CN102366459A

CN102366459A - Traditional Chinese medicinal composition for treating Herpes zoster and preparation method thereof

Info

Publication number: CN102366459A
Application number: CN2011102396298A
Authority: CN
Inventors: 钱家美
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-08-20
Filing date: 2011-08-20
Publication date: 2012-03-07

Abstract

The invention relates to a traditional Chinese medicinal composition for treating Herpes zoster. The traditional Chinese medicinal composition is prepared by coptis, Ligusticum wallichii, heydyotis, weeping forsythia, isatis root, bitter organe, fructus toosendan, safflower, Fructus Gardeniae, Cortex moutan, radix paeoniae rubrathe, purslane, root of large-flowered skullcap, Plantain seed, Peach Seed, clerodendroa cyrtophyllum, gentian, spatholobus stem, Poria peel, fructus liquidambaris and/or a carrier which is acceptable on the pharmacy. The invention also relates to a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition has functions of clearing heat, eliminating dampness, promoting blood circulation, removing blood stasis, detoxifying and relieving pain, and is used for treating symptoms of ache of affected part, general fatigue and weakness, inappetence and feveret which are caused by Herpes zoster.

Description

A kind of Chinese medicine composition of treating herpes zoster and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition of treating herpes zoster and preparation method thereof.

Background technology

Herpes zoster is the acute inflammation dermatoses that is caused by varicella zoster virus, and the traditional Chinese medical science is called " skirt-roof HUOLONG ", " herpes zoster ".Among the people being commonly called as " herpes zoster ", " herpes zoster ".

This disease virus is by in the respiratory tract infection intrusive body, hides in the neurocyte of dorsal root neuroganglion or other site of pathological change.This virus can not fallen ill at ordinary times, but because the people of old people and weakness due to chronic disease, the whole body resistance descends, and runs into inducements such as fatigue, flu again, then is prone to send out this disease.Pathogenesis: primary infection can take place in the crowd of no immunity or low immunity behind the viral infection (majority is the child), and chickenpox promptly takes place.Or viral inapparent infection, the capable dermal sensation teleneuron that propagates into of menses is through nervous pathway root or nervi trigeminus behind the spinal nerves; Propagate into the neuron of ganglia sensorialia nervi encephalici then, when immunity of organisms descends (for example: wound, flu, cancer, disease of immune system or the like), the virus of hiding will be bred in a large number; Make neuroganglion inflammation, necrosis; Cause patient's pain, virus passes down along nervous pathway simultaneously, causes the segmental herpes to this innerv zone.Virus also can infect motor neuron, causes patient's myasthenia and paralysis motorica, but rarely found.At the beginning of the morbidity, it is tired unable mainly to show as whole body, inappetence, and feveret, very fast site of pathological change feels scorching hot, is jumping pain.If occur in chest or waist, constant error is examined and is heart disease or acute abdomen etc.

After getting herpes zoster l～3 day, Semen phaseoli radiati grain size, pimple, vesicle that tension force is very big promptly appear in the skin of site of pathological change, distribute along neural, and collection bunch shape is arranged, and is ribbon.If occur in chest, waist, how from a skew back of spinal column to the front lower place, few symmetry morbidity.The among the people biography: promptly being in peril of one's life if a circle herpes occurs around waist, is insecure.Suffer from this patient, every bunch of the lighter can between be separated with normal skin, the person of being in a bad way can be merged large stretch of zonal distribution, the vesicle by clear after a few days becomes muddy pustule, but the part ulceration forms erosion.The old people shows as bulla, blood blister more, even occurs downright bad.The lighter can be dried up, form a scab by nature about three weeks, did not stay cicatrix after coming off; Heavy person's course of disease can extend to more than one month.Having an intense pain often appears in the gerontal patient, and influence sleep if treat untimelyly, after skin lesion disappears, is still left over pain, and the several months can not disappear fully.If herpes zoster appears at head, face, watch out for headache, the facial paralysis invading women's head-ornaments portion nerve and occur.If the eyes cornea is invaded, even also can cause losing one's sight.Older, Low and suffer from chronic disease person such as tumor, the state of an illness can be even more serious.It should be noted that also common clinically a kind of not holotype herpes zoster that arrives, patient is except that conscious site of pathological change has an intense pain, and vesicle does not occur or occurs seldom, is easy to should give great attention by mistaken diagnosis, in order to avoid affect treatment adversely, finds serious consequence.Herpes zoster can occur in facial nervi trigeminus sections, a nerve fiber is arranged, i.e. the ophthalmic nerve fiber in the nervi trigeminus; To such an extent as to part of nerve fibers is distributed in human eyeball's the whole eyeball of cornea, conjunctiva; If the nerve fiber at this position receives herpesvirus infection, keratitis, corneal ulcer, conjunctivitis can take place, the patient can keep in dark place, sheds tears, ocular pain; So that visual deterioration, panophthalmitis takes place and causes losing one's sight in weight person.During the Motor nerve fibre of herpesvirus infection in nervus facialis, will produce facial paralysis, the Ipsilateral eyes occurring can not be closed, and the Ipsilateral facial expression is stiff, and bicker slants tiltedly to strong, can not do the action etc. of blowing.The generation of herpes zoster is many by feelings will internal injury, depression of liver-QI, the stagnation of QI with the passing of time and fire-transformation, the excessive skin of Liver Channel fire-toxin and sending out; Or because of dysfunction of the spleen in transportation, endogenous dampness accumulates heat of wetting, retention of damp-heat in the interior, excessive skin and giving birth to; Or it is evil to infect poison, and damp and hot fire-toxin accumulates long-pending skin and forms.

The traditional Chinese medical science is divided into three types with this disease:

1. excessive heat type: local skin lesion is scarlet, tonic vesicle wall, scorching hot twinge.Conscious bitter taste in the mouth and dry throat, thirsty, the unhappy irritability that is prone to is off one's feed.Red urine, big dry stool or not well.Red tongue, tongue fur BOHUANG or yellow thick, the little number of stringy and rolling pulse.

2. wet Sheng type: skin color is lighter, flaccid vesicle wall, and pain is slightly light, and mouth is yearningly or thirsty and not desire drink not, anorexia, abdominal distention after meal, the common leucorrhea of female patient is many.Pale tongue is fat, and tongue fur is white thick or white greasy, deep-slow pulse or cunning.

3. qi stagnation and blood stasis type: local pain is more than after the deflorescence.Dark tongue quality, tongue is white, stringy and thready pulse.The traditional Chinese medical science adopts eliminating damp-heat, blood circulation promoting and blood stasis dispelling, this disease of detoxifcation analgesic decoction for the treatment.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition of treating herpes zoster.The present invention also aims to provide a kind of method for preparing of this Chinese medicine composition.

In order to realize the object of the invention; The invention provides a kind of Chinese medicine composition of treating herpes zoster; Be to be processed by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is processed by following raw materials according by weight: Rhizoma Coptidis 10-20 part, Rhizoma Chuanxiong 5-15 part, Herba Hedyotidis Diffusae 5-10 part, Fructus Forsythiae 15-25 part, Radix Isatidis 15-25 part, Fructus Aurantii 10-20 part, Fructus Toosendan 5-10 part, Flos Carthami 10-15 part, Fructus Gardeniae 5-10 part, Cortex Moutan 20-30 part, Radix Paeoniae Rubra 15-25 part, Herba Portulacae 5-20 part, Radix Scutellariae 15-25 part, Semen Plantaginis 10-15 part, Semen Persicae 15-25 part, Folium Isatidis 10-20 part, Radix Gentianae 5-10 part, Caulis Spatholobi 10-15 part, Cortex Sclerotii Poriae 20-25 part, Fructus Liquidambaris 10-20 part.

Effective ingredient is preferably processed by following raw materials according by weight: 16 parts of Rhizoma Coptidis, 10 parts of Rhizoma Chuanxiongs, 8 parts of Herba Hedyotidis Diffusaes, 21 parts of Fructus Forsythiaes, 20 parts of Radix Isatidis, 16 parts of Fructus Aurantiis, 8 parts of Fructus Toosendans, 13 parts on Flos Carthami, 8 parts of Fructus Gardeniae, 26 parts of Cortex Moutans, 21 parts of Radix Paeoniae Rubra, 16 parts of Herba Portulacaes, 21 parts of Radix Scutellariaes, 13 parts of Semen Plantaginiss, 21 parts in Semen Persicae, 16 parts of Folium Isatidiss, 8 parts of Radix Gentianaes, 13 parts of Caulis Spatholobis, 23 parts of Cortex Sclerotii Poriae, 16 parts of Fructus Liquidambaris.

The present invention also provides a kind of method for preparing of this Chinese medicine composition, comprises the steps:

(1) Rhizoma Coptidis, Cortex Moutan, Caulis Spatholobi are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Rhizoma Chuanxiong, Herba Hedyotidis Diffusae, Fructus Forsythiae, Radix Isatidis, Fructus Aurantii, Fructus Toosendan, Flos Carthami, Fructus Gardeniae, Radix Paeoniae Rubra, Herba Portulacae, Radix Scutellariae, Semen Plantaginis, Semen Persicae, Folium Isatidis, Radix Gentianae, Cortex Sclerotii Poriae, Fructus Liquidambaris decocte with water secondary each 2 hours, filter; Merging filtrate; Left standstill 48 hours, and got supernatant, it is the thick paste of 1. 20 (60 ℃) that concentrating under reduced pressure becomes relative density; Add above-mentioned clear paste, process gel with pharmaceutically acceptable carrier.

Chinese medicine composition of the present invention has effects such as eliminating damp-heat, blood circulation promoting and blood stasis dispelling, detoxifcation pain relieving, and it is tired unable to be used for affected part pain, whole body that herpes zoster causes, inappetence, diseases such as feveret.

The specific embodiment

Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.

Embodiment: Chinese medicine composition gel of the present invention

(1) Fructus Aurantii 160g, Rhizoma Coptidis 160g, Cortex Moutan 260g, Caulis Spatholobi 130g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1. 05 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Rhizoma Chuanxiong 100g, Herba Hedyotidis Diffusae 80g, Fructus Forsythiae 210g, Radix Isatidis 200g, Fructus Aurantii 160g, Fructus Toosendan 80g, Flos Carthami 130g, Fructus Gardeniae 80g, Radix Paeoniae Rubra 210g, Herba Portulacae 160g, Radix Scutellariae 210g, Semen Plantaginis 130g, Semen Persicae 210g, Folium Isatidis 160g, Radix Gentianae 80g, Cortex Sclerotii Poriae 230g, Fructus Liquidambaris 160g decocte with water secondary; Each 2 hours, filter merging filtrate; Left standstill 48 hours; Get supernatant, it is the thick paste of 1. 05 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned clear paste; Stir, subsequent use.Carbomer 30g mixes with tween 80 4g and 500ml pure water, adds 4% sodium hydroxide 500ml, stirs, and adds after Nipagin ester 2g is dissolved in 150ml ethanol, stirs.Again cream liquid is added to stir and promptly get.

Claims

1. Chinese medicine composition of treating herpes zoster; Be to process by effective ingredient and/or pharmaceutically acceptable carrier; It is characterized in that described effective ingredient is processed by following raw materials according by weight: Rhizoma Coptidis 10-20 part, Rhizoma Chuanxiong 5-15 part, Herba Hedyotidis Diffusae 5-10 part, Fructus Forsythiae 15-25 part, Radix Isatidis 15-25 part, Fructus Aurantii 10-20 part, Fructus Toosendan 5-10 part, Flos Carthami 10-15 part, Fructus Gardeniae 5-10 part, Cortex Moutan 20-30 part, Radix Paeoniae Rubra 15-25 part, Herba Portulacae 5-20 part, Radix Scutellariae 15-25 part, Semen Plantaginis 10-15 part, Semen Persicae 15-25 part, Folium Isatidis 10-20 part, Radix Gentianae 5-10 part, Caulis Spatholobi 10-15 part, Cortex Sclerotii Poriae 20-25 part, Fructus Liquidambaris 10-20 part.

2. Chinese medicine composition according to claim 1 is characterized in that described effective ingredient processed by following raw materials according by weight: 16 parts of Rhizoma Coptidis, 10 parts of Rhizoma Chuanxiongs, 8 parts of Herba Hedyotidis Diffusaes, 21 parts of Fructus Forsythiaes, 20 parts of Radix Isatidis, 16 parts of Fructus Aurantiis, 8 parts of Fructus Toosendans, 13 parts on Flos Carthami, 8 parts of Fructus Gardeniae, 26 parts of Cortex Moutans, 21 parts of Radix Paeoniae Rubra, 16 parts of Herba Portulacaes, 21 parts of Radix Scutellariaes, 13 parts of Semen Plantaginiss, 21 parts in Semen Persicae, 16 parts of Folium Isatidiss, 8 parts of Radix Gentianaes, 13 parts of Caulis Spatholobis, 23 parts of Cortex Sclerotii Poriae, 16 parts of Fructus Liquidambaris.

3. according to the arbitrary described Chinese medicine composition of claim 1-2, it is characterized in that said Chinese medicine composition can be made into gel.

4. according to the method for preparing of the arbitrary described Chinese medicine composition of claim 1 to 3, comprise the steps:

(1) Fructus Aurantii Rhizoma Coptidis, Cortex Moutan, Caulis Spatholobi are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(2) Rhizoma Chuanxiong, Herba Hedyotidis Diffusae, Fructus Forsythiae, Radix Isatidis, Fructus Toosendan, Flos Carthami, Fructus Gardeniae, Radix Paeoniae Rubra, Herba Portulacae, Radix Scutellariae, Semen Plantaginis, Semen Persicae, Folium Isatidis, Radix Gentianae, Cortex Sclerotii Poriae, Fructus Liquidambaris decocte with water secondary each 2 hours, filter; Merging filtrate; Left standstill 48 hours, and got supernatant, it is the thick paste of 1. 20 (60 ℃) that concentrating under reduced pressure becomes relative density; Add above-mentioned clear paste, process gel with pharmaceutically acceptable carrier.