CN102357073A - Methyl salicylate aerosol and preparation method thereof - Google Patents

Abstract

The invention discloses a methyl salicylate aerosol and a preparation method thereof. The methyl salicylate aerosol is prepared by 3 to 7 parts of methyl salicylate, 500 to 600 parts of 1, 1, 1, 2-tetrafluorethane and 440 to 450 parts of ethanol. The methyl salicylate aerosol is stable in product quality, even in concentration, stable to operate in the preparation process, accurate in filling quantity and low in energy consumption, and has remarkable economic and social benefit.

Description

A kind of methyl salicylate aerosol and preparation method thereof

Technical field

The invention belongs to field of pharmaceutical preparations, be specifically related to a kind of methyl salicylate aerosol and preparation method thereof.

Background technology

Because the large-scale production in fluorine Lyons and use have produced adverse influence to the ecological environment of human survival; Gas is diffused into stratosphere when fluorine Lyons, highly meets with ozone layer at the place in 20 kilometers～50 kilometers in atmosphere, when receiving intensive solar ultraviolet irradiation; Chloride fluorine Lyons molecule just decomposites the free fluorine atom; And chlorine atom meeting catalytic decomposition ozone molecule consequently causes the violent reduction of ozone layer concentration, ozone layer to receive seriously and destroys.International community sounds the alarm to fluorine Lyons environmental pollution problem, and China forbids that also general aerosol products uses fluorine Lyons, and seeking satisfactory medicinal aerosol propellant becomes a great problem.

1,1,1, the 2-tetrafluoroethane is called for short HFC-134a or R-134a.It is a kind of novel machine refrigerant that has, have nontoxic, tasteless, colourless, do not fire, characteristics such as not quick-fried, Heat stability is good, chemical property is very stable.(CFC-12) compares with dichlorodifluoromethane, and its ODP (promptly consuming the ozone latent energy value) is 0, and refrigerating capacity is suitable, and boiling point-26.5 ℃ is a kind of ideal fluorine Lyons substitute.HFC-134a has been widely used in the cold-producing medium of industries such as air conditioning for automobiles, refrigerator, central air-conditioning, commercial refrigeration at present; And can be used as aerosol propellant and fire retardant, the foaming agent etc. of products such as medicine, pesticide, cosmetics, cleaning; Be novel fluorine Lyons substitute that generally acknowledge in the whole world, be used widely in western countries.The HFC-134a stable performance, safe and convenient to use, be a kind of HFC that contains, the bond energy of fluorine carbon bond is very high, thereby general fluorocarbons has better heat stability and chemical stability.In addition, HFC-134a is nontoxic do not fire etc. advantage can guarantee to adopt with the same process conditions of CFC-12 under fill and keep in repair original HFC-12 refrigeration plant, and do not need special safeguard procedures.And this propellant is residual few in human body, and is good to the dissolubility of other chemical compounds, can better let the skin absorbs medicine, reaches blood drug level and prolong drug action time sooner.

Summary of the invention

The object of the present invention is to provide a kind of methyl salicylate aerosol and preparation method thereof, constant product quality, concentration is even, and the preparation process operation is steady, loading amount is accurate, energy consumption is low, has remarkable economical and social benefit.

For realizing above-mentioned purpose, the present invention adopts following technical scheme:

A kind of raw material of methyl salicylate aerosol and the mass fraction of each raw material: methyl salicylate 3-7 part, 1,1,1,2-tetrafluoroethane 500-600 part, ethanol 440-450 part.

The concrete steps of its preparation method are following:

1) material-compound tank is evacuated to 0.094-0.098MPa with vacuum pump, methyl salicylate is sucked by proportioning raw materials;

2) will pour in the material-compound tank by the load weighted ethanol of proportioning raw materials, stirring is dissolved methyl salicylate fully;

3) propellant 1,1,1, and the basin of 2-tetrafluoroethane is opened bung in room temperature below 20 ℃; Should be if room temperature is higher than 20 ℃ with 1,1,1, the basin of 2-tetrafluoroethane places water-bath; Load onto packing valve, the temperature of the water-bath that progressively raises then makes 1,1; 1, the 2-tetrafluoroethane slowly injects material-compound tank, stirs;

4) pick test is qualified, and medicinal liquid is filled in the aerosol container after filtering;

5) aerosol is filled in the aerosol bottle, all aerosol bottles carry out the water-bath leak detection, and no bubble is regarded as not having gas leak phenomenon, otherwise chooses recovery.

Methyl salicylate aerosol of the present invention is a bentoquatam class nonprescription drugs medicine.

Function with cure mainly: be used for the emergence therapeutic of soft tissue injury, as sprain, myalgia etc.

Usage and consumption: external.During use shower nozzle apart from illing skin 5-10 centimetre place the pressing valve, sustained firing 2-3 second, if need to reuse, half a minute at interval, but one day must not be above 3 times.

Preparation packing specification: 60g/ bottle

Pharmacological toxicology: methyl salicylate has detumescence, analgesic effect.

Points for attention: must carry out the protection of mouth, eye, nose during spray plane portion, avoid being sprayed on mucosa position and suction.Jolting gently before the use.Use when storing not near naked light or inflammable thing.One time injecting time should not surpass for 3 seconds, to avoid cold injury.Forbidding when these article character changes.The child must use under adult's monitoring.Please these article are placed on the impalpable place of child.

Untoward reaction: accidental skin irritation such as burn feeling, or anaphylaxis such as erythra, pruritus etc.

Taboo: these article allergy sufferers is forbidden.Skin injury and infection place forbidding.The infant forbidding.

Remarkable advantage of the present invention is:

1) constant product quality, concentration is even, and the preparation process operation is steady, loading amount is accurate, energy consumption is low, has remarkable economical and social benefit.

2) with 1,1,1, the 2-tetrafluoroethane replaces dichlorodifluoromethane, makes method for preparing of the present invention become a kind of method of environmental protection, has promotional value.

The specific embodiment

Embodiment 1

A kind of raw material of methyl salicylate aerosol and the mass fraction of each raw material: 3 parts of methyl salicylate, 1,1,1,500 parts of 2-tetrafluoroethane, 440 parts of ethanol.

The concrete steps of its preparation method are following:

1) material-compound tank is evacuated to 0.094MPa with vacuum pump, methyl salicylate is sucked by proportioning raw materials;

2) will pour in the material-compound tank by the load weighted ethanol of proportioning raw materials, stirring is dissolved methyl salicylate fully;

3) propellant 1,1,1, and the basin of 2-tetrafluoroethane is opened bung in room temperature below 20 ℃; Should be if room temperature is higher than 20 ℃ with 1,1,1, the basin of 2-tetrafluoroethane places water-bath; Load onto packing valve, the temperature of the water-bath that progressively raises then makes 1,1; 1, the 2-tetrafluoroethane slowly injects material-compound tank, stirs;

4) pick test is qualified, and medicinal liquid is filled in the aerosol container after filtering;

5) aerosol is filled in the aerosol bottle, all aerosol bottles carry out the water-bath leak detection, and no bubble is regarded as not having gas leak phenomenon, otherwise chooses recovery.

Embodiment 2

A kind of raw material of methyl salicylate aerosol and the mass fraction of each raw material: 7 parts of methyl salicylate, 1,1,1,600 parts of 2-tetrafluoroethane, 450 parts of ethanol.

The concrete steps of its preparation method are following:

1) material-compound tank is evacuated to 0.098MPa with vacuum pump, methyl salicylate is sucked by proportioning raw materials;

2) will pour in the material-compound tank by the load weighted ethanol of proportioning raw materials, stirring is dissolved methyl salicylate fully;

3) propellant 1,1,1, and the basin of 2-tetrafluoroethane is opened bung in room temperature below 20 ℃; Should be if room temperature is higher than 20 ℃ with 1,1,1, the basin of 2-tetrafluoroethane places water-bath; Load onto packing valve, the temperature of the water-bath that progressively raises then makes 1,1; 1, the 2-tetrafluoroethane slowly injects material-compound tank, stirs;

4) pick test is qualified, and medicinal liquid is filled in the aerosol container after filtering;

5) aerosol is filled in the aerosol bottle, all aerosol bottles carry out the water-bath leak detection, and no bubble is regarded as not having gas leak phenomenon, otherwise chooses recovery.

Embodiment 3

A kind of raw material of methyl salicylate aerosol and the mass fraction of each raw material: 5 parts of methyl salicylate, 1,1,1,550 parts of 2-tetrafluoroethane, 445 parts of ethanol.

The concrete steps of its preparation method are following:

1) material-compound tank is evacuated to 0.096MPa with vacuum pump, methyl salicylate is sucked by proportioning raw materials;

2) will pour in the material-compound tank by the load weighted ethanol of proportioning raw materials, stirring is dissolved methyl salicylate fully;

3) propellant 1,1,1, and the basin of 2-tetrafluoroethane is opened bung in room temperature below 20 ℃; Should be if room temperature is higher than 20 ℃ with 1,1,1, the basin of 2-tetrafluoroethane places water-bath; Load onto packing valve, the temperature of the water-bath that progressively raises then makes 1,1; 1, the 2-tetrafluoroethane slowly injects material-compound tank, stirs;

4) pick test is qualified, and medicinal liquid is filled in the aerosol container after filtering;

5) aerosol is filled in the aerosol bottle, all aerosol bottles carry out the water-bath leak detection, and no bubble is regarded as not having gas leak phenomenon, otherwise chooses recovery.

The above is merely preferred embodiment of the present invention, and all equalizations of doing according to claim of the present invention change and modify, and all should belong to covering scope of the present invention.

Claims (2)

1. a methyl salicylate aerosol is characterized in that: the raw material of described methyl salicylate aerosol and the mass fraction of each raw material: methyl salicylate 3-7 part, 1,1,1,2-tetrafluoroethane 500-600 part, ethanol 440-450 part.

2. the method for preparing of a methyl salicylate aerosol as claimed in claim 1, it is characterized in that: the concrete steps of described method for preparing are following:

1) material-compound tank is evacuated to 0.094-0.098MPa with vacuum pump, methyl salicylate is sucked by proportioning raw materials;

2) will pour in the material-compound tank by the load weighted ethanol of proportioning raw materials, stirring is dissolved methyl salicylate fully;

3) propellant 1,1,1, and the basin of 2-tetrafluoroethane is opened bung in room temperature below 20 ℃; Should be if room temperature is higher than 20 ℃ with 1,1,1, the basin of 2-tetrafluoroethane places water-bath; Load onto packing valve, the temperature of the water-bath that progressively raises then makes 1,1; 1, the 2-tetrafluoroethane slowly injects material-compound tank, stirs;

4) pick test is qualified, and medicinal liquid is filled in the aerosol container after filtering;

5) aerosol is filled in the aerosol bottle, all aerosol bottles carry out the water-bath leak detection, and no bubble is regarded as not having gas leak phenomenon, otherwise chooses recovery.