CN102380011A - Traditional Chinese medicine composition for treating polyarteritis nodosa - Google Patents
Traditional Chinese medicine composition for treating polyarteritis nodosa Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating polyarteritis nodosa, which is prepared from cassia twig, radix astragali, radix paeoniae alba, peach kernel, rhizoma atractylodis, green tangerine orange peel, prepared rhizoma cyperi, radix achyranthis bidentatae, lumbricus, scorpion, giant knotweed, pawpaw, centipede, honey-suckle stem and licorice root. The traditional Chinese medicine composition can be used for treating polyarteritis nodosa in clinic.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine composition of treating polyarteritis nodosa.
Background technology
Polyarteritis nodosa is claimed polyarteritis again, or periarteritis nodosa, is in a kind of involving, arteriolar necrotizing vasculitis property disease.Polyarteritis nodosa can involve any organ of human body, but the most common with skin, joint, peripheral nervous, gastrointestinal tract and renal involvement.The order of severity interindividual variation of pathological changes is very big.Polyarteritis nodosa can also be incorporated in other diseases such as rheumatoid arthritis, sjogren syndrome etc.According to the involved vessels size; Be divided into classic polyarteritis nodosa and miniature multiple arteritis, the former invades medium-sized artery and bifurcation thereof, and the latter involves small artery and venule; Characteristics are middle arteriolonecrosis property, non-granulomatous angiitis; This is because blood vessel injury is not only to involve the arterial wall skin, causes necrotizing arteritis but possibly involve each layer of arterial wall simultaneously, causes multiple aneurysm, thrombosis or infarction at last.
Polyarteritis nodosa belongs to traditional Chinese medical science disorders of meridian category; No matter which vascular lesion be phase; Always dialectical is the resistance of venation numbness, and dialectical according to different stadium again is the resistance of pyretic toxicity venation numbness, the resistance of stasis of blood expectorant venation numbness, the resistance of deficiency of vital energy venation numbness, the resistance of blood stasis venation numbness, the resistance of deficiency of YIN venation numbness etc.Mostly clinical manifestation is that Semen Glycines arrives Semen Viciae fabae or bigger tuberosity, one or morely arranges along skin table shallow artery, accumulate in brokenly sometimes blood vessel near, normal cerise of color of the leather or lividity, can promote or with the skin adhesion, tangible pain and tenderness are arranged.Primary disease is by the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, in have damp and hotly, accumulate the steaming skin, so that meridians intercept, blood stasis stagnates and forms.
Summary of the invention
The object of the present invention is to provide that a kind of therapeutic effect is good, effective percentage is high, to the Chinese medicine composition of the treatment polyarteritis nodosa of human non-toxic side effect.
The objective of the invention is to realize like this,, utilize the unique property of medicine of Chinese medicine, adopt Ramulus Cinnamomi, the Radix Astragali, the Radix Paeoniae Alba, Semen Persicae according to Chinese medical theory; Rhizoma Atractylodis, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi (processed), Radix Achyranthis Bidentatae, Pheretima, Scorpio; Rhizoma Polygoni Cuspidati, Fructus Chaenomelis, Scolopendra, Caulis Lonicerae, Radix Glycyrrhizae is according to certain compatibility requirement, through being processed into.
Preparing Chinese medicine composition of the present invention is processed by following raw material medicaments: Ramulus Cinnamomi 8-12 gram, Radix Astragali 25-35 gram, Radix Paeoniae Alba 8-12 gram, Semen Persicae 8-12 gram; Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram, Radix Achyranthis Bidentatae 7-12 gram; Pheretima 7-12 gram, Scorpio 7-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram, Fructus Chaenomelis 4-8 gram; 2 of Scolopendras, Caulis Lonicerae 25-35 gram, Radix Glycyrrhizae 4-8 gram.
Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams; Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams; Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
The pharmacological action of Chinese medicine of the present invention is following:
Ramulus Cinnamomi: hot, sweet, warm, GUIXIN, lung, urinary bladder channel.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI.Be used for anemofrigid cold, cold coagulation stasis, phlegm retention, syndrome of water-retention.
The Radix Astragali: sweet, warm, return lung, spleen channel.Benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Be used for diarrhea due to hypofunction of the spleen, wait the card of all Qi and blood deficiencies.
The Radix Paeoniae Alba: bitter, sour, be slightly cold, return liver, spleen channel.Nourish blood and seek relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly the blood deficiency cold and heat, epigastric pain, it is dizzy to have a headache.
Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for multiple blood stasis symptom, dryness of the intestine constipation, lung abscess, acute appendicitis.
Rhizoma Atractylodis: hot, bitter, warm, return spleen, stomach warp.Drying damp and strengthening spleen, wind-damp dispelling.Be used for the burnt card of humidity hysteresis, the rheumatism arthromyodynia, affection of exogenous wind-cold is held wet exterior syndrome under the arm.
Pericarpium Citri Reticulatae Viride: bitter, hot, warm.Return liver, gallbladder, stomach warp.Soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnates.Be used to coerce rib, breast, gastral cavilty distending pain, acute mastitis 、 lumps in the chest and abdomen etc.
Rhizoma Cyperi: hot, sweet, little hardship, flat.Return liver, tri-jiao channel.Regulate the flow of vital energy resolving depression, regulating menstruation, antiabortive.Be used for distending pain over the hypochondrium, gastral cavity abdomen feeling of fullness pain, abdominal pain during menstruation etc.
Radix Achyranthis Bidentatae: bitter, sweet, sour, flat.Return liver, kidney channel.Promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, relieving stranguria by diuresis, it is descending to ignite.Be used for amenorrhea, dysmenorrhea, the menoxenia of stagnation of blood stasis, lumbago due to renal deficiency and lingering arthralgia soreness of waist and knee joint are weak, headache, and dizzy grade intimately goes up the card of inflammation.
Pheretima: salty, cold.Return lung, liver, kidney channel.Relieving convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and collateral dredging is relievingd asthma.It is manic to cure mainly the calentura heating, and infantile convulsion is twitched, rheumatism hemiplegia, cards such as cough due to lung-heat.
Scorpio: salty, hot, flat, poisonous, return Liver Channel.Relieving spasm by subduing liver-wind, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation.Be used for infantile convulsion and twitch epilepsy, apoplexy and hemiplegia, rheumatoid arthritis stubborn.
Rhizoma Polygoni Cuspidati: bitter, cold.Return liver, gallbladder, lung meridian.Promoting the function of the gallbladder to alleviate jaundice, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expelling phlegm for arresting cough.Be used for jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, carbuncle sore tumefacting virus, venom, cough due to lung-heat etc.
Fructus Chaenomelis: sour, warm, return liver, spleen channel.Relaxing muscles and tendons and activating QI and blood in the collateral, the dehumidifying stomach function regulating.Cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins, beriberi swells and ache, the convulsion etc. of vomiting and diarrhoea.
Scolopendra: hot, temperature, poisonous.Return Liver Channel.Dispel the wind, arresting convulsion, counteracting toxic substances, eliminating stagnation.Be used for apoplexy, rheumatoid arthritis stubborn, skin infection, scrofula etc.
Caulis Lonicerae: sweet, cold.GUIXIN, lung meridian.Heat-clearing and toxic substances removing, collateral dredging.Be used for epidemic febrile disease heating, ulcer sore pain, acute appendicitis, acute mastitis, toxic-heat and blood stasis, rheumatic arthralgia etc.
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp.The QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.The severe palpitation, the irregularly intermittent and regularly intermittent pulse that are used for deficiency of heart-QI, pathopyretic ulcer, laryngopharynx swelling and pain.
Ramulus Cinnamomi of the present invention, the Radix Astragali, Pericarpium Citri Reticulatae Viride, Radix Achyranthis Bidentatae, Rhizoma Atractylodis, Pheretima, Scorpio, Fructus Chaenomelis, Scolopendra QI invigorating activate yang, blood-activating and qi-promoting, collateral dredging YIN nourishing; The Radix Paeoniae Alba, Semen Persicae, Rhizoma Cyperi (processed), Caulis Lonicerae, Rhizoma Polygoni Cuspidati blood-activating analgetic; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is found through clinical practice, and polyarteritis nodosa is had unique curative effect, and all medicines are played heat-clearing and toxic substances removing altogether, cooling blood and removing stasis, and the effect of dispelling wind and removing obstruction in the collateral reaches the purpose of treating polyarteritis nodosa.
Chinese medicine composition of the present invention was in 2002 to 2008 clinical observation polyarteritis nodosa 20 routine patients, and clinical report is following:
1, physical data
Among the 20 routine patients, male's 15 examples, women's 5 examples, minimum 25 years old of age, maximum 65 years old, 42.6 years old mean age.
2, diagnostic criteria
With reference to classification (diagnosis) standard of nineteen ninety U.S. ACR about PAN, meeting in the standards 3 or 3 above persons can make a definite diagnosis:
(1) weight loss >=4kg, except go on a diet or other factors; (2) livedo reticularis: extremity or trunk are speckle and netted speckle; (3) testicular pain or tenderness: except owing to infect, due to wound or the other reasons;
(4) myalgia, unable or lower limb are touched a tender spot, and fill the air myalgia (except muscles of shoulder girdle and hip band flesh) and myasthenia or the tenderness of lower limb flesh; (5) mononeuropathy or polyneuropathy; (6) diastolic pressure >=12.0kPa (90mmHg); (7) creatinine, blood urea nitrogen raises: serum creatinine >=132.7 μ mol/L (1.5mg/dl) or blood urea nitrogen >=14.3mmol/L (40mg/dl); (8) hepatitis B virus: detect HBsAg or HbsAb in the serum; (9) angiography is unusual: comprise visceral vessel aneurysm or obstruction, except arteriosclerosis; (10) medium and small artery biopsy: pathology show in the arterial wall granulocyte with (or) monocyte infiltration.
3, Therapeutic Method
3.1 prescription: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams, Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams, Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams, Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
3.2 method for preparing: said medicine is processed decoction by common process.
3.3 instructions of taking: each 1 dose, every day 2 times, 30 days was 1 course of treatment.
4, therapeutic outcome:
4.1 treatment evaluation criteria:
Cure: after 1～2 course of therapy, symptom, sign disappear, and follow up a case by regular visits to and do not see recurrence in 1 year;
Effectively: after 1～2 course of therapy, symptom, sign take a turn for the better;
Invalid: after 1～2 course of therapy, symptom, sign still exist.
4.2 result: among the 20 routine patients, 14 examples of fully recovering (70%), effective 5 examples (25%), invalid 1 example (5%), total effective rate is 95%.
5, model case
5.1 the woman, 35 years old, earlier after how tame hospital diagnosis is a polyarteritis nodosa.Whenever in acute stage take hormone, cyclophosphamide, the Radix Tripterygii Wilfordii tablet treatment is alleviated the state of an illness.Whole body pain during prescription on individual diagnosis, myasthenia of limbs, stiff, aversion to cold, the black dull amount of menstruation is few, and leucorrhea is many and smelly dirty, deep,thready and forceless pulse, pale tongue with indented margin, Tai Genbai can advance a small amount of diet, takes medicine of the present invention transference cure after two courses of treatment, follows up a case by regular visits to not recurrence in 1 year.
5.2 the man, 40 years old, discontinuity stomachache and whole skin livedo reticularis appearred in tuberculation property polyarteritis 6 months; Companion's pruritus, painless property subcutaneous nodule appears in two lower limb repeatedly, and self-induction is weak, becomes thin; Idol has uncomfortable in chestly, and the body constitution amount alleviates 14.5kg, and lower limb muscles pain gradually increases the weight of, and squats down, difficulty in walking; Be interrupted and occur walk lamely, idol has two lower limb muscles to tremble, and takes medicine of the present invention transference cure after two courses of treatment, follows up a case by regular visits to and does not recur in 2 years.
5.3 the woman, 43 years old, first visit in August, 2002.Go to a doctor and suffered from hypertension in preceding 4 months, the previous month left lower limb of going to a doctor found scleroma, the red pain of color, and afterwards, right arm left side lower limb all played scleroma, the difficulty of walking, heating in afternoon every day (38.4-38.7 ℃), hyperhidrosis is become thin, headache.After taking a course of treatment, heating is disappeared, and the upper limb tuberosity disappears, take two courses of treatment after, transference cure.Followed up a case by regular visits to 1 year, not recurrence.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, following this embodiment only is used to the present invention is described and the present invention is not limited.
Embodiment 1, a kind of Chinese medicine composition of treating polyarteritis nodosa, and it is to be processed by following raw material medicaments: Ramulus Cinnamomi 8 grams, the Radix Astragali 25 grams, the Radix Paeoniae Alba 8 grams; Semen Persicae 8 grams, Rhizoma Atractylodis 8 grams, Pericarpium Citri Reticulatae Viride 4 grams, Rhizoma Cyperi (processed) 4 grams; Radix Achyranthis Bidentatae 7 grams, Pheretima 7 grams, Scorpio 7 grams, Rhizoma Polygoni Cuspidati 8 grams; Fructus Chaenomelis 4 grams, 2 of Scolopendras, Caulis Lonicerae 25 grams, Radix Glycyrrhizae 4 grams.
Embodiment 2, a kind of Chinese medicine composition of treating polyarteritis nodosa, and it is to be processed by following raw material medicaments: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams; Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams; Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams; Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
Embodiment 3, a kind of Chinese medicine composition of treating polyarteritis nodosa, and it is to be processed by following raw material medicaments: Ramulus Cinnamomi 12 grams, the Radix Astragali 35 grams, the Radix Paeoniae Alba 12 grams; Semen Persicae 12 grams, Rhizoma Atractylodis 12 grams, Pericarpium Citri Reticulatae Viride 8 grams, Rhizoma Cyperi (processed) 8 grams; Radix Achyranthis Bidentatae 12 grams, Pheretima 12 grams, Scorpio 12 grams, Rhizoma Polygoni Cuspidati 12 grams; Fructus Chaenomelis 8 grams, 2 of Scolopendras, Caulis Lonicerae 35 grams, Radix Glycyrrhizae 8 grams.
Claims (2)
1. a Chinese medicine composition of treating polyarteritis nodosa is characterized in that being processed by following crude drug: Ramulus Cinnamomi 8-12 gram, Radix Astragali 25-35 gram, Radix Paeoniae Alba 8-12 gram; Semen Persicae 8-12 gram, Rhizoma Atractylodis 8-12 gram, Pericarpium Citri Reticulatae Viride 4-8 gram, Rhizoma Cyperi (processed) 4-8 gram; Radix Achyranthis Bidentatae 7-12 gram, Pheretima 7-12 gram, Scorpio 7-12 gram, Rhizoma Polygoni Cuspidati 8-12 gram; Fructus Chaenomelis 4-8 gram, 2 of Scolopendras, Caulis Lonicerae 25-35 gram, Radix Glycyrrhizae 4-8 gram.
2. Chinese medicine composition according to claim 1 is characterized in that being processed by following crude drug: Ramulus Cinnamomi 10 grams, the Radix Astragali 30 grams, the Radix Paeoniae Alba 10 grams; Semen Persicae 10 grams, Rhizoma Atractylodis 10 grams, Pericarpium Citri Reticulatae Viride 6 grams, Rhizoma Cyperi (processed) 6 grams; Radix Achyranthis Bidentatae 9 grams, Pheretima 9 grams, Scorpio 9 grams, Rhizoma Polygoni Cuspidati 10 grams; Fructus Chaenomelis 6 grams, 2 of Scolopendras, Caulis Lonicerae 30 grams, Radix Glycyrrhizae 6 grams.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656073A (en) * | 2013-12-12 | 2014-03-26 | 黄根强 | Traditional Chinese medicine for treating polyarteritis nodosa |
| CN104857391A (en) * | 2015-06-04 | 2015-08-26 | 董春霞 | Traditional Chinese medicine preparation for curing polyarteritis nodosa and preparation method thereof |
| CN106266594A (en) * | 2016-08-23 | 2017-01-04 | 万龙 | A kind of Chinese medicine preparation for gerontal patient's liver-kidney Yin deficiency type giant cell arteritis |
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| CN1695644A (en) * | 2004-05-14 | 2005-11-16 | 姚秀芸 | Medicament for treating rheumatoid arthritis and artjritis pauperum |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1695644A (en) * | 2004-05-14 | 2005-11-16 | 姚秀芸 | Medicament for treating rheumatoid arthritis and artjritis pauperum |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656073A (en) * | 2013-12-12 | 2014-03-26 | 黄根强 | Traditional Chinese medicine for treating polyarteritis nodosa |
| CN104857391A (en) * | 2015-06-04 | 2015-08-26 | 董春霞 | Traditional Chinese medicine preparation for curing polyarteritis nodosa and preparation method thereof |
| CN106266594A (en) * | 2016-08-23 | 2017-01-04 | 万龙 | A kind of Chinese medicine preparation for gerontal patient's liver-kidney Yin deficiency type giant cell arteritis |
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