CN102362908B - Medicinal composition for treating kidney-yang deficiency and preparation method thereof - Google Patents
Medicinal composition for treating kidney-yang deficiency and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating kidney-yang deficiency and a preparation method thereof. According to a formula, the medicinal composition is prepared from cistanche deserticola, common cnidium fruit, south dodder seed, morinda officinalis, Chinese magnoliavine fruit, eucommia ulmoides, divaricate saposhnikovia root, thinleaf milkwort rootbark, sea horse and sea dragon in a certain ratio. The preparation method comprises the following steps of: processing all medicinal materials, and crushing a part of medicinal materials and sieving; impregnating a part of the medicinal materials by using ethanol, and refluxing and recovering by using ethanol; decocting a part of medicinal materials and concentrating, mixing the medicinal materials and an ethanol extracting solution, concentrating, drying, and crushing; and totally mixing, pelletizing, and drying and thus obtaining capsules for invigorating kidney and nourishing heart. By the method, active ingredients ofthe Chinese medicine can be extracted completely, and a set medicinal effect can be achieved; and the capsules for invigorating kidney and nourishing heart have the functions of tonifying kidney and supporting Yang and nourishing heart and soothing the nerves. The medicinal composition can be used for treating kidney-yang deficiency, and symptoms of soreness and weakness of waist and knees, chilly sensation and limb coldness, exhausted mind and tired body, frequent urination and clear abundant urine, palpitation and amnesia, insomnia and dreaminess and the like.
Description
Technical field
The present invention relates to a kind of drug regimen that insufficiency of kidney-YANG loses and preparation method thereof that is used for the treatment of, belong to the Medicines and Health Product technical field.
Background technology
The TCM Culture origin stream of China is long, and Chinese medicine is ancient Chinese ancients crystallizations of wisdom, is the wealth of our preciousness.
Herba Cistanches, claim again Herba Stellariae Saxatilis, to face extinct specie on the our times frequently, medical value is high, have the good reputation of " desert Radix Ginseng ", be the highest medicine of grade in more than the 60 kind of traditional tonic medicine finding of China, contain the rare nutritious tonifying composition of a large amount of aminoacid, cystine, vitamin and mineral, the sexual organs such as male's kidney, testis, penis, spongy body are had great tonification effect.
The Cortex Eucommiae is the dry bark of the Eucommiaceae plant Cortex Eucommiae, is Chinese famous and precious tonic herb.Tool invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering, many effects such as antiabortive.
Fructus Cnidii, another name Daucus carota L. is the dry mature fruit of samphire cnidium monnieri.Summer, two season of autumn gather during fruit maturation, remove impurity, dry.Nature and flavor: warm in nature, acrid in the mouth, hardship.Function cures mainly: warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.
Semen Cuscutae is a kind of parasitic plant, and Cuscuta chinensis is the seeds such as dicotyledon scammonia section plant Semen Cuscutae, southern Semen Cuscutae, cuscuta japonica Choisy, has the effect of the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, solid tire stopping leak.
Fructus Schisandrae Chinensis is commonly called as Fructus Zanthoxyli Plansipini, sliding weight of steelyard, medicine Fructus Schisandrae Chinensis, face rattan, five Fructus Armeniacae Mumes etc., and " the sweet acid of five tastes skin and flesh is worked hard in the nuclear, and saline taste is arranged " carried in Tang etc. " Newly Revised Canon of Materia Medica ", therefore the name of Fructus Schisandrae Chinensis is arranged.Ancient medical book Cheng Ta Chi Zhu, profound and, can and, list in the earliest the Sheng Nong's herbal classic top grade, herbal function is the power of strengthening by means of tonics, medical value is high.
Summary of the invention
The purpose of this invention is to provide and a kind ofly be used for the treatment of the medicine that insufficiency of kidney-YANG loses, and preparation method and the corresponding preparation of this kind medicine are provided.
Technical scheme of the present invention is, the present invention is a kind of to be used for the treatment of drug regimen that insufficiency of kidney-YANG loses and preparation method thereof and to select Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, Radix Polygalae, Hippocampus, Solenognathus to fill a prescription according to a certain percentage a part of pulverizing medicinal materials after concocting; A part of medical material reclaims through the process of preparing Chinese medicine, alcohol dipping, alcohol reflux, ethanol; After some medical materials decoct, concentrate, with above-mentioned ethanol extract merging, concentrated, dry, pulverizing; Then through technical processs such as always mixing, granulate, be dry, make preparation.
The present invention is a kind of to be used for the treatment of the pharmaceutical composition that insufficiency of kidney-YANG loses, and its crude drug forms weight ratio and is: 200-400 parts of Herba Cistanches, 200-400 parts of Fructus Cnidiis, 200-400 parts of Semen Cuscutae (salt stir-fry), 200-400 parts of Radix Morindae Officinaliss, 200-400 parts of Fructus Schisandrae Chinensis, 200-400 parts of the Cortexs Eucommiae (salt stir-fry), 200-400 parts of Radix Saposhnikoviaes, 200-400 parts of Radix Polygalaes, 10-30 parts of Hippocampus, 10-30 parts of Solenognathus.
Described a kind of insufficiency of kidney-YANG that is used for the treatment of loses the preferred crude drug of drug regimen and forms weight ratio and be: 300 parts of Herba Cistanches, 300 parts of Fructus Cnidiis, 300 parts of Semen Cuscutae (salt stir-fry), 300 parts of Radix Morindae Officinaliss, 300 parts of Fructus Schisandrae Chinensis, 300 parts of the Cortexs Eucommiae (salt stir-fry), 300 parts of Radix Saposhnikoviaes, 300 parts of Radix Polygalaes, 15 parts of Hippocampus, 15 parts of Solenognathus.
The present invention is a kind of to be used for the treatment of the step that insufficiency of kidney-YANG loses the preparation method of drug regimen and to be:
Concoct Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, Radix Polygalae, Hippocampus, Solenognathus ten flavor medical materials rear by preferred component prescription;
Hippocampus, Solenognathus are sterilized, 60-121 ℃ of sterilising temps, 10-120 minutes time, take out and pulverize, after 80 mesh sieves, fine powder is for subsequent use, and the prostitute enters next step;
With Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Fructus Cnidii flooded 12-48 hours with 3-8 times of amounts of 50-95% ethanol together with the prostitute of previous step, reflux, extract, twice adds 3-8 times of amounts of 50-95% ethanol, each 1-4 hours at every turn, filter, merging filtrate, for subsequent use behind the decompression recycling ethanol;
Medicinal residues with after Herba Cistanches, Semen Cuscutae, Radix Saposhnikoviae, Radix Polygalae and the above-mentioned alcohol extraction decoct with water twice, add 3-10 times of amounts of water at every turn, the each decoction 1-4 hours, filter, merging filtrate, being concentrated into relative density is 1.05-1.40(85 ℃-95 ℃) clear paste, the extracting solution that adds above-mentioned Radix Morindae Officinalis etc., continuing to be concentrated into relative density is 1.10-1.40(80 ℃-85 ℃) clear paste, vacuum drying is pulverized, cross 80 mesh sieves, powder gets dry extract;
Get dried cream powder, Hippocampus, Solenognathus fine powder and conventional oral formulations adjuvant make corresponding oral formulations;
The preparation of capsule: get 20 parts of dried cream powders, 1-5 parts of Hippocampus, Solenognathus fine powders, 5-30 parts of starch, mixing is granulated, and drying is made capsule.
The present invention's beneficial effect compared with the prior art is, active ingredient in the Chinese medicine formula fully can be extracted by the method, reaches the medicinal effects of setting, and the kidney tonifying heart tonifying capsule of the present invention's preparation has reinforcing the kidney and supporting YANG, the function of tranquilizing by nourishing the heart.Can be used for insufficiency of kidney-YANG and lose, disease is seen soreness of the waist and knees, aversion to cold and cold limbs, and physical fatigue and lassitude of spirit, frequent micturition is length and palpitation and amnesia clearly, the treatment of the diseases such as insomnia and dreamful sleep.
Description of drawings
Fig. 1 is that the present invention treats the drug regimen process chart that insufficiency of kidney-YANG loses a kind of being used for the treatment of.
The specific embodiment
The specific embodiment of the present invention as shown in Figure 1.
The embodiment of the invention is a kind of to be used for the treatment of the drug regimen that insufficiency of kidney-YANG loses and to select Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, Radix Polygalae, Hippocampus, Solenognathus Ten Herbs, fill a prescription according to a certain percentage, its preparation process is as follows:
1, prepare raw material, and raw material is concocted arrangement: Herba Cistanches is removed impurity, cleans, and runs through, and cuts sheet, drying; Fructus Cnidii is removed impurity, drying; Semen Cuscutae is removed impurity, cleaning, drying; Radix Morindae Officinalis is removed impurity; Fructus Schisandrae Chinensis is removed impurity, and the time spent smashs to pieces; Radix Saposhnikoviae is removed impurity, cleans, and runs through, and cuts sheet; The Cortex Eucommiae scrapes off residual rough bark, cleans, and is cut into piece or silk, drying; Radix Polygalae is removed impurity, slightly washes, and runs through cutting, drying; Solenognathus, Hippocampus are except the dedust bits, and the time spent smashs to pieces, the raw material for standby of the above process of preparing Chinese medicine.
Press Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, each 300g of Radix Polygalae, the proportioning of Hippocampus, each 15g of Solenognathus is got the raw materials ready.
2, with Hippocampus, Solenognathus is put into sterilizing cabinet and sterilizes, 121 ℃ of temperature, and 30 minutes time, pulverize after the taking-up, after 80 mesh sieves, fine powder is for subsequent use, and the prostitute enters next step;
3, with Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Fructus Cnidii flooded twice of reflux, extract, together with the prostitute of previous step 24 hours with 5 times of amounts of 75% ethanol, add for the first time 6 times of amounts of 75% ethanol, add 5 times of amounts of 75% ethanol, each 2 hours for the second time, filter, merging filtrate, for subsequent use behind the decompression recycling ethanol;
4, with the medicinal residues after Herba Cistanches, Semen Cuscutae, Radix Saposhnikoviae, Radix Polygalae and the above-mentioned alcohol extraction, decoct with water twice, add 6 times of amounts of water for the first time, for the second time add 5 times of amounts of water, decocted 2 hours at every turn, filter, merging filtrate, be concentrated into relative density 1.15-1.25(85 ℃-95 ℃) clear paste, add the extracting solution of above-mentioned Radix Morindae Officinalis etc., continue to be concentrated into relative density 1.35(80 ℃-85 ℃) thick paste, vacuum drying, pulverize, cross 80 mesh sieves, get extract powder;
5, get extract powder, Hippocampus, Solenognathus fine powder add appropriate amount of starch and are made into 350g.
6, the powder for preparing was mixed 15 minutes in three-dimensional mixer, granulate, drying in 1000 capsules of packing into, and get final product.
Claims (2)
1. one kind is used for the treatment of the pharmaceutical composition that insufficiency of kidney-YANG loses, and it is characterized in that, the preparation method of described pharmaceutical composition is as follows:
(1) prepare raw material, and raw material is concocted arrangement: Herba Cistanches is removed impurity, cleans, and runs through, and cuts sheet, drying; Fructus Cnidii is removed impurity, drying; Semen Cuscutae is removed impurity, cleaning, drying; Radix Morindae Officinalis is removed impurity; Fructus Schisandrae Chinensis is removed impurity, and the time spent smashs to pieces; Radix Saposhnikoviae is removed impurity, cleans, and runs through, and cuts sheet; The Cortex Eucommiae scrapes off residual rough bark, cleans, and is cut into piece or silk, drying; Radix Polygalae is removed impurity, slightly washes, and runs through cutting, drying; Solenognathus, Hippocampus are except the dedust bits, and the time spent smashs to pieces, the raw material for standby of the above process of preparing Chinese medicine;
Press Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, each 300g of Radix Polygalae, the proportioning of Hippocampus, each 15g of Solenognathus is got the raw materials ready;
(2) with Hippocampus, Solenognathus is put into sterilizing cabinet and sterilizes, 121 ℃ of temperature, and 30 minutes time, pulverize after the taking-up, after 80 mesh sieves, fine powder is for subsequent use, and the prostitute enters next step;
(3) with Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Fructus Cnidii flooded twice of reflux, extract, together with the prostitute of previous step 24 hours with 5 times of amounts of 75% ethanol, add for the first time 6 times of amounts of 75% ethanol, add 5 times of amounts of 75% ethanol, each 2 hours for the second time, filter, merging filtrate, for subsequent use behind the decompression recycling ethanol;
(4) with the medicinal residues after Herba Cistanches, Semen Cuscutae, Radix Saposhnikoviae, Radix Polygalae and the above-mentioned alcohol extraction, decoct with water twice, add 6 times of amounts of water for the first time, for the second time add 5 times of amounts of water, decocted 2 hours at every turn, filter, merging filtrate, being concentrated into 85 ℃ of-95 ℃ of lower relative densities is the clear paste of 1.15-1.25, adds the extracting solution that step (3) obtains, and continuing to be concentrated into 80 ℃ of-85 ℃ of lower relative densities is 1.35 thick paste, vacuum drying, pulverize, cross 80 mesh sieves, get extract powder;
(5) get extract powder, Hippocampus, Solenognathus fine powder add appropriate amount of starch and are made into 350g;
(6) powder for preparing was mixed 15 minutes in three-dimensional mixer, granulate, drying in 1000 capsules of packing into, and get final product.
2. the described preparation method that is used for the treatment of the pharmaceutical composition that insufficiency of kidney-YANG loses of claim 1 is characterized in that, described method is as follows:
(1) prepare raw material, and raw material is concocted arrangement: Herba Cistanches is removed impurity, cleans, and runs through, and cuts sheet, drying; Fructus Cnidii is removed impurity, drying; Semen Cuscutae is removed impurity, cleaning, drying; Radix Morindae Officinalis is removed impurity; Fructus Schisandrae Chinensis is removed impurity, and the time spent smashs to pieces; Radix Saposhnikoviae is removed impurity, cleans, and runs through, and cuts sheet; The Cortex Eucommiae scrapes off residual rough bark, cleans, and is cut into piece or silk, drying; Radix Polygalae is removed impurity, slightly washes, and runs through cutting, drying; Solenognathus, Hippocampus are except the dedust bits, and the time spent smashs to pieces, the raw material for standby of the above process of preparing Chinese medicine;
Press Herba Cistanches, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis, Fructus Schisandrae Chinensis, the Cortex Eucommiae, Radix Saposhnikoviae, each 300g of Radix Polygalae, the proportioning of Hippocampus, each 15g of Solenognathus is got the raw materials ready;
(2) with Hippocampus, Solenognathus is put into sterilizing cabinet and sterilizes, 121 ℃ of temperature, and 30 minutes time, pulverize after the taking-up, after 80 mesh sieves, fine powder is for subsequent use, and the prostitute enters next step;
(3) with Radix Morindae Officinalis, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Fructus Cnidii flooded twice of reflux, extract, together with the prostitute of previous step 24 hours with 5 times of amounts of 75% ethanol, add for the first time 6 times of amounts of 75% ethanol, add 5 times of amounts of 75% ethanol, each 2 hours for the second time, filter, merging filtrate, for subsequent use behind the decompression recycling ethanol;
(4) with the medicinal residues after Herba Cistanches, Semen Cuscutae, Radix Saposhnikoviae, Radix Polygalae and the above-mentioned alcohol extraction, decoct with water twice, add 6 times of amounts of water for the first time, for the second time add 5 times of amounts of water, decocted 2 hours at every turn, filter, merging filtrate, being concentrated into 85 ℃ of-95 ℃ of lower relative densities is the clear paste of 1.15-1.25, adds the extracting solution that step (3) obtains, and continuing to be concentrated into 80 ℃ of-85 ℃ of lower relative densities is 1.35 thick paste, vacuum drying, pulverize, cross 80 mesh sieves, get extract powder;
(5) get extract powder, Hippocampus, Solenognathus fine powder add appropriate amount of starch and are made into 350g;
(6) powder for preparing was mixed 15 minutes in three-dimensional mixer, granulate, drying in 1000 capsules of packing into, and get final product.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100942A (en) * | 1993-09-30 | 1995-04-05 | 邓小安 | Health-care capsule for male |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100942A (en) * | 1993-09-30 | 1995-04-05 | 邓小安 | Health-care capsule for male |
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