CN102327556A - Radix scutellariae and coptis root capsules for treating throat disease and preparation method thereof - Google Patents
Radix scutellariae and coptis root capsules for treating throat disease and preparation method thereof Download PDFInfo
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- CN102327556A CN102327556A CN201110280580A CN201110280580A CN102327556A CN 102327556 A CN102327556 A CN 102327556A CN 201110280580 A CN201110280580 A CN 201110280580A CN 201110280580 A CN201110280580 A CN 201110280580A CN 102327556 A CN102327556 A CN 102327556A
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Abstract
The invention discloses radix scutellariae and coptis root capsules for treating throat disease and a preparation method thereof, and belongs to the technical field of medicaments. The preparation method of the radix scutellariae and coptis root capsules for treating throat disease comprises the following steps of: weighing coptis root, radix scutellariae extract, cape jasmine fruit, radix curcumae and rhubarb extract according to the weight parts, pulverizing and screening by using a 100-mesh sieve, then weighing and blending, directly weighing and blending calculus bovis factitious, borneol, starch and talc powder, separately spreading weighed and blended coptis root, radix scutellariae extract, cape jasmine fruit, radix curcumae, rhubarb extract, starch and talc powder on baking plates, then drying with a hot air circulating oven, then mixing the dried calculus bovis factitious, radix scutellariae extract powder, starch, talc powder and borneol fine powder in a three-dimensional mixer for 20 minutes, then adding coptis root, cape jasmine fruit, radix curcumae and rhubarb extract powder and mixing for 20 minutes. The whole preparation process lasts 7 hours at most, thus the processing time of a conventional process is greatly shortened and the production cost is lowered.
Description
Technical field
The present invention relates to the yellow larynx disease of a kind of a kind of reed mentioned in ancient books capsule and preparation method thereof, belong to field of pharmaceutical technology.
Background technology
The yellow larynx disease of a kind of reed mentioned in ancient books capsule is a kind of Chinese patent medicine; Effect with heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Laryngopharynx swelling and pain, foreign body in pharynx sense due to being used for containing in the temperature; Acute pharyngitis, chronic pharyngitis, acute laryngitis, tonsillitis, fever and cough, acute diseases such as acute upper respiratory tract infection symptom and gingival swelling and pain, aphtha of the mouth and tongue.It is to be formed by medication preparation such as Rhizoma Coptidis, artificial Calculus Bovis, Borneolum Syntheticum, Radix Scutellariae extractum, Fructus Gardeniae, Radix Curcumae, extractum rheis.Because its effect is remarkable, moderate cost, and approved by extensive patients.Have how tame pharmaceutical manufacturer to produce this medicine in the market, but there is long processing time in the yellow larynx disease of existing a kind of reed mentioned in ancient books capsule, the problem that cost is high in the factory mass production process.Wherein existing preparation technology's weighing allotment needs 2 hours; Granulation needs 4-6 hour, and this kind is not granulated usually, and the content uniformity project is difficult to control when filling, so producer granulates usually; Need carry out drying after the granulation, drying need 8-9 hour, total mixed needs 2 hours.The whole process of preparation needs 16 hours at least, and efficient is low, has increased production cost.
Summary of the invention
The present invention provides the yellow larynx disease of a kind of a kind of reed mentioned in ancient books capsule and preparation method thereof in order to solve the problems of the technologies described above, purpose is in order to shorten process time, to reduce production costs.
In order to solve the problems of the technologies described above, the present invention realizes through following technical proposals.
The yellow larynx disease of a kind of a kind of reed mentioned in ancient books capsule, it is to count ratio following raw materials in parts by weight to be prepared from: 238 parts of Rhizoma Coptidis powder, 23.8 parts of artificial Calculus Boviss, 23.8 parts of Borneolum Syntheticums, 17.5 parts of Radix Scutellariae extractums, 85.8 parts of Fructus Gardeniaes, Radix Curcumae, extractum rhei, 5.54 parts of starch, 5.54 parts of Pulvis Talci.
The capsular method for preparing of the yellow larynx disease of a kind of said a kind of reed mentioned in ancient books is got Rhizoma Coptidis, Radix Scutellariae extractum and the Fructus Gardeniae, Radix Curcumae, the extractum rhei that meet said parts by weight and is advanced crushing screening with 100 eye mesh screens, carries out the weighing allotment then, and artificial Calculus Bovis, Borneolum Syntheticum, starch, Pulvis Talci directly carry out the weighing allotment; With the Rhizoma Coptidis after the weighing allotment, Radix Scutellariae extractum, Fructus Gardeniae, Radix Curcumae, extractum rhei, starch, Pulvis Talci; Be layered on respectively on the drip pan, carry out drying with heated-air circulation oven, every dish material thickness must not surpass 2cm; Baking temperature is controlled at 60～70 ℃, and drying time is about 3～4 hours, when detecting moisture < 8% the time; The dry end places three-dimensional mixer with dried artificial Calculus Bovis, Radix Scutellariae extractum powder, starch, Pulvis Talci, Borneolum Syntheticum fine powder, mixes after 20 minutes; Add Rhizoma Coptidis and Fructus Gardeniae, Radix Curcumae, extractum rhei powder again, mixed 20 minutes, make the mixing of materials uniformity; The material that mixes is packed in the clean container, incapsulate then, obtain the yellow larynx disease of a kind of reed mentioned in ancient books capsule.
Owing to adopt technique scheme, make the present invention have following advantage and effect:
The weighing allotment time of the present invention is 2 hours, need not to granulate, and be 3～4 hours drying time; Always do time is 40 minutes; Whole process of preparation at most need be less than 7 hours, and because of granularity and moisture content to raw material have carried out effective control, it is mobile to have improved product; Shorten the process time of common process when making the content uniformity project of product up to specification greatly, reduced production cost.The yellow larynx disease of a kind of reed mentioned in ancient books capsule that makes by the inventive method all meets National Drug Administration's standard, has reduced production cost simultaneously.
The specific embodiment
Below in conjunction with embodiment the present invention is explained further details, but protection scope of the present invention is not limit by embodiment.
Experimental technique among the following embodiment is conventional method if no special instructions.
Percentage composition among the following embodiment is the quality percentage composition if no special instructions.
Embodiment 1:
The yellow larynx disease of a kind of a kind of reed mentioned in ancient books capsule, it is to count ratio following raw materials in parts by weight to be prepared from: 238 parts of Rhizoma Coptidis powder, 23.8 parts of artificial Calculus Boviss, 23.8 parts of Borneolum Syntheticums, 17.5 parts of Radix Scutellariae extractums, 85.8 parts of Fructus Gardeniaes, Radix Curcumae, extractum rhei, 5.54 parts of starch, 5.54 parts of Pulvis Talci.
The capsular method for preparing of the yellow larynx disease of a kind of said a kind of reed mentioned in ancient books is got Rhizoma Coptidis, Radix Scutellariae extractum and the Fructus Gardeniae, Radix Curcumae, the extractum rhei that meet said parts by weight and is advanced crushing screening with 100 eye mesh screens, carries out the weighing allotment then, and artificial Calculus Bovis, Borneolum Syntheticum, starch, Pulvis Talci directly carry out the weighing allotment; With the Rhizoma Coptidis after the weighing allotment, Radix Scutellariae extractum, Fructus Gardeniae, Radix Curcumae, extractum rhei, starch, Pulvis Talci; Be layered on respectively on the drip pan, carry out drying with heated-air circulation oven, every dish material thickness must not surpass 2cm; Baking temperature is controlled at 60～70 ℃, and drying time is about 3～4 hours, when detecting moisture < 8% the time; The dry end places three-dimensional mixer with dried artificial Calculus Bovis, Radix Scutellariae extractum powder, starch, Pulvis Talci, Borneolum Syntheticum fine powder, mixes after 20 minutes; Add Rhizoma Coptidis and Fructus Gardeniae, Radix Curcumae, extractum rhei powder again, mixed 20 minutes, make the mixing of materials uniformity; The material that mixes is packed in the clean container, incapsulate then, obtain the yellow larynx disease of a kind of reed mentioned in ancient books capsule.
Further specify effect of the present invention below in conjunction with experimental data.
The product of taking three batches in the sample of the embodiment of the invention 1 gained carries out the content uniformity project and detects; Detection method is following: get 20 of test samples; After weight decided in accurate respectively title, inclining content (must not lose softgel shell), and hard capsule is wiped away only with little brush or other suitable apparatus; Softgel shell weight decided in accurate respectively again title, obtains tolerant loading amount of every intragranular and average loading amount.Every loading amount is compared with average loading amount, and what exceed content uniformity limit (limit is ± 7.5%) must not be more than 2, and 1 times of 1 overrun must not be arranged.
Standard loading amount: 0.4g (content uniformity scope: 0.37～0.43g)
| Sample number | First batch of loading amount (g) | Second batch of loading amount (g) | The 3rd batch of loading amount (g) |
| 1 | 0.406 | 0.401 | 0.398 |
| 2 | 0.412 | 0.397 | 0.397 |
| 3 | 0.393 | 0.411 | 0.389 |
| 4 | 0.407 | 0.398 | 0.412 |
| 5 | 0.424 | 0.423 | 0.417 |
| 6 | 0.408 | 0.414 | 0.398 |
| 7 | 0.413 | 0.417 | 0.379 |
| 8 | 0.422 | 0.396 | 0.387 |
| 9 | 0.416 | 0.387 | 0.396 |
| 10 | 0.413 | 0.421 | 0.421 |
| 11 | 0.397 | 0.413 | 0.416 |
| 12 | 0.389 | 0.399 | 0.417 |
| 13 | 0.388 | 0.397 | 0.403 |
| 14 | 0.416 | 0.416 | 0.406 |
| 15 | 0.394 | 0.411 | 0.387 |
| 16 | 0.421 | 0.421 | 0.407 |
| 17 | 0.413 | 0.413 | 0.412 |
| 18 | 0.421 | 0.386 | 0.409 |
| 19 | 0.417 | 0.397 | 0.394 |
| 20 | 0.421 | 0.415 | 0.399 |
| Average loading amount | 0.410 | 0.407 | 0.402 |
Claims (2)
1. the yellow larynx disease of an a kind of reed mentioned in ancient books capsule is characterized in that it is to count ratio following raw materials in parts by weight to be prepared from: 238 parts of Rhizoma Coptidis powder, 23.8 parts of artificial Calculus Boviss; 23.8 parts of Borneolum Syntheticums, 17.5 parts of Radix Scutellariae extractums, 85.8 parts of Fructus Gardeniaes, Radix Curcumae, extractum rhei; 5.54 parts of starch, 5.54 parts of Pulvis Talci.
2. the capsular method for preparing of the yellow larynx disease of the said a kind of reed mentioned in ancient books of claim 1 is characterized in that getting Rhizoma Coptidis, Radix Scutellariae extractum and the Fructus Gardeniae, Radix Curcumae, the extractum rhei that meet said parts by weight and advances crushing screening with 100 eye mesh screens, carries out the weighing allotment then; Artificial Calculus Bovis, Borneolum Syntheticum, starch, Pulvis Talci directly carry out the weighing allotment, with the Rhizoma Coptidis after the weighing allotment, Radix Scutellariae extractum; Fructus Gardeniae, Radix Curcumae, extractum rhei, starch, Pulvis Talci are layered on respectively on the drip pan, carry out drying with heated-air circulation oven; Every dish material thickness must not surpass 2cm, and baking temperature is controlled at 60～70 ℃, and drying time is about 3～4 hours; < 8% the time, the dry end places three-dimensional mixer with dried artificial Calculus Bovis, Radix Scutellariae extractum powder, starch, Pulvis Talci, Borneolum Syntheticum fine powder when detecting moisture; Mix after 20 minutes, add Rhizoma Coptidis and Fructus Gardeniae, Radix Curcumae, extractum rhei powder again, mixed 20 minutes; Make the mixing of materials uniformity; The material that mixes is packed in the clean container, incapsulate then, obtain the yellow larynx disease of a kind of reed mentioned in ancient books capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110280580A CN102327556A (en) | 2011-09-21 | 2011-09-21 | Radix scutellariae and coptis root capsules for treating throat disease and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110280580A CN102327556A (en) | 2011-09-21 | 2011-09-21 | Radix scutellariae and coptis root capsules for treating throat disease and preparation method thereof |
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| CN102327556A true CN102327556A (en) | 2012-01-25 |
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| CN201110280580A Pending CN102327556A (en) | 2011-09-21 | 2011-09-21 | Radix scutellariae and coptis root capsules for treating throat disease and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311557A (en) * | 2015-02-16 | 2016-02-10 | 辽宁格林生物药业集团股份有限公司 | Method for preparing Qinhuang capsules for laryngeal symptoms and application of Qinhuang capsules |
-
2011
- 2011-09-21 CN CN201110280580A patent/CN102327556A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 刘亚梅: "慢性咽炎的辨证分型治疗及用药体会", 《新中医》 * |
| 国家药品监督管理局编: "《国家药品中药标准(耳鼻喉科 眼科 皮肤科分册)》", 31 December 2002 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311557A (en) * | 2015-02-16 | 2016-02-10 | 辽宁格林生物药业集团股份有限公司 | Method for preparing Qinhuang capsules for laryngeal symptoms and application of Qinhuang capsules |
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Application publication date: 20120125 |