CN102318837A - Compound anticoagulant of animal blood - Google Patents
Compound anticoagulant of animal blood Download PDFInfo
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- CN102318837A CN102318837A CN201110242178A CN201110242178A CN102318837A CN 102318837 A CN102318837 A CN 102318837A CN 201110242178 A CN201110242178 A CN 201110242178A CN 201110242178 A CN201110242178 A CN 201110242178A CN 102318837 A CN102318837 A CN 102318837A
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Abstract
The invention discloses a preparation method of a compound anticoagulant for animal blood deep processing. The compound anticoagulant is prepared from five food grade materials of sodium citrate, sodium tripolyphosphate, EDTA-2Na, glucose and salt by mixing according to a certain ratio, wherein a ratio of the four sodium salts to glucose is 2.85+/-0.05: 1 (g/g). Compared with other compound anticoagulants or traditional single anticoagulants, the compound anticoagulant has strong effects of anticoagulation, can effectively inhibit hemolysis, is suitable for a small blood collection point or a blood collection point without a refrigerating plant, improves obviously anticoagulation effects of animal blood, and is beneficial for large-scale application by related companies.
Description
Technical field:
The invention discloses a kind of blood anticoagulant and preparation method thereof, compound anti-coagulants of particularly a kind of animal blood and preparation method thereof, the anti-coagulants that this method is prepared are applicable to the anti-freezing of the blood of the large-scale or small-sized blood point that utilizes the animal blood deep processing.
Background technology:
China's animal blood aboundresources, in Europe, pig blood utilization rate reaches more than 50%.Contain great deal of bioactive substances in the pig blood, be widely used at feed, food, health products, medicine, chemical field.
But because the existence of clotting factor in the blood, blood is left behind the body get final product self-solidifying several seconds.So the research for blood anticoagulant seems particularly important.Good anti-coagulants can not only stop solidifying of blood, and will be widely used, and all uses at scale blood point and small family's blood point; And can extend the shelf life, reduce because the blood point blood that causes far away lumps, especially summer; Reduce the blood caking, reduce the blood plasma liquid eggs and separate out in vain.
The domestic enterprise that much utilizes blood to carry out deep processing is fewer in the research of anti-coagulants at present, and a lot of scientific research institutions just lay particular emphasis on laboratory research, and real suitability for industrialized production has just received certain restriction.
Guarantee the prolongation of blood anticoagulant time, prerequisite is to guarantee that the physics and chemistry variation does not take place or takes place less the various compositions in the blood, reaches the equilibrium of pH value, acid-base value.Traditional anti-coagulants is difficult to accomplish this point.
Summary of the invention:
The object of the invention just is to provide compound anti-coagulants of a kind of animal blood and preparation method thereof; The anti-coagulants that this method is prepared is in slaughterhouse and transportation, to occur haemolysis or blood coagulation easily to animal blood to separate out the problem of albumen and develop; It not only can reduce the haemolysis and the blood coagulation problem of blood effectively; Reduce the loss of blood, improve the yield rate and the product quality of final products, and be suitable for any large-scale and small-sized blood point in each link.
As above design, technical scheme of the present invention is: the compound anti-coagulants of a kind of animal blood is characterized in that: be the mixture of natrium citricum, sodium phosphate trimer, EDTA-2Na, salt and glucose, four kinds of sodium salts: grape grain=2.85 ± 0.05: 1 (g/g).
The weight proportion of above-mentioned natrium citricum, sodium phosphate trimer, EDTA-2Na, salt is: 1: (1-2): (0.15-0.25): (1-2).
Above-mentioned compound anti-coagulants in use with water in 1: 5-1: 10 ratio (g/g) is dissolving fully.
The above-mentioned compound anti-coagulants ratio of addition and former blood in use is 4.5: 1000 (g/g).
The present invention has following advantage and good effect:
1, can regulate anion-cation balance in the blood, can guarantee pH value of blood along with the prolongation of time is relatively stable, thereby can effectively suppress condensing of blood.
2, compare with other compound anti-coagulants, this anti-coagulants can make blood albumen occur to separate out time lengthening be more than 72 hours, especially at little blood point with there is not the blood point of refrigerating plant, its anti-hemolysis effect also clearly, the hemolysis time prolongs 36 hours;
3, compare with traditional sodium citrate anticoagulant, can make blood albumen occur and separate out time lengthening 96-120 hour, the hemolysis time prolongs 72-96 hour.
4, use at small-sized blood point, can not only guarantee the quality of blood, can also improve former blood dry to greatest extent, do not need the consumption of extra increase water, thus the energy consumption that needs when having reduced transpiring moisture.
The specific embodiment:
Below in conjunction with embodiment the present invention is further specified:
Embodiment 1:
Small-sized pig slaughtering factory, 100 of day amount of butchering live pigs.Blood volume 3.3kg, then total blood volume 330kg.Mix anti-coagulants and need 1.485kg.According to anti-coagulants: the ratio of water=1: 10 needs anti-freezing water 16.335kg.Need the quality of natrium citricum, sodium phosphate trimer, EDTA-2Na, salt, glucose to be respectively respectively: 0.370kg, 0.590kg, 0.064kg, 0.076kg, 0.385kg.
Embodiment 2:
Common live pig slaughterhouse scale is general, 500 of day amount of butchering live pigs.Blood volume 3.3kg, then total blood volume 1650kg.Mix anti-coagulants and need 7.425kg.According to anti-coagulants: the ratio of water=1: 8 needs anti-freezing water 66.825kg.Need the quality of natrium citricum, sodium phosphate trimer, EDTA-2Na, salt, glucose to be respectively respectively: 1.842kg, 2.930kg, 0.320kg, 0.400kg, 1.933kg.
Embodiment 3:
Large-scale pig slaughtering factory, 5000 of day amount of butchering live pigs.Blood volume 3.3kg, then total blood volume 16500kg.Mix anti-coagulants and need 74.25kg.According to anti-coagulants: the ratio of water=1: 5 needs anti-freezing water 445.5kg.Need the quality of natrium citricum, sodium phosphate trimer, EDTA-2Na, salt, glucose to be respectively respectively: 18.40kg, 29.40kg, 3.18kg, 4.10kg, 19.17kg.
The method for using of the compound anti-coagulants of this animal blood is: before butchering, anti-coagulants is splashed uniformly in the blood groove; After butchering beginning; The anti-coagulants solution for preparing is splashed on the surface of blood uniformly; And in time stir with wooden rake, in the final blood, mix the addition of anti-coagulants: former blood=4.5: 1000 (g/g).
Evidence:
Compare with other compound anti-coagulants, this anti-coagulants can make blood albumen occur to separate out time lengthening be more than 72 hours, especially at little blood point with there is not the blood point of refrigerating plant, its anti-hemolysis effect also clearly, the hemolysis time prolongs 36 hours;
Compare with traditional sodium citrate anticoagulant, can make blood albumen occur and separate out time lengthening 96-120 hour, the hemolysis time prolongs 72-96 hour.
Use at small-sized blood point, can not only guarantee the quality of blood, can also improve former blood dry to greatest extent, do not need the consumption of extra increase water, thus the energy consumption that needs when having reduced transpiring moisture.
The foregoing description is a preferred implementation of the present invention; But embodiment of the present invention is not restricted to the described embodiments; Other any do not deviate from spirit of the present invention with the original change of being done down, modification, substitute, combination, simplify; All should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (4)
1. compound anti-coagulants of animal blood is characterized in that: be the mixture of natrium citricum, sodium phosphate trimer, EDTA-2Na, salt and glucose, and four kinds of sodium salts: glucose=2.85 ± 0.05: 1 (g/g).
2. the compound anti-coagulants of a kind of animal blood according to claim 1, it is characterized in that: the weight proportion of above-mentioned natrium citricum, sodium phosphate trimer, EDTA-2Na, salt is: 1: (1-2): (0.15-0.25): (1-2).
3. the method for using of the compound anti-coagulants of a kind of animal blood according to claim 1 is characterized in that: with compound anti-coagulants and water in 1: 5-1: 10 ratio (g/g) is dissolving fully.
4. the method for using of the compound anti-coagulants of a kind of animal blood according to claim 3 is characterized in that: the above-mentioned compound anti-coagulants ratio of addition and former blood in use is 4.5: 1000 (g/g).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110242178A CN102318837A (en) | 2011-08-23 | 2011-08-23 | Compound anticoagulant of animal blood |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201110242178A CN102318837A (en) | 2011-08-23 | 2011-08-23 | Compound anticoagulant of animal blood |
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| CN102318837A true CN102318837A (en) | 2012-01-18 |
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| CN201110242178A Pending CN102318837A (en) | 2011-08-23 | 2011-08-23 | Compound anticoagulant of animal blood |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719425A (en) * | 2013-12-24 | 2015-06-24 | 天津宝迪农业科技股份有限公司 | Novel pig blood anti-coagulation and fresh-keeping compound preparation |
| CN107836701A (en) * | 2017-09-04 | 2018-03-27 | 韩山师范学院 | A kind of pig blood anti-coagulants |
| CN109077242A (en) * | 2018-10-17 | 2018-12-25 | 山东农业大学 | A kind of production method of Bean curd with duck blood |
| CN109907170A (en) * | 2019-03-08 | 2019-06-21 | 刘晋芳 | A kind of compound anti-coagulants of animal blood |
| CN112841610A (en) * | 2021-01-12 | 2021-05-28 | 毕泽勋 | Pig blood anticoagulant fresh-keeping compound preparation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101451120A (en) * | 2008-12-31 | 2009-06-10 | 厦门大学 | Abalone blood cell anticoagulation protecting agent and preparation method thereof |
| CN101822312A (en) * | 2009-12-22 | 2010-09-08 | 安徽宝迪肉类食品有限公司 | Composite type animal blood anticoagulant agent |
-
2011
- 2011-08-23 CN CN201110242178A patent/CN102318837A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101451120A (en) * | 2008-12-31 | 2009-06-10 | 厦门大学 | Abalone blood cell anticoagulation protecting agent and preparation method thereof |
| CN101822312A (en) * | 2009-12-22 | 2010-09-08 | 安徽宝迪肉类食品有限公司 | Composite type animal blood anticoagulant agent |
Non-Patent Citations (2)
| Title |
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| 世界卫生组织: "《生物标准化》", 30 April 1997, 人民卫生出版社 * |
| 王海涛等: "枸橼酸-葡萄糖抗凝溶液在高危出血患者连续性血液净化中的应用", 《中华肾脏病杂志》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104719425A (en) * | 2013-12-24 | 2015-06-24 | 天津宝迪农业科技股份有限公司 | Novel pig blood anti-coagulation and fresh-keeping compound preparation |
| CN107836701A (en) * | 2017-09-04 | 2018-03-27 | 韩山师范学院 | A kind of pig blood anti-coagulants |
| CN109077242A (en) * | 2018-10-17 | 2018-12-25 | 山东农业大学 | A kind of production method of Bean curd with duck blood |
| CN109907170A (en) * | 2019-03-08 | 2019-06-21 | 刘晋芳 | A kind of compound anti-coagulants of animal blood |
| CN112841610A (en) * | 2021-01-12 | 2021-05-28 | 毕泽勋 | Pig blood anticoagulant fresh-keeping compound preparation and preparation method thereof |
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Application publication date: 20120118 |