CN102357237A - 一种治疗老年顽固性失眠的中药组合物 - Google Patents
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Abstract
本发明是一种治疗老年顽固性失眠的中药组合物，由下述重量配比的原料制成：桂枝9-15克，生姜9-15克，人参9-15克，生地45-55克，麦冬8-12克，麻仁8-12克，合欢花8-12克，朱砂3-5克，灸甘草10-14克，大枣8-10枚。本发明纯属中草药配制而成，通过服本发明的药能标本兼治，能迅速消除无眠或不眠症状，对于治疗老年顽固性失眠具有很好的作用。
Description
技术领域
本发明涉及一种治疗老年顽固性失眠的中药组合物，是纯中草药。
背景技术
老年顽固性失眠主要是由于老年人入睡前对入睡、睡眠质量、睡眠时声音干扰、早醒等现象的过敏情绪反应和过度的焦虑、紧张情绪而引发的长期性失眠。目前的治疗多采用口服西药安眠药，副作用大，易反复，其它中药效果大多不理想。
发明内容
本发明所要解决的技术问题在于：提供治疗一种治疗老年顽固性失眠的中药组合物，通过选择合适的药物及其配比，达到消除症状，预后良好恢复健康的目的。
本发明的技术方案如下：
一种治疗老年顽固性失眠的中药组合物，其特征在于由下述重量配比的原料制成：桂枝9-15克，生姜9-15克，人参9-15克，生地45-55克，麦冬8-12克，麻仁8-12克，合欢花8-12克，朱砂3-5克，灸甘草10-14克，大枣8-10枚。
优选的原料配方如下：桂枝12克，生姜12克，人参12克，生地50克，麦冬10克，麻仁10克，合欢花10克，朱砂4克，灸甘草12克，大枣9枚。
本发明方剂主要的中草药根据传统医学及现代医学分析，药性及药理作用如下：
桂枝：性味归经：温；辛、甘；归心、肺、膀胱经。功能主治：发汗解肌，温通经脉，助阳化气。用于风寒感冒，腕腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
生姜：性味归经：微温；辛；归肺、脾、胃经。功能主治：解表散寒，温中止呕，化痰止咳。用于风寒感冒，胃寒呕吐，寒痰咳嗽。
人参：性味归经：微温；甘、微苦；归心、肺、脾经。功能主治：大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。
生地：性味归经：寒；甘、苦；归心、肝、肾经。功能主治：用于热病舌绛烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。
麦冬：性味归经：微寒；甘、微苦；归心、肺、胃经。功能主治：养阴生津，润肺清心。用于肺燥干咳。虚痨咳嗽，津伤口渴，心烦失眠，内热消渴，肠燥便秘；咽白喉。
麻仁：性味归经：平；甘；归肺、胃、大肠经。功能主治：润肠通便。用于血虚津亏，肠燥便秘。
合欢花：性味归经：平；甘；归心、肝经。功能主治：解郁安神。用于心神不安，忧郁失眠。
朱砂：性味归经：寒；甘；归心经；毒。功能主治：清心镇惊，安神解毒。用于心悸易惊，失眠多梦，癫痫发狂，小儿惊风，视物昏花，口疮，喉痹，疮疡肿毒。
灸甘草：性味归经：平；甘；归心、肺、脾、胃经。功能主治：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
大枣：性味归经：温；甘；归脾、胃经。功能主治：补中益气，养血安神。用于脾虚食少,乏力便溏，妇人脏燥。
方解与积极效果：老年人因血亏虚，血行不畅症，表现为难以安寐，寐则梦多，形体瘦弱，头昏耳鸣，倦怠乏力，舌暗红少津，脉细无力，神难守舍。本发明重用生地黄滋阴养血为君药。配伍灸干草、人参、大枣、益心气，补脾气，以资气血生化之源；阿胶、麻仁、麦冬滋心阴，养心血，充血脉，共为臣药。佐以桂枝、生姜温辛走散，温心阳。通血脉；合欢、朱砂安神镇惊。诸药合用，使阴血足而血脉充，阳气足而心脉通，共奏镇惊安神催眠之功效。通过服本发明的药，标本兼治，能迅速消除不寐症状，对于治疗老年顽固性失眠具有很好的作用。
具体实施方式
为了更好地理解和实施，下面结合制备实施例进一步说明本发明。
实施例一
取桂枝9克，生姜9克，人参9克，生地45克，麦冬8克，麻仁8克，合欢花8克，朱砂3克，灸甘草10克，大枣8枚。
服法与用法：水煎服，每日一剂，7天一疗程。
实施例二
取桂枝12克，生姜12克，人参12克，生地50克，麦冬10克，麻仁10克，合欢花10克，朱砂4克，灸甘草12克，大枣9枚。
服法与用法同实施例一。
实施例三
取桂枝15克，生姜15克，人参15克，生地55克，麦冬12克，麻仁12克，合欢花12克，朱砂5克，灸甘草14克，大枣10枚。
服法与用法同实施例一。
临床应用：
自2008年1月至2010年11月在烟台市芝罘区某医院以本发明实施例二制备的药治疗老年顽固性失眠75例，治愈率88%，总有效率100%。
治疗老年顽固性失眠的药效实验结果：
1、临床资料
一般资料观察病例共105例，随机分为2组。治疗组75例，病程(3±1)月；对照组30例，病程(3±1)月。2组一般资料经统计学处理，差异均无显著性意义(P＞0.05)具有可比性。
2、治疗方法
2.1对照组采用口服安眠酮，每次0.1g，1日3次。催眠：0.1～0.2g，睡前半小时服用。疗程3周。
2.2治疗组采用口服本发明的药。疗程3周。
2.3观察项目：治疗前后睡眠症状变化，改善程度。观察2个月有无反复。
2.4统计学方法采用SPSS统计软件进行分析。
3、疗效标准与治疗结果
3.1疗效标准参照《中医病症判断疗效标准》中有关疗效标准。痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
治疗结果
两组临床疗效比较见表1。总有效率治疗组为100%，对照组为86.6%，2组比较，差异有显著性意义(P＜0.05)。
表1 两组临床疗效比较
组别 n 痊愈 好转 无效 总有效率(%)
治疗组 75 66(88%) 9（12%) 0 （0%） 100%
对照组 30 19(63.3%) 7(23.3%) 4(13.4%) 86.6%
与治疗前比较※P＜0.01；与对照组治疗后比较，△P＜0.01。
由此可见，本发明的药对于治疗老年顽固性失眠效果优于其它药物，治愈有效率高。
Claims (2)
1.一种治疗老年顽固性失眠的中药组合物，其特征在于由下述重量配比的原料制成：桂枝9-15克，生姜9-15克，人参9-15克，生地45-55克，麦冬8-12克，麻仁8-12克，合欢花8-12克，朱砂3-5克，灸甘草10-14克，大枣8-10枚。
2.如权利要求1所述治疗老年顽固性失眠的中药组合物，其特征在于由下述重量配比的原料制成：桂枝12克，生姜12克，人参12克，生地50克，麦冬10克，麻仁10克，合欢花10克，朱砂4克，灸甘草12克，大枣9枚。
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| CN115252753A (zh) * | 2022-08-05 | 2022-11-01 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 治疗失眠的中药组合物及其应用 |
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| CN104940888A (zh) * | 2015-07-27 | 2015-09-30 | 黄名珠 | 用于治疗失眠多梦的中药 |
| CN105213867A (zh) * | 2015-11-10 | 2016-01-06 | 夏放军 | 一种安神的中药煎膏剂及其制备方法 |
| CN115252753A (zh) * | 2022-08-05 | 2022-11-01 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 治疗失眠的中药组合物及其应用 |
| CN115252753B (zh) * | 2022-08-05 | 2023-09-15 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 治疗失眠的中药组合物及其应用 |
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| CN102357237B (zh) | 2013-03-27 |
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