CN102327539B - Externally-used medicine for curing stomachache - Google Patents
Externally-used medicine for curing stomachache Download PDFInfo
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- CN102327539B CN102327539B CN 201110291113 CN201110291113A CN102327539B CN 102327539 B CN102327539 B CN 102327539B CN 201110291113 CN201110291113 CN 201110291113 CN 201110291113 A CN201110291113 A CN 201110291113A CN 102327539 B CN102327539 B CN 102327539B
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Abstract
The invention belongs to the field for curing the stomachache with the traditional Chinese medicine, and in particular relates to an externally-used patch which is directly absorbed by the skin so as to avoid the first-pass effect of active ingredients of orally-taken medicine on the stomach and the liver. Pepper, grass mass in goat stomach, pugionium cornutum, hot pepper, herba belladonnae and galangal are selected according to weight ratio and the grass mass in goat stomach and the hot pepper are pulverized and extracted to obtain alhocol-leached extract, the galangal, the pepper and the pugionium cornutum are supercritically extracted with carbon dioxide (CO2) to obtain extract; and the ingredients are mixed with each other, and different matrixes are added into the mixture to be made into plaster or cataplasm. The produced plaster or cataplasm is proved by the application results of Taiwan Taotang Chinese medicine Chain Clinical Research Center on acute gastritis and chronic gastritis with the main symptom of abdominal pain. At the same time, the externally-used medicine for curing the stomachache has the advantages of convenience in use and high quality with low price.
Description
[technical field]
The invention belongs to the field for the treatment of by Chinese herbs stomachache, especially use the Therapeutic Method of external use plaster, the approach that directly absorbs by skin makes medicine directly arrive the affected part.
[background technology]
Stomachache is a common clinical symptoms from Chinese medicine, refers generally to because taste are impaired, and qi and blood disorder causes gastral cavilty section pain, therefore claim again gastric abscess.The common cause that stomachache occurs has that cold-evil visitor stomach, diet injure one's stomach, hyperactive liver-QI attacking the stomach and weakness of the spleen and stomach etc.Present stage is main to the treatment of stomachache mainly with endo-medicine.From the research of modern medicines dynamic metabolism as can be known, all there is first pass effect (First Pass Effect) in all oral drugs, i.e. the absorption of all oral drugs must see through gastrointestinal wall, then access door Venous system.First-pass effect by extensively metabolism, elimination, occurs in effective ingredient in gastrointestinal wall or liver.Because the existence of first pass effect so that drug metabolism strengthens, absorbs and reduces, the treatment effect descends.
[summary of the invention]
Technical problem to be solved by this invention is to use the modern Chinese medicine technology, with specific Chinese prescription and with the form of therapy of external patch and the symptom of alleviation Stomach in Patients pain.
For overcoming the above problems, the present invention takes following technical scheme:
Get by weight Fructus Piperis 80～120g, Calcucus Stomachi Bovis 60～90g, Herba Pugionii Cornuti 100～130g, Fructus Capsici 50～80g, Herba Belladonnae 50～80g, Rhizoma Alpiniae Officinarum 80～120g.Adopt following preparation technology:
Get Calcucus Stomachi Bovis, Fructus Capsici powder is broken into coarse granule, adds 70% ethanol, is 4 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight for the first time, second and third time is 3 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight, heating and refluxing extraction three times each 2 hours, obtains pure extractum;
Get Rhizoma Alpiniae Officinarum, Fructus Piperis with Herba Pugionii Cornuti CO
2Supercritical extraction is extracted thing;
Get Banewort and be broken into coarse powder, make solvent with 85% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, collect the approximately 3000ml of liquid that just filters, at 60 ℃ of decompression recycling ethanols, obtain pure extractum;
Above-mentioned each component is merged, add various dosage form adjuvant, make external use plaster.
This external use plaster both can be rubber-emplastrum, also can be cataplasma.
[specific embodiment]
Embodiment 1
Get by weight Fructus Piperis 90～110g, Calcucus Stomachi Bovis 60～80g, Herba Pugionii Cornuti 110～125g, Fructus Capsici 60～80g, Herba Belladonnae 60～80g, Rhizoma Alpiniae Officinarum 90～120g.Adopt following preparation technology:
Get Calcucus Stomachi Bovis, Fructus Capsici powder is broken into coarse granule, adds 70% ethanol, is 4 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight for the first time, second and third time is 3 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight, heating and refluxing extraction three times each 2 hours, obtains pure extractum;
Get Rhizoma Alpiniae Officinarum, Fructus Piperis with Herba Pugionii Cornuti CO
2Supercritical extraction is extracted thing;
Get Banewort and be broken into coarse powder, make solvent with 85% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, collect the approximately 3000ml of liquid that just filters, at 60 ℃ of decompression recycling ethanols, obtain pure extractum;
Above-mentioned each component is merged, add the substrate that rubber 680g, zinc oxide 760g, Colophonium material 640g, lanoline 80g make, make coating, be coated with and cut into slices, make rubber-emplastrum.
The rubber-emplastrum that makes according to the present invention, the result that uses through Gaotang, Taiwan traditional Chinese medical science interlocking gear Clinical Research Center confirms clinically: the treatment works well as primary symptom with abdominal pain in to acute and chronic gastritis.Statistics sees the following form:
| Acute or chronic gastritis | |
| The example number | 130 |
| Produce effects | 43 |
| Effectively | 76 |
| Invalid | 11 |
| Effective percentage | 91.5％ |
The clinical discrimination standard:
Produce effects: the stomachache symptom is all alleviated;
Effectively: stomachache symptom part is obviously alleviated;
Invalid: the stomachache symptom is without any alleviation.
Note: 1. clinical observation time: observed 12 hours after using plaster.
2. case Sex distribution: the male accounts for 42%, and the women accounts for 58%.
3. case age distribution: below 15 years old: 8%, 15-60 year: more than 68%, 60 years old: 24%.
Embodiment 2
Get by weight Fructus Piperis 100～105g, Calcucus Stomachi Bovis 70～75g, Herba Pugionii Cornuti 115～120g, Fructus Capsici 70～75g, Herba Belladonnae 70～75g, Rhizoma Alpiniae Officinarum 100～110g.Adopt following preparation technology:
Get Calcucus Stomachi Bovis, Fructus Capsici powder is broken into coarse granule, adds 70% ethanol, is 4 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight for the first time, second and third time is 3 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight, heating and refluxing extraction three times each 2 hours, obtains pure extractum;
Get Rhizoma Alpiniae Officinarum, Fructus Piperis with Herba Pugionii Cornuti CO
2Supercritical extraction is extracted thing;
Get Banewort and be broken into coarse powder, make solvent with 85% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, collect the approximately 3000ml of liquid that just filters, at 60 ℃ of decompression recycling ethanols, obtain pure extractum;
Above-mentioned each component is merged, add the substrate such as sodium polyacrylate, gelatin, make cataplasma.
The cataplasma that makes according to the present invention, the result that uses through Gaotang, Taiwan traditional Chinese medical science interlocking gear Clinical Research Center confirms clinically: the treatment works well as primary symptom with abdominal pain in to stomach neurosis.Statistics sees the following form:
| Stomach neurosis | |
| The example number | 80 |
| Produce effects | 28 |
| Effectively | 43 |
| Invalid | 9 |
| Effective percentage | 88.8％ |
The clinical discrimination standard:
Produce effects: the stomachache symptom is all alleviated;
Effectively: stomachache symptom part is obviously alleviated;
Invalid: the stomachache symptom is without any alleviation.
Note: 1. clinical observation time: observed 12 hours after using plaster.
2. case Sex distribution: the male accounts for 45%, and the women accounts for 55%.
3. case age distribution: below 15 years old: 6%, 15-60 year: more than 66%, 60 years old: 28%.
Claims (3)
1. external used medicine for the treatment of stomachache is characterized by:
This medicine comprises 80～120 parts in Fructus Piperis by weight, 60～90 parts of Calcucus Stomachi Bovis, 100～130 parts of Herba Pugionii Cornutis, 50～80 parts in Fructus Capsici, 50～80 parts of Herba Belladonnaes, 80～120 parts of Rhizoma Alpiniae Officinarum;
Adopt following preparation technology to make:
Get Calcucus Stomachi Bovis, Fructus Capsici powder is broken into coarse granule, adds 70% ethanol, is 4 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight for the first time, second and third time is 3 times of amounts of Calcucus Stomachi Bovis and Fructus Capsici weight, heating and refluxing extraction three times each 2 hours, obtains pure extractum;
Get Fructus Piperis, Herba Pugionii Cornuti with Rhizoma Alpiniae Officinarum CO
2Supercritical extraction is extracted thing;
Get Banewort and be broken into coarse powder, make solvent with 85% ethanol, flood after 48 hours, with the speed of per minute 1～3ml percolation slowly, collect the approximately 3000ml of liquid that just filters, at 60 ℃ of decompression recycling ethanols, obtain pure extractum;
Above-mentioned each component is merged, add various dosage form adjuvant, make external use plaster.
2. a kind of external used medicine for the treatment of stomachache as claimed in claim 1, it is characterized by the dosage form adjuvant is rubber, zinc oxide, Colophonium material and lanoline, it is made coating as substrate after, be coated with and cut into slices, make rubber-emplastrum.
3. a kind of external used medicine for the treatment of stomachache as claimed in claim 1 is characterized by the dosage form adjuvant and adopts sodium polyacrylate and gelatin, makes cataplasma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110291113 CN102327539B (en) | 2011-09-30 | 2011-09-30 | Externally-used medicine for curing stomachache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110291113 CN102327539B (en) | 2011-09-30 | 2011-09-30 | Externally-used medicine for curing stomachache |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102327539A CN102327539A (en) | 2012-01-25 |
| CN102327539B true CN102327539B (en) | 2013-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110291113 Active CN102327539B (en) | 2011-09-30 | 2011-09-30 | Externally-used medicine for curing stomachache |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912558A (en) * | 2010-08-09 | 2010-12-15 | 刘剑虹 | Medicine bag for protecting spleen and stomach |
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2011
- 2011-09-30 CN CN 201110291113 patent/CN102327539B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912558A (en) * | 2010-08-09 | 2010-12-15 | 刘剑虹 | Medicine bag for protecting spleen and stomach |
Non-Patent Citations (2)
| Title |
|---|
| 唐龙.谈温法治胃痛.《河北中医》.1998,第20卷(第02期), |
| 谈温法治胃痛;唐龙;《河北中医》;19980315;第20卷(第02期);87-88 * |
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| Publication number | Publication date |
|---|---|
| CN102327539A (en) | 2012-01-25 |
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