CN103169832A - Traditional Chinese medicine for treating polyarteritis nodosa - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating polyarteritis nodosa. The traditional Chinese medicine is prepared from astragalus, white paeony roots, peach kernels, rhizome atractylodis, green tangerine peels, prepared rhizoma cyperi, radix achyranthis bidentatae, honeysuckle stems and licorice and can be clinically applied to the treatment of polyarteritis nodosa.

Description

A kind of Chinese medicine for the treatment of polyarteritis nodosa

Technical field

The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine for the treatment of polyarteritis nodosa.

Background technology

Polyarteritis nodosa is in a kind of involving, arteriolar necrotizing vasculitis disease.Polyarteritis nodosa can also be incorporated in other diseases such as rheumatoid arthritis, sjogren syndrome etc.According to the involved vessels size, be divided into classic polyarteritis nodosa and miniature multiple arteritis, the former invades medium-sized artery and bifurcation thereof, the latter involves small artery and venule, characteristics are middle arteriolonecrosis, non-granulomatous angiitis, this is because blood vessel injury is not only to involve the arterial wall skin, causes necrotizing arteritis but may involve simultaneously each layer of arterial wall, causes at last Multiple aneurysms, thrombosis or infarction.Primary disease is by the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, in have damp and hotly, accumulate the steaming skin, so that meridians intercept, blood stasis stagnates and forms.

Summary of the invention

The Chinese medicine of the treatment polyarteritis nodosa that the object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, human body is had no side effect.

The object of the present invention is achieved like this, according to Chinese medical theory, utilizes the property of medicine of Chinese medicine uniqueness, adopts the Radix Astragali, the Radix Paeoniae Alba, and Semen Persicae, Rhizoma Atractylodis, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi (processed), Radix Achyranthis Bidentatae, Caulis Lonicerae, Radix Glycyrrhizae is according to certain compatibility requirement, through being processed into.

Preparing Chinese medicine of the present invention is made by following raw material medicaments: Radix Astragali 8-12 gram, Radix Paeoniae Alba 8-12 gram, Semen Persicae 8-12 gram, Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram, Radix Achyranthis Bidentatae 7-12 gram, Caulis Lonicerae 20-30 gram, Radix Glycyrrhizae 4-8 gram.

Optimum weight part of raw material of Chinese medicine medicine of the present invention is: the Radix Astragali 10 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 6 grams.

The pharmacological action of Chinese medicine of the present invention is as follows:

The Radix Astragali: sweet, warm, return lung, spleen channel.Benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Be used for diarrhea due to hypofunction of the spleen, wait the card of all Qi and blood deficiencies.

The Radix Paeoniae Alba: bitter, sour, be slightly cold, return liver, spleen channel.Nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly the blood deficiency cold and heat, epigastric pain is had a headache dizzy.

Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for multiple blood stasis symptom, dryness of the intestine constipation, lung abscess, acute appendicitis.

Rhizoma Atractylodis: acrid, bitter, warm, return spleen, stomach warp.Drying damp and strengthening spleen, wind-damp dispelling.Be used for the burnt card of humidity hysteresis, the rheumatism arthromyodynia, affection of exogenous wind-cold is held wet exterior syndrome under the arm.

Pericarpium Citri Reticulatae Viride: bitter, hot, warm.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.Be used for side of body rib, breast, epigastric distending pain, acute mastitis, lumps in the chest and abdomen etc.

Rhizoma Cyperi: hot, sweet, little hardship, flat.Return liver, tri-jiao channel.Regulate the flow of vital energy resolving depression, regulating menstruation, antiabortive.Be used for distending pain over the hypochondrium, gastral cavity abdomen feeling of fullness pain, abdominal pain during menstruation etc.

Radix Achyranthis Bidentatae: bitter, sweet, sour, flat.Return liver, kidney channel.Promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis is ignited descending.Be used for amenorrhea, dysmenorrhea, the menoxenia of stagnation of blood stasis, lumbago due to renal deficiency and lingering arthralgia soreness of waist and knee joint are weak, headache, and dizzy grade intimately goes up the card of inflammation.

Caulis Lonicerae: sweet, cold.GUIXIN, lung meridian.Heat-clearing and toxic substances removing, collateral dredging.Be used for epidemic febrile disease heating, ulcer sore pain, acute appendicitis, acute mastitis, toxic-heat and blood stasis, rheumatic arthralgia etc.

Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.The QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.The severe palpitation, the irregularly intermittent and regularly intermittent pulse that are used for deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.

The Radix Astragali of the present invention, Pericarpium Citri Reticulatae Viride, Radix Achyranthis Bidentatae, Rhizoma Atractylodis QI invigorating are activated yang, blood-activating and qi-promoting, collateral dredging YIN nourishing; The Radix Paeoniae Alba, Semen Persicae, Rhizoma Cyperi (processed), Caulis Lonicerae blood-activating analgetic; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is found through clinical practice, and polyarteritis nodosa is had unique curative effect.

Chinese medicine of the present invention was in 2009 to 2012 the routine patients of clinical observation polyarteritis nodosa 20, and clinical report is as follows:

1, physical data

In 20 routine patients, male's 13 examples, women's 7 examples, minimum 22 years old of age, maximum 67 years old, 41.5 years old mean age.

2, diagnostic criteria

With reference to classification (diagnosis) standard of nineteen ninety U.S. ACR about PAN, meeting in following standard 3 or 3 above persons can make a definite diagnosis:

(1) weight loss 〉=4kg, except go on a diet or other factors;

(2) livedo reticularis: extremity or trunk are speckle and netted speckle;

(3) testicular pain or tenderness: except due to infection, due to wound or other reasons;

(4) myalgia, unable or lower limb are touched a tender spot, and fill the air myalgia (except muscles of shoulder girdle and hip band flesh) and myasthenia or lower limb flesh and touch a tender spot;

(5) mononeuropathy or polyneuropathy;

(6) diastolic pressure 〉=12.0kPa (90mmHg);

(7) creatinine, blood urea nitrogen raises: serum creatinine 〉=132.7 μ mol/L (1.5mg/dl) or blood urea nitrogen 〉=14.3mmol/L (40mg/dl);

(8) hepatitis B virus: HBsAg or HbsAb detected in serum;

(9) angiography is abnormal: comprise visceral vessel aneurysm or obstruction, except arteriosclerosis;

(10) medium and small artery biopsy: pathology show in arterial wall granulocyte and (or) monocyte infiltration.

3, Therapeutic Method

3.1 prescription: the Radix Astragali 10 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 6 grams.

3.2 preparation method: said medicine technique is routinely made decoction.

3.3 instructions of taking: each 1 dose, every day 2 times, 30 days was 1 course for the treatment of.

4, therapeutic outcome:

In 20 routine patients, recovery from illness 14 examples (70%), effective 5 examples (25%), invalid 1 example (5%), total effective rate is 95%.

5, model case

5.1 the female, 29 years old, tuberculation polyarteritis 2 years.Often long-term steroid, cyclophosphamide, Radix Tripterygii Wilfordii tablet treatment are alleviated the state of an illness in acute stage.Whole body pain when medical, myasthenia of limbs, stiff, aversion to cold, the black dull amount of menstruation is few, pale tongue with indented margin, Tai Genbai can advance a small amount of diet, takes medicine of the present invention transference cure after two courses for the treatment of, follows up a case by regular visits to not recurrence in 1 year.

5.2 the man, 47 years old, tuberculation polyarteritis 6 months, the Silent Neuritis subcutaneous nodule appears in two lower limb repeatedly, and self-induction is weak, becomes thin, occasionally have uncomfortable in chest, weight alleviates 14.5kg, and lower limb muscles pain gradually increases the weight of, and squats down, difficulty in walking, be interrupted and occur walking lamely, occasionally there are two lower limb muscles to tremble, take medicine of the present invention transference cure after three courses for the treatment of, follow up a case by regular visits to and do not recur in 2 years.

The specific embodiment

The present invention is further illustrated below in conjunction with embodiment, and following this embodiment only is used for explanation the present invention and the present invention is not limited.

Embodiment 1, a kind of Chinese medicine for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: the Radix Astragali 8 grams, the Radix Paeoniae Alba 8 grams, Semen Persicae 8 grams, Rhizoma Atractylodis 8 grams, Pericarpium Citri Reticulatae Viride 4 grams, Rhizoma Cyperi (processed) 4 grams, Radix Achyranthis Bidentatae 7 grams, Caulis Lonicerae 20 grams, Radix Glycyrrhizae 4 grams.

Embodiment 2, a kind of Chinese medicine for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: the Radix Astragali 10 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 6 grams.Embodiment 3, a kind of Chinese medicine for the treatment of polyarteritis nodosa, and it is to be made by following raw material medicaments: the Radix Astragali 12 grams, the Radix Paeoniae Alba 12 grams, Semen Persicae 12 grams, Rhizoma Atractylodis 12 grams, Pericarpium Citri Reticulatae Viride 8 grams, Rhizoma Cyperi (processed) 8 grams, Radix Achyranthis Bidentatae 12 grams, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 8 grams.

Claims (2)

1. a Chinese medicine for the treatment of polyarteritis nodosa, is characterized in that being made by following crude drug: Radix Astragali 8-12 gram, Radix Paeoniae Alba 8-12 gram, Semen Persicae 8-12 gram, Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram, Radix Achyranthis Bidentatae 7-12 gram, Caulis Lonicerae 20-30 gram, Radix Glycyrrhizae 4-8 gram.

2. Chinese medicine according to claim 1, is characterized in that being made by following crude drug: the Radix Astragali 10 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 6 grams.