CN102342499B - Health food with auxiliary blood sugar and blood lipid lowering functions - Google Patents
Health food with auxiliary blood sugar and blood lipid lowering functions Download PDFInfo
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- CN102342499B CN102342499B CN201010242161.3A CN201010242161A CN102342499B CN 102342499 B CN102342499 B CN 102342499B CN 201010242161 A CN201010242161 A CN 201010242161A CN 102342499 B CN102342499 B CN 102342499B
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Abstract
The invention relates to a health food with auxiliary blood sugar and blood lipid lowering functions. The health food is characterized in that: each 1000 granules of capsules comprise 90-110g of purified konjak powder, 72-88g of extracts from acanthopanax, 54-66g of extracts from gynostemma pentaphylla, and 54-66g of extracts from green tea. The weight of contents in each granule of the capsule is 0.3g, and each 100g of the contents comprises 33.67-40.33g of glucomannan, 10.01-11.99g of tea polyphenol, and 3.01-3.59g of total saponins. The health food which is an oral capsule preparation and has the advantages of accurate efficacy, rapid action, safety and reliability, and small taking dosage is convenient for carrying and long-term taking; and the health food which simultaneously has dual auxiliary blood sugar and blood lipid lowering functions is helpful for rehabilitation of patients who only have hyperglycemia or hyperlipidemia, or simultaneously have hyperglycemia and hyperlipidemia, and also allows concurrent cardiovascular and cerebrovascular diseases and the like of diabetes and hyperlipidemia to be prevented. The health food of the invention is different from simple blood sugar and blood lipid products in the recent market.
Description
Technical field
The present invention relates to a kind of health food formula composition, particularly a kind of can auxiliary hyperglycemic, auxiliary antilipemic health food.
Background technology
At present, the hypoglycemic medicine of China, mainly based on Western medicine, accounts for 70% of whole market share, and Chinese patent drug is auxiliary, accounts for more than 20%.Although chemical classes hypoglycemic prescription medicine effect is comparatively obvious, the drug resistance that Long-term taking medicine causes, the resistance to the action of a drug, hepatic injury etc. all can allow diabetic feel more painful.In global best-selling medicines in 2002,8 kinds are had to be blood fat-reducing product; Global sales rank the first and second are all reducing blood lipid medicines, be the LiPitoR (Atorvastatin) of Pfizer and the ZoCoR (Simvastatin) of Merck respectively.Though and these two kinds of medicine lipid-lowering effects are obvious, have certain side effect.
Hypoglycemic series products is mainly divided into two parts in the market, and a class is the medicine with hypoglycemic, effect for reducing fat, as Effects of Xuezhikang, simvastatin, Fufang Danshen Pian etc.; Another kind of is the health products with hypoglycemic, effect for reducing fat, as wind curing capsule, sugar are determined health sheet, Kang Li relieving capsule, spirulina, lecithin, fish oil, promise recovering capsule, red sage root fat recovering capsule, pacify open capsule, return Siberian cocklebur capsule, joined Qi capsule, auspicious of fat, soybean lecithin soft capsule, but these products still can not meet the demand of hyperglycaemia people with hyperlipidemia far away, also lack competitiveness simultaneously.
The market of hypoglycemic, lipopenicillinase series products is still based on medicine, and the main purchase approach of consumer is hospital.Along with improving constantly of Chinese common people's OBD level, hypoglycemic, fat reducing health product market are just persistently overheating.Due to the raising of China's medical and health conditions, population life significantly increases, and hyperlipidemia and relevant disease incidence thereof continue to increase, increasing to the demand of lipopenicillinase series products.From the growth trend of health-product market, hypoglycemic health products have huge development space in field, future market.
Summary of the invention
A kind of pure natural that object of the present invention is exactly deficiency for above-mentioned health-product market background and technology and provides, have no side effect, there is auxiliary hyperglycemic, reducing blood lipid and having concurrently is calmed the nerves, antifatigue, anti-oxidant, the health food that strengthens immunologic function.
Technical solution of the present invention is: containing purifying konjaku flour 90-110g, siberian Ginseng P.E 72-88g, Herb Gynostemmae Pentaphylli extract 54-66g, green-tea extract 54-66g in every 1000 capsules of this health food.
The heavy 0.3g of every capsules content, wherein contains Glucomannan 33.67-40.33g, Tea Polyphenols 10.01-11.99g, total saposins 3.01-3.59g in every 100g content.
The good effect that the present invention produces is:
From the angle of prevention and health care, this product has the advantage place of its uniqueness.First, purifying konjaku flour, siberian Ginseng P.E, Tea Polyphenols, Herb Gynostemmae Pentaphylli extract are the active skull cap components extracted from plant, and each raw material makes capsule through modern crafts, eat, have no side effect by RD.Carried out animal (rat) acute toxicity test simultaneously, genetic toxicity test (mouse marrow cell micro nuclear test, mouse inbred strain, Salmonella reversion test), rat 30 days feeding trials, animal test results shows that this product is nontoxic level, and hereditary-less toxicity, without obvious harmful effect.
Secondly, this product raw material used all has the function regulating blood sugar, adjusting blood lipid in various degree, has carried out auxiliary hyperglycemic function animal experiment and human feeding trial, also carried out auxiliary lipid-lowering function animal experiment and human feeding trial after making capsule.Auxiliary hyperglycemic function animal experiment shows that this product can raise the hyperglycemia model glucose tolerance in mice (P < 0.05) of alloxan induction; Human feeding trial shows that this product significantly can improve type ii diabetes patient clinical symptom, and reduction fasting blood-glucose and after the meal 2h sugar (P < 0.01), have no significant effect experimenter's health, have auxiliary hyperglycemic effect.Auxiliary lipid-lowering function animal experiment shows, this product obviously can reduce serum TC, TG (P < 0.01) and raise HDL-C (P < 0.05), it is remarkable that human feeding trial shows that this product has auxiliary lipid-lowering function, and have no adverse effects to body.
Again, this product is oral capsule preparation, exact efficacy, and onset is rapid, and safe and reliable, taking dose is little, is easy to carry and long-term taking.There is unique auxiliary hyperglycemic, auxiliary antilipemic dual-use function simultaneously, both contributed to simple hyperglycaemia, high fat of blood and suffered from hyperglycaemia, hyperlipemic patients rehabilitation simultaneously, also can the concurrent cardiovascular and cerebrovascular diseases etc. of prophylactic treatment diabetes, hyperlipidemia.This product is different from hypoglycemic, blood fat-reducing product simple on current market.Full side four taste, reasonable compatibility, treats both principal and secondary aspect of disease, and tonification and purgation in combination, and gathering altogether reduces phlegm disappears long-pending, and the merit of strengthening spleen, tonifying kidney, long-term taking effectively can assist hyperglycaemia, hyperlipemic patients rehabilitates.
Detailed description of the invention
Of the present invention there is auxiliary hyperglycemic, the health food of auxiliary lipid-lowering function be component containing following weight in 1000 capsules:
Embodiment 1:
Purifying konjaku flour 90-110g siberian Ginseng P.E 72-88g
Herb Gynostemmae Pentaphylli extract 54-66g green-tea extract 54-66g
Embodiment 2:
Purifying konjaku flour 90g siberian Ginseng P.E 88g
Herb Gynostemmae Pentaphylli extract 56g green-tea extract 66g
Embodiment 3:
Purifying konjaku flour 110g siberian Ginseng P.E 82g
Herb Gynostemmae Pentaphylli extract 54g green-tea extract 54g
The heavy 0.3g of every capsules content, wherein contains Glucomannan 37.0g, Tea Polyphenols 11.0g, total saposins 3.3g in every 100g content.
The present invention records and the experience of State Food and Drug Administration's health food database retrieval and comprehensive brainstrust according to amount of literature data, determine to select have reduce phlegm, the natural plants of long-pending, the strengthening spleen, tonifying kidney effect of disappearing and can be used for the konjaku of health food, wilsonii, gynostemma pentaphylla, green tea is the formula of this product.In these four kinds of raw materials, konjaku contains a large amount of glucomannans, and wilsonii and gynostemma pentaphylla contain saponin constituent, and tealeaves contains Tea Polyphenols, and these compositions all have the function of auxiliary hyperglycemic, auxiliary antilipemic, anti-oxidant, scavenging free radicals and strengthening by means of tonics.
Traditional Chinese medical theory foundation:
Hyperglycaemia, high fat of blood belong to that the traditional Chinese medical science " is quenched one's thirst ", " phlegm syndrome " category, and prevention and health care should to reduce phlegm, to disappear long-pending, strengthening spleen, tonifying kidney, to receive the merit of strengthening vital QI to eliminate pathogenic factors, reinforce insufficiency and reduce excessiveness.
Formula is made up of konjaku, wilsonii, gynostemma pentaphylla, green tea.
(1). konjaku: nature and flavor are pungent, bitter, cold in nature, return liver, spleen, lung, kidney channel, having reduces phlegm disappears long-pending, and detoxicating and resolving a mass, row stasis of blood analgesic efficacy, playing primary treatment effect mainly for essential resistance of turbid phlegm primary symptom, is monarch drug in a prescription in side.
(2). wilsonii: pungent, the micro-hardship of taste, slightly warm in nature, returns spleen, kidney, the heart channel of Hang-Shaoyin, has and replenish qi to invigorate the spleen, and tonify the kidney to relieve mental strain effect, auxiliary monarch drug in a prescription, and control deficiency of spleen and stomach disease is ministerial drug in side.
(3). gynostemma pentaphylla: bitter, micro-sweet, cool in nature, return lung, spleen, kidney channel, have reduce phlegm, eliminate the phlegm, boosting qi and nourishing yin effect, both can help principal drug assistance and reduce phlegm, and can help again and help ministerial drug kidney and spleen invigorating, take in the merit of reinforce insufficiency and reduce excessiveness concurrently.
(4). green tea: bitter, sweet, cold nature, gas delicate fragrance, has clearing heat and moistening lung, the merit of promote the production of body fluid, quenching the thirst, and assistant helps monarch-minister drug to strengthen its clear and rich effect of promoting the production of body fluid further.
Modern medical theory foundation:
Modern medicine study proves in konjaku, wilsonii, gynostemma pentaphylla, green tea containing abundant konjac glucomannan, acanthopanax senticosus saponins, gypenoside, Tea Polyphenols etc.Pharmacological research shows that these compositions all have the function of hypoglycemic, reducing blood lipid, anti-oxidant, scavenging free radicals and strengthening by means of tonics.
(1) konjaku:
Konjaku contains abundant glucomannan, has good hypoglycemic, reducing blood lipid, anticancer, fat-reducing, clean stomach, prevents and treats the effects such as hypertension.Modern pharmacology shows that konjac glucomannan molecular weight is high, and viscosity is large, the absorption of energy delay glucose, thus alleviates the burden of pancreas islet, impels diabetes patient to be in benign cycle.Secondly konjaku glucomannan particle has extremely strong water imbibition, can increase satiety, alleviates diabetes patient's hunger pangs and reduce feed.Konjac glucomannan reduces the free fatty acid levels in blood circulation, improves the susceptibility of insulin, sugar tolerance is reduced.Konjaku in alimentary canal can with the combination such as cholesterol, hinder the absorption of neutral fat and cholesterol; Konjac glucomannan can adsorb cholic acid in intestines, stops colic acid resorption, makes it discharge with ight soil, thus accelerate the conversion of cholesterol to cholic acid direction, cause the reduction of cholesterol level; Konjac glucomannan is decomposed by fermentable in colon, and produce the SCFAs such as propionic acid, these SCFAs are absorbed by the body, thus produces effect for reducing blood fat.
(2) wilsonii:
Wilsonii contains the multiple saponin(e similar to ginseng etc., is mainly eleutheroside A (daucosterol), Syringin (syringin), Syringin
1(isofraxidin glucoside), eleutheroside C (galactite glycosides), eleutheroside D and E (2 kinds of different configurations of the glucoside of syringaresinol) etc.Modern medicine research shows that eleutheroside has effects such as replenishing qi to invigorate the spleen, tonify the kidney to relieve mental strain, the vigor of superoxide dismutase in cell can be improved, reduce the content of blood plasma inner lipid peroxide, alleviate the infringement of radical pair beta Cell of islet or promote the reparation of impaired β cell, playing effect that is hypoglycemic, reducing blood lipid.
(3) gynostemma pentaphylla:
Gynostemma pentaphylla contains the saponin(e that kind more than 80 and ginsenoside have similar skeleton, and these saponin(es have stronger antioxidation, scavenging activated oxygen; Reducing blood lipid; Antiaggregating activity on platelet; Exciting human cell viability; Improve the effects such as immunologic function.Multinomial research confirms that gypenoside can direct intervention have definite curative effect to multiple morbidity links of diabetes.Gynostemma pentaphylla also can significantly reduce blood lipids, whole blood viscosity, Plasma Viscosity and packed cell volume, and also obviously increase ED, microcirculation obviously improves, and blood flow accelerates, and is one not only lipopenicillinase but also improve hemorheological medicine.
(4) green tea:
Green tea main component is Tea Polyphenols, Tea Polyphenols has another name called tea tannin, tea tannin, it is the general name of thirties kinds of aldehydes matters in tealeaves, Tea Polyphenols is a kind of antioxidant of pure natural, there is superior oxidation resistance, and there is the effects such as hypoglycemic, hypotensive, reducing blood lipid, removing human free radical, prevention cardiovascular and cerebrovascular diseases.Modern pharmacological research shows that Tea Polyphenols can suppress the activity of a-amylase and a-glucuroide, reduces the Glucose transport activity of rabbit intestinal brush border vesica, delay or slow down sugar enteron aisle absorption and digestion thus improve its sugar tolerance, stabilizing blood sugar.Tea Polyphenols is the potent inhibitor of LDL oxidation, effectively can suppress the oxidative modification of LDL.It is a kind of antioxidant of efficiency natural, by autoxidation, suppress cholesterol and unsaturated fatty oxidation, minimizing cholesterol and oxide thereof deposit on arterial wall, promote that unsaturated fat is to the running of cholesterol and removing, platelet aggregation-against, improves blood peripheral circulation, thus play prevention hyperlipidemia, suppress artery sclerosis to be formed.
Above four kinds of raw materials are composite, without incompatibility between each component, mild in medicine property and, dosage is suitable for, various composition all has auxiliary hyperglycemic, the health care of auxiliary antilipemic and mutual coordinative role, and therefore we by the extract combination of these four kinds of compositions together, are processed into capsule through modern crafts, 0.3 gram every, every 100g content contains glucomannan 37%; Total saposins 3.3%; Tea Polyphenols 11.0%.Health food made by the present invention through all experiments and the Ministry of Public Health, national Bureau of Drugs Supervision directly under authoritative department checking, the present invention has innovation, remarkable and the auxiliary hyperglycemic of highly significant, the precise effects of auxiliary antilipemic.
The preparation of purifying konjaku flour, siberian Ginseng P.E, Tea Polyphenols, Herb Gynostemmae Pentaphylli extract:
1, purifying konjaku flour
Fresh Amorphophallus rivieri cleans, removing impurity, and pure water cleans, peeling, and be cut into 110 DEG C of heated-air dryings after the thick thin slice of 0.4cm, select certified products, pulverize, the impurity such as separate ash, grinding, selection by winnowing separation, obtains konjaku powder; Konjaku powder 3 times amount 38% ethanol agitator treating 3 times, each 40 minutes, centrifugation also reclaimed ethanol, obtains konjaku and washes powder; Konjaku washes powder again with molten 2 hours of 3 times amount water purification constant temperature 20 DEG C leaching, konjaku flour and water is made to become swelling liquid, then 3 times amount 85% alcohol settling is added 1 hour, centrifugal high pressure is separated, continuous dip is molten, precipitation, lock out operation three times, and waste liquid merges and reclaims ethanol, filter residue vacuum drying 2.5 hours under-0.08Mpa, 70 DEG C of conditions, 40 DEG C of cryogrindings 3 minutes, selection by winnowing is separated to obtain purifying konjaku flour.
2, siberian Ginseng P.E
Wilsonii cleans, and removing impurity, sieve is dust, purified rinse water to the greatest extent, suitable cutting.Wilsonii meal 8 times amount 75% alcohol refluxs extract 3 times, each 2 hours, filter, merging filtrate, reclaim ethanol, be concentrated into the clear cream that relative density is 1.25 (when 60 DEG C), vacuum drying under-0.07MPa (80 DEG C), is ground into fine powder, crosses 100 mesh sieves, load sterile bag, for subsequent use.
3, Tea Polyphenols
Green tea cleans, removing impurity, and sieve is dust, purified rinse water to the greatest extent, 3 times are got by 10 times amount, 80 DEG C of water extractions, each 1.5 hours, filter, merging filtrate, be concentrated into the clear cream that relative density is 1.25 (when 80 DEG C), vacuum drying under-0.07MPa (80 DEG C), is ground into fine powder, crosses 100 mesh sieves, load sterile bag, for subsequent use.
4, Herb Gynostemmae Pentaphylli extract
Gynostemma pentaphylla cleans, removing impurity, and sieve is dust, purified rinse water to the greatest extent, suitable cutting, extracts 3 times with 8 times amount 70% alcohol refluxs, each 2 hours, filter, merging filtrate, reclaims ethanol, is concentrated into the clear cream that relative density is 1.25 (when 60 DEG C), vacuum drying under-0.07MPa (80 DEG C), be ground into fine powder, cross 100 mesh sieves, load sterile bag, for subsequent use.
Capsule 's content is prepared:
1, take purifying konjaku flour, siberian Ginseng P.E, tea polyphenol extract thing, Herb Gynostemmae Pentaphylli extract by formula ratio, load mixer mixing, sterilizing, is up to the standards, and is capsule 's content.
2, filled capsules:
The supply of Capsules, arrangement, makes correction for direction, and separately, mixed content material is inserted for capsule cap, body, and defective goods are rejected, and capsule cap, body combine.
3, packaging, inspection, finished product warehouse-in.
Main supplementary material quality standard
1, purifying konjaku flour meets Ankang Qin Dong konjak food Co., Ltd purifying konjaku flour quality standard Q/QD 001-2008
2, siberian Ginseng P.E meets Ankang Qin Dong konjak food Co., Ltd wilsonii and gets thing quality standard Q/QD 001-2008
3, Tea Polyphenols meets Ankang Qin Dong konjak food Co., Ltd Tea Polyphenols quality standard Q/QD001-2008
4, Herb Gynostemmae Pentaphylli extract meets Ankang Qin Dong konjak food Co., Ltd gynostemma pentaphylla and gets thing quality standard Q/QD 001-2008
5, Capsules meets two requirements of " Chinese Pharmacopoeia " version in 2000
Extraction solvent quality standard
Ethanol: meet GB10343-2002 edible alcohol standard-required
Above-described konjaku, wilsonii, gynostemma pentaphylla, green tea all can be buied in market or medicinal material market.
The health food made by the present invention through toxicological test, product quality that the relevant authoritative department in Shaanxi Province and country carries out check inspection, animal function test and human feeding trial the results detailed in following table:
Claims (2)
1. a health food for auxiliary hyperglycemic, auxiliary antilipemic, is characterized in that the weight of each component of content in 1000 capsules is: purifying konjaku flour 90-110g, siberian Ginseng P.E 72-88g, Herb Gynostemmae Pentaphylli extract 54-66g, green-tea extract 54-66g.
2. the health food of a kind of auxiliary hyperglycemic as claimed in claim 1, auxiliary antilipemic, it is characterized in that the heavy 0.3g of every capsules content, in every 100g content, the weight of each functional component is: Glucomannan 33.67-40.33g, Tea Polyphenols 10.01-11.99g, total saposins 3.01-3.59g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010242161.3A CN102342499B (en) | 2010-07-30 | 2010-07-30 | Health food with auxiliary blood sugar and blood lipid lowering functions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010242161.3A CN102342499B (en) | 2010-07-30 | 2010-07-30 | Health food with auxiliary blood sugar and blood lipid lowering functions |
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| Publication Number | Publication Date |
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| CN102342499A CN102342499A (en) | 2012-02-08 |
| CN102342499B true CN102342499B (en) | 2015-03-11 |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403017A (en) * | 2002-10-24 | 2003-03-19 | 田轩 | Selenium-rich konjaku-green tea health food |
| WO2005009351A2 (en) * | 2003-07-17 | 2005-02-03 | Santé International, Inc. | Dietary supplement for promoting control of blood-sugar levels and associated pathology in type 2 diabetics |
| CN1820775A (en) * | 2005-12-19 | 2006-08-23 | 余内逊 | Process for preparing micrometer yinlanzha, konjak, sugar, fat reaucing and weight reducing granule, capsule and tablet |
| CN101518595A (en) * | 2008-02-28 | 2009-09-02 | 北京中泰天和科技有限公司 | Medical composition with functions of lowering lipid, reducing fat and oxidation resistance and preparation method thereof |
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