CN102349552A - 一种防治重症监护病房病菌感染的药剂 - Google Patents
一种防治重症监护病房病菌感染的药剂 Download PDFInfo
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Abstract
本发明涉及一种防治重症监护病房病菌感染的药剂，它是由下述重量配比的物质制成：金银花3-5份、蛇床子0.5-1.5份、透骨草0.1-0.3份、三七4-8份、白芷0.1-0.5份、木槿皮3-7份、白头翁5-11份、百部3-5份。本发明的防治重症监护病房病菌感染的药剂成本较为低廉，安全性较好，消毒效果明显，适于在临床上大规模推广。
Description
技术领域
本发明涉及医药领域，具体来说涉及一种防治重症监护病房病菌感染的药剂。
背景技术
近年来，重症监护室(ICU)内细菌感染发生率逐渐升高，引起越来越多临床医生的重视。与普通呼吸科病房不同，重症监护室(ICU)主要收治各种危重病患者。因病情危重，病员存在严重的机体内环境紊乱，免疫功能失调，且慢性基础疾病较多，易产生各种并发症，加之侵人性操作较多，病员人ICU前多有使用抗生素史，故人ICU病人院内感染发生率明显高于普通病房。同时对于医护人员而言，在这种工作环境下工作而受到病菌感染的机率大增。据了解，在ICU中主要致病菌是金黄色葡萄球菌(Staphylococcus aureus)和白色念珠菌(Candida albicans)，因此，寻找能够杀菌这两种细菌的药剂是临床上很有意义的工作。
发明内容
本发明的目的是提供一种防治重症监护病房病菌感染的药剂。
为了实现本发明的目的，本发明提供一种防治重症监护病房病菌感染的药剂，它是由下述重量配比的物质制成：金银花3-5份、蛇床子0.5-1.5份、透骨草0.1-0.3份、三七4-8份、白芷0.1-0.5份、木槿皮3-7份、白头翁5-11份、百部3-5份。
优选地，所述的防治重症监护病房病菌感染的药剂是由下述重量配比的物质制成：金银花4份、蛇床子1份、透骨草0.2份、三七5份、白芷0.2份、木槿皮4份、白头翁7份、百部4份。
优选地，所述药剂为片剂、分散片、颗粒剂或喷雾剂。
本发明的防治重症监护病房病菌感染的药剂成本较为低廉，安全性较好，消毒效果明显，适于在临床上大规模推广。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明，但这并非是对本发明的限制，本领域技术人员根据本发明的基本思想，可以做出各种修改或改进，但是只要不脱离本发明的基本思想，均在本发明的范围之内。
实施例1：
称取金银花40g、蛇床子10g、透骨草2g、三七50g、白芷2g、木槿皮40g、白头翁70g、百部40g和水1000毫升，置于密封的烧瓶内。在30℃的水浴下加热5小时，过滤，收集滤液，浓缩至500毫升，放入喷雾器中，制成喷雾剂。
实验例1：抑菌试验
采用本领域中经典的滤纸片法来进行抑菌试验，其中：
1.材料
1.1供试菌种
金黄色葡萄球菌(Staphylococcus aureus)ATCC 25923，白色念珠菌(Candida albicans)ACTT 12228，均购自中国生物制品检定所。
1.2培养液
营养琼脂和营养肉汤，均购自北京中科晨宇实验设备有限公司。
1.3试验方法
将金黄色葡萄球菌和白色念珠菌接种于琼脂平板营养液平面上，接种时均匀密布。镊取无菌圆形滤纸片，喷洒实施例1中制备的喷雾剂至完全润湿，贴在已接种细菌的琼脂平板营养液平面上。将琼脂平板置于37℃的培养箱内，温育24小时。测量抑菌环的直径。测定3次取平均值。
1.4结果
金黄色葡萄球菌的抑菌环的平均直径为8.23mm，白色念珠菌的抑菌环的平均直径为6.87mm，表明本发明的喷雾剂具有明显的抑菌效果。
实验例2：病房中的抑菌试验
在室内面积等于30m2病房中均匀地喷洒实施例1中制备的喷雾剂100毫升。在喷洒后的12小时、24小时、48小时用平皿沉降法采样，设3个采样点，在1条对角线上取3点，即中间1点、两端距墙1m处各取1点，并重复10次。采样后，将培养基置35℃温箱中培养48h，于光线明亮处观察培养基上细菌菌落数量，按以下公式计算细菌数量，空气含菌量(cfu/m3)＝每皿平均菌落数×50 000/平皿暴露时间×平皿面积。所有细菌均按《全国临床检验操作规程》进行鉴定。在喷洒后的12小时、24小时、48小时，细菌数量(cfu/m3)分别为94、124、160，符合重视监护室对于细菌数量的要求(≤200)。
Claims (3)
1.一种防治重症监护病房病菌感染的药剂，其特征在于它是由下述重量配比的物质制成：金银花3-5份、蛇床子0.5-1.5份、透骨草0.1-0.3份、三七4-8份、白芷0.1-0.5份、木槿皮3-7份、白头翁5-11份、百部3-5份。
2.根据权利要求1所述的防治重症监护病房病菌感染的药剂，其特征在于它是由下述重量配比的物质制成：金银花4份、蛇床子1份、透骨草0.2份、三七5份、白芷0.2份、木槿皮4份、白头翁7份、百部4份。
3.根据权利要求1或2所述的防治重症监护病房病菌感染的药剂，其特征在于所述药剂为片剂、分散片、颗粒剂或喷雾剂。
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105994435A (zh) * | 2016-06-02 | 2016-10-12 | 牛文倩 | 一种针对多种致病病菌的用于重症监护室杀菌的药剂及其制备方法 |
| CN108157406A (zh) * | 2017-12-26 | 2018-06-15 | 庞振方 | 一种手术室消毒液及其制备方法 |
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| CN1079144A (zh) * | 1993-04-23 | 1993-12-08 | 徐殿基 | 一种天然植物(即中草药)合成清洗液及其制备方法 |
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Cited By (2)
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| CN105994435A (zh) * | 2016-06-02 | 2016-10-12 | 牛文倩 | 一种针对多种致病病菌的用于重症监护室杀菌的药剂及其制备方法 |
| CN108157406A (zh) * | 2017-12-26 | 2018-06-15 | 庞振方 | 一种手术室消毒液及其制备方法 |
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