CN102357223B - Medicine for curing acute soft tissue injury and preparation method thereof - Google Patents
Medicine for curing acute soft tissue injury and preparation method thereof Download PDFInfo
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- CN102357223B CN102357223B CN 201110323904 CN201110323904A CN102357223B CN 102357223 B CN102357223 B CN 102357223B CN 201110323904 CN201110323904 CN 201110323904 CN 201110323904 A CN201110323904 A CN 201110323904A CN 102357223 B CN102357223 B CN 102357223B
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- acute soft
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- 239000003814 drug Substances 0.000 title claims abstract description 35
- 230000001154 acute effect Effects 0.000 title claims abstract description 18
- 208000026137 Soft tissue injury Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 229940079593 drug Drugs 0.000 title claims description 7
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 12
- 241000218176 Corydalis Species 0.000 claims abstract description 12
- 239000004863 Frankincense Substances 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000009286 sanguis draxonis Substances 0.000 claims description 12
- 241000717739 Boswellia sacra Species 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 11
- 241001057584 Myrrha Species 0.000 claims description 11
- 239000010238 camphora Substances 0.000 claims description 11
- 229940025250 camphora Drugs 0.000 claims description 11
- 229940098465 tincture Drugs 0.000 claims description 8
- 239000004615 ingredient Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 4
- 238000007598 dipping method Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000005325 percolation Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 abstract description 10
- 230000008961 swelling Effects 0.000 abstract description 9
- 239000008280 blood Substances 0.000 abstract description 8
- 210000004369 blood Anatomy 0.000 abstract description 8
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 1
- 240000007551 Boswellia serrata Species 0.000 abstract 1
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 244000062241 Kaempferia galanga Species 0.000 abstract 1
- 235000013421 Kaempferia galanga Nutrition 0.000 abstract 1
- 235000019510 Long pepper Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 240000003455 Piper longum Species 0.000 abstract 1
- 240000004824 Trimezia steyermarkii Species 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 210000000582 semen Anatomy 0.000 abstract 1
- 230000010354 integration Effects 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 5
- 206010014080 Ecchymosis Diseases 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000004087 circulation Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- UIAGMCDKSXEBJQ-IBGZPJMESA-N 3-o-(2-methoxyethyl) 5-o-propan-2-yl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)[C@H]1C1=CC=CC([N+]([O-])=O)=C1 UIAGMCDKSXEBJQ-IBGZPJMESA-N 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960000715 nimodipine Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- -1 tincture Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a medicine for curing acute soft tissue injury and a preparation method thereof. Red flower, long pepper, asarum, semen brassicae, galangal, dragon's blood, rhizoma corydalis, raw frankincense, raw myrrh, camphor and borneol are used cooperatively and have the functions of promoting blood circulation, removing blood stasis, eliminating swelling and relieving pain. The medicine has obvious curative effect and does not have adverse effects.
Description
Technical field
The invention discloses a kind of Chinese medicine medicine, specifically relate to a kind of medicine that is used for the treatment of acute soft tissue injury; The invention also discloses the preparation method of this medicine.
Background technology
Acute soft tissue injury mean a series of acute contusion that the tissue outside human motion system, the following skeleton of skin takes place or (with) laceration, comprise the acute injury of the different situations of tissues such as muscle, ligament, fascia, tendon, synovial membrane, fat, joint capsule and peripheral nerve, blood vessel.These tissues are subjected to the effect of external or inherent different causative factors of injury, cause the temporary transient disorder of organizing acute destruction and tissue physiology's function and produce damage.Acute soft tissue injury generally is the effect that is subjected to external mechanism's stress, bears load when stress reaches certain intensity above soft tissue, can bring out damage, produces symptom.
Summary of the invention
In order to solve the problems of the technologies described above, the object of the present invention is to provide a kind of, blood circulation promoting and blood stasis dispelling comparatively remarkable at the acute soft tissue injury curative effect, the medicine of reducing swelling and alleviating pain; Simultaneously, the present invention also provides the preparation method of this medicine.
The technical solution used in the present invention is as follows:
Be used for the treatment of the medicine of acute soft tissue injury, it is characterized in that, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 9～12g; Fructus Piperis Longi 15～20g; Herba Asari 9～12g;
Semen Sinapis Albae 9～12g; Rhizoma Alpiniae Officinarum 20～25g; Sanguis Draxonis 4～6g;
Rhizoma Corydalis 9～12g; Olibanum 5～10g; Myrrha 5～10g;
Camphora 45～50g; Borneolum Syntheticum 35～40g.
More preferably, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 11.5～12g; Fructus Piperis Longi 17～18g; Herba Asari 11.5～12g;
Semen Sinapis Albae 11.5～12g; Rhizoma Alpiniae Officinarum 23～24g; Sanguis Draxonis 5～5.5g;
Rhizoma Corydalis 11.5～12g; Olibanum 8～9g; Myrrha 8～9g;
Camphora 49～50g; Borneolum Syntheticum 39～40g.
Most preferably, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 11.76g; Fructus Piperis Longi 17.65g; Herba Asari 11.76g;
Semen Sinapis Albae 11.76g; Rhizoma Alpiniae Officinarum 23.53g; Sanguis Draxonis 5.23g;
Rhizoma Corydalis 11.76g; Olibanum 8.82g; Myrrha 8.82g;
Camphora 49.02g; Borneolum Syntheticum 39.22g.
The hot temperature of loosing of Rhizoma Corydalis is logical, and " stasis in the stagnation of QI, the gas in the energy promoting the circulation of blood ", its merit promoting blood circulation and stopping pain circulation of qi promoting is principal agent.Sanguis Draxonis is sweet, flat, goes into blood system and eliminating stasis to stop pain; The hot temperature of Flos Carthami is specially gone into blood system, blood circulation and promoting silt, unobstructed blood vessels, reducing swelling and alleviating pain, with Sanguis Draxonis be ministerial drug altogether; Gas in Olibanum, the Myrrha promoting the circulation of blood, detumescence and promoting granulation; Herba Asari, Semen Sinapis Albae, Rhizoma Alpiniae Officinarum, Fructus Piperis Longi warming the meridian removing obstruction for relieving pain are adjuvant drug altogether; Borneolum Syntheticum, Camphora erosion prevention and muscle growing are antipruritic for making medicine, and all medicines share plays blood circulation promoting and blood stasis dispelling, the merit of reducing swelling and alleviating pain altogether.
Blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Be used for acute soft tissue injury and neck, shoulder, waist, skelalgia etc., use for many years in my institute, evident in efficacy, do not see untoward reaction.
The present invention is used for the treatment of the medicine of acute soft tissue injury, can make multiple exterior-applied formulation in the pharmaceutics, as liniment, tincture, ointment etc., preferably makes tincture, the preparation method of its tincture, and step is as follows:
1., Flos Carthami, Fructus Piperis Longi, Herba Asari, Semen Sinapis Albae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, Olibanum, Myrrha are ground into coarse powder, mixing is made solvent with 80% ethanol (percent by volume) of 8 times of coarse powder weight, dipping, and percolation is collected percolate;
2., Sanguis Draxonis, Borneolum Syntheticum, Camphora are dissolved in step 1. in the percolate, left standstill 48 hours, filter, filtrate adds 80% ethanol (percent by volume) to 1000ml, namely.
Preparation technology is simple, does not have other additives, and is pollution-free, environmental protection.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
One, be used for the treatment of the medicine (ten prolong red tincture simply) of acute soft tissue injury, effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 11.76g; Fructus Piperis Longi 17.65g; Herba Asari 11.76g;
Semen Sinapis Albae 11.76g; Rhizoma Alpiniae Officinarum 23.53g; Sanguis Draxonis 5.23g;
Rhizoma Corydalis 11.76g; Olibanum 8.82g; Myrrha 8.82g;
Camphora 49.02g; Borneolum Syntheticum 39.22g.
The preparation method step of this medicine being made tincture is as follows:
1., Flos Carthami, Fructus Piperis Longi, Herba Asari, Semen Sinapis Albae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, Olibanum, Myrrha are ground into coarse powder, mixing is made solvent with 80% ethanol of 8 times of amounts, dipping, and percolation is collected percolate;
2., Sanguis Draxonis, Borneolum Syntheticum, Camphora are dissolved in step 1. in the percolate, left standstill 48 hours, filter, filtrate adds 80% ethanol to 1000ml, namely.
Two, therapeutic effect
1, select 450 examples to organize as treatment at random in 500 routine patients of outpatient service, 50 examples are organized in contrast and are carried out system's clinical observation on the therapeutic effect, and two groups have comparability at aspects such as the state of an illness, sex, age and the courses of disease.
2, treatment group adopts the medicine (ten prolong red tincture simply) of embodiment preparation to treat; Matched group adopts blue or green roc cream (Qizheng Tibetan Medicine limited company) treatment.
3, treatment time
Use every day 4 times, 7 days is a course for the treatment of.
4, criterion of therapeutical effect
Clinical recovery: symptoms such as pain, tenderness, swelling, ecchymosis, sign integration reduce 〉=95%, and joint motion is normal.
Produce effects: symptom, sign integrations such as pain, tenderness, swelling, ecchymosis decrease between 70%～95%, and joint motion is not limited.
Effectively: symptom, sign integrations such as pain, tenderness, swelling, ecchymosis decrease between 30%～70%; Joint motion improves.
Invalid: symptom and sign integrations such as pain, tenderness, swelling, ecchymosis reduce＜30%, and joint motion does not have change.
Annotate: computing formula (nimodipine method) is: [integration before (integration before the treatment-treatment back integration)/treatment] * 100%.
5, efficacy evaluation the results are shown in Table 1
Table 1 liang group clinical efficacy relatively
Annotate: compare with matched group: * P＜0.05.
As can be known from Table 1, compare with matched group, the treatment group is evident in efficacy, and clinical cure and total effective rate all are higher than matched group.
Claims (6)
1. be used for the treatment of the medicine of acute soft tissue injury, it is characterized in that, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 9～12g; Fructus Piperis Longi 15～20g; Herba Asari 9～12g;
Semen Sinapis Albae 9～12g; Rhizoma Alpiniae Officinarum 20～25g; Sanguis Draxonis 4～6g;
Rhizoma Corydalis 9～12g; Olibanum 5～10g; Myrrha 5～10g;
Camphora 45～50g; Borneolum Syntheticum 35～40g.
2. the medicine that is used for the treatment of acute soft tissue injury according to claim 1 is characterized in that, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 11.5～12g; Fructus Piperis Longi 17～18g; Herba Asari 11.5～12g;
Semen Sinapis Albae 11.5～12g; Rhizoma Alpiniae Officinarum 23～24g; Sanguis Draxonis 5～5.5g;
Rhizoma Corydalis 11.5～12g; Olibanum 8～9g; Myrrha 8～9g;
Camphora 49～50g; Borneolum Syntheticum 39～40g.
3. the medicine that is used for the treatment of acute soft tissue injury according to claim 2 is characterized in that, its effective ingredient is made by the raw material of Chinese medicine of following weight:
Flos Carthami 11.76g; Fructus Piperis Longi 17.65g; Herba Asari 11.76g;
Semen Sinapis Albae 11.76g; Rhizoma Alpiniae Officinarum 23.53g; Sanguis Draxonis 5.23g;
Rhizoma Corydalis 11.76g; Olibanum 8.82g; Myrrha 8.82g;
Camphora 49.02g; Borneolum Syntheticum 39.22g.
4. according to claim 1 or the 2 or 3 described medicines that are used for the treatment of acute soft tissue injury, it is characterized in that described medicine is made external-use drug form.
5. the medicine that is used for the treatment of acute soft tissue injury according to claim 4 is characterized in that, described medicine is made tincture.
6. preparation is characterized in that as the method for tincture as described in according to claim 5 step is as follows:
1., Flos Carthami, Fructus Piperis Longi, Herba Asari, Semen Sinapis Albae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, Olibanum, Myrrha are ground into coarse powder, mixing is made solvent with 80% ethanol of 8 times of amounts, dipping, and percolation is collected percolate;
2., Sanguis Draxonis, Borneolum Syntheticum, Camphora are dissolved in step 1. in the percolate, left standstill 48 hours, filter, filtrate adds 80% ethanol to 1000ml, namely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110323904 CN102357223B (en) | 2011-10-21 | 2011-10-21 | Medicine for curing acute soft tissue injury and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110323904 CN102357223B (en) | 2011-10-21 | 2011-10-21 | Medicine for curing acute soft tissue injury and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102357223A CN102357223A (en) | 2012-02-22 |
| CN102357223B true CN102357223B (en) | 2013-08-21 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103800882A (en) * | 2014-02-25 | 2014-05-21 | 郭洁松 | Moxibustion ointment with automatic transmission of wave heat energy and preparation method thereof |
| CN104042852A (en) * | 2014-06-25 | 2014-09-17 | 陈文灵 | Traditional Chinese medicine liquid with anesthesia effect and preparation method |
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2011
- 2011-10-21 CN CN 201110323904 patent/CN102357223B/en not_active Expired - Fee Related
Non-Patent Citations (6)
| Title |
|---|
| 中药外用治疗急性软组织损伤的研究进展;王乐杨等;《医药导报》;20100831;72-74 * |
| 刘德春等.自制复方活血酊治疗急性软组织损伤300例临床观察.《安徽中医临床杂志》.2002,第14卷(第3期),192-193. |
| 彭锐等.紫金酒配合红外线照射治疗尾骨痛症35例报告.《中医正骨》.2000,第12卷(第6期),18. |
| 王乐杨等.中药外用治疗急性软组织损伤的研究进展.《医药导报》.2010,72-74. |
| 紫金酒配合红外线照射治疗尾骨痛症35例报告;彭锐等;《中医正骨》;20000630;第12卷(第6期);18 * |
| 自制复方活血酊治疗急性软组织损伤300例临床观察;刘德春等;《安徽中医临床杂志》;20020630;第14卷(第3期);192-193 * |
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