CN102366473B - Oral traditional Chinese medicine preparation for treating swine high fever disease and preparation method thereof - Google Patents
Oral traditional Chinese medicine preparation for treating swine high fever disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an oral traditional Chinese medicine preparation for treating the swine high fever disease and a preparation method thereof. The oral traditional Chinese medicine preparation is prepared from the following traditional Chinese medicine raw materials by weight: 150-160g of gypsum, 120-130g of scutellaria, 150-160g of dried rehmannia root, 150-160g of cortex moutan, 130-140g of bezoar, 90-110g of rhizoma atractylodis, 150-160g of phellodendron,150-160g of gardenia, 130-140g of rhubarb, 60-80g of coptis, 90-110g of forsythia, 90-110g of gentian and 90-110g of licorice. The preparation method comprises the following steps: (1) extracting volatile oil from rhizoma atractylodis for standby, storing medicine liquid for standby and reserving medicine residues for standby; (2) decocting the traditional Chinese medicine raw materials except rhizoma atractylodis in water, and pouring rhizoma atractylodis medicine residue to obtain filtrate; (3) combining the filtrate with the rhizoma atractylodis medicine liquid, uniformly mixing, adding ethanol, filtering and collecting the supernatant for standby; and (4) adding Tween-80, uniformly mixing, adding rhizoma atractylodis volatile oil, adding water, filtering, filling and sterilizing to obtain the oral preparation. After the preparation is taken by the swine, better curative effect can be achieved, thus the mortality rate is reduced and the pork quality is improved.
Description
Technical field
The present invention relates to veterinary drug, is a kind of oral preparation of Chinese traditional medicinal for the treatment of porcine hyperthermia and preparation method thereof.
Background technology
Porcine hyperthermia also claims high fever syndrome of pigs or claims unknown high fever of pigs etc., is the equal disease with high of a kind of M ﹠ M.The clinical manifestation of sick pig is mainly fervescence, inappetence, dyspnea, breathes, the sick pig of part is with the skin rubefaction purpling, petechia, the sick Pilus Sus domestica hole of minority etc., higher infectiousness is arranged, as can not in time treating, the mortality rate of sick pig is generally at 50-90%, and can make poor growth or the stagnation of pig.Because this sick sickness rate height, so, in order to prevent the generation of this disease, generally be in feedstuff, to add antibiotic, make behind the pig feed antibiotic to improve resistance against diseases, also adopt antibiotic therapy after the pig morbidity, antibiotic residual in the pig body is owing to produce bigger infringement to health, therefore, those skilled in the art provide compound formulation and Chinese medicine preparation in the hope of reaching under the better therapeutic effect prerequisite, and meat quality is increased.Though several preparations of having reported have some advantage, but its therapeutic effect still can not reach high requirement, through market survey as can be known, the swine rearing base still can't these products of relieved use, and the phenomenon that causes adopting a large amount of various antibiotic prophylaxis and treatment porcine hyperthermia is ubiquity still.Because the pig antimicrobial resistance is higher, when porcine hyperthermia takes place, cause bigger loss easily for the swine rearing base.
Summary of the invention
The objective of the invention is, a kind of oral preparation of Chinese traditional medicinal for the treatment of porcine hyperthermia and preparation method thereof is provided, it adopts pure raw material of Chinese medicine to make, make pig behind edible preparation of the present invention, can reach better therapeutic effect, thereby reduce the mortality rate of pig, and can improve meat quality.
The present invention for achieving the above object; be achieved through the following technical solutions: a kind of oral preparation of Chinese traditional medicinal for the treatment of porcine hyperthermia, made by the raw material of Chinese medicine of following weight ratio: Gypsum Fibrosum 150-160g, Radix Scutellariae 120-130g, Radix Rehmanniae 150-160g, Cortex Moutan 150-160g, Calculus Bovis 130-140g, Rhizoma Atractylodis 90-110g, Cortex Phellodendri 150-160g, Fructus Gardeniae 150-160g, Radix Et Rhizoma Rhei 130-140g, Rhizoma Coptidis 60-80g, Fructus Forsythiae 90-110g, Radix Gentianae 90-110g and Radix Glycyrrhizae 90-110g.
Described a kind of oral preparation of Chinese traditional medicinal for the treatment of porcine hyperthermia is made by the raw material of Chinese medicine of following weight ratio: Gypsum Fibrosum 150g, Radix Scutellariae 125g, Radix Rehmanniae 150g, Cortex Moutan 150g, Calculus Bovis 130g, Rhizoma Atractylodis 100g, Cortex Phellodendri 150g, Fructus Gardeniae 150g, Radix Et Rhizoma Rhei 130g, Rhizoma Coptidis 70g, Fructus Forsythiae 100g, Radix Gentianae 100g and Radix Glycyrrhizae 100g.
Described a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of porcine hyperthermia comprises the steps:
1. get Rhizoma Atractylodis 90-110g, 6-8 times of water logging to Rhizoma Atractylodis weight of adding steeped 30-40 minute, the volatile oil of extraction Rhizoma Atractylodis 10 hours, and it is standby to collect volatile oil, and it is standby that the medicinal liquid behind the extraction volatile oil is inserted the interior storage of reservoir, and medicinal residues are standby;
2. get Gypsum Fibrosum 150-160g, Radix Scutellariae 120-130g, Radix Rehmanniae 150-160g, Cortex Moutan 150-160g, Calculus Bovis 130-140g, Cortex Phellodendri 150-160g, Fructus Gardeniae 150-160g, Radix Et Rhizoma Rhei 130-140g, Rhizoma Coptidis 60-80g, Fructus Forsythiae 90-110g, Radix Gentianae 90-110g and Radix Glycyrrhizae 90-110g and mix back adding 12-24 doubly to the water that mixes back raw material of Chinese medicine weight, soaked 50-60 minute, decocting boils, pour the Rhizoma Atractylodis medicinal residues after step is extracted volatile oil in 1. simultaneously into, intense fire boiling back when decocting boils, slow fire boiling 60-80 minute, decoction liquor is filtered, and obtains filtrate;
3. filtrate and the step medicinal liquid that 1. extract volatile oil after of step in 2. merged mixing, adds ethanol, leave standstill 24 hours after, the leaching supernatant is standby;
4. under stirring condition, in supernatant, add Tween 80 40-80g, behind the mixing, add the 1. middle Rhzoma Atractylodis Lanceae volatile oil that extracts of step again, add water move to 2000ml, filter back fill sterilization, be oral formulations.
The consumption of described Tween 80 is 70g.
In the raw material that oral formulations of the present invention adopts, Gypsum Fibrosum is used for expelling pathogenic factors from muscles for clearing heat; Radix Scutellariae is used for heat-clearing and toxic substances removing; The Radix Rehmanniae is used for heat clearing away YIN nourishing, cooling blood for hemostasis; Cortex Moutan is used for promoting blood circulation to remove blood stasis; Calculus Bovis is used for heat-clearing and toxic substances removing; Rhizoma Atractylodis are used for dampness, spleen invigorating, expelling wind and removing dampness; Cortex Phellodendri is used for heat clearing away, pathogenic fire purging, detoxifcation; Fructus Gardeniae is used for pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Radix Et Rhizoma Rhei is used for purging heat, warming the spleen; Rhizoma Coptidis is used for heat clearing and damp drying, eliminating fire and detoxication; Fructus Forsythiae is used for heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens; Radix Gentianae is used for heat clearing away, eliminating pathogen in the liver, removing pathogenic heat from blood and toxic substance from the body; Radix Glycyrrhizae is used for coordinating the actions of various ingredients in a prescription.The combination of above-mentioned all medicines has heat-clearing and toxic substances removing, removing heat from blood purges heat, nurses one's health effects such as spleen liver, cooling blood for hemostasis, dispelling wind and heat pathogens, for the hyperpyrexia disease disease of pig notable therapeutic effect is arranged, and has the little characteristics of side effect simultaneously.
Oral formulations of the present invention can be used for treating porcine hyperthermia.Preparation of the present invention was tried out and shown in 3 years in 5 swine rearing bases: effect is remarkable.The long-term follow porcine hyperthermia breaks out process and sums up: the ill temperature of pig body of institute is generally at 40.1-42 ℃, at the porcine hyperthermia their early stage, sick pig about 60% is arranged approximately at asymptomatic down sudden death, dead back whole skin is red and white, the dead pig of part abdominal distention is in various degree arranged, the hog snout hole has blood to flow out, at this moment, can tentatively judge the generation porcine hyperthermia, need to give sick pig to reach with group pig medication treatment, afterwards, appear suddenly gradually with classical symptom in the group pig: 1-3 monthly age pig morbidity is the most common, and its disease is generally: loss of appetite, cough, bradykinesia, palpitate quickly, the ear tip is blue, blepharoedema; Part pig arthroncus, cuing open in inspection breast, abdominal cavity, the articular cavity has a large amount of weak yellow liquids, and pericardial fluid increases, and there is one deck fibrin exudate on the heart, lung, liver, gastrointestinal surface.The symptom of nursery pig and growing and fattening pigs is: appetite descends, with cough, dyspnea, the dorsal body setae gross porosity, and myasthenia of limbs, hind leg occur walking lamely carpal joint and tarsal joint swelling.The symptom of replacement gilt is: spirit is depressed, and extremity are stiff, the strong slight swelling in place of joint and flesh, and the nursing sow classical symptom is: walk lamely, and descend with appetite.The sick pig of trouble hyperpyrexia disease is taken oral formulations statistics of the present invention and shows: take every day twice, take by the 2mg/kg.bw consumption, 612 1-3 monthly age, sick pig took that appetite obviously increases after 1 day, after taking three days, the cough transference cure, the arthroncus phenomenon goes down, and body temperature descends, and 96 sick temperature of pig body are down to 38.7 ℃-39.1 ℃.Took medicine 5-6 days, there are 509 sick temperature of pig body to be down to 38.1-38.9 ℃, the loss of appetite transference cure, arthroncus, cough, palpitate quickly, bradykinesia, blue, the blepharoedema transference cure of the ear tip, between 39.8-41 ℃, body temperature was down to 38 to body temperature after taking medicine 9 days always during 2 sick pigs were taken medicine 5-6 days.2 ℃, ill pig transference cure.After 1 sick pig was taken medicine 5 days, body temperature increased cephalo plug furan sodium injection composite reagent one time by the 4mg/kg.bw consumption simultaneously still at 41 ℃ every day, and sick pig symptom all disappears after 4 days.
The sick pig of child care and fatten 21 of disease pigs, the medication symptom of coughing after 1 day obviously reduces, after taking medicine 3 days, appetite increases, dyspnea, dorsal body setae gross porosity transference cure, limb force obviously increases, after taking medicine 5 days, the limping transference cure, body temperature is down to 38 ℃, the limping transference cure, and carpal joint and tarsal joint swelling obviously alleviate, continued to take medicine 3 days, ill pig symptom all disappears again.9 of the female sick pigs of suckling, appetite increases after taking medicine 1 day, and after taking medicine 3 days, body temperature is down to 38.1 ℃, and extremity are strong, the limping transference cure.17 of the female sick pigs of reserve, spirit is clearly better after taking medicine 1 day, the stiff transference cure of extremity after taking medicine 3 days, after taking medicine 5 days, the slight swelling transference cure in joint and extremity place, body temperature is down to 38 ℃, and appetite returns to the preceding state of disease.
Oral formulations of the present invention also has preventive effect preferably, when having in the pig one to fall ill to two with the group, give pig continuous use 5-7 days of other not morbidity as yet, dosage is 50% of therapeutic dose, and statistical data shows: can make pig about 90% avoid the generation of porcine hyperthermia.
The specific embodiment
A kind of oral preparation of Chinese traditional medicinal for the treatment of porcine hyperthermia of the present invention is made by the raw material of Chinese medicine of following weight ratio: Gypsum Fibrosum 150-160g, Radix Scutellariae 120-130g, Radix Rehmanniae 150-160g, Cortex Moutan 150-160g, Calculus Bovis 130-140g, Rhizoma Atractylodis 90-110g, Cortex Phellodendri 150-160g, Fructus Gardeniae 150-160g, Radix Et Rhizoma Rhei 130-140g, Rhizoma Coptidis 60-80g, Fructus Forsythiae 90-110g, Radix Gentianae 90-110g and Radix Glycyrrhizae 90-110g.
The raw material that uses in the oral formulations of the present invention can have following multiple weight ratio combination:
1, Gypsum Fibrosum 150g, Radix Scutellariae 125g, Radix Rehmanniae 150g, Cortex Moutan 150g, Calculus Bovis 130g, Rhizoma Atractylodis 100g, Cortex Phellodendri 150g, Fructus Gardeniae 150g, Radix Et Rhizoma Rhei 130g, Rhizoma Coptidis 70g, Fructus Forsythiae 100g, Radix Gentianae 100g and Radix Glycyrrhizae 100g.
2, Gypsum Fibrosum 150g, Radix Scutellariae 120g, Radix Rehmanniae 150g, Cortex Moutan 150g, Calculus Bovis 130g, Rhizoma Atractylodis 90g, Cortex Phellodendri 150g, Fructus Gardeniae 150g, Radix Et Rhizoma Rhei 130g, Rhizoma Coptidis 60g, Fructus Forsythiae 90g, Radix Gentianae 90g and Radix Glycyrrhizae 90g.
3, Gypsum Fibrosum 1160g, Radix Scutellariae 130g, Radix Rehmanniae 160g, Cortex Moutan 160g, Calculus Bovis 140g, Rhizoma Atractylodis 110g, Cortex Phellodendri 160g, Fructus Gardeniae 160g, Radix Et Rhizoma Rhei 140g, Rhizoma Coptidis 80g, Fructus Forsythiae 110g, Radix Gentianae 110g and Radix Glycyrrhizae 110g.
4, Gypsum Fibrosum 140g, Radix Scutellariae 125g, Radix Rehmanniae 155g, Cortex Moutan 155g, Calculus Bovis 135g, Rhizoma Atractylodis 100g, Cortex Phellodendri 155g, Fructus Gardeniae 155g, Radix Et Rhizoma Rhei 135g, Rhizoma Coptidis 70g, Fructus Forsythiae 100g, Radix Gentianae 100g and Radix Glycyrrhizae 100g.
The oral formulations of the above-mentioned various combinations of the present invention is all made as follows.
A kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of porcine hyperthermia of the present invention comprises the steps:
1. get Rhizoma Atractylodis 90-110g, 6-8 times of water logging to Rhizoma Atractylodis weight of adding steeped 30-40 minute, the volatile oil of extraction Rhizoma Atractylodis 10 hours, and it is standby to collect volatile oil, and it is standby that the medicinal liquid behind the extraction volatile oil is inserted the interior storage of reservoir, and medicinal residues are standby;
2. get Gypsum Fibrosum 150-160g, Radix Scutellariae 120-130g, Radix Rehmanniae 150-160g, Cortex Moutan 150-160g, Calculus Bovis 130-140g, Cortex Phellodendri 150-160g, Fructus Gardeniae 150-160g, Radix Et Rhizoma Rhei 130-140g, Rhizoma Coptidis 60-80g, Fructus Forsythiae 90-110g, Radix Gentianae 90-110g and Radix Glycyrrhizae 90-110g and mix back adding 12-24 doubly to the water that mixes back raw material of Chinese medicine weight, soaked 50-60 minute, decocting boils, pour the Rhizoma Atractylodis medicinal residues after step is extracted volatile oil in 1. simultaneously into, intense fire boiling back when decocting boils, slow fire boiling 60-80 minute, decoction liquor is filtered, and obtains filtrate;
3. filtrate and the step medicinal liquid that 1. extract volatile oil after of step in 2. merged mixing, adds ethanol, leave standstill 24 hours after, the leaching supernatant is standby;
4. under stirring condition, in supernatant, add Tween 80 40-80g, behind the mixing, add the 1. middle Rhzoma Atractylodis Lanceae volatile oil that extracts of step again, add water move to 2000ml, filter back fill sterilization, be oral formulations.
The consumption of described Tween 80 is 70g.
Claims (2)
1. a preparation method for the treatment of the oral preparation of Chinese traditional medicinal of porcine hyperthermia is characterized in that: comprise the steps:
1. get Rhizoma Atractylodis 90-110g, 6-8 times of water logging to Rhizoma Atractylodis weight of adding steeped 30-40 minute, the volatile oil of extraction Rhizoma Atractylodis 10 hours, and it is standby to collect volatile oil, and it is standby that the medicinal liquid behind the extraction volatile oil is inserted the interior storage of reservoir, and medicinal residues are standby;
2. get Gypsum Fibrosum 150-160g, Radix Scutellariae 120-130g, Radix Rehmanniae 150-160g, Cortex Moutan 150-160g, Calculus Bovis 130-140g, Cortex Phellodendri 150-160g, Fructus Gardeniae 150-160g, Radix Et Rhizoma Rhei 130-140g, Rhizoma Coptidis 60-80g, Fructus Forsythiae 90-110g, Radix Gentianae 90-110g and Radix Glycyrrhizae 90-110g and mix back adding 12-24 doubly to the water that mixes back raw material of Chinese medicine weight, soaked 50-60 minute, decocting boils, pour the Rhizoma Atractylodis medicinal residues after step is extracted volatile oil in 1. simultaneously into, intense fire boiling back when decocting boils, slow fire boiling 60-80 minute, decoction liquor is filtered, and obtains filtrate;
3. filtrate and the step medicinal liquid that 1. extract volatile oil after of step in 2. merged mixing, adds ethanol, leave standstill 24 hours after, the leaching supernatant is standby;
4. under stirring condition, in supernatant, add Tween 80 40-80g, behind the mixing, add the 1. middle Rhzoma Atractylodis Lanceae volatile oil that extracts of step again, add water move to 2000ml, filter back fill sterilization, be oral formulations.
2. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of porcine hyperthermia according to claim 1, it is characterized in that: the consumption of described Tween 80 is 70g.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103585556B (en) * | 2013-11-22 | 2015-12-02 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
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| CN103405713B (en) * | 2013-07-09 | 2015-06-03 | 刘华武 | Sanhuang powder for preventing and treating swine heat stress in summer |
| CN103585558B (en) * | 2013-11-22 | 2015-11-25 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN103585559B (en) * | 2013-11-22 | 2015-11-25 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585555B (en) * | 2013-11-22 | 2015-12-02 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585553B (en) * | 2013-11-22 | 2015-12-30 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN103585552B (en) * | 2013-11-22 | 2015-12-09 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585557B (en) * | 2013-11-22 | 2015-10-28 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN103585550B (en) * | 2013-11-22 | 2015-10-28 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585549B (en) * | 2013-11-22 | 2015-10-28 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN107281404A (en) * | 2017-07-11 | 2017-10-24 | 田鑫 | A kind of Chinese medicine for preventing and treating porcine hyperthermia |
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| CN101156916A (en) * | 2007-09-30 | 2008-04-09 | 中国农业大学 | A medicine for treating hyperpyrexia disease of pig |
| CN102188601A (en) * | 2011-04-28 | 2011-09-21 | 完颜德杰 | Chinese medicinal powder for treating mixed infection of swine diseases |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156916A (en) * | 2007-09-30 | 2008-04-09 | 中国农业大学 | A medicine for treating hyperpyrexia disease of pig |
| CN102188601A (en) * | 2011-04-28 | 2011-09-21 | 完颜德杰 | Chinese medicinal powder for treating mixed infection of swine diseases |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103585556B (en) * | 2013-11-22 | 2015-12-02 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
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