CN102369172A - 放射性标记方法 - Google Patents

放射性标记方法 Download PDF

Info

Publication number
CN102369172A
CN102369172A CN2010800157775A CN201080015777A CN102369172A CN 102369172 A CN102369172 A CN 102369172A CN 2010800157775 A CN2010800157775 A CN 2010800157775A CN 201080015777 A CN201080015777 A CN 201080015777A CN 102369172 A CN102369172 A CN 102369172A
Authority
CN
China
Prior art keywords
formula
compound
alkyl
bromo
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800157775A
Other languages
English (en)
Chinese (zh)
Inventor
E·G·罗宾斯
E·阿斯塔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Amersham Health AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Health AS filed Critical Amersham Health AS
Publication of CN102369172A publication Critical patent/CN102369172A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
CN2010800157775A 2009-03-31 2010-03-15 放射性标记方法 Pending CN102369172A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16496409P 2009-03-31 2009-03-31
GBGB0905515.3A GB0905515D0 (en) 2009-03-31 2009-03-31 Radiolabelling methods
GB0905515.3 2009-03-31
US61/164964 2009-03-31
PCT/US2010/027278 WO2010117557A1 (en) 2009-03-31 2010-03-15 Radiolabelling methods

Publications (1)

Publication Number Publication Date
CN102369172A true CN102369172A (zh) 2012-03-07

Family

ID=40672014

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800157775A Pending CN102369172A (zh) 2009-03-31 2010-03-15 放射性标记方法

Country Status (6)

Country Link
US (1) US20120004404A1 (https=)
EP (1) EP2414308A1 (https=)
JP (1) JP2012522051A (https=)
CN (1) CN102369172A (https=)
GB (1) GB0905515D0 (https=)
WO (1) WO2010117557A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113769121A (zh) * 2020-09-18 2021-12-10 中国原子能科学研究院 针对冠状病毒或流感病毒引发疾病的放射性治疗药物及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014194169A1 (en) * 2013-05-31 2014-12-04 The General Hospital Corporation Radiosynthesis of tau radiopharmaceuticals
CN107628926B (zh) * 2017-09-29 2020-07-28 四川理工学院 一种单氟乙基取代芳香化合物的制备方法
WO2024254253A2 (en) * 2023-06-07 2024-12-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Boronic acid mediated cellular delivery of therapeutic oligonucleotides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1758925A (zh) * 2003-03-13 2006-04-12 安盛药业有限公司 生物活性载体的放射氟化方法
CN101035755A (zh) * 2004-10-05 2007-09-12 通用电气健康护理有限公司 脱保护的方法
WO2008023780A1 (en) * 2006-08-25 2008-02-28 Gifu University Method of rapid methylation, kit for preparing pet tracer and method of producing pet tracer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222426D0 (en) 2002-09-27 2002-11-06 Imaging Res Solutions Ltd Chemical process
JP4940721B2 (ja) * 2005-03-30 2012-05-30 東ソー株式会社 触媒組成物及びそれを用いたクロスカップリング化合物の製造方法
JP5513378B2 (ja) * 2007-06-15 2014-06-04 ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド 治療化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1758925A (zh) * 2003-03-13 2006-04-12 安盛药业有限公司 生物活性载体的放射氟化方法
CN101035755A (zh) * 2004-10-05 2007-09-12 通用电气健康护理有限公司 脱保护的方法
WO2008023780A1 (en) * 2006-08-25 2008-02-28 Gifu University Method of rapid methylation, kit for preparing pet tracer and method of producing pet tracer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BJOERN STEINIGER ET AL.: "ynthesis of 18F-labelled biphenyls via Suzuki cross-coupling with 4-[18F]fluoroiodobenzene", 《J. LABEL. COMPOUNDS RADIOPHARM.》 *
FRANCISCO GONZÁLEZ-BOBES等: "Amino Alcohols as Ligands for Nickel-Catalyzed Suzuki Reactions of Unactivated Alkyl Halides, Including Secondary Alkyl Chlorides, with Arylboronic Acids", 《J. AM. CHEM. SOC.》 *
PING LIU ET AL: "Discovery of N-{(1S,2S)-2-(3-cyanophenyl)-3-[4-(2-[18F] fluoroethoxy)phenyl]-1-methylpropyl}-2-met hyl-2-[(5-methylpyridin-2-yl)oxy]propanami de, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use", 《J. MED. CHEM》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113769121A (zh) * 2020-09-18 2021-12-10 中国原子能科学研究院 针对冠状病毒或流感病毒引发疾病的放射性治疗药物及其制备方法

Also Published As

Publication number Publication date
JP2012522051A (ja) 2012-09-20
WO2010117557A1 (en) 2010-10-14
EP2414308A1 (en) 2012-02-08
US20120004404A1 (en) 2012-01-05
GB0905515D0 (en) 2009-05-13

Similar Documents

Publication Publication Date Title
Tay et al. 19F-and 18F-arene deoxyfluorination via organic photoredox-catalysed polarity-reversed nucleophilic aromatic substitution
Pike Hypervalent aryliodine compounds as precursors for radiofluorination
CN1938244B (zh) 氟化方法
KR102007053B1 (ko) 18ｆ―표지된 생분자의 합성 방법
JP2014028837A (ja) インビボ造影剤としてのアニリド誘導体及びベンゾチアゾールフルオリネート誘導体のフッ素化法
Ermert 18F‐Labelled intermediates for radiosynthesis by modular build‐up reactions: newer developments
CN102369172A (zh) 放射性标记方法
EP2766326B1 (en) Method for the synthesis of 18f-labelled biomolecules
KR101859782B1 (ko) 합성 방법
US7999139B2 (en) Solid-phase preparation of [18F]fluorohaloalkanes
Kwon et al. Catalyst-free aromatic radiofluorination via oxidized Iodoarene precursors
Médoc et al. Nucleophilic radiofluorination at room temperature via aziridinium intermediates
KR101478140B1 (ko) １８ｆ-표지 ｐｅｔ 방사성의약품의 전구체 및 그 제조방법
US8614360B2 (en) Method for the preparation of [18F]fluoroalkylhalides
JP2019515929A (ja) アルキル化の方法
Spivey et al. Opportunities for isotopic labelling via phase‐tagged synthesis with organogermanium linkers
Calderwood Novel methods for 18F-radiolabelling
KR20140069001A (ko) [18f]플루오로메틸 브로마이드의 단순화된 방사합성
Miller IV Selective Iodination Using Diaryliodonium Salts
Karimi et al. The Role of Recent Development of 18F Radiochemistry in Drug Development
Tseng The Synthesis of Bioactive Compounds by Using Phase-tagged Germanium Chemistry
Topley The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20120307