CN102370762A - Self-heating Chinese medicinal adhesive plaster for improving constipation - Google Patents
Self-heating Chinese medicinal adhesive plaster for improving constipation Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation, in particular to a self-heating Chinese medicinal adhesive plaster for improving constipation. The self-heating Chinese medicinal adhesive plaster consists of a sealing bag, and plaster and a self-heating bag which are wrapped in the sealing bag and are adhered vertically, wherein the self-heating bag consists of a permeable bag and a chemical heating material which is wrapped in the permeable bag for iron oxidation-reduction reaction; the plaster consists of a back lining layer, a medicament storage layer and an anti-adhesion layer; the self-heating Chinese medicinal adhesive plaster is characterized in that: the medicament storage layer consists of a pharmaceutically acceptable substrate and active ingredients of the raw material medicaments which are equivalently 40 percent of the weight of the substrate; the active ingredients consist of 1.5-3 percent of borneol and water extracts of the following raw material medicaments in weight percentage of the raw material medicaments: 20-40 percent of rhubarb, 10-30 percent of immature bitter orange, 10-20 percent of radish seed, 10-30 percent of root of bidentate achyranthes and 10-20 percent of cinnamon. The self-heating Chinese medicinal adhesive plaster has the advantages of quick response, good transdermal absorption and clear curative effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Constipation is the common a kind of disease of modern society, and its complex genesis is how relevant with gastrointestinal function, the kind of ingesting and custom, living habit, environmental factors, the mental status etc.The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.At present, still do not have specific medicament and be used to treat various constipation, motherland's medical science has remarkable advantages aspect the preventing and treating of constipation.Because the incidence rate of constipation is higher, this just requires its means of prevention and method necessary popular, therefore, seeks that a kind of can to bring into play the popular again constipation method of preventing and treating of tcm characteristic be desirability.
Because it is many and complicated influence the factor of constipation, therefore be directed against various factors and the too many levels of developing, multi-level compound Chinese medicinal preparation become a kind of trend.
Summary of the invention
Technical problem to be solved by this invention provides a kind of self-heating Chinese medicine patch unguentum that improves constipation, and this emplastrum is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is described below:
A kind of self-heating Chinese medicine patch unguentum that improves constipation; This self-heating Chinese medicine patch unguentum is made up of sealing bag and bag plaster that is bonded together up and down and self-heating bag within it; Wherein, said self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Said plaster is made up of backing layer, medicine storing layer, adherent layer, it is characterized in that,
Said medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, and wherein said effective ingredient is to be made up of the water extract of Borneolum Syntheticum 1.5%-3% and following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 20%-40%, Fructus Aurantii Immaturus 10%-30%, Semen Raphani 10%-20%, Radix Achyranthis Bidentatae 10%-30%, Cortex Cinnamomi 10%-20%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said active ingredient are preferably pressed the percentage by weight of crude drug and are made up of the water extract of Borneolum Syntheticum 2% and following crude drug: Radix Et Rhizoma Rhei 30%, Fructus Aurantii Immaturus 20%, Semen Raphani 15%, Radix Achyranthis Bidentatae 20%, Cortex Cinnamomi 13%.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said water extract can adopt this area water extracting method commonly used to prepare; The method that the inventor recommends is described below: get by proportioning and close Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Semen Raphani, Radix Achyranthis Bidentatae, Cortex Cinnamomi; Add 6-10 times of water gaging earlier, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate drying becomes extract powder to get final product.Borneolum Syntheticum is added in the prepared extract powder, mix thoroughly, promptly get described effective ingredient.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said substrate can be the substrate of conventional patch; As; 2005 editions first appendix I rules of preparations of Chinese Pharmacopoeia is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommended is made up of following raw materials by weight percent: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerin (glycerol) and propylene glycol, perhaps is one or both the mixture in glycerin (glycerol), propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or three in citric acid, sodium citrate and the aluminum chloride.
Self-heating Chinese medicine patch unguentum of the present invention, the desirable method for preparing of wherein said medicine storing layer is: said effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling is transferred PH to 8, component one; To in component one, be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the said component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in said component one, component two and the component three.
Self-heating Chinese medicine patch unguentum of the present invention, wherein, said backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is processed by non-woven fabrics; Described sealing bag is processed by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is promptly got said plaster.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat; Usually form by reduced iron powder, water and catalyst; The inner packing (promptly removing sealed external package) of the self-heating bag of producing like, Qingdao ADO industry and trade company limited is that the scheme that application for a patent for invention disclosed of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is made up of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%; Preferably form: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15% by following raw material by weight percentage.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and ideal fever time is suitable with 7-11 hour.
The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid.This Chinese medicine compound is made up of Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Pericarpium Arecae, Fructus Gleditsia, Radix Achyranthis Bidentatae, the Radix Rehmanniae, Cortex Cinnamomi, Borneolum Syntheticum etc., and its monarch drug is a Radix Et Rhizoma Rhei, and Fructus Aurantii Immaturus has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, dispelling the stagnated QI removing food stagnancy, the merit of the diffusing painful abdominal mass of reducing phlegm; Ministerial drug is a Cortex Cinnamomi, Radix Achyranthis Bidentatae, ability promoting flow of QI and blood; Adjuvant drug is a Semen Raphani, can help digestion to remove to expand; Messenger drug is a Borneolum Syntheticum, and the ability waking up the patient from unconsciousness by clearing away heat has the merit of priming.The mutual reinforcement between of full side's Six-element, Xiang Zuo reach loosening bowel to relieve constipation, improve effects such as gastrointestinal function.
During use, the sealing bag of self-heating Chinese medicine patch unguentum of the present invention is taken apart, be pasted on constipation person's abdominal part; Oxidation reaction just takes place and generates heat in the chemical exothermic material chance oxygen of venting bags; Heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body; Regulate function, and then reach the purpose of improving constipation.
In order to understand the present invention better, its effect is explained in the clinical trial that improves constipation with self-heating Chinese medicine patch unguentum of the present invention below.
Clinical experiment
One, physical data
All cases are the volunteer that the constipation symptom is arranged, male's 30 examples, age 40-76 year; Women's 30 examples, 37～74 years old age.Be divided into self-heating Chinese medicine patch unguentum group 30 examples (male 15 examples, women 15 examples) at random; Blank group 30 examples (male 15 examples, women 15 examples).Treat preceding two groups of patients' sex, age, symptom integral there are no significant difference (P＞0.05), have comparability.
Two, include standard in
For including standard in, promptly in the past 12 months, have at least 12 weeks (needn't continuously) that following situation more than 2 or 2 takes place: 1. the defecation more than 1/4 is had a sense of urgency with Rome standard I I; 2. the defecation more than 1/4 is dry and hard or hard; 3. there is defecation to feel not to the utmost during 1/4 above defecation; 4. there is anorectal to block during 1/4 above defecation or blocks sense; 5. 1/4 above defecation person want extra help (as point scratch dig, massage at the bottom of the basin); 6. defecation＜3 time weekly do not have the passage of loose stools phenomenon, and are not enough to diagnose IBS.
Three, method
Self-heating Chinese medicine patch unguentum group: the self-heating Chinese medicine patch unguentum (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Blank control group: the blank substrate subsides (specification is 10cm*10cm) that do not contain effective composition are affixed on abdominal part, once a day, and each 6h, continuous 1 week.
Four, observation of curative effect
The clinical symptoms standards of grading: adopt " the constipation symptom and the curative effect evaluation questionnaire " of surgery branch of Chinese Medical Association anorectal surgical group establishment in 2005, this questionnaire is divided into 6 aspect problems: 1. difficult defecation; 2. feces character; 3. defecation time; 4. tenesmus, not to the utmost, the sense of expanding; 5. defecation frequency; 6. abdominal distention.Each problem score is 4 grade standards, and being respectively does not have 0 fen, and slight 1 minute, moderate 2 minutes, severe 3 minutes.According to score respectively in various degree, high more this problem symptom of representative of score is heavy more, and 6 aspect problem score additions just are constipation symptom total points.Evaluation time is respectively before the treatment beginning and after the treatment end.
Efficacy assessment standard: formulate with reference to " new Chinese medicine clinical research guideline "; Elder generation is by formula during concrete the execution---and clinical symptoms integration score value improvement rate=(symptom integral score value before the treatment-treatment back symptom integral the score value)/preceding score value of treatment * 100% calculates the improvement rate, adopts criterion evaluation curative effect then.
Produce effects: the symptom integral value reduces >=70%;
Effectively: the symptom integral value reduces >=50%;
Invalid: symptom does not see that obvious improvement or counter sees deterioration, and the symptom integral value reduces＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, and measurement data is with mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test
The clinical symptoms integration is relatively seen table 1 before and after self-heating Chinese medicine patch unguentum group and the blank control group.Can know from table 2, self-heating Chinese medicine patch unguentum group produce effects 20 examples, effective 6 examples, invalid 4 examples, total effective rate is 86.67%, blank control group produce effects 0 example, effective 6 examples, invalid 24 examples, total effective rate is 20%.Self-heating Chinese medicine patch unguentum group effect is apparently higher than blank control group.N in table 1～table 3 representes number.
(x ± s divides) compared in the clinical symptoms scoring before and after table 1 a liang group sticked
| Group | n | Before sticking | After sticking |
| Self-heating Chinese medicine patch unguentum group | 30 | 14.43±2.23 | 8.23±2.67a?b |
| Blank control group | 30 | 14.09±3.69 | 13.56±3.58 |
With stick preceding comparison: Pa＜0.05, with matched group relatively: Pb＜0.05
Table 2 liang group curative effect relatively
Table 3 self-heating Chinese medicine patch unguentum group and blank control group cardinal symptom sign are improved relatively
Stick preceding comparison: Pa＜0.05 with this group, stick the back relatively with blank control group: Pb＜0.05
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 120g, Fructus Aurantii Immaturus 80g, Semen Raphani 60g, Radix Achyranthis Bidentatae 80g, Cortex Cinnamomi 52g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerin 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: with Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Semen Raphani, Radix Achyranthis Bidentatae and Cortex Cinnamomi decocte with water secondary, add 6 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 1.5 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey); 80 ℃ of dryings are ground into fine powder, and sieving promptly gets.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerin mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Radix Et Rhizoma Rhei 90g, Fructus Aurantii Immaturus 72g, Semen Raphani 63g, Radix Achyranthis Bidentatae 106g, Cortex Cinnamomi 63g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerin 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerin, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 11g, Radix Et Rhizoma Rhei 89g, Fructus Aurantii Immaturus 60g, Semen Raphani 60g, Radix Achyranthis Bidentatae 100g, Cortex Cinnamomi 80g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g; Polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerin 156g, propylene glycol 156g; Micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 12g, Radix Et Rhizoma Rhei 140g, Fructus Aurantii Immaturus 48g, Semen Raphani 50g, Radix Achyranthis Bidentatae 80g, Cortex Cinnamomi 70g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g; Glycerin 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g; Zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 10g, Radix Et Rhizoma Rhei 147g, Fructus Aurantii Immaturus 92g, Semen Raphani 40g, Radix Achyranthis Bidentatae 56g, Cortex Cinnamomi 55g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerin 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Carbomer, sodium carboxymethyl cellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 130g, Fructus Aurantii Immaturus 111g, Semen Raphani 65g, Radix Achyranthis Bidentatae 40g, Cortex Cinnamomi 46g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerin 246g; Propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g; Sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 7g, Radix Et Rhizoma Rhei 80g, Fructus Aurantii Immaturus 92g, Semen Raphani 74g, Radix Achyranthis Bidentatae 92g, Cortex Cinnamomi 55g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerin 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Polyvinyl alcohol, sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 9g, Radix Et Rhizoma Rhei 98g, Fructus Aurantii Immaturus 40g, Semen Raphani 68g, Radix Achyranthis Bidentatae 117g, Cortex Cinnamomi 68g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g; Pressure sensitive adhesive 108g, carbomer 30g, glycerin 224g, propylene glycol 224g, butanediol 38g; Zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 7g, Radix Et Rhizoma Rhei 148g, Fructus Aurantii Immaturus 93g, Semen Raphani 56g, Radix Achyranthis Bidentatae 56g, Cortex Cinnamomi 40g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerin 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerin and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, mixing, component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Radix Et Rhizoma Rhei 94g, Fructus Aurantii Immaturus 112g, Semen Raphani 66g, Radix Achyranthis Bidentatae 75g, Cortex Cinnamomi 47g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerin 258g; Propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g; Micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerin and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 92g, Fructus Aurantii Immaturus 60g, Semen Raphani 80g, Radix Achyranthis Bidentatae 100g, Cortex Cinnamomi 60g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerin 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 9g, Radix Et Rhizoma Rhei 100g, Fructus Aurantii Immaturus 51g, Semen Raphani 50g, Radix Achyranthis Bidentatae 120g, Cortex Cinnamomi 70g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerin 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Claims (6)
1. self-heating Chinese medicine patch unguentum that improves constipation; This self-heating Chinese medicine patch unguentum is made up of sealing bag and bag plaster that is bonded together up and down and self-heating bag within it; Wherein, said self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Said plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Said medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, and wherein said effective ingredient is to be made up of the water extract of Borneolum Syntheticum 1.5%-3% and following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 20%-40%, Fructus Aurantii Immaturus 10%-30%, Semen Raphani 10%-20%, Radix Achyranthis Bidentatae 10%-30%, Cortex Cinnamomi 10%-20%.
2. a kind of self-heating Chinese medicine patch unguentum that improves constipation according to claim 1; It is characterized in that; Described active ingredient is to be made up of the water extract of Borneolum Syntheticum 2% and following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 30%, Fructus Aurantii Immaturus 20%, Semen Raphani 15%; Radix Achyranthis Bidentatae 20%, Cortex Cinnamomi 13%.
3. a kind of self-heating Chinese medicine patch unguentum that improves constipation according to claim 1 and 2; It is characterized in that described water extract is prepared by following method: get by proportioning and close Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Semen Raphani, Radix Achyranthis Bidentatae, Cortex Cinnamomi, add 6-10 times of water gaging earlier; Decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate drying becomes extract powder to get final product.
4. a kind of self-heating Chinese medicine patch unguentum that improves constipation according to claim 1 and 2; It is characterized in that; Described substrate is made up of following raw materials by weight percent: sticker 6.1%-26.5%, wetting agent 20%-80%, filler 0.5%-1.5%; Cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerin and propylene glycol, perhaps is one or both the mixture in glycerin, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or three in citric acid, sodium citrate and the aluminum chloride.
5. a kind of self-heating Chinese medicine patch unguentum that improves constipation according to claim 4 is characterized in that described medicine storing layer is prepared by following method: said effective ingredient is soluble in water, add described wetting agent mixing, and get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling is transferred PH to 8, component one; To in component one, be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the said component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the described substrate of claim 4 in said component one, component two and the component three.
6. a kind of self-heating Chinese medicine patch unguentum that improves constipation according to claim 1 and 2; It is characterized in that the following raw materials by weight percent of described chemical exothermic material is formed: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110313321 CN102370762B (en) | 2011-10-16 | 2011-10-16 | Self-heating Chinese medicinal adhesive plaster for improving constipation |
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| CN 201110313321 CN102370762B (en) | 2011-10-16 | 2011-10-16 | Self-heating Chinese medicinal adhesive plaster for improving constipation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103550112A (en) * | 2013-11-26 | 2014-02-05 | 中国药科大学 | Whitening hand mask and preparation method thereof, special hot compress device and manufacturing method thereof |
| CN108938722A (en) * | 2018-09-18 | 2018-12-07 | 左耀武 | A kind of intelligence system emplastrum and preparation method thereof for treating various constipation |
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| KR20080069297A (en) * | 2007-01-23 | 2008-07-28 | 김우원 | Novel method for preparing a functional chocolate |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103550112A (en) * | 2013-11-26 | 2014-02-05 | 中国药科大学 | Whitening hand mask and preparation method thereof, special hot compress device and manufacturing method thereof |
| CN108938722A (en) * | 2018-09-18 | 2018-12-07 | 左耀武 | A kind of intelligence system emplastrum and preparation method thereof for treating various constipation |
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| CN102370762B (en) | 2013-08-14 |
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