CN102580038A - Borneol cape jasmine pain releasing aerosol - Google Patents
Borneol cape jasmine pain releasing aerosol Download PDFInfo
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- CN102580038A CN102580038A CN2012100716879A CN201210071687A CN102580038A CN 102580038 A CN102580038 A CN 102580038A CN 2012100716879 A CN2012100716879 A CN 2012100716879A CN 201210071687 A CN201210071687 A CN 201210071687A CN 102580038 A CN102580038 A CN 102580038A
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- cape jasmine
- aerosol
- borneol
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- ice
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Abstract
The invention discloses borneol cape jasmine pain releasing aerosol. The formula of the raw materials comprises rheum officinale, cape jasmine, 100g of herb of glabrous sarcandra, radix rehmanniae, lignum dalbergiae odoriferae, fragrant-flowered garlic root, nux vomica, borneol, peach kernel, loose knot, rhizoma zingiberis, pepper, pepper, Sappanwood, camphortree root and masson pine branchlet-tip. The borneol cape jasmine pain releasing aerosol is characterized in that propellants use hydrofluoroalkane tetrafluoroethane, tetrafluoroethane (HFA227), dimethyl ether (DME) and hydrocarbon or compressed gases. The volume ratio or weight ratio of the propellants and the raw materials of the formula is 1:1. The compressed gases include compressed carbon dioxide. HFA134a is used as the propellants, so that not only damage to the ozone layer of the atmosphere can be avoided, but also energy can be saved and consumption can be reduced in the pharmacy process. The borneol cape jasmine pain releasing aerosol is stable and controllable in medicine quality, good in curative effect and remarkable in social value and economic value.
Description
Technical field
The present invention relates to the grieved aerosol of a kind of ice Cape jasmine.
Background technology
The grieved aerosol medicine of ice Cape jasmine is used to treat traumatic injury, and swelling and pain due to blood stasis etc. belong to the biphase aerosol of external, are made up of medicinal liquid, propellant, pressure vessel and valve system.This medicine is as the new-type traditional Chinese dosage form, and is easy to use, safe owing to good effect since listing, good market prospects.But, in its adjuvant as the freon (F of aerosol propellant
12) atmospheric ozone layer is had destruction.
In order to protect ozone layer, in March, 1985, the government representative of 21 countries has signed " Vienna Convention of protection ozone layer " in Vienna, indicates the beginning of protection ozone layer international uniform action, and " pact " came into force in JIUYUE, 1989.In JIUYUE, 1987,24 countries have signed Montreal Protocol on Substances that Deplete the Ozone Layer in the Montreal, CAN city, and international control is carried out in production, the use of cfc material ODSs (ODS) such as (CFCs).
Chinese Government has added " Vienna Convention of protection ozone layer " in JIUYUE, 1989; And added Montreal Protocol on Substances that Deplete the Ozone Layer (London amendment) (hereinafter to be referred as " protocol ") in 1991, become by " protocol " the 5th section of contracting party that acts.On January 12nd, 1993, Chinese Government approves to execute " Chinese ODS progressively eliminate national scheme " (hereinafter to be referred as " national scheme "), as the programme of action of implementing " protocol ", and in 1999 " national scheme " is revised." Chinese CFCs quickens to eliminate plan " that the Chinese government formulates promises to undertake that China will eliminate the CFCs (except the necessary purposes) in the medicinal aerosol before 1 day January in 2010.
In order to give full play to the medical value of original formulation raw material, the people that continue to satisfy cure the disease, health needs of persons, are badly in need of seeking the pharmaceutic adjuvant in the medicinal aerosol that is fit to, to develop the grieved aerosol of a kind of novel ice Cape jasmine.
Summary of the invention
The technical problem that the present invention will solve is, provides a kind of ice Cape jasmine grieved aerosol, is freon (F to overcome the pharmaceutic adjuvant that prior art exists
12) atmospheric ozone layer had a deficiency of destruction.
In order to solve described technical problem; The present invention adopts following technical scheme: its composition of raw materials comprises Radix Et Rhizoma Rhei, Fructus Gardeniae, Herba Sarcandrae, the Radix Rehmanniae, Lignum Dalbergiae Odoriferae, Radix et Bulbus Allii tuberosi, Semen Strychni, Borneolum Syntheticum, Semen Persicae, Lignum Pini Nodi, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Camphora, Lignum Sappan, Camphor tree root, Ramulus Pini massonianae, and propellant adopts fluoric ether tetrafluoroethane, heptafluoro-propane (HFA227), dimethyl ether (DME), Hydrocarbon or Compressed Gas class.
The volumetric ratio of described propellant and formula material or weight ratio are 1:1.
Described Compressed Gas class comprises carbon dioxide compression gas.
The material of propellant as aerosol for external use at present commonly used has new fluoric ether tetrafluoroethane (HFA134a), heptafluoro-propane (HFA227), dimethyl ether (DME), Hydrocarbon (iso-butane), Compressed Gas class (CO
2) etc.It is good wherein to count HFA134a character, and it does not contain the CL atom, and atmospheric ozone layer is not had destruction.In addition, has good security performance (nonflammable, do not explode, nontoxic, nonirritant, no corruption property).The heat transfer property of HFA134a and F
12More approaching, so the remodeling of refrigeration system ratio is easier to.The heat transfer property of HFA134a compares F
12Good, therefore, the consumption of cold-producing medium can significantly reduce.HFA134a is colourless gas at normal temperatures, under self pressure, is colourless transparent liquid, is F
12Good substituting
Article.
Annotate: ODP is for destroying the ozone latent energy value, and GWP is the global warming coefficient value
Because of boiling point, vapour pressure, density, critical temperature, critical pressure is close.Therefore, bigger change can not take place in the operation in alternative Process.
GDP is 0, and ozone layer is not had destruction.GWP is 0.129, and is less to the influence of temperature.
Behind the change propellant, prove original propellant F through the grieved aerosol of ice Cape jasmine being carried out production technology, quality standard, specification, Study on Stability
12Do not influence production technology after changing tetrafluoroethane (HFAl34a) into, the drug inspection result meets the regulation of quality standard; Adopt the simulation commercially available back, carry out study on the stability, each item index all meets the regulation of quality standard as a result.Therefore, the substituting of propellant in the grieved aerosol of ice Cape jasmine, adopt new propellant tetrafluoroethane (HFAl34a) after, in the quality of production technology, finished product, stability can both meet the demands.So replacement is feasible as propellant to adopt tetrafluoroethane (HFAl34a).
Because of HFAl34a does not contain CL, atmospheric ozone layer is not played destruction, and have good security performance (nonflammable, do not explode, nontoxic, nonirritant, no corruption property).The heat transfer property of HFAl34a and F
12More approaching, so the remodeling of refrigeration system ratio is easier to.The heat transfer property of HFAl34a compares F
12Good, therefore, the consumption of cold-producing medium can significantly reduce.HFAl34a is colourless gas at normal temperatures, under self pressure, is colourless transparent liquid, is F
12Favorable substitutes.Therefore use HFAl34a to substitute F
12As propellant, not only can avoid destruction, and in pharmacy procedure, can save energy and reduce the cost atmospheric ozone layer; Its drug quality is stable, controlled, good effect, and social value and economic worth are remarkable.
The specific embodiment
Embodiments of the invention: its composition of raw materials comprises Radix Et Rhizoma Rhei, Fructus Gardeniae, Herba Sarcandrae, the Radix Rehmanniae, Lignum Dalbergiae Odoriferae, Radix et Bulbus Allii tuberosi, Semen Strychni, Borneolum Syntheticum, Semen Persicae, Lignum Pini Nodi, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Camphora, Lignum Sappan, Camphor tree root, Ramulus Pini massonianae, and propellant adopts the fluoric ether tetrafluoroethane.
The volumetric ratio of described propellant and formula material or weight ratio are 1:1.
The formula material amount of getting during making is:
Radix Et Rhizoma Rhei 80g Fructus Gardeniae 50g Herba Sarcandrae 100g
Radix Rehmanniae 40g Lignum Dalbergiae Odoriferae 30g Radix et Bulbus Allii tuberosi 60g
Semen Strychni 40g Borneolum Syntheticum 30g Semen Persicae 30g
Lignum Pini Nodi 30g Rhizoma Zingiberis 30g Pericarpium Zanthoxyli 30g
Camphora 40g Lignum Sappan 50g Camphor tree root 30g
Ramulus Pini massonianae 40g
Manufacture method is following:
More than ten Six-element medicines, except that Camphora, Borneolum Syntheticum, Radix Et Rhizoma Rhei, Semen Strychni and all the other Herba Sarcandraes etc. 12 flavor medicines are ground into coarse powder respectively 60 ℃ of dryings, cross 10 mesh sieves.
12 flavor medicines such as Herba Sarcandrae, Radix Et Rhizoma Rhei medicated powder, Semen Strychni medicated powder weigh percolation with 90% ethanol with 5ml/kgmin percolation speed respectively, collect just filter liquid 600ml, 80ml, 120ml respectively.
The liquid of filtering at the beginning of above-mentioned three kinds mixed stir, camphorate, after Borneolum Syntheticum dissolves fully, add ethyl cellulose 36g, azone 10ml, propylene glycol 3.5ml stirring and dissolving again, mix homogeneously is adjusted total amount to 1000ml with 90% ethanol, and packing is pressed into propellant
HFA134a(tetrafluoroethane)], seal, promptly get.
The grieved aerosol of ice Cape jasmine selects for use propellant to do
HFA134a,
HFA134aOzone layer is not had destruction, meet the requirement of national relevant policies.So both help bringing into play the society and the economic worth of product, also helped the quality control of medicine; And, meet the prescription of country to the special industry pharmaceutical production.The substitution studies of the propellant of the grieved aerosol of ice Cape jasmine, the adjuvant of change is fit to explained hereafter, can satisfy the control needs of safety, effectiveness and the stability of medicine.
Claims (3)
1. ice the grieved aerosol of Cape jasmine for one kind; Its composition of raw materials comprises Radix Et Rhizoma Rhei, Fructus Gardeniae, Herba Sarcandrae 100g, the Radix Rehmanniae, Lignum Dalbergiae Odoriferae, Radix et Bulbus Allii tuberosi, Semen Strychni, Borneolum Syntheticum, Semen Persicae, Lignum Pini Nodi, Rhizoma Zingiberis, Pericarpium Zanthoxyli, Camphora, Lignum Sappan, Camphor tree root, Ramulus Pini massonianae, it is characterized in that: propellant adopts fluoric ether tetrafluoroethane, heptafluoro-propane, dimethyl ether, Hydrocarbon or Compressed Gas class.
2. the grieved aerosol of ice Cape jasmine according to claim 1, it is characterized in that: the volumetric ratio of described propellant and formula material or weight ratio are 1:1.
3. the grieved aerosol of ice Cape jasmine according to claim 1 is characterized in that: described Compressed Gas class comprises carbon dioxide compression gas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100716879A CN102580038A (en) | 2012-03-19 | 2012-03-19 | Borneol cape jasmine pain releasing aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100716879A CN102580038A (en) | 2012-03-19 | 2012-03-19 | Borneol cape jasmine pain releasing aerosol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102580038A true CN102580038A (en) | 2012-07-18 |
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ID=46469639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100716879A Pending CN102580038A (en) | 2012-03-19 | 2012-03-19 | Borneol cape jasmine pain releasing aerosol |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103969376A (en) * | 2014-05-16 | 2014-08-06 | 贵州安泰药业有限公司 | Quality standard testing method for borneol and fructus gardeniae pain-relieving aerosol |
| CN104415129A (en) * | 2013-08-22 | 2015-03-18 | 何伊仁 | Plaster for treating injuries and fever |
| CN105708945A (en) * | 2016-02-03 | 2016-06-29 | 扬州大学 | Traditional Chinese medicine aerosol composition for external use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153055A (en) * | 1995-12-29 | 1997-07-02 | 叶延春 | Chinese medicinal herb coat aerosol for treatment of mild burn scald, soft tissue damage and frostbite |
| CN1418655A (en) * | 2002-11-28 | 2003-05-21 | 贵州安泰药业有限公司 | Aerosol for treating burn and scald, and its prepn-process |
-
2012
- 2012-03-19 CN CN2012100716879A patent/CN102580038A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1153055A (en) * | 1995-12-29 | 1997-07-02 | 叶延春 | Chinese medicinal herb coat aerosol for treatment of mild burn scald, soft tissue damage and frostbite |
| CN1418655A (en) * | 2002-11-28 | 2003-05-21 | 贵州安泰药业有限公司 | Aerosol for treating burn and scald, and its prepn-process |
Non-Patent Citations (2)
| Title |
|---|
| 易朝丽等: "气雾剂抛射剂氟利昂替代品的研究现状", 《科技致富向导》, no. 24, 31 August 2010 (2010-08-31) * |
| 陆振达等: "气雾剂的进展", 《药学进展》, vol. 12, no. 2, 30 April 1988 (1988-04-30) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104415129A (en) * | 2013-08-22 | 2015-03-18 | 何伊仁 | Plaster for treating injuries and fever |
| CN103969376A (en) * | 2014-05-16 | 2014-08-06 | 贵州安泰药业有限公司 | Quality standard testing method for borneol and fructus gardeniae pain-relieving aerosol |
| CN103969376B (en) * | 2014-05-16 | 2015-11-25 | 贵州景诚制药有限公司 | The grieved aerosol quality standard detecting method of ice Cape jasmine |
| CN105708945A (en) * | 2016-02-03 | 2016-06-29 | 扬州大学 | Traditional Chinese medicine aerosol composition for external use |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20120718 |