CN102325531B - 化合物和使用方法 - Google Patents

化合物和使用方法 Download PDF

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Publication number
CN102325531B
CN102325531B CN200980157162.3A CN200980157162A CN102325531B CN 102325531 B CN102325531 B CN 102325531B CN 200980157162 A CN200980157162 A CN 200980157162A CN 102325531 B CN102325531 B CN 102325531B
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Prior art keywords
benzo
ylcarbamoyl
thiazol
tetrahydroquinolin
thiazole
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Chinese (zh)
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CN102325531A (zh
Inventor
乔纳森·B·贝尔
金·西恩·布伊
彼得·科尔曼
达内特·A·达德利
韦恩·J·费尔布罗瑟
约翰·A·弗莱加尔
纪劳姆·L·莱塞尼
查迪·杜巴库
乔治·尼克拉科普罗斯
卡尔·史蒂文·拉伊
布拉德·E·斯利布斯
布赖恩·J·史密斯
K·G·沃特森
S·W·艾尔摩尔
A·M·佩特洛斯
A·J·索尔斯
彼得·扎博塔尔
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Inst Medical W & E Hall
Genentech Inc
AbbVie Inc
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Walter and Eliza Hall Institute of Medical Research
Abbott Laboratories
Genentech Inc
AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN200980157162.3A 2008-12-19 2009-12-17 化合物和使用方法 Active CN102325531B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13947908P 2008-12-19 2008-12-19
US61/139,479 2008-12-19
PCT/US2009/068400 WO2010080478A1 (en) 2008-12-19 2009-12-17 Compounds and methods of use

Publications (2)

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CN102325531A CN102325531A (zh) 2012-01-18
CN102325531B true CN102325531B (zh) 2014-04-02

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US (3) US8114893B2 (https=)
EP (1) EP2376085B1 (https=)
JP (1) JP5683484B2 (https=)
KR (1) KR101633532B1 (https=)
CN (1) CN102325531B (https=)
AU (1) AU2009335818A1 (https=)
BR (1) BRPI0918337A2 (https=)
CA (1) CA2747161C (https=)
CO (1) CO6390110A2 (https=)
CR (1) CR20110389A (https=)
DO (1) DOP2011000198A (https=)
EC (1) ECSP11011214A (https=)
ES (1) ES2462715T3 (https=)
IL (1) IL213547A0 (https=)
MX (1) MX2011006514A (https=)
NZ (1) NZ593536A (https=)
PE (1) PE20120305A1 (https=)
RU (1) RU2561109C2 (https=)
SG (1) SG172266A1 (https=)
WO (1) WO2010080478A1 (https=)
ZA (1) ZA201104463B (https=)

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US20100190782A1 (en) 2010-07-29
EP2376085B1 (en) 2014-02-26
IL213547A0 (en) 2011-07-31
EP2376085A1 (en) 2011-10-19
AU2009335818A1 (en) 2011-07-21
MX2011006514A (es) 2011-10-11
KR101633532B1 (ko) 2016-06-24
US9067928B2 (en) 2015-06-30
BRPI0918337A2 (pt) 2017-05-30
RU2561109C2 (ru) 2015-08-20
US8114893B2 (en) 2012-02-14
DOP2011000198A (es) 2012-08-31
CR20110389A (es) 2011-07-13
CA2747161C (en) 2017-07-18
US20140005190A1 (en) 2014-01-02
PE20120305A1 (es) 2012-04-09
RU2011129789A (ru) 2013-01-27
ECSP11011214A (es) 2011-09-30
JP5683484B2 (ja) 2015-03-11
KR20110114581A (ko) 2011-10-19
SG172266A1 (en) 2011-07-28
JP2012512887A (ja) 2012-06-07
NZ593536A (en) 2013-07-26
ZA201104463B (en) 2012-09-26
CN102325531A (zh) 2012-01-18
CA2747161A1 (en) 2010-07-15
EP2376085A4 (en) 2012-08-15
US8518970B2 (en) 2013-08-27
HK1161094A1 (en) 2012-08-24
ES2462715T3 (es) 2014-05-26
WO2010080478A1 (en) 2010-07-15
CO6390110A2 (es) 2012-02-29

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