CN102335232A - Device and method for preparing scutellaria baicalensis extract - Google Patents
Device and method for preparing scutellaria baicalensis extract Download PDFInfo
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- CN102335232A CN102335232A CN2011103136387A CN201110313638A CN102335232A CN 102335232 A CN102335232 A CN 102335232A CN 2011103136387 A CN2011103136387 A CN 2011103136387A CN 201110313638 A CN201110313638 A CN 201110313638A CN 102335232 A CN102335232 A CN 102335232A
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Abstract
The invention discloses a device and a method for preparing a scutellaria baicalensis extract. The device comprises an extraction tank which is used for water extraction operation, an acid precipitation tank which is used for acid adjusting and standing, a container for precipitation, a centrifugation device for centrifugation, and a vacuum dryer. The method comprises the following steps of: a) cleaning scutellaria baicalensis, removing non-medicinal parts, mud and other impurities, slicing, placing in the extraction tank and performing boiling water extraction, wherein baicalin is dissolved in hot water, and is extracted, and water extraction time is 2 to 2.5 hours; b) filtering liquid medicines which are subjected to water extraction in the acid precipitation tank and adjusting acid, wherein the temperature of acid adjusting is kept 80 to 85 DEG C, and time of acid adjusting is 1 to 1.5 hours, and stirring continuously; c) putting liquid medicines which are subjected to acid adjusting in a centrifugation machine and centrifuging for 2 to 3 hours to obtain filter cakes; and d) drying the filter cakes obtained through centrifugation to finally obtain green yellow baicalin powder. The scutellaria baicalensis extract prepared by the method can be absorbed by a human body easily, and has pure quality, and high baicalin content.
Description
Technical field
The present invention relates to a kind of preparation facilities and method of Radix Scutellariae extract.
Background technology
Radix Scutellariae has the effect that benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.It is weak to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
At present, Radix Scutellariae mainly still is that decoct, water logging agent etc. are taken, and does not also see the report that has its extracts active ingredients is come out.
Summary of the invention
The method for preparing that the purpose of this invention is to provide a kind of Radix Scutellariae extract.
In order to solve the problems of the technologies described above, the present invention is able to solve through following technical proposals: a kind of manufacture method of Radix Scutellariae extract is characterized in that; May further comprise the steps: a) Radix Scutellariae is cleaned dis-medicinal part, impurity such as earth are cut into slices after the cleaning; Put into extraction pot and carry out boiling water extraction; Baicalin is dissolved in hot water, and baicalin is extracted out, and it is 2～2.5 hours that water is carried the time; B) will pass through and put into the acid precipitation jar behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80～85 ℃, and the time is 1～1.5 hour, constantly stirs; C) medicinal liquid after the acid adjustment is put into centrifuge and carry out centrifugal treating, the centrifugal treating time is 2～3 hours, obtains filter cake; D) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
Preferable methods is to adopt following steps: a) Radix Scutellariae is cleaned dis-medicinal part, impurity such as earth are cut into slices after the cleaning, put into extraction pot and carry out boiling water extraction, and baicalin is dissolved in hot water, and baicalin is extracted out, and it is 2～2.5 hours that water is carried the time; B) will pass through and put into the acid precipitation jar behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80～85 ℃, and the time is 1～1.5 hour, constantly stirs; The medicinal liquid that c) will pass through after the acid adjustment was placed 20～40 minutes, and it is two-layer that medicinal liquid is divided into, and lower floor is that precipitate, upper strata are supernatant; D) remove supernatant, take out precipitate and put into container, and add purified water, obtain mixture, make the pH value of mixture reach 4～5 at precipitate; E) mixture in the steps d is put into centrifuge and carry out centrifugal treating, obtain filter cake, the centrifugal treating time is 2～3 hours; F) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
Centrifugal treating is between pH value 4～5, and content of baicalin is difficult for descending, and extraction effect is better.
Another object of the present invention provides a kind of preparation facilities of Radix Scutellariae extract.
In order to solve the problems of the technologies described above, the present invention is able to solve through following technical proposals: a kind of preparation facilities of Radix Scutellariae extract is characterized in that; Comprise: an extraction pot, this extraction pot are used for water and propose operation, an acid precipitation jar; Medicinal liquid after extraction pot water is carried gets into this acid precipitation jar to carry out acid adjustment and leaves standstill, and a container is after the acid adjustment of acid precipitation jar and leave standstill this container of putting into of postprecipitation thing; One centrifugal device; Mixture in the container is put into this centrifugal device carry out centrifugally, a vacuum desiccator, the filter cake after the centrifugal device centrifugal treating are put into vacuum desiccator and are carried out vacuum drying.
In the technique scheme, the top of said container is provided with water supply installation.
The present invention compared with prior art has following beneficial effect: make Radix Scutellariae extract through the present invention, be absorbed by the body easily, and quality is pure, content of baicalin is high.
Description of drawings
Fig. 1 is a configuration diagram of the present invention.
The specific embodiment
Embodiment describes in further detail the present invention below in conjunction with accompanying drawing.
Referring to Fig. 1, a kind of preparation facilities of Radix Scutellariae extract comprises extraction pot 1, and this extraction pot 1 is used for water and proposes operation, and said extraction pot 1 is connected with acid precipitation jar 3 through a pipeline, and said acid precipitation jar 3 is used for acid adjustment.
The discharge end of said acid precipitation jar 3 is connected with a container 5, and the top of this container 5 is provided with water supply installation 9, and this container 5 also is connected with centrifuge, and an end of said centrifuge is connected with vacuum desiccator 11.
Describe in detail in the face of the method for preparing of Radix Scutellariae extract down: embodiment one: a) Radix Scutellariae is cleaned dis-medicinal part; Impurity such as earth, back medical material are cut into slices rapidly with the quick wash material of cylinder medicine-washing machine; Put into extraction pot 1 and carry out boiling water extraction; It is 2 hours that water is carried the time, and baicalin is dissolved in hot water, thereby baicalin is extracted out; B) will pass through and put into acid precipitation jar 3 behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80 ℃, and the time is 1.5 hours, constantly stirs; C) medicinal liquid after the acid adjustment is put into centrifuge and is carried out centrifugal treating (promptly discard liquid, get deposition), and the centrifugal treating time is 2 hours; D) filter cake after the centrifugal treating is carried out drying, finally obtain finished product.
Through detection, finished product content of baicalin 64.22%, color is yellow partially.
Embodiment two: a) Radix Scutellariae is cleaned dis-medicinal part, and impurity such as earth, back medical material is with the quick wash material of cylinder medicine-washing machine; Section is put into extraction pot 1 and is carried out boiling water extraction rapidly, and baicalin is dissolved in hot water; Baicalin is extracted out, and it is 2.5 hours that water is carried the time; B) will pass through and put into acid precipitation jar 3 behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 85 ℃, and the time is 1 hour, constantly stirs; C) medicinal liquid after the acid adjustment is put into centrifuge and is carried out centrifugal treating (promptly discard liquid, get deposition), and the centrifugal treating time is 2.5 hours; D) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
Through detection, finished product content of baicalin 65.32%, color is yellow partially.
Among embodiment one and the embodiment two, carry out centrifugal treating, make baicalin be in for a long time in the concentrated acid like this because the medicinal liquid after the acid adjustment is directly put into centrifuge, its colour changed into yellow, baicalin slightly descends.
Embodiment three: a) Radix Scutellariae is cleaned dis-medicinal part, and impurity such as earth, back medical material is with the quick wash material of cylinder medicine-washing machine; Section is put into extraction pot 1 and is carried out boiling water extraction rapidly, and it is 2 hours that water is carried the time; Baicalin is dissolved in hot water, thereby baicalin is extracted out; B) will pass through and put into acid precipitation jar 3 behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80 ℃, and the time is 1.5 hours, constantly stirs; The medicinal liquid that c) will pass through after the acid adjustment was placed 20 minutes, and it is two-layer that medicinal liquid is divided into, and lower floor is that precipitate, upper strata are supernatant; D) remove supernatant, take out precipitate, and add purified water, obtain mixture, make the pH value of mixture reach 4 at precipitate; E) mixture in the steps d is put into centrifuge and carry out centrifugal treating, promptly discard medicinal liquid, getting the deposition centrifugal treating time is 2 hours; F) filter cake after the centrifugal treating is carried out drying, finally obtain finished product.
Through detection, finished product content of baicalin 76.22%, color is a yellow green.
Embodiment four: a) Radix Scutellariae is cleaned dis-medicinal part, and impurity such as earth, back medical material is with the quick wash material of cylinder medicine-washing machine; Section is put into extraction pot 1 and is carried out boiling water extraction rapidly, and baicalin is dissolved in hot water; Baicalin is extracted out, and it is 2.5 hours that water is carried the time; B) will pass through and put into acid precipitation jar 3 behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 85 ℃, and the time is 1 hour, constantly stirs; The medicinal liquid that c) will pass through after the acid adjustment was placed 30 minutes, and it is two-layer that medicinal liquid is divided into, and lower floor is that precipitate, upper strata are supernatant; D) remove supernatant, take out precipitate and put into container 5, and add purified water, obtain mixture, make the pH value of mixture reach 4.5 at precipitate; E) mixture in the steps d is put into centrifuge and carry out centrifugal treating, promptly discard medicinal liquid, getting the deposition centrifugal treating time is 2.5 hours; F) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
Through detection, finished product content of baicalin 75.87%, color is a yellow green.
Embodiment five: a) Radix Scutellariae is cleaned dis-medicinal part, and impurity such as earth, back medical material is with the quick wash material of cylinder medicine-washing machine; Section is put into extraction pot 1 and is carried out boiling water extraction rapidly, and baicalin is dissolved in hot water; Baicalin is extracted out, and it is 2.5 hours that water is carried the time; B) will pass through and put into acid precipitation jar 3 behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 85 ℃, and the time is 1 hour, constantly stirs; The medicinal liquid that c) will pass through after the acid adjustment was placed 40 minutes, and it is two-layer that medicinal liquid is divided into, and lower floor is that precipitate, upper strata are supernatant; D) remove supernatant, take out precipitate, and add purified water, obtain mixture, make the pH value of mixture reach 5 at precipitate; E) mixture in the steps d is put into centrifuge and carry out centrifugal treating, promptly discard medicinal liquid, getting the deposition centrifugal treating time is 3 hours; F) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
Through detection, finished product content of baicalin 77.04%, color is a yellow green.
Find out through top contrast; Embodiment three, embodiment four and embodiment five are superior to embodiment one and embodiment two, and tracing it to its cause is, embodiment three, embodiment four and embodiment centrifugal treating are between pH value 4～5; Content of baicalin is difficult for descending, and extraction effect is better.
Claims (4)
1. the method for preparing of a Radix Scutellariae extract is characterized in that, may further comprise the steps: a) Radix Scutellariae is cleaned dis-medicinal part; Impurity such as earth; Cut into slices after the cleaning, put into extraction pot (1) and carry out boiling water extraction, baicalin is dissolved in hot water; Baicalin is extracted out, and it is 2～2.5 hours that water is carried the time; B) will pass through and put into acid precipitation jar (3) behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80～85 ℃, and the time is 1～1.5 hour, constantly stirs; C) medicinal liquid after the acid adjustment is put into centrifuge and carry out centrifugal treating, the centrifugal treating time is 2～3 hours, obtains filter cake; D) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
2. the method for preparing of a Radix Scutellariae extract is characterized in that, may further comprise the steps: a) Radix Scutellariae is cleaned dis-medicinal part; Impurity such as earth; Cut into slices after the cleaning, put into extraction pot (1) and carry out boiling water extraction, baicalin is dissolved in hot water; Baicalin is extracted out, and it is 2～2.5 hours that water is carried the time; B) will pass through and put into acid precipitation jar (3) behind the medical filtration after water is carried and carry out acid adjustment, the acid adjustment temperature remains on 80～85 ℃, and the time is 1～1.5 hour, constantly stirs; The medicinal liquid that c) will pass through after the acid adjustment was placed 20～40 minutes, and it is two-layer that medicinal liquid is divided into, and lower floor is that precipitate, upper strata are supernatant; D) remove supernatant, take out precipitate and put into container (5), and add purified water, obtain mixture, make the pH value of mixture reach 4～5 at precipitate; E) mixture in the steps d is put into centrifuge and carry out centrifugal treating, obtain filter cake, the centrifugal treating time is 2～3 hours; F) filter cake after the centrifugal treating is carried out drying, finally obtain the baicalin of yellow green powder.
3. the preparation facilities of a Radix Scutellariae extract is characterized in that, comprising: an extraction pot (1), and this extraction pot (1) is used for water and proposes operation, an acid precipitation jar (3), this acid precipitation jar (3) of medicinal liquid entering after extraction pot (1) water is carried carries out acid adjustment and leaves standstill,
One container (5); After acid precipitation jar (3) acid adjustment and leave standstill the postprecipitation thing put into this container (5); One centrifugal device; Mixture in the container (5) is put into this centrifugal device carry out centrifugally, a vacuum desiccator (11), the filter cake after the centrifugal device centrifugal treating are put into vacuum desiccator (11) and are carried out vacuum drying.
4. the preparation facilities of Radix Scutellariae extract as claimed in claim 3 is characterized in that, the top of said container (5) is provided with water supply installation (9).
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| CN2011103136387A CN102335232A (en) | 2011-10-17 | 2011-10-17 | Device and method for preparing scutellaria baicalensis extract |
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| CN2011103136387A CN102335232A (en) | 2011-10-17 | 2011-10-17 | Device and method for preparing scutellaria baicalensis extract |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873573A (en) * | 2015-06-08 | 2015-09-02 | 山西鑫中大生物科技有限公司 | Method for being suitable for industrial production and extracting crude baicalin from scutellaria baicalensis |
| CN111533774A (en) * | 2020-05-07 | 2020-08-14 | 青岛宝和信生物科技有限公司 | Continuous automatic baicalin extracting and producing process |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454899A (en) * | 2003-05-25 | 2003-11-12 | 韩桂茹 | Process of extracting baicalin from scutellaria baicalensis |
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- 2011-10-17 CN CN2011103136387A patent/CN102335232A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454899A (en) * | 2003-05-25 | 2003-11-12 | 韩桂茹 | Process of extracting baicalin from scutellaria baicalensis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104873573A (en) * | 2015-06-08 | 2015-09-02 | 山西鑫中大生物科技有限公司 | Method for being suitable for industrial production and extracting crude baicalin from scutellaria baicalensis |
| CN111533774A (en) * | 2020-05-07 | 2020-08-14 | 青岛宝和信生物科技有限公司 | Continuous automatic baicalin extracting and producing process |
| CN111533774B (en) * | 2020-05-07 | 2024-02-06 | 青岛宝和信生物科技有限公司 | Continuous automatic extraction production process of baicalin |
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Application publication date: 20120201 |