hot, bitter, warm, return spleen, stomach warp.Drying damp and strengthening spleen, wind-damp dispelling.Be used for the burnt card of humidity hysteresis, the rheumatism arthromyodynia, affection of exogenous wind-cold is held wet exterior syndrome under the arm.
Pericarpium Citri Reticulatae Viride: bitter, hot, warm.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.Be used for side of body rib, breast, epigastric distending pain, acute mastitis, lumps in the chest and abdomen etc.
Rhizoma Cyperi: hot, sweet, little hardship, flat.Return liver, tri-jiao channel.Regulate the flow of vital energy resolving depression, regulating menstruation, antiabortive.Be used for distending pain over the hypochondrium, gastral cavity abdomen feeling of fullness pain, abdominal pain during menstruation etc.
Radix Achyranthis Bidentatae: bitter, sweet, sour, flat.Return liver, kidney channel.Promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, it is descending to ignite.Be used for amenorrhea, dysmenorrhea, the menoxenia of stagnation of blood stasis, lumbago due to renal deficiency and lingering arthralgia soreness of waist and knee joint are weak, headache, and dizzy grade intimately goes up the card of inflammation.
Pheretima: salty, cold.Return lung, liver, kidney channel.Relieving convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and collateral dredging is relievingd asthma.It is manic to cure mainly the calentura heating, and infantile convulsion is twitched, rheumatism hemiplegia, the cards such as cough due to lung-heat.
Scorpio: salty, hot, flat, poisonous, return Liver Channel.Relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Be used for infantile convulsion and twitch epilepsy, apoplexy and hemiplegia, rheumatoid arthritis stubborn.
Rhizoma Polygoni Cuspidati: bitter, cold.Return liver, gallbladder, lung meridian.Promoting the function of the gallbladder to alleviate jaundice, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expelling phlegm for arresting cough.Be used for jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, carbuncle sore tumefacting virus, venom, cough due to lung-heat etc.
Fructus Chaenomelis: sour, warm, return liver, spleen channel.Relaxing muscles and tendons and activating QI and blood in the collateral, the dehumidifying stomach function regulating.Cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins, beriberi swells and ache, the convulsion etc. of vomiting and diarrhoea.
Scolopendra: hot, temperature, poisonous.Return Liver Channel.Dispel the wind, arresting convulsion, counteracting toxic substances, eliminating stagnation.Be used for apoplexy, rheumatoid arthritis stubborn, skin infection, scrofula etc.
Caulis Lonicerae: sweet, cold.GUIXIN, lung meridian.Heat-clearing and toxic substances removing, collateral dredging.Be used for epidemic febrile disease heating, ulcer sore pain, acute appendicitis, acute mastitis, toxic-heat and blood stasis, rheumatic arthralgia etc.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.The QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.The severe palpitation, the irregularly intermittent and regularly intermittent pulse that are used for deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.
Ramulus Cinnamomi of the present invention, the Radix Astragali, Pericarpium Citri Reticulatae Viride, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Pheretima, Scorpio, Fructus Chaenomelis, Scolopendra QI invigorating are activated yang, blood-activating and qi-promoting, collateral dredging YIN nourishing; The Radix Paeoniae Alba, Semen Persicae, Rhizoma Cyperi (processed), Caulis Lonicerae, Rhizoma Polygoni Cuspidati blood-activating analgetic; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is found through clinical practice, and polyarteritis nodosa is had unique curative effect, and all medicines are played heat-clearing and toxic substances removing altogether, cooling blood and removing stasis, and the effect of dispelling wind and removing obstruction in the collateral reaches the purpose for the treatment of polyarteritis nodosa.
Chinese medicine composition of the present invention was in 2002 to 2008 clinical observation polyarteritis nodosa 20 routine patients, and clinical report is as follows:
1, physical data
Among the 20 routine patients, male's 15 examples, women's 5 examples, minimum 25 years old of age, maximum 65 years old, 42.6 years old mean age.
2, diagnostic criteria
With reference to classification (diagnosis) standard of nineteen ninety U.S. ACR about PAN, meeting in the following standard 3 or 3 above persons can make a definite diagnosis:
(1) weight loss 〉=4kg, except go on a diet or other factors; (2) livedo reticularis: extremity or trunk are speckle and netted speckle; (3) testicular pain or tenderness: except owing to infect, due to wound or the other reasons;
(4) myalgia, unable or lower limb are touched a tender spot, and fill the air myalgia (except muscles of shoulder girdle and hip band flesh) and myasthenia or lower limb flesh and touch a tender spot; (5) mononeuropathy or polyneuropathy; (6) diastolic pressure 〉=12.0kPa (90mmHg); (7) creatinine, blood urea nitrogen raises: serum creatinine 〉=132.7 μ mol/L (1.5mg/dl) or blood urea nitrogen 〉=14.3mmol/L (40mg/dl); (8) hepatitis B virus: detect HBsAg or HbsAb in the serum; (9) angiography is unusual: comprise visceral vessel aneurysm or obstruction, except arteriosclerosis; (10) medium and small artery biopsy: pathology show in the arterial wall granulocyte and (or) monocyte infiltration.
3, Therapeutic Method
3.1 prescription: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
3.2 preparation method: said medicine routinely technique is made decoction.
3.3 instructions of taking: each 1 dose, every day 2 times, 30 days was 1 course for the treatment of.
4, therapeutic outcome:
4.1 treatment evaluation criteria:
Cure: after 1～2 course of therapy, symptom, sign disappear, and follow up a case by regular visits to and have no recurrence in 1 year;
Effectively: after 1～2 course of therapy, symptom, sign take a turn for the better;
Invalid: after 1～2 course of therapy, symptom, sign still exist.
4.2 result: among the 20 routine patients, 14 examples of fully recovering (70%), effective 5 examples (25%), invalid 1 example (5%), total effective rate is 95%.
5, model case
5.1 the woman, 35 years old is polyarteritis nodosa by many hospital diagnosis first.Whenever long-term steroid, cyclophosphamide, Radix Tripterygii Wilfordii tablet treatment are alleviated the state of an illness in acute stage.Whole body pain when medical, myasthenia of limbs, stiff, aversion to cold, the black dull amount of menstruation is few, and leucorrhea is many and smelly dirty, deep,thready and forceless pulse, pale tongue with indented margin, Tai Genbai can advance a small amount of diet, takes medicine of the present invention transference cure after two courses for the treatment of, follows up a case by regular visits to not recurrence in 1 year.
5.2 the man, 40 years old, tuberculation polyarteritis 6 months, discontinuity stomachache and whole skin livedo reticularis appear, companion's pruritus, and the Silent Neuritis subcutaneous nodule appears in two lower limb repeatedly, self-induction is weak, becomes thin, and idol has uncomfortable in chest, weight alleviates 14.5kg, and lower limb muscles pain gradually increases the weight of, and squats down, difficulty in walking, be interrupted and occur walking lamely, idol has two lower limb muscles to tremble, and takes medicine of the present invention transference cure after two courses for the treatment of, follows up a case by regular visits to and does not recur in 2 years.
5.3 the woman, 43 years old, first visit in August, 2002.Suffered from hypertension in medical front 4 months, left lower limb was found scleroma in medical previous month, the red pain of color, and afterwards, the left lower limb of right arm all played scleroma, the difficulty of walking, heating in afternoon every day (38.4-38.7 ℃), hyperhidrosis is become thin, headache.After taking a course for the treatment of, heating is disappeared, and the upper limb tuberosity disappears, take two courses for the treatment of after, transference cure.Followed up a case by regular visits to 1 year, not recurrence.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following this embodiment only for explanation the present invention to the present invention without limits.
Embodiment 1, a kind of Chinese medicine composition for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: Ramulus Cinnamomi 8 grams, the Radix Astragali 25 grams, the Radix Paeoniae Alba 8 grams, Semen Persicae 8 grams, Rhizoma Atractylodis 8 grams, Pericarpium Citri Reticulatae Viride 4 grams, Rhizoma Cyperi (processed) 4 grams, Radix Achyranthis Bidentatae 7 grams, Pheretima 7 grams, Scorpio 7 grams, Rhizoma Polygoni Cuspidati 8 grams, Fructus Chaenomelis 4 grams, 2 of Scolopendras, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 4 grams.
Embodiment 2, a kind of Chinese medicine composition for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
Embodiment 3, a kind of Chinese medicine composition for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: Ramulus Cinnamomi 12 grams, the Radix Astragali 35 grams, the Radix Paeoniae Alba 12 grams, Semen Persicae 12 grams, Rhizoma Atractylodis 12 grams, Pericarpium Citri Reticulatae Viride 8 grams, Rhizoma Cyperi (processed) 8 grams, Radix Achyranthis Bidentatae 12 grams, Pheretima 12 grams, Scorpio 12 grams, Rhizoma Polygoni Cuspidati 12 grams, Fructus Chaenomelis 8 grams, 2 of Scolopendras, Caulis Lonicerae 35 grams, Radix Glycyrrhizae 8 grams.
Claims (2)
1. a Chinese medicine composition for the treatment of polyarteritis nodosa is characterized in that being made by following crude drug: Ramulus Cinnamomi 8-12 gram, Radix Astragali 25-35 gram, Radix Paeoniae Alba 8-12 gram, Semen Persicae 8-12 gram, Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram, Radix Achyranthis Bidentatae 7-12 gram, Pheretima 7-12 gram, Scorpio 7-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram, Fructus Chaenomelis 4-8 gram, 2 of Scolopendras, Caulis Lonicerae 25-35 gram, Radix Glycyrrhizae 4-8 gram.
2. Chinese medicine composition according to claim 1 is characterized in that being made by following crude drug: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
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| CN103656073A (en) * | 2013-12-12 | 2014-03-26 | 黄根强 | Traditional Chinese medicine for treating polyarteritis nodosa |
| CN104857391A (en) * | 2015-06-04 | 2015-08-26 | 董春霞 | Traditional Chinese medicine preparation for curing polyarteritis nodosa and preparation method thereof |
| CN106266594A (en) * | 2016-08-23 | 2017-01-04 | 万龙 | A kind of Chinese medicine preparation for gerontal patient's liver-kidney Yin deficiency type giant cell arteritis |
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| CN1695644A (en) * | 2004-05-14 | 2005-11-16 | 姚秀芸 | Medicament for treating rheumatoid arthritis and artjritis pauperum |
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| CN1695644A (en) * | 2004-05-14 | 2005-11-16 | 姚秀芸 | Medicament for treating rheumatoid arthritis and artjritis pauperum |
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