CN101342369A - Safety environment-friendly type medicinal propellant - Google Patents
Safety environment-friendly type medicinal propellant Download PDFInfo
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- CN101342369A CN101342369A CNA2008100302839A CN200810030283A CN101342369A CN 101342369 A CN101342369 A CN 101342369A CN A2008100302839 A CNA2008100302839 A CN A2008100302839A CN 200810030283 A CN200810030283 A CN 200810030283A CN 101342369 A CN101342369 A CN 101342369A
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
The present invention relates to a non-toxic, safe and environment-friendly novel non-freon officinal aerosol propellant, which is composed of the following weight proportion of components: 15 to 50 portions of propane and 50 to 85 portions of isobutene; and the aerosol propellant is then added with different active pharmaceutical ingredients according to different applications, so that different types of officinal aerosols can be prepared. The aerosol propellant has the advantages of good atomizing performance, good stability, non-toxicity, safety and environment-friendliness and does not destroy other ingredients in liquor, and because both the ozone depletion potential (ODP) value and the global warmhouse-effect potential (GWP) value are low, the aerosol propellant does not destroy the ozonosphere.
Description
Technical field
The present invention relates to the medicinal aerosol propellant of novel non-freon class of a kind of nontoxic, safety, environmental protection, particularly relate to and a kind ofly be equipped with different active constituents of medicine, be made into the safety environment-friendly type medicinal propellant of dissimilar medicinal aerosols according to different purposes.
Background technology
At present, China's medicinal aerosol is to adopt fluorochloroparaffins (CFCs) as propellant, because the high ozone of fluorochloroparaffins consume potential (ODP) value and high room temperature effect potential (GWP) value, be the ozone layer that destroys the atmospheric advection layer, cause one of main ODS of environmental hazard, therefore be listed in " blacklist " of Montreal protocol controlled substance.Developed country has just stopped the production and consumption of CFCs substantially as far back as 1996, the Chinese government formulated in aerosol industry in December in 1997 and eliminated the CFCs plan fully on the 31st, stopped production and the use of CFCs fully by 2010.For the environment of preserving our planet, the substituting propellant of new non-environmental-pollution is all paid close attention in global aerosol industry, just to be substituted in technology and the trade CFCs and other VOC (VOC) in mass production, sale, use
In the face of the situation of paces are eliminated in strictness restriction and the acceleration of CFCs both at home and abroad; China's medicinal aerosol industry will be faced with stern challenge; therefore; the substitution studies of CFCs is the research tendency of medicinal aerosol industry development; for the earth environment of protecting the mankind to depend on for existence; break through the bottleneck of aerosol industry development, just press for the medicinal propellant of seeking a kind of nontoxic, safety, environmental protection, research worker has been done deep research to this.Patent CN200410056970.X has studied the aerosol propellant that is mixed with safety, environmental protection with dimethyl ether, ethanol, water according to a certain percentage, can be applied in parasite killing, aspect such as medical; Patent CN93111889.1 has studied alkane and carbon dioxide has been made safe, the novel propellant of a kind of suitable hair jelly and mousse use according to a certain ratio, patent CN200610143870.X adopts solid acids and carbonate to be mixed with the protecting solid inhalator propellant of safety, environmental protection by a certain percentage, can be widely used in industries such as medicine, hygienic biocide, hair jelly cosmetics.These have all promoted the plan that domestic aerosol industry is eliminated CFCs to a certain extent, and certain beneficial effect is arranged.
Summary of the invention
The object of the present invention is to provide the novel medicinal aerosol propellant of a kind of nontoxic, safety, environmental protection, according to a certain percentage propane and iso-butane are mixed with the third butane propellant; Be equipped with medicine according to concrete purposes again, thereby obtain the aerosol solution of homogeneous, stable, safety, environmental protection;
Technical scheme of the present invention is with 15～50 parts of propane, and the set of dispense of 50～85 parts of iso-butane weight proportions is made the third butane medicinal propellant;
According to different purposes, be equipped with the active constituents of medicine of different conventional effective doses with described medicinal aerosol propellant, can be made into dissimilar medicinal aerosols, as: lignocaine, chlorhexidine acetate, Octoxinol, nonoxynolum or benzalkonium chloride, econazole nitrate, ketoconazole or miconazole medicinal liquid, diclofenac sodium medicinal liquid etc.;
The preparation method of above-mentioned aerosol is known in those skilled in the art, can carry out according to the preparation method of common aerosol.
Aerosol propellant of the present invention has the following advantages:
1. nontoxic, safe, thought unique aerosol propellant of " it is generally acknowledged safety " with Food Contact by U.S. food Drug Administration (FDA).
2.ODP value and GWP value are lower, can not damage the ozone layer.
3. good foaming effect is arranged, be more suitable for the foam type aerosol.
4. atomization is good, compares with CFCs, uses less amount can reach identical pressure and same atomizing effect.
5. good stability does not destroy other composition in the medicinal liquid.
The specific embodiment
Below the invention will be further described by specific embodiment, and these embodiment only are used to illustrate the present invention, are not limited to scope of the present invention.
Embodiment 1
With 15 parts of propane, the set of dispense of 85 parts of iso-butane weight proportions is made the third butane aerosol propellant.
Embodiment 2
With 12 parts of lignocaine, 3 parts of chlorhexidine acetates are dissolved in 452 parts the ethanol, add 0.6 part of benzalkonium bromide and 32 parts of isopropyl alcohols again, above-mentioned solution is joined in the pressure bottle, seal, add 100 parts the third butane propellant again from check valve, promptly make lidocaine and chlorhexidine aerosol.
Embodiment 3
5 parts nanometer silvers, Octoxinol or nonoxynolum or benzalkonium chloride medicinal liquid are joined in the pressure bottle, seal, from check valve, add 2 parts the third butane propellant again, promptly make corresponding aerosol.
Embodiment 4
3.5 parts econazole nitrates or ketoconazole or miconazole medicinal liquid are joined in the pressure bottle, seal, add 1.5 parts the third butane propellant again from check valve, promptly make corresponding aerosol.
Embodiment 5
5 parts diclofenac sodium medicinal liquid is joined in the pressure bottle, seal, add 2 part of third butane propellant from check valve again, promptly make the diclofenac sodium aerosol.
Claims (7)
1. a safety environment-friendly type medicinal propellant is characterized in that: the component that comprises following weight proportion: 15～50 parts in propane, 50～85 parts of iso-butanes.
2. safety environment-friendly type medicinal propellant as claimed in claim 1 is used to prepare aerosol.
3. aerosol comprises the active constituents of medicine of described medicinal propellant of claim 1 and conventional effective dose.
4. aerosol as claimed in claim 3 is characterized in that: described active constituents of medicine is lignocaine, chlorhexidine acetate and organic solvent ethanol, benzalkonium bromide and the isopropyl alcohol that dissolves them.
5. aerosol as claimed in claim 3 is characterized in that: described active constituents of medicine is Octoxinol, nonoxynolum or benzalkonium chloride.
6. aerosol as claimed in claim 3 is characterized in that: described active constituents of medicine is econazole nitrate or ketoconazole or miconazole medicinal liquid.
7. aerosol as claimed in claim 3 is characterized in that: described active constituents of medicine is the diclofenac sodium medicinal liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100302839A CN101342369A (en) | 2008-08-20 | 2008-08-20 | Safety environment-friendly type medicinal propellant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100302839A CN101342369A (en) | 2008-08-20 | 2008-08-20 | Safety environment-friendly type medicinal propellant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101342369A true CN101342369A (en) | 2009-01-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100302839A Pending CN101342369A (en) | 2008-08-20 | 2008-08-20 | Safety environment-friendly type medicinal propellant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101342369A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785766B (en) * | 2010-01-26 | 2011-10-19 | 江苏天济药业有限公司 | Lidocaine and chlorhexidine aerosol |
| CN101856328B (en) * | 2009-04-09 | 2013-01-30 | 北京京卫燕康药物研究所有限公司 | Ketoconazole foaming agent and preparation method thereof |
| CN106562928A (en) * | 2016-08-30 | 2017-04-19 | 广东同德药业有限公司 | Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol |
| CN112972385A (en) * | 2021-02-26 | 2021-06-18 | 广东同德药业有限公司 | Inflammation-diminishing and pain-relieving aerosol and preparation method thereof |
| CN115414268A (en) * | 2022-09-06 | 2022-12-02 | 天津澳宏环保材料有限公司 | Cosmetic propellant and preparation method thereof |
-
2008
- 2008-08-20 CN CNA2008100302839A patent/CN101342369A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856328B (en) * | 2009-04-09 | 2013-01-30 | 北京京卫燕康药物研究所有限公司 | Ketoconazole foaming agent and preparation method thereof |
| CN101785766B (en) * | 2010-01-26 | 2011-10-19 | 江苏天济药业有限公司 | Lidocaine and chlorhexidine aerosol |
| CN106562928A (en) * | 2016-08-30 | 2017-04-19 | 广东同德药业有限公司 | Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol |
| CN112972385A (en) * | 2021-02-26 | 2021-06-18 | 广东同德药业有限公司 | Inflammation-diminishing and pain-relieving aerosol and preparation method thereof |
| CN112972385B (en) * | 2021-02-26 | 2022-03-29 | 广东同德药业有限公司 | Inflammation-diminishing and pain-relieving aerosol and preparation method thereof |
| CN115414268A (en) * | 2022-09-06 | 2022-12-02 | 天津澳宏环保材料有限公司 | Cosmetic propellant and preparation method thereof |
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Application publication date: 20090114 |