CN102379841A - Preparation method of furacilin solution - Google Patents
Preparation method of furacilin solution Download PDFInfo
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- CN102379841A CN102379841A CN2010102672880A CN201010267288A CN102379841A CN 102379841 A CN102379841 A CN 102379841A CN 2010102672880 A CN2010102672880 A CN 2010102672880A CN 201010267288 A CN201010267288 A CN 201010267288A CN 102379841 A CN102379841 A CN 102379841A
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- furacilin
- furacilin solution
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Abstract
The invention discloses a preparation method of a furacilin solution, and the product belongs to the field of pharmacy. The furacilin solution is an external local antibiotic medicine which is commonly used clinically in hospitals in China, is the yellow clear and transparent liquid in appearance, has slight bitter taste, and has the functions of interfering the sugar metabolic process and the oxidase system of bacteria, and accordingly, the bacteriostatic or bactericidal purpose is realized. The product is produced from the raw materials of: furacilin powder, officinal sodium chloride, analytically pure sodium benzoate, polysorbate, officinal diluted hydrochloric acid and distilled water. The product adopts the improved method to produce the furacilin solution, and the method has simple technology, high product concentration, good bactericidal effects and good stability.
Description
Technical field:
Product of the present invention belongs to pharmaceutical field, it is characterized in that relating to a kind of compound method of furacilin solution.
Background technology:
Furacilin solution is domestic hospital clinical local external use's antibacterials commonly used, and outward appearance is yellow clear liquid, mildly bitter flavor.These article have the carbohydrate metabolism process of interfere with bacterial and thereby the effect of oxidase system reaches antibacterial or germ-resistant purpose; The glycometabolic commitment of the main interfere with bacterial of furacilin solution; Cause bacterial metabolism disorderly and dead, its antimicrobial spectrum is wider, and multiple Grain-positive and negative bacterium are had antibacterial action; A little less than the bacillus pyocyaneus antimicrbial power, Pseudomonas and Proteus there is drug resistance.External can suppress general antibacterial, but antibacterial during high concentration, external flushing or soak are handled body surface and are infected and dermatosis, and effect is satisfactory, and bacterial number is significantly reduced.The microbial infection of ear, nose, skin infection, wound, burn, suppurative dermatitis, otitis media, dacryocystisis, decubital ulcer and anaerobism that causes for multiple Grain-positive and negative bacteria also has certain curative effect.Product processes of the present invention is comparatively simple, simply gets final product to directly being dissolved in distilled water to the nitrofural powder, and such result is: low, the poor stability of concentration, concentration is low will directly to cause its bactericidal effect poor.How producing high-quality furacilin solution is exactly the content of the present invention's research; Practice finds that the quality of producing furacilin solution all has relation to temperature, dissolution time, pH value, light; Temperature, time, pH value have influence on the dissolubility of nitrofural, and light then can make its variable color, crystallization.Therefore select suitable temperature, dissolution time and pH value, add the dissolubility that a certain amount of cosolvent, solubilizing agent, stabilizing agent improve nitrofural again, increase the stability of furacilin solution, thereby produce high-quality furacilin solution.
Summary of the invention:
In order to produce high-quality furacilin solution; The present invention provides a kind of compound method of new furacilin solution; This method is through selecting suitable temperature, time, pH value; And add a certain amount of cosolvent, solubilizing agent, stabilizing agent, and the concentration of the furacilin solution of producing and stability are further improved, be the good furacilin solution of a kind of result of use.The raw material of producing this product use has: nitrofural powder 0.02% (being antibacterial and germ-resistant main medicine), medicinal sodium chloride 0.36% (regulator), analytical pure sodium benzoate 0.2% (being cosolvent, stabilizing agent and antiseptic), Polysorbate 0.01%, (solubilizing agent), medicinal dilute hydrochloric acid an amount of (being used to regulate pH value), distilled water 99.5%.
The present invention can realize through following technical scheme:
A kind of method of batch preparation furacilin solution is characterized in that being made up of following steps:
1. the primary response device is that capacity is 100 liters a heatable stainless steel cask, adds earlier distilled water, adds nitrofural powder, medicinal sodium chloride, analytical pure sodium benzoate, Polysorbate more successively, continuous stirring after bringing up to 100 ℃ to water temperature.
2. add medicinal dilute hydrochloric acid and regulate pH value, the nitrofural powder is all dissolved.
3. send into sterilization tank to lysate, sterilization is 30 minutes under 100 ℃-110 ℃ temperature, and packing gets product.
The beneficial effect of product of the present invention is: adopt the method after improving to produce furacilin solution, this method technology is simple, product design is high, bactericidal effect good, good stability.
The specific embodiment:
Embodiment 1:
The primary response device is that capacity is 100 liters a heatable stainless steel cask, adds earlier distilled water, adds nitrofural powder, medicinal sodium chloride, analytical pure sodium benzoate, Polysorbate more successively after bringing up to 100 ℃ to water temperature, stirs 20 minutes; Add medicinal dilute hydrochloric acid and regulate pH value, the pH value to 4.5 of adjusting all dissolves the nitrofural powder; Send into sterilization tank to lysate, sterilization is 30 minutes under 100 ℃ temperature, and packing gets product.
Embodiment 2:
The primary response device is that capacity is 100 liters a heatable stainless steel cask, adds earlier distilled water, adds nitrofural powder, medicinal sodium chloride, analytical pure sodium benzoate, Polysorbate more successively after bringing up to 100 ℃ to water temperature, stirs 30 minutes; Add medicinal dilute hydrochloric acid and regulate pH value, the pH value to 5.5 of adjusting all dissolves the nitrofural powder; Send into sterilization tank to lysate, sterilization is 30 minutes under 105 ℃ temperature, and packing gets product.
Embodiment 3:
The primary response device is that capacity is 100 liters a heatable stainless steel cask, adds earlier distilled water, adds nitrofural powder, medicinal sodium chloride, analytical pure sodium benzoate, Polysorbate more successively after bringing up to 100 ℃ to water temperature, stirs 40 minutes; Add medicinal dilute hydrochloric acid and regulate pH value, the pH value to 6.5 of adjusting all dissolves the nitrofural powder; Send into sterilization tank to lysate, sterilization is 30 minutes under 110 ℃ temperature, and packing gets product.
Claims (4)
1. the compound method of a furacilin solution; It is characterized in that:, distilled water 99.5% an amount of with nitrofural powder 0.02%, medicinal sodium chloride 0.36%, analytical pure sodium benzoate 0.2%, Polysorbate 0.01%, medicinal dilute hydrochloric acid is raw material, obtains finished product through following steps.
2. the compound method of a kind of furacilin solution according to claim 1; The characteristic of its first step is: the primary response device is that capacity is 100 liters a heatable stainless steel cask; Add distilled water earlier; Add nitrofural powder, medicinal sodium chloride, analytical pure sodium benzoate, Polysorbate more successively, continuous stirring after bringing up to 100 ℃ to water temperature.
3. the compound method of a kind of furacilin solution according to claim 1, the characteristic in its second step is: add medicinal dilute hydrochloric acid and regulate pH value, the nitrofural powder is all dissolved.
4. the compound method of a kind of furacilin solution according to claim 1, the characteristic in its 3rd step is: send into sterilization tank to lysate, sterilization is 30 minutes under 100 ℃-110 ℃ temperature, and packing gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672880A CN102379841A (en) | 2010-08-30 | 2010-08-30 | Preparation method of furacilin solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102672880A CN102379841A (en) | 2010-08-30 | 2010-08-30 | Preparation method of furacilin solution |
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| Publication Number | Publication Date |
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| CN102379841A true CN102379841A (en) | 2012-03-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010102672880A Pending CN102379841A (en) | 2010-08-30 | 2010-08-30 | Preparation method of furacilin solution |
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| CN (1) | CN102379841A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107164A (en) * | 2014-07-07 | 2014-10-22 | 海南华拓天涯制药有限公司 | Method for preparing antifreeze type furacilin lotion |
| CN106974926A (en) * | 2017-04-27 | 2017-07-25 | 牡丹江医学院 | It is a kind of to be used to treat pharmaceutical composition of pressure sore and its production and use |
| CN108743529A (en) * | 2018-06-09 | 2018-11-06 | 江苏海尔滋生物科技有限公司 | Nitrofurazone microballoon biogum body fluid and preparation method thereof |
| RU2692772C2 (en) * | 2017-11-15 | 2019-06-27 | Общество с ограниченной ответственностью "Технофарм" | Composition and method for preparing rapidly soluble antifungal drug based on nitrofural |
| RU2696573C1 (en) * | 2019-02-11 | 2019-08-06 | Общество с ограниченной ответственностью "Квадрат-С" | Antimicrobial medicinal preparation in the form of tablets of furacilin with accelerated release |
| RU2712123C1 (en) * | 2018-12-14 | 2020-01-27 | Общество с ограниченной ответственностью "Технофарм" | Composition and method for preparing a rapidly soluble antimicrobial drug based on nitrofural (versions) |
-
2010
- 2010-08-30 CN CN2010102672880A patent/CN102379841A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107164A (en) * | 2014-07-07 | 2014-10-22 | 海南华拓天涯制药有限公司 | Method for preparing antifreeze type furacilin lotion |
| CN106974926A (en) * | 2017-04-27 | 2017-07-25 | 牡丹江医学院 | It is a kind of to be used to treat pharmaceutical composition of pressure sore and its production and use |
| CN106974926B (en) * | 2017-04-27 | 2019-07-02 | 牡丹江医学院 | A kind of pharmaceutical composition and its preparation method and application for treating pressure sore |
| RU2692772C2 (en) * | 2017-11-15 | 2019-06-27 | Общество с ограниченной ответственностью "Технофарм" | Composition and method for preparing rapidly soluble antifungal drug based on nitrofural |
| CN108743529A (en) * | 2018-06-09 | 2018-11-06 | 江苏海尔滋生物科技有限公司 | Nitrofurazone microballoon biogum body fluid and preparation method thereof |
| RU2712123C1 (en) * | 2018-12-14 | 2020-01-27 | Общество с ограниченной ответственностью "Технофарм" | Composition and method for preparing a rapidly soluble antimicrobial drug based on nitrofural (versions) |
| RU2696573C1 (en) * | 2019-02-11 | 2019-08-06 | Общество с ограниченной ответственностью "Квадрат-С" | Antimicrobial medicinal preparation in the form of tablets of furacilin with accelerated release |
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20120321 |