CN102342404A - Composite calcium preparation - Google Patents
Composite calcium preparation Download PDFInfo
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- CN102342404A CN102342404A CN2011102846938A CN201110284693A CN102342404A CN 102342404 A CN102342404 A CN 102342404A CN 2011102846938 A CN2011102846938 A CN 2011102846938A CN 201110284693 A CN201110284693 A CN 201110284693A CN 102342404 A CN102342404 A CN 102342404A
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Abstract
The invention discloses a composite calcium preparation, and belongs to the technical field of health-care food. Calcium citrate, collagen peptide, glucosamine and chondroitin sulfate are used as main materials; lactose, starch, dextrin and magnesium stearate are used as auxiliary materials; and the main materials and the auxiliary materials are prepared into tablets or capsules. The composite calcium preparation comprises the following components based on total weight: 40 to 60 percent of calcium citrate, 10 to 30 percent of collagen peptide, 10 to 25 percent of glucosamine, 5 to 15 percent of chondroitin sulfate, 2 to 8 percent of lactose, 2 to 6 percent of dextrin, 5 to 10 percent of starch and 0.2 to 2 percent of magnesium stearate. The composite calcium preparation has the advantages that: by adopting an organic calcium source, the biological utilization rate of the body on calcium can be effectively increased; and meanwhile, by using the complexing effect of the collagen peptide and calcium ions, absorption of the calcium is enhanced. Compared with the prior art, the composite calcium preparation can enhance the immunity of the body at the same time of supplementing the calcium, further promotes the absorption of the calcium, is a good calcium supplementing preparation, is safe and reliable, and has no toxic or side effect.
Description
Technical field
The invention belongs to the health food technology field, particularly a kind of compounded calcium preparation, the compounded calcium preparation of processing by calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate; Health care with enhance bone density can also play effective protection bone joint, the arthritic effect of auxiliary curing simultaneously.
Background technology
At present, because China resident diet structure is unbalanced, add that milk series products amount is few, the present situation of calcium deficiency is very general.According to " Chinese residents nutrition and Health Situation " survey report in 2004, resident's calcium intake was 391 milligrams only, is equivalent to 41% of recommended intake.Along with the raising of people's living standard, carry out replenishing of calcium through variety of way, be subjected to widely and paid close attention to.
Calcium citrate is the outstanding calcium source that generally acknowledge countries in the world, has all obtained using widely in the U.S., Japan, Germany.Calcium citrate has the advantages that very easily be absorbed by the body, and solubility is high, and clarity is good, and absorptivity reaches 40%, is widely used in fields such as medicine and food.Contained citrate also is the active material to the human body beneficial in the calcium citrate, and free calcium is to exist with the form that combines attitude, and most of calcium ion then is to exist with the form that combines with citrate in the human body.In addition, the ion stability of calcium citrate is good, helps the absorption by human body utilization more, and its content of beary metal is stipulated far below the world, takes safety, and suitable crowd is in extensive range.
Collagen is the especially important composition composition of cartilaginous tissue of skeleton, is the maximum a kind of protein of people's in-vivo content.Collagen is participated in each item physiological activity of inside of human body, has the raising immunity of organisms, suppresses cancer cell, the activating cell function, and functions such as treatment of arthritis are called as on " the life support " of human body.The characteristic amino acid hydroxy-proline of collagen is that transportation calcium is to the delivery vehicle of osteocyte in the blood plasma, and research shows, collagen can make and calcareously can combine unlikely loss with osteocyte; When the collagen in the bone ran off, the calcium amount also can correspondingly reduce in the bone, and only increase the calcium pickup amount this moment, is difficult for improving the phenomenon of calciprivia.Because collagen constitutes three strands of superhelixes by 3 α polypeptide chains, its molecular structure is very stable, relative molecular weight more than 30KDa, thereby cause it to digest and assimilate difficulty, be difficult for being made full use of by human body.What application was more at present is its hydrolysate---collagen peptide, also claims Hydrolyzed Collagen.Collagen peptide is to be raw material with the animal collagen through the powdery product that purifies purification, enzymolysis, filtration, concentrates, processings such as spray-drying processed, and its color is generally white or faint yellow.Compare with macromolecular collagen protein without hydrolysis, collagen peptide digest and assimilate, aspect such as nutrition, functional characteristic all has significant superiority.Many researchs confirm that collagen peptide can effectively promote the formation of bone, strengthen the ossein structure under the low calcium level, thereby improve bone strength, reach the effect of prevention of osteoporosis disease.Aspects such as in addition, it raises at skin health, inhibition blood pressure, protection gastric mucosa also have remarkable efficacy.
Glucosamine extensively is present in humans and animals cartilage, flesh key and the ligament, is the necessary important component of synthesizing amino polysaccharide in the human articular cartilage matrix.Glucosamine can activate NK, LAK cell as the final degradation product of chitin, has the effect of immunological regulation, antitumor activity, and is more in Application for Field such as biological medicines.Glucosamine can participate in making up tissue and cell membrane, is the intermediate material of the big molecule synthesis of proteoglycan, has the biologically active of aspects such as treatment of arthritis, SP polysaccharide be synthetic.Research shows; Glucosamine can the effective stimulus cartilage cell synthesize collagen and proteoglycan, promotes the synthetic of cartilage matrix, suppresses the degraded of cartilage; Help to improve inflammatory reactions such as the pain that causes because of osteoarthritis and swelling, effectively delay the development of degenerative osteoarthritis.
Chondroitin sulfate (CS) is the important component part of connective tissue, and its molecular structure mainly is made up of D-glucuronic acid and 2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-sulfuric acid-D-galactolipin.CS keeps cell phenotype participating in the transmission of iuntercellular information, is all bringing into play extremely important biological function with aspects such as other matrix interphase interactions and maintenance organized whole functions.Research shows that CS can synthesize HA, PG and collagen through stimulating the cartilage cell, and then promotes the formation of new cartilaginous tissue.CS has tangible close cartilage property; Can preferentially get into cartilaginous tissue; The protection cartilage; While CKIs hydrolase and lysosomal enzyme; Like pancreatopeptidase E; N-acetylaminoglucosidases etc. damage the generation of the enzyme of articular cartilage, improve synovial membrane and produce hyaluronic ability, have avoided further developing of cartilage infringement.Can know that through experiment in external and the body CS has the characteristic of protection articular cartilage, also can ameliorate osteoarthritis in clinical practice and the symptom of arthralgia.
Summary of the invention
The object of the present invention is to provide a kind of compounded calcium preparation of processing by calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate; Overcome the deficiency that present single calcium preparation absorptivity is low, aspect such as calcium deposition be prone to take place, had the bone density of increasing and the arthritic function of auxiliary curing.The crowd who is particularly useful for calcium deficiency, osteoporosis and has bone joint problem can effectively increase bone density, enhancing body immunity, protection bone joint.Through evidence, take nontoxic, side effect safely, effectively, for a long time.
The present invention is a major ingredient with calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate, is auxiliary material with lactose, starch, dextrin, dolomol, processes tablet or capsule; Wherein calcium citrate accounts for the 40-60% of gross weight, and collagen peptide accounts for the 10-30% of total amount, and Glucosamine accounts for the 10-25% of gross weight, and chondroitin sulfate accounts for the 5-15% of gross weight.Describedly add the 2-8% that the auxiliary material lactose accounts for gross weight, dextrin accounts for the 2-6% of gross weight, and starch accounts for the 5-10% of gross weight, and dolomol accounts for the 0.2-2% of gross weight.
Glucosamine of the present invention is D-aminoglucose hydrochloride or D-aminoglucose sulfate, is got through acid, alkali treatment and enzymolysis production by shrimp and crab shells; Described chondroitin sulfate extracts from shark or ox cartilage; Described collagen peptide, its molecular weight is at 1-5KDa.
Technical characterstic of the present invention is: calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate are combined, through rational distribution, each component is worked in coordination with play a role.When increasing bone density, take into account many-sided demands such as enhancing of osteoarticular protection and immunity of organisms, play effective protection bone joint, the effect of auxiliary curing arthritis and arthralgia.The scientific matching of each component can more comprehensively be regulated physical function, effectively strengthens the bioavailability of each component, play complement each other, sorbefacient effect.Can know that to sum up the science compatibility of calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate is taken, effect is more remarkable, and is safe.
The invention has the advantages that, adopt the organic calcium source, can effectively increase the bioavailability of body calcium; Utilize the complexing of collagen peptide and calcium ion simultaneously, strengthen the absorption of calcium.Compared with prior art, this product is all right enhancing body immunity when replenishing calcium, promotes cartilage cell's generation; Strengthen the binding ability of calcium and osteocyte; Through the synergy of each component, further promote the absorption of calcium, be a kind of good calcium-supplementing preparation.Taking safe and reliablely, have no side effect, is a kind of health food safely and efficiently.
The animal function test is the result show, these article have the effect of good enhance bone density; The safety evaluatio result of the test shows, these article safe without toxic side effect; Study on the stability is the result show, these article steady quality before the deadline are reliable.
The specific embodiment
Embodiment 1:335g calcium citrate, the 160g collagen peptide, 135g D-Glucosamine Sulfate Potassium salt, the 50g chondroitin sulfate adds 60g starch, 32g lactose, 24g dextrin, 4g dolomol.In above-mentioned prescription, with calcium citrate, collagen peptide, D-Glucosamine Sulfate Potassium salt, chondroitin sulfate, starch, lactose, dextrin is crossed 80 mesh sieves respectively, is weighed, fully mixing.With 90% ethanol is adhesive system softwood, crosses 16 eye mesh screen system wet granulars, and the whole grain of 20 mesh sieves is crossed in dry back, with compressing tablet behind the dolomol mixing, processes 1000 tablets.Every heavy 0.780-0.850g.Every day, dose should be above 6.
Embodiment 2:400g calcium citrate, the 120g collagen peptide, 120g D-Glucosamine Sulfate Potassium salt, the 50g chondroitin sulfate adds 50g starch, the 32g lactose, the 24g dextrin, the 4g dolomol is processed 1000 tablets by method described in the embodiment 1.Every heavy 0.780-0.850g.Every day, dose should be above 6.
Claims (4)
1. a compounded calcium preparation is characterized in that, is major ingredient with calcium citrate, collagen peptide, Glucosamine and chondroitin sulfate, is auxiliary material with lactose, starch, dextrin, dolomol, processes tablet or capsule; Wherein, calcium citrate accounts for the 40-60% of gross weight, and collagen peptide accounts for the 10-30% of total amount, and Glucosamine accounts for the 10-25% of gross weight, and chondroitin sulfate accounts for the 5-15% of gross weight; Add the auxiliary material lactose and account for the 2-8% of gross weight, dextrin accounts for the 2-6% of gross weight, and starch accounts for the 5-10% of gross weight, and dolomol accounts for the 0.2-2% of gross weight.
2. compounded calcium preparation according to claim 1 is characterized in that, described collagen peptide, and its molecular weight is at 1-5KDa.
3. compounded calcium preparation according to claim 1 is characterized in that, described Glucosamine is D-aminoglucose hydrochloride or D-aminoglucose sulfate, is got through acid, alkali treatment and enzymolysis production by shrimp and crab shells.
4. compounded calcium preparation according to claim 1 is characterized in that, described chondroitin sulfate extracts from shark or ox cartilage.
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| CN2011102846938A CN102342404A (en) | 2011-09-23 | 2011-09-23 | Composite calcium preparation |
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| CN2011102846938A CN102342404A (en) | 2011-09-23 | 2011-09-23 | Composite calcium preparation |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239705A (en) * | 2013-05-10 | 2013-08-14 | 汪华东 | Composition for crocodile collagen antibacterial peptide and preparation method thereof |
| CN103750310A (en) * | 2014-01-03 | 2014-04-30 | 吉林修正修元生物科技有限公司 | Plant-sourced calcium capable of supplementing calcium and promoting calcium absorption and preparation method thereof |
| CN104116022A (en) * | 2013-04-26 | 2014-10-29 | 中国科学院理化技术研究所 | Composite health-care food for improving woman climacteric syndrome and preparation method thereof |
| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
| CN105770850A (en) * | 2016-04-25 | 2016-07-20 | 南京邦康生物技术有限公司 | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product |
| CN106036362A (en) * | 2016-05-16 | 2016-10-26 | 彭涛 | Net-reinforcing, calcium-supplementing, calcium-fixing, body-strengthening and beautifying tablets as well as preparation method thereof |
| CN107373467A (en) * | 2017-07-01 | 2017-11-24 | 浦江县泰如食品科技有限公司 | Compound based on hairtail activity extract and preparation method thereof |
| CN107668724A (en) * | 2017-11-20 | 2018-02-09 | 江苏艾兰得营养品有限公司 | A kind of compound preparation of ammonia sugar chondroitin collagen turmeric and preparation method thereof |
| CN108785651A (en) * | 2018-07-06 | 2018-11-13 | 常同喜 | A kind of preparation method for the Bone gillg ammonia sugar-tablet increasing bone density |
| JP2020054262A (en) * | 2018-10-01 | 2020-04-09 | ユーハ味覚糖株式会社 | Mucus membrane protection-related gene expression enhancer and use of the same |
| CN112716994A (en) * | 2020-12-26 | 2021-04-30 | 付军磊 | Preparation method of active calcium |
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| US20080069862A1 (en) * | 2006-09-15 | 2008-03-20 | Marni Markell Hurwitz | Joint preserving nutritional vitamin, mineral and herbal pet supplement |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104116022B (en) * | 2013-04-26 | 2016-08-10 | 中国科学院理化技术研究所 | For composite heal-care food improving climacteric syndrome and preparation method thereof |
| CN104116022A (en) * | 2013-04-26 | 2014-10-29 | 中国科学院理化技术研究所 | Composite health-care food for improving woman climacteric syndrome and preparation method thereof |
| CN103239705B (en) * | 2013-05-10 | 2015-07-15 | 汪华东 | Composition for crocodile collagen antibacterial peptide and preparation method thereof |
| CN103239705A (en) * | 2013-05-10 | 2013-08-14 | 汪华东 | Composition for crocodile collagen antibacterial peptide and preparation method thereof |
| CN103750310A (en) * | 2014-01-03 | 2014-04-30 | 吉林修正修元生物科技有限公司 | Plant-sourced calcium capable of supplementing calcium and promoting calcium absorption and preparation method thereof |
| CN103750310B (en) * | 2014-01-03 | 2015-05-20 | 吉林修正修元生物科技有限公司 | Plant-sourced calcium capable of supplementing calcium and promoting calcium absorption and preparation method thereof |
| CN104886553A (en) * | 2015-04-30 | 2015-09-09 | 威海特伦斯生物工程有限公司 | A production method of a preparation for alleviating osteoporosis and increasing bone mineral density |
| CN105770850A (en) * | 2016-04-25 | 2016-07-20 | 南京邦康生物技术有限公司 | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product |
| CN106036362A (en) * | 2016-05-16 | 2016-10-26 | 彭涛 | Net-reinforcing, calcium-supplementing, calcium-fixing, body-strengthening and beautifying tablets as well as preparation method thereof |
| CN107373467A (en) * | 2017-07-01 | 2017-11-24 | 浦江县泰如食品科技有限公司 | Compound based on hairtail activity extract and preparation method thereof |
| CN107668724A (en) * | 2017-11-20 | 2018-02-09 | 江苏艾兰得营养品有限公司 | A kind of compound preparation of ammonia sugar chondroitin collagen turmeric and preparation method thereof |
| CN108785651A (en) * | 2018-07-06 | 2018-11-13 | 常同喜 | A kind of preparation method for the Bone gillg ammonia sugar-tablet increasing bone density |
| JP2020054262A (en) * | 2018-10-01 | 2020-04-09 | ユーハ味覚糖株式会社 | Mucus membrane protection-related gene expression enhancer and use of the same |
| JP7095536B2 (en) | 2018-10-01 | 2022-07-05 | ユーハ味覚糖株式会社 | Mucosal protection-related gene expression promoter and its uses |
| CN112716994A (en) * | 2020-12-26 | 2021-04-30 | 付军磊 | Preparation method of active calcium |
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Application publication date: 20120208 |