CN101036661A - Methyl salicylate aerosol preparing method - Google Patents
Methyl salicylate aerosol preparing method Download PDFInfo
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- CN101036661A CN101036661A CN 200610064936 CN200610064936A CN101036661A CN 101036661 A CN101036661 A CN 101036661A CN 200610064936 CN200610064936 CN 200610064936 CN 200610064936 A CN200610064936 A CN 200610064936A CN 101036661 A CN101036661 A CN 101036661A
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- methyl salicylate
- tank
- aerosol
- dichlorodifluoromethane
- filling
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Abstract
The invention discloses a method for preparing methyl salicylate aerosol. The method comprises the following steps: methyl salicylate, fluortrichloromethane and dichlorodifluoromethane are used based on formula ratio; 1) draw ing a material store tank to 0.096 MPa vacuum degree and absorbing the methyl salicylate having the said ratio into the material store tank; 2) putting a store tank for the fluortrichloromethane in a room temperature, opening the tank cover to mount a separating valve, inversing the store tank to make the fluortrichloromethane having the said formula ratio accessing the material tank, completely and uniformly mixing; 3) the same as the step 2), accessing the dichlorodifluoromethane having the said formula ratio into the material tank, inversing the store tank to mix uniformly in 10 minutes, arranging a titanium stick filter of 10 mu m, test filling, and batch filling after qualified; washing the tank and drying; filling; while freedom from bubbles, outer packing and box packing. The whole technical process has stable operation, accurate filling quantity, stable quality, less discharge of waste water, low consumption of material and energy, and even concentration of the drugs.
Description
Affiliated technical field:
The present invention relates to a kind of preparation method of methyl salicylate aerosol.
Background technology:
Present methyl salicylate aerosol, its preparation method is: the proportioning by methyl salicylate 0.5%, fluoro trichloromethane 49.5%, dichlorodifluoromethane 50% is carried out weighing, bottle washed back oven dry, the component of above-mentioned weighing is mixed into medicine, medicine fill, leak detection, packing shipment; There is following which shortcoming in existing step: the content instability, density unevenness is even.
Summary of the invention:
The object of the present invention is to provide the simple and stable content of a kind of processing technology, the preparation method of the uniform methyl salicylate aerosol of concentration.
Purpose of the present invention is by being that following technical proposal realizes:
Raw material of the present invention is: 5 parts of methyl salicylate, 450 parts of 550 parts of fluoro trichloromethanes and dichlorodifluoromethanes.
The preparation method of methyl salicylate aerosol of the present invention comprises the steps:
1. claim the formula ratio methyl salicylate, fluoro trichloromethane and dichlorodifluoromethane;
2. medicinal liquid preparation: 1) dosing storage tank is evacuated to 0.096Mpa vacuum,, sucks in the dosing storage tank the methyl salicylate of above-mentioned amount; 2) the fluoro trichloromethane basin is placed under the room temperature, open fluoro trichloromethane basin lid, load onto packing valve, basin is inverted the fluoro trichloromethane that makes above-mentioned formulation weight inserts material-compound tank, stir; 3) with above-mentioned step 2) method, the dichlorodifluoromethane of above-mentioned formulation weight is accurately inserted in the material-compound tank, the upset tank body at 10 minutes with interior mix homogeneously, incorporation time preferably is no more than 10 minutes, loads onto the titanium rod filter of 10um, the examination fill, after qualified after testing, bulk filling;
8. cleaning of evaporator, oven dry: the intact aerosol jar of oven dry, proper alignment is carried out two water, two gas by bottle washer and is cleaned on bottle managing machine, is loaded on pallet and enters two door leafs oven for drying, standby;
Fill: the intact aerosol jar proper alignment of oven dry on bottle managing machine, is poured into medicinal liquid in the jar by filling and sealing machine, gravimetry, content uniformity is controlled at ± and 1.5%, regulate weight and after qualified, enter the subsequent processing leak detection;
4. water-bath leak detection: the aerosol jar carries out the water-bath leak detection after embedding, and no bubble is considered as not having gas leak phenomenon, otherwise chooses recovery;
5. adorn box after the outsourcing.
In addition, when the temperature of the basin of adorning fluoro trichloromethane or dichlorodifluoromethane is higher than 20 ℃, place water-bath, be cooled to below 20 ℃.
Methyl salicylate aerosol indication of the present invention: the emergence therapeutic that is used for soft tissue injury;
Usage and dosage: external, shower nozzle is apart from illing skin 5-10 centimeters pressing valve during use, and sustained firing 2-3 gets final product second, if need to reuse, half a minute at interval, but one day can not be above 3 times.
Advantage of the present invention: the present invention adopts methyl salicylate 5g, fluoro trichloromethane 550g and dichlorodifluoromethane 450g, be mixed with methyl salicylate aerosol, overcome the shortcoming in the traditional handicraft, whole process operation is steady, and loading amount is accurate, steady quality, and wastewater discharge is few, reduced material consumption and energy consumption, the environmental protection effect is remarkable; Easy to operate, the safety of this preparation method technology, the production time is short.Drug concentration evenly, stable content, accurate measurement.
The specific embodiment:
The present invention is described in detail below in conjunction with embodiment:
Embodiment
Preparation process and process conditions
1) makes up a prescription
Comprise get the raw materials ready, the preparation of weighing, medicinal liquid, and in 100,000 grades of districts, carry out;
Get the raw materials ready, weighing carries out weighing methyl salicylate 5g, fluoro trichloromethane 550g and dichlorodifluoromethane 450g in the usual way;
Medicinal liquid preparation: 1) dosing storage tank is evacuated to 0.096Mpa (720mmHg) vacuum, accurately takes by weighing the methyl salicylate of recipe quantity, suck in the dosing storage tank.2) the fluoro trichloromethane basin is put under the room temperature (when temperature is higher than 20 ℃, should place water-bath, be cooled to below 20 ℃), can open fluoro trichloromethane basin lid, load onto packing valve, claim to decide weight, make the basin inversion fluoro trichloromethane insert material-compound tank, claim to decide weight, make the difference of twice weight be the prescription ormal weight of being prepared, stir.3) with above-mentioned step 2) method, dichlorodifluoromethane is accurately inserted in the material-compound tank by recipe quantity, the upset tank body made mix homogeneously in 9 minutes, incorporation time preferably is no more than 10 minutes, loads onto the titanium rod filter of 10um, 5 of examination fills, qualified after testing after, fill.
2) cleaning of evaporator, oven dry: the intact aerosol jar of oven dry, proper alignment is carried out two water, two gas by bottle washer and is cleaned on bottle managing machine, is loaded on pallet and enters two door leafs oven for drying, standby;
Fill: the intact aerosol jar proper alignment of oven dry on bottle managing machine, is poured into medicinal liquid in the jar by filling and sealing machine, gravimetry, content uniformity is controlled at ± and 1.5%, regulate weight and after qualified, enter the subsequent processing leak detection;
3) water-bath leak detection: the aerosol jar carries out the water-bath leak detection after embedding, and no bubble is considered as not having gas leak phenomenon, otherwise chooses recovery;
4) adorn box after the outsourcing.
The above-mentioned methyl salicylate aerosol that makes is the methyl salicylate suspension aerosol, and character is colourless or yellowish suspension, is loaded in the aerosol jar, and pressing valve, medicinal liquid promptly are the droplet ejection; Add ethanol by the ferric chloride test solution and identify, show purple; The inspection injection rate is: 2 ± 0.6 gram Grams Per Seconds.
Indication: the emergence therapeutic that is used for soft tissue injury;
Usage and dosage: external, shower nozzle is apart from illing skin 5-10 centimeters pressing valve during use, and sustained firing 2-3 gets final product second, if need to reuse, half a minute at interval, but one day can not be above 3 times.
Claims (3)
1, a kind of preparation method of methyl salicylate aerosol comprises the steps:
1. claim the formula ratio methyl salicylate, fluoro trichloromethane and dichlorodifluoromethane;
2. medicinal liquid preparation: 1) dosing storage tank is evacuated to 0.096Mpa vacuum,, sucks in the dosing storage tank the methyl salicylate of above-mentioned amount; 2) the fluoro trichloromethane basin is placed under the room temperature, open fluoro trichloromethane basin lid, load onto packing valve, basin is inverted the fluoro trichloromethane that makes above-mentioned formulation weight inserts material-compound tank, stir; 3) with above-mentioned step 2) method, the dichlorodifluoromethane of above-mentioned formulation weight is accurately inserted in the material-compound tank, the upset tank body 10 minutes with interior mix homogeneously, load onto the titanium rod filter of 10um, the examination fill, qualified after testing after, bulk filling;
3. cleaning of evaporator, oven dry: the intact aerosol jar of oven dry, proper alignment is carried out two water, two gas by bottle washer and is cleaned on bottle managing machine, is loaded on pallet and enters two door leafs oven for drying, standby;
Fill: the intact aerosol jar proper alignment of oven dry on bottle managing machine, is poured into medicinal liquid in the jar by filling and sealing machine, gravimetry, content uniformity is controlled at ± and 1.5%, regulate weight and after qualified, enter the subsequent processing leak detection;
4. water-bath leak detection: the aerosol jar carries out the water-bath leak detection after embedding, and no bubble is considered as not having gas leak phenomenon, otherwise chooses recovery.
2, the preparation method of methyl salicylate aerosol according to claim 1 is characterized in that: 5 parts of weighing methyl salicylate, 450 parts of 550 parts of fluoro trichloromethanes and dichlorodifluoromethanes.
3, the preparation method of methyl salicylate aerosol according to claim 1 is characterized in that: when the temperature of the basin of adorning fluoro trichloromethane or dichlorodifluoromethane is higher than 20 ℃, place water-bath, be cooled to below 20 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610064936 CN101036661A (en) | 2006-03-17 | 2006-03-17 | Methyl salicylate aerosol preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610064936 CN101036661A (en) | 2006-03-17 | 2006-03-17 | Methyl salicylate aerosol preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101036661A true CN101036661A (en) | 2007-09-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610064936 Pending CN101036661A (en) | 2006-03-17 | 2006-03-17 | Methyl salicylate aerosol preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101036661A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357073A (en) * | 2011-10-31 | 2012-02-22 | 福建南少林药业有限公司 | Methyl salicylate aerosol and preparation method thereof |
-
2006
- 2006-03-17 CN CN 200610064936 patent/CN101036661A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357073A (en) * | 2011-10-31 | 2012-02-22 | 福建南少林药业有限公司 | Methyl salicylate aerosol and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070919 |