CN102326544A - Oncomelania killing medicine of niclosamide ethanolamine particle preparation and preparation method thereof - Google Patents
Oncomelania killing medicine of niclosamide ethanolamine particle preparation and preparation method thereof Download PDFInfo
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- CN102326544A CN102326544A CN2011102624078A CN201110262407A CN102326544A CN 102326544 A CN102326544 A CN 102326544A CN 2011102624078 A CN2011102624078 A CN 2011102624078A CN 201110262407 A CN201110262407 A CN 201110262407A CN 102326544 A CN102326544 A CN 102326544A
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- ethanolamine salt
- niclosamide
- niclosamide ethanolamine
- snail
- killing medicine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses oncomelania killing medicine of a niclosamide ethanolamine particle preparation and a preparation method thereof. The particle preparation consists of the following ingredients in percentage by mass: 1 percent to 20 percent of niclosamide ethanolamine, 0.1 percent to 2.0 percent of wetting agents, 0.1 percent to 3.0 percent of dispersing agents, 0.01 percent to 0.2 percent of binding agents and the balance carriers. The oncomelania killing effect of the niclosamide ethanolamine is enhanced, the use is convenient, the pollution is reduced, and the particle preparation is favorable for laying the foundation for further controlling the schistosomiasis during the oncomelania killing in dry and waterless marshland.
Description
Technical field
The present invention relates to a kind of snail-killing medicine niclosamide ethanolamine salt granule and preparation method thereof, specifically belong to snail-killing medicine preparation technique field.
Background technology
Niclosamide be the unique recommendation of the World Health Organization at the on-the-spot snail killing agent that uses of China, be made into usually that 50% niclosamide ethanolamine salt wetting powder, 26% 4 gathers the niclosamide suspending agent, 70% niclosamide wetting powder, 25% niclosamide missible oil use.But these several kinds of preparations all need be converted water and use when using; In rivers and lakes Zhou Tan has the environment of oncomelania growth and comparatively dry lack of water, uses and be restricted, directly spray, cause dust to drift about easily though it can process pulvis; Contaminated environment, and the user of service become drug damages easily.
Summary of the invention
The purpose of this invention is to provide a kind of niclosamide ethanolamine salt granule; There is the environment of oncomelania growth and comparatively dry lack of water to be used to kill oncomelania to be suitable for rivers and lakes Zhou Tan; To solve the current problem of killing oncomelania medication difficulty; Also can use, solve the culture zone and lack the situation that molluscacide can be used, help controlling the popular of schistosomiasis on the bank of culture zone.
Another object of the present invention provides a kind of preparation method of above-mentioned niclosamide ethanolamine salt granule.The present invention adopts comminution by gas stream; Mixing such as niclosamide ethanolamine salt, wetting agent, dispersant agent are processed earlier be prepared into niclosamide ethanolamine salt wetting powder; Be mixed and made into niclosamide ethanolamine salt granule with carrier with binding agent again, use with convenient, and have slow releasing function concurrently; Strengthen the molluscicidal effect of niclosamide ethanolamine salt, lay the foundation for further controlling schistosomiasis.
The object of the invention can reach through following measure:
A kind of snail-killing medicine niclosamide ethanolamine salt granule, it is made up of following mass content component: niclosamide ethanolamine salt 1%-20%, wetting agent 0.1%-2.0%, dispersant 0.1-3.0%, binding agent 0.01%-0.2%, all the other are carrier.
Wherein, wetting agent is one or more among lauryl sodium sulfate, neopelex, alkyl amide cow-bezoar hydrochlorate, APES formaldehyde condensation products sulphate, Geropon L-WET/P (the inferior auxiliary agent in sieve ground) or the MorwetEFW (alkylnaphthalene sulfonate and anion wetting agent mixture); Dispersant is alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether sulfonate, lignosulfonates, polyvinylpyrrolidone, Chinese honey locust, tea is withered or polycarboxylate in one or more; Binding agent is one or more in polyvinyl acetate, polyvinyl alcohol, polyacrylic acid, sodium carboxymethylcellulose, dextrin, gelatin or the paraffin; Carrier is one or more in quartz sand, marble, gangue or the calcium carbonate.
Experiment is found; Adopt withered associating of wetting agent neopelex and dispersant tea to use prepared granule; It not only has characteristics easy to use; And the two and niclosamide ethanolamine salt synergy more can further promote the insect killing effect to oncomelania, and this possibly be because some active component and other the component coefficient result of tea in withered.Wherein the content of neopelex is preferably 0.2%～0.5%, and the withered content of tea is preferably 1%～2%.The content of niclosamide ethanolamine salt is preferably 5%～20%.
The preparation method of above-mentioned snail-killing medicine niclosamide ethanolamine salt granule is: prepares burden by the mass content prescription, and niclosamide ethanolamine salt 1%-20%, wetting agent 0.1%-2.0%, dispersant 0.1-3.0%, binding agent 0.01%-0.2%, all the other are carrier.Earlier with niclosamide ethanolamine salt, wetting agent, dispersant evenly after, adopt comminution by gas stream (cracker operating pressure 0.6Mpa-1.0Mpa) to pulverize, mixes with carrier and adhesive solution again, dry and process niclosamide ethanolamine salt granule.
Binding agent generally is mixed with the aqueous solution earlier, mixes use with other raw materials again.Wherein the mass concentration of adhesive solution is 0.5～5%, is preferably 0.5～2%, most preferably adopts 1%.
This granule can adopt and shed method (manual work or machine are shed) use in the oncomelania breeding place in schistosomiasis endemic district, avoids the use of the harm to environment and human body that pulvis brings, and can guarantee certain lasting period.Its every square metre is sprayed niclosamide ethanolamine salt valid density 1.5-2.5g (some prescriptions more can use the concentration of 0.5-2.5g), is used to have the spiral shell area spiral shell that goes out.
Beneficial effect of the present invention: adopt comminution by gas stream that slightly solubility niclosamide ethanolamine salt is mixed the back with wetting agent, dispersant agent and pulverize, mix, dry with adhesive solution with carrier again, process a kind of snail-killing medicine niclosamide ethanolamine salt granule.Available manual work of this agent or machine are shed, and be easy to use, reduces and pollute, and reduced drug cost, increased oncomelania effect extremely, for prevention and cure of snail fever work is laid a good foundation.
Embodiment
Embodiment 1: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 1% niclosamide ethanolamine salt, 0.1% lauryl sodium sulfate, 0.5% APES formaldehyde condensation products sulphate after the mixing, is pulverized through airslide disintegrating mill, obtains powder; Mix with 98.3% quartz sand and 0.05% (in polyvinyl alcohol content) polyvinyl alcohol water solution (mass concentration is 1%, down together), oven dry gets niclosamide ethanolamine salt granule again.
Embodiment 2: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 5% niclosamide ethanolamine salt, 0.2% lauryl sodium sulfate, 1% alkylphenol-polyethenoxy base ether sulfonate after the mixing, is pulverized through airslide disintegrating mill, obtains powder; Mix with 93.7% quartz sand and 0.1% (in polyvinyl alcohol content) polyvinyl alcohol water solution, oven dry gets niclosamide ethanolamine salt granule again.
Embodiment 3: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 10% niclosamide ethanolamine salt, 0.5%Geropon L-WET/P, 1.5% APES formaldehyde condensation products sulphate after the mixing, is pulverized through airslide disintegrating mill, obtains powder; Mix with 87.8% quartz sand and 0.1% (in polyvinyl alcohol content) polyvinyl alcohol water solution, oven dry gets niclosamide ethanolamine salt granule again.
Embodiment 4: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 10% niclosamide ethanolamine salt, 0.5%MorwetEFW, 1.5% APES formaldehyde condensation products sulphate after the mixing, is pulverized through airslide disintegrating mill, obtains powder; Mix with 87.8% gangue and 0.1% (in polyvinyl alcohol content) polyvinyl alcohol water solution, oven dry gets niclosamide ethanolamine salt granule again.
Embodiment 5: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 20% niclosamide ethanolamine salt, 0.5% lauryl sodium sulfate, 2% polyvinylpyrrolidone after the mixing, is pulverized through airslide disintegrating mill, obtains powder; Even with 76.4% quartz sand and 0.1% (in polyacrylic acid content) polyacrylic acid aqueous solution again, oven dry gets niclosamide ethanolamine salt granule.
Embodiment 6: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 20% niclosamide ethanolamine salt, 0.5% lauryl sodium sulfate, 3% lignosulfonates after the mixing, are pulverized through airslide disintegrating mill, obtain powder; Even with 76.4% gangue and 0.1% (in polyacrylic acid content) polyacrylic acid aqueous solution again, oven dry gets niclosamide ethanolamine salt granule.
Embodiment 7: the preparation of niclosamide ethanolamine salt granule
By percentage to the quality, 5% niclosamide ethanolamine salt, 0.2% neopelex, 1% tea is withered, after the mixing, pulverizes through airslide disintegrating mill, obtains powder; Mix with 93.7% quartz sand and 0.1% (in polyvinyl alcohol content) polyvinyl alcohol water solution again, dry niclosamide ethanolamine salt granule.
Embodiment 8: the laboratory is sprayed and is killed the oncomelania effect
Pollution-free earth is got in 25 ℃ of laboratories, dries and breaks into pieces, gets fine earth with 20 mesh sieves sieve.Take by weighing fine earth 500g pour into enamel tray (20 * 25cm), process the thick mud pan of 1～2cm, put into 100 on oncomelania, get embodiment 5 products by effective ingredient concentration be 0.5,1.0,2.0g/m
2Evenly be sprinkled into, 125ml dechlorination running water is evenly sprayed in the back, contrasts with 4% niclosamide ethanolamine salt powder simultaneously, and consumption is effective ingredient concentration 1.0g/m
2, establish the dechlorination running water and make blank, take out 1 experiment mud pan behind 1d, 3d and the 7d respectively, pick all oncomelanias in the dish, flushing with clean water after 48h recovers to raise, is identified oncomelania death toll and survival number with hammering method.Table 1 data show that niclosamide ethanolamine salt granule has molluscicidal effect and lasting period preferably preferably; Same consumption effect when observing in the 7th day slightly is better than pulvis; We recommend consumption is every square metre of 1-2 gram active ingredient, can obtain the better prevention effect and can guarantee certain lasting period.
Molluscicidal effect is sprayed in table 1 laboratory
Embodiment 9: the on-the-spot sprinkling killed the oncomelania effect
Select Nanjing, Jiangsu Province Jiangning District Jiang Tan to carry out the scene spiral shell that goes out, select the Jiangning District snail river beach,, choose oncomelania density＞10/frame (0.1m through the baseline investigation
2) the oncomelania breeding place, be divided into 5 sub-districts, the about 100m in each sub-district
2, removing is higher than the weeds of 5cm and shifts out the test region in the sub-district.Wherein 3 sub-districts are experimental group, get embodiment 2 products according to effective ingredient concentration 0.5,1.0,2.0g/m
2Evenly shed medicine, 1 sub-district is medicine control group (4% niclosamide ethanolamine salt powder, effective ingredient concentration 1.0g/m
2), according to every square metre 1 kg of water watering, 1 sub-district is blank group (clear water) after the dispenser.Execute back 1,3 and 7d approximately,, extract 10 frames in each test region and check plot respectively with checkerboard type methods of sampling investigation oncomelania; Catch whole oncomelanias in the frame; With the frame is that unit wraps with paper bag, record number, catches spiral shell number etc., returns indoor flushing with clean water; After 48h recovers to raise, identify oncomelania death toll and survival number with hammering method.The result shows that niclosamide ethanolamine salt granule has molluscicidal effect and lasting period preferably, is an environmental protection formulation, convenient use (table 2).
The on-the-spot sprinkling of table 2 killed the spiral shell result of the test
Above result shows the effective dose calculating by the niclosamide ethanolamine salt, and niclosamide ethanolamine salt granule is using 1g/m
2The time, can reach satisfied molluscicidal effect and long lasting period, use granule can reduce environmental pollution simultaneously, reduce harm to human body, can guarantee efficiently to go out spiral shell according to actual spiral shell a situation arises increase and decrease consumption, control schistosomiasis popular.
Embodiment 10: the on-the-spot sprinkling killed the oncomelania effect
Adopt the method for embodiment 9 to get embodiment 2 and embodiment 7 products respectively according to effective ingredient concentration 0.5g/m
2Evenly shed medicine.Experimental result is seen table 3.
The on-the-spot sprinkling of table 3 killed the spiral shell result of the test
Above result shows that neopelex and tea are withered unites when using when adopting, and prepared granule compares oncomelania with general granule and has better insect killing effect.
Claims (9)
1. snail-killing medicine niclosamide ethanolamine salt granule, it is made up of following mass content component: niclosamide ethanolamine salt 1%～20%, wetting agent 0.1%～2.0%, dispersant 0.1%～3.0%, binding agent 0.01%～0.2%, all the other are carrier.
2. snail-killing medicine niclosamide ethanolamine salt granule according to claim 1 is characterized in that: said wetting agent is one or more among lauryl sodium sulfate, neopelex, alkyl amide cow-bezoar hydrochlorate, APES formaldehyde condensation products sulphate, Geropon L-WET/P or the MorwetEFW.
3. the snail-killing medicine niclosamide ethanolamine salt granule of stating according to claim 2, it is characterized in that: said wetting agent is a neopelex, its content is 0.2%～0.5%.
4. snail-killing medicine niclosamide ethanolamine salt granule according to claim 1 is characterized in that: said dispersant is alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether sulfonate, lignosulfonates, polyvinylpyrrolidone, Chinese honey locust, tea is withered or polycarboxylate in one or more.
5. snail-killing medicine niclosamide ethanolamine salt granule according to claim 4, it is characterized in that: said dispersant is that tea is withered, its content is 1%～2%.
6. snail-killing medicine niclosamide ethanolamine salt granule according to claim 1, it is characterized in that: said binding agent is one or more in polyvinyl acetate, polyvinyl alcohol, polyacrylic acid, sodium carboxymethylcellulose, dextrin, gelatin or the paraffin.
7. snail-killing medicine niclosamide ethanolamine salt granule according to claim 1, it is characterized in that: said carrier is one or more in quartz sand, marble, gangue or the calcium carbonate.
8. the preparation method of the described snail-killing medicine niclosamide of claim 1 ethanolamine salt granule; It is characterized in that: after niclosamide ethanolamine salt, wetting agent and dispersant; Carry out comminution by gas stream, add carrier again and adhesive solution mixes, be drying to obtain.
9. the application of the described snail-killing medicine niclosamide of claim 1 ethanolamine salt granule aspect go out spiral shell or prevention and cure of schistosomiasis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2011102624078A CN102326544A (en) | 2011-06-29 | 2011-09-06 | Oncomelania killing medicine of niclosamide ethanolamine particle preparation and preparation method thereof |
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| CN201110178912.4 | 2011-06-29 | ||
| CN201110178912 | 2011-06-29 | ||
| CN2011102624078A CN102326544A (en) | 2011-06-29 | 2011-09-06 | Oncomelania killing medicine of niclosamide ethanolamine particle preparation and preparation method thereof |
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| CN102326544A true CN102326544A (en) | 2012-01-25 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734131A (en) * | 2013-12-12 | 2014-04-23 | 江苏艾津农化有限责任公司 | Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof |
| CN103766332A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Novel environment-friendly oncomelania killing granule capable of being sprayed and preparation method thereof |
| CN104186542A (en) * | 2014-07-29 | 2014-12-10 | 华南农业大学 | Environment-friendly pomacea canaliculata prevention and control agent and applications thereof |
| CN114208825A (en) * | 2021-12-21 | 2022-03-22 | 恒诚制药集团淮南有限公司 | Preparation process of niclosamide ethanolamine salt granules |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106621A (en) * | 1994-07-15 | 1995-08-16 | 四川省寄生虫病防治研究所 | Slow-released molluscacide |
| CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
| CN101323547A (en) * | 2008-07-05 | 2008-12-17 | 惠州市中迅化工有限公司 | Medicine fertilizer granular formulation for killing molluscous harmful to rice and manufacturing method thereof |
-
2011
- 2011-09-06 CN CN2011102624078A patent/CN102326544A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106621A (en) * | 1994-07-15 | 1995-08-16 | 四川省寄生虫病防治研究所 | Slow-released molluscacide |
| CN1620867A (en) * | 2004-10-16 | 2005-06-01 | 江苏省血吸虫病防治研究所 | Niclosamide ethanolamine salt powder and its preparation method |
| CN101323547A (en) * | 2008-07-05 | 2008-12-17 | 惠州市中迅化工有限公司 | Medicine fertilizer granular formulation for killing molluscous harmful to rice and manufacturing method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734131A (en) * | 2013-12-12 | 2014-04-23 | 江苏艾津农化有限责任公司 | Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof |
| CN103766332A (en) * | 2014-01-26 | 2014-05-07 | 江苏艾津农化有限责任公司 | Novel environment-friendly oncomelania killing granule capable of being sprayed and preparation method thereof |
| CN103766332B (en) * | 2014-01-26 | 2016-05-18 | 江苏艾津农化有限责任公司 | A kind of novel environment friendly that can be used for spraying kills oncomelania granule and preparation method thereof |
| CN104186542A (en) * | 2014-07-29 | 2014-12-10 | 华南农业大学 | Environment-friendly pomacea canaliculata prevention and control agent and applications thereof |
| CN114208825A (en) * | 2021-12-21 | 2022-03-22 | 恒诚制药集团淮南有限公司 | Preparation process of niclosamide ethanolamine salt granules |
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Inventor after: Dai Yanlin Inventor after: Liang Xiaotian Inventor before: Dai Yanlin Inventor before: Liang Xiaotian Inventor before: Dai Jianrong |
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Application publication date: 20120125 |