CN102343095A - Xylitol medicinal intermediate - Google Patents
Xylitol medicinal intermediate Download PDFInfo
- Publication number
- CN102343095A CN102343095A CN2011101760022A CN201110176002A CN102343095A CN 102343095 A CN102343095 A CN 102343095A CN 2011101760022 A CN2011101760022 A CN 2011101760022A CN 201110176002 A CN201110176002 A CN 201110176002A CN 102343095 A CN102343095 A CN 102343095A
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- CN
- China
- Prior art keywords
- xylitol
- medicinal intermediate
- medicinal
- maltitol
- maltose alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The invention provides a xylitol medicinal intermediate. According to the invention, xylitol is adopted as a main component. The intermediate is characterized in that: the intermediate is prepared from 75% of xylitol, 5% of powdered pepper and 20% of maltitol; and the materials are blended at a temperature of 120 to 145 DEG C, such that the intermediate is prepared. The cold property of xylitol can be neutralized by the warm property of powdered pepper, and maltitol is hard to be absorbed, such that the intermediate can be used as a good medicinal intermediate used in medicines with mixed release retarding functions and targeting functions.
Description
Technical field
The present invention relates to medicine food, especially the xylitol medicinal intermediate.
Background technology
Xylitol is the normal intermediate product of xylose metabolism, pure xylitol, and profile is white crystal or white powder crystal.At occurring in nature, extensively be present in the plant such as group food and timber, Caulis et Folium Oryzae, corn cob of fruit, vegetable, frumentum, mushroom.It can be used as the extensive use in industry such as chemical industry, food, medicine of sweeting agent, nutrient and medicament.
Its molecular formula is C5H12O5, is a kind of pentose alcohol.Do not specify that if having people are difficult to xylitol and sucrose are differentiated.Xylitol originates in Finland, is a kind of natural plant sweetening agent that from plants such as silver birch, Oak Tree, corn cob, bagasse, extracts.It is better that xylitol low temperature is tasted effect, and its sugariness can reach 1.2 times of sucrose.Often with slight refrigerant sense, this is because it is soluble in water behind the xylitol inlet, and when dissolving, can absorb certain heat.The cleannes that also help tooth to a certain extent, but the over-drastic edible diarrhoea of also might bringing waits side effect, and this point is also very important.
Xylitol is excessive can not get fat.And from physicochemical property, xylitol is cooler, and as the food of seafood, Semen phaseoli radiati and so on, it is difficult for being decomposed by gastric enzyme, directly gets into intestinal, and overeating has certain stimulation to gastrointestinal, possibly cause abdominal discomfort, flatulence, borborygmus.Because xylitol less than 20%, in the intestinal wall accumulation, is prone to cause osmotic diarrhea in the intestinal internal absorption factor easily.With Chinese body constitution, the upper limit of taking in xylitol in one day is 50 grams.Light chews gum and should have no problem, if but eat other a large amount of xylitol food, just should be noted that consumption.Excessive edible xylitol can make blood fat raise.The same carbohydrate of all being made up of carbon, hydrogen, oxygen element of xylose alcohol and glucose, xylitol is initial in metabolism, possibly not need insulin to participate in, but in the metabolism later stage, just need the promotion of insulin.Therefore, xylitol can not place of glucose be corrected metabolism disorder, can not blood sugar lowering, glucose in urine, improve clinical symptoms.Clinical practice shows that xylitol can not treat diabetes, and the xylitol overfeeding, and triglyceride raises in the blood, causes coronary atherosclerosis.
But it does not possess the medicinal intermediate function.
Summary of the invention
The present invention provides the xylitol of coating functional effect.
Technical scheme is following:
The xylitol medicinal intermediate is a main component with the xylitol, it is characterized in that being formed 120～145 degrees centigrade of modulation by 75% xylitol, 5% Fructus Piperis powder, 20% maltose alcohol, is used for the medicinal intermediate of medicament mixed slow release, target function.
Because the warm performance of the cold and Fructus Piperis powder of xylitol neutralizes, and cooperates the absorption function that is difficult to of maltose alcohol again, can be used as good medicinal intermediate.
The specific embodiment
In the actual fabrication, grind refinement then, be made into the above powder particle of 200 orders for xylitol, Fructus Piperis powder, maltose alcohol elder generation drying.Can be with reference to this method and make xylitol: specifically comprise two reactions step, the first step be that sugar fermentation is changed into pentitol, and second step was that the pentitol catalytic chemistry is isomerizated into xylitol.Alternatively xylitol is separated from other pentitol.
Also having a kind of is to produce the method that bacterium prepares xylitol with xylitol, prepares purity of xylose alcohol from the gained xylitol solution.The method for preparing of high-purity xylitol (a step desalination process) is characterized in that in aqueous culture medium, cultivating xylitol and produces bacterium, removes the solid content in the culture fluid; Use cation exchange resin and anion exchange resin and remove deionizing material the liquid, make it desalination from the gained solid content; With storng-acid cation exchange resin the gained desalinization liquor is carried out chromatography, separate xylitol and other sugar and sugar alcohols; From gained xylitol solution (fraction), separate and prepare high-purity xylitol; And the method for preparing of high-purity xylitol (two step desalination processs), it is characterized in that, in the desalting processing of this method for preparing operation, want to carry out desalting processing to remove most ionic species through the ion exclusive method earlier.
Such xylitol can be used for the medical science targeted drug, can xylitol, the component ratio of maltose alcohol, and the adjustment medicine arrives organ sites.
Claims (2)
1. the xylitol medicinal intermediate is a main component with the xylitol, it is characterized in that being formed 120～145 degrees centigrade of modulation by 75% xylitol, 5% Fructus Piperis powder, 20% maltose alcohol, is used for the medicinal intermediate of medicament mixed slow release, target function.
2. xylitol medicinal intermediate as claimed in claim 1, it is characterized in that can xylitol, the component ratio of maltose alcohol, and the adjustment medicine arrives organ sites.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101760022A CN102343095A (en) | 2011-06-28 | 2011-06-28 | Xylitol medicinal intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101760022A CN102343095A (en) | 2011-06-28 | 2011-06-28 | Xylitol medicinal intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102343095A true CN102343095A (en) | 2012-02-08 |
Family
ID=45542413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101760022A Pending CN102343095A (en) | 2011-06-28 | 2011-06-28 | Xylitol medicinal intermediate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102343095A (en) |
-
2011
- 2011-06-28 CN CN2011101760022A patent/CN102343095A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120208 |