CN102318641B - Bactericidal compound containing fenoxanil - Google Patents
Bactericidal compound containing fenoxanil Download PDFInfo
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- CN102318641B CN102318641B CN 201110231815 CN201110231815A CN102318641B CN 102318641 B CN102318641 B CN 102318641B CN 201110231815 CN201110231815 CN 201110231815 CN 201110231815 A CN201110231815 A CN 201110231815A CN 102318641 B CN102318641 B CN 102318641B
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Abstract
The invention provides a bactericidal compound; the compound comprises two effective components-an effective component A and an effective component B, the effective component A is fenoxanil, the active component is one of ethylicin or phosethyl-aluminum. The mass ratio of two components is 50-0.02. The invention also provides a preparation method and an application of the compound. Test results prove that the bactericidal compound has obvious synergism, and more importantly, the application amount is greatly reduced, and the usage cost is decreased. The bactericidal compound is capable of effectively preventing and treating certain fungal diseases of grain crops, vegetables and the like, especially certain fungal diseases of paddy rice. By combining the bactericides with different active mechanisms and different models of action, the application rates of each single chemical insecticide can be effectively reduced, so that the bactericidal compound has good effects of enlarging an anti-fungal spectrum, delaying the antifungal performance, enhancing the control effect and the like.
Description
Technical field
The invention belongs to the bactericide field, particularly relate to a kind of application at agriculture field that contains composite bactericide and this bactericide of fenoxanil.
Background technology
Fenoxanil (Fenoxanil) is a kind of high-efficiency low-toxicity class amide-type systemic fungicide, has novel mechanism of action, belong to melanin biosynthesis inhibitor, rice blast is had special efficacy, the diseases such as downy mildew of garpe, potato and tomato late blight are also had very high preventive effect.
S-Ethyl ethylthio sulfonate (ethylicin) is the ethyl homologue of allicin, belongs to plant resource bionic type bactericide.Medicament is little yellow liquid, and garlic and acetic acid stink are arranged.Its bactericidal effect is superior, easily is absorbed and degrades, and is difficult for developing immunity to drugs, and can also stimulate plant growth, realizes volume increase.Be mainly used in seed treatment, and prevent and treat vegetable epidemic disease, bacterial wilt, climing rot, fusarium wilt, anthracnose, seedling blight, damping off, root rot etc.Can use separately, also can with other bactericide or pesticide compositional, increase control efficiency.
Phosethyl-Al (phosethyl-Al) all has stronger prevention and treatment to the wide scope disease such as rice blast, banded sclerotial blight, powdery mildew of cucumber, gray mold, downy mildew.
Actual agricultural chemicals experience shows, repeat and single-mindedly use a kind of reactive compound and prevent and treat harmful fungoid and will cause the fast selective of fungal bacterial strain under many circumstances, optionally dangerous for reducing the resistance fungal bacterial strain, usually prevent and treat harmful fungoid with the mixture of different activities compound at present.Make up by the reactive compound that will have the different mechanisms of action, but the delaying drug resistance generation reduces amount of application, reduces cost accounting.
Summary of the invention
The technical problem to be solved in the present invention is: for bactericide resistance and pedo relict problem in actual applications, the bactericide that filters out two kinds of different sterilizing mechanismses carries out composite, to improve the bactericidal agent for preventing and treating effect.
For solving the problems of the technologies described above, the invention provides a kind of bactericidal composition, said composition is comprised of two kinds of active components A and B, active component A is fenoxanil (Fenoxanil), and active component B is for being selected from a kind of in S-Ethyl ethylthio sulfonate (ethylicin) or phosethyl-Al (phosethyl-Al).The inventor finds by test, and above-mentioned bactericidal composition synergy is obvious.Contain component A different from the compound structure type of B component, mechanism of action is different, and both are composite can enlarge fungicidal spectrum, and can delay to a certain extent generation and the development speed of pathogen resistance, and between component A and B component without cross resistance.
Another object of the present invention is to provide the preparation method who comprises two kinds of effective constituents A and B bactericidal composition and prevents and treats the application of crop pest at agriculture field.
In above-mentioned bactericidal composition, the weight ratio between component A and B component two components is 50～0.02.According to the physicochemical property between component and practical application, active component fenoxanil (A) is 30～0.03 with the preferred weight ratio of active component S-Ethyl ethylthio sulfonate (B), and active component fenoxanil (A) is 0.06～35 with active component phosethyl-Al (B) preferred weight ratio.
Bactericidal composition of the present invention is comprised of the active component of 8～85% weight portions and the insecticides adjuvant of 92～15% weight portions.
The invention provides and comprise component A(fenoxanil) and the purposes of bactericidal composition in controlling plant diseases of B component (be selected from S-Ethyl ethylthio sulfonate or phosethyl-Al a kind of), said composition can effectively be prevented and treated as Pyricularia oryzae, sheath blight fungus, also can effectively prevent and treat gray mold of cucumber, powdery mildew, downy mildew, graw mold of tomato, late blight, potato late blight, downy mildew of garpe etc.
Composition of the present invention preferably is suitable for preventing and treating the microbial plant disease of rice blast.
Above-mentioned composition also comprises carrier, auxiliary agent and/or surfactant.Can mix auxiliary agent commonly used in the process of using.
Suitable auxiliary agent can be solid or liquid, and they are material commonly used in the formulation process normally, natural or mineral matter regeneration for example, solvent, dispersant, wetting agent, adhesive, thickener, adhesive or fertilizer.
The application process of the present composition comprises the acrial part, particularly leaf section or blade face that composition of the present invention is used for plant growth.The frequency of using and amount of application depend on biology and the weather life condition of pathogene.Can be with the growth place of plant, as the rice field, soak with the liquid preparation of composition, perhaps composition is applied in soil with solid form, as with particle form (soil application), composition can be by soil in plant root enters plant corpus (systemic action).
These compositions can only comprise active component to be used, and also can mix together with additive, and therefore composition of the present invention can be prepared into various formulations, for example missible oil, aqueous emulsion, microemulsion, wetting powder, suspending agent or granule.According to the character of these compositions and use purpose and the ambient conditions that composition will reach, can select composition with spraying, atomizing, dust, broadcast sowing or sprinkle the method for watering etc. and so on and use.
Available known method can be prepared into various formulations with composition of the present invention, active ingredient and auxiliary agent as solvent, solid carrier, can evenly can be mixed, grind together with surfactant when needing, and is prepared into needed formulation.
Above-mentioned solvent can be selected from aromatic hydrocarbon, preferably contains 8-12 carbon atom, as the benzene of xylene mixture or replacement, phthalate, as sad in Dibutyl phthalate or phthalandione two, fat hydrocarbon, as thiacyclohexane or paraffin, pure and mild ethylene glycol and their ether and ester, as ethanol, ethylene glycol, glycol monomethyl methyl; Ketone, as cyclohexanone, the solvent of strong polarity, as METHYLPYRROLIDONE, dimethyl sulfoxide (DMSO) or dimethyl formamide, and vegetable oil or vegetable oil are as soybean oil.
Above-mentioned solid carrier, but as being used for the normally natural minerals filler of pulvis and dispersant, for example talcum, kaolin, montmorillonite or atlapulgite.In order to manage the physical property of composition, also can add polymolecularity silicic acid or polymolecularity adsorpting polymerization thing carrier, for example granular absorption carrier or non-absorption carrier, suitable granular absorption carrier is porous type, as float stone, bentonite or bentonite; Suitable non-absorption carrier such as calcite or sand.In addition, can use the granular material of being prefabricated into of a large amount of inorganic in nature or organic nature as carrier, particularly dolomite.
chemical property according to the active ingredient in composition of the present invention, suitable surfactant is lignin sulfonic acid, naphthalene sulfonic acids, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonates, alkyl sulfate, alkylsulfonate, aliphatic alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the condensation product that also has sulfonated naphthalene and naphthalene derivatives and formaldehyde, the condensation product of naphthalene or naphthalene sulfonic acids and phenol and formaldehyde, NONIN HS 240, the ethoxylation isooctylphenol, octyl phenol, nonyl phenol, alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol, ethoxylated castor oil, polyoxyethylene alkyl ether, the ethylene oxide condensation product, the ethoxylation polyoxypropylene, lauric acid polyglycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
In composition of the present invention, two kinds of active ingredients show as synergistic effect, and the specific activity of said composition is used the activity expection summation of individualized compound, and the independent activity of individualized compound is more remarkable.Synergistic effect show as allow amount of application to reduce, wider antifungal is controlled spectrum, instant effect, more lasting control efficiency, by only once or minority use several times better control plant harmful fungoid and widened the possible administration interval time.These characteristics are that plant epiphyte is controlled special needs in practice process.
Other characteristics main manifestations that shows of bactericidal composition of the present invention is: 1, because two single dose chemical constitutions of this composition are widely different, the mechanism of action is fully different, there is not cross resistance, can delays two single doses and use separately the resistance problem that produces; 2, composition of the present invention is good to crop safety, preventive effect.Through evidence, microbicide compositions stable chemical nature of the present invention, synergy is remarkable, and controlling object is shown obvious synergy and complementation; 3, reduce dosage, thereby reduced cost and the pollution that has alleviated environment.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention, all any modifications of making within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
In all formulas of following examples, percentage all is weight percentage.The processing technology of the various preparations of the present composition is prior art, can change to some extent according to different situations.
One, formulation Preparation Example
(1) processing of wetting powder and embodiment
The active component fenoxanil is fully mixed in proportion with S-Ethyl ethylthio sulfonate or phosethyl-Al, various auxiliary agent and filler etc., make wetting powder after ultra-fine pulverizer disintegrating.
Embodiment 1:55% fenoxanil S-Ethyl ethylthio sulfonate wetting powder
Fenoxanil 5%, S-Ethyl ethylthio sulfonate 50%, sodium lignin sulfonate 5%, NONIN HS 240 3%, white carbon 11%, kaolin complements to 100%.
Embodiment 2:40% fenoxanil S-Ethyl ethylthio sulfonate wetting powder
Fenoxanil 20%, S-Ethyl ethylthio sulfonate 20%, calcium lignosulfonate 8%, neopelex 11%, bentonite 15%, attapulgite complements to 100%.
Embodiment 3:78% fenoxanil S-Ethyl ethylthio sulfonate wetting powder
Fenoxanil 76%, S-Ethyl ethylthio sulfonate 2%, alkyl polyoxy ethyl ether sulfonate 1% pulls open powder 5%, bentonite 1.2%, white carbon 4%, diatomite complements to 100%.
Embodiment 4:50% fenoxanil phosethyl-Al wetting powder
Fenoxanil 20%, phosethyl-Al 30%, alkylsulfonate 5%, calcium lignosulfonate 8%, white carbon 4%, attapulgite complements to 100%.
Embodiment 5:55% fenoxanil phosethyl-Al wetting powder
Fenoxanil 50%, phosethyl-Al 5%, NONIN HS 240 4%, sodium lignin sulfonate 6%, white carbon 11%, diatomite complements to 100%.
Embodiment 6:80% fenoxanil phosethyl-Al wetting powder
Fenoxanil 5%, phosethyl-Al 75%, neopelex 3%, calcium lignosulfonate 5%, bentonite 4%, attapulgite complements to 100%.
(2) processing of suspending agent and embodiment
Active component fenoxanil and S-Ethyl ethylthio sulfonate or each components such as phosethyl-Al, dispersant, wetting agent, thickener and water ratio in formula is mixed, after sand milling and/or high speed shear, obtain semi-finished product, add water after analysis and mix to filter and get product.
Embodiment 7:30% fenoxanil S-Ethyl ethylthio sulfonate suspending agent
Fenoxanil 25%, S-Ethyl ethylthio sulfonate 5%, sodium lignin sulfonate 6%, xanthans 0.6%, bentonite 3%, Magnesiumaluminumsilicate 1%, ethylene glycol 4%, water complements to 100%.
Embodiment 8:18% fenoxanil S-Ethyl ethylthio sulfonate suspending agent
Fenoxanil 7%, S-Ethyl ethylthio sulfonate 11%, methyl naphthalene sulfonate formaldehyde condensate 5%, bentonite 3%, glycerine 5%, water complements to 100%.
Execute routine 9:8% fenoxanil phosethyl-Al suspending agent
Fenoxanil 5%, phosethyl-Al 3%, aliphatic alcohol polyoxyvinethene phosphate 6%, white carbon 2%, glycerine 5%, Sodium Benzoate 1.5%, water complements to 100%.
Execute routine 10:15% fenoxanil phosethyl-Al suspending agent
Fenoxanil 3%, phosethyl-Al 12%, sodium lignin sulfonate 6%, white carbon 2%, ethylene glycol 5%, xanthans 0.6%, water complements to 100%.
(3) processing of water dispersible granules and embodiment
Active component fenoxanil and S-Ethyl ethylthio sulfonate or phosethyl-Al, auxiliary agent and the filler ratio in formula is mixed, become wetting powder through air-flow crushing, then add a certain amount of water mixings extruder grain, drying makes the water dispersible granules product after sieving.
Embodiment 11:85% fenoxanil S-Ethyl ethylthio sulfonate water dispersible granules
Fenoxanil 80%, S-Ethyl ethylthio sulfonate 5%, methyl naphthalene sulfonate formaldehyde condensate 6%, dodecyl sodium sulfate 2%, ammonium sulfate 4%, precipitated calcium carbonate complements to 100%.
Embodiment 12:63% fenoxanil S-Ethyl ethylthio sulfonate water dispersible granules
Fenoxanil 5%, S-Ethyl ethylthio sulfonate 58%, Negel 5%, sodium lignin sulfonate 6%, lauryl sodium sulfate 2%, diatomite complements to 100%.
Embodiment 13:80% fenoxanil phosethyl-Al water dispersible granules
Fenoxanil 70%, phosethyl-Al 10%, sodium lignin sulfonate 5%, dodecyl sodium sulfate 2%, xanthans 1%, sodium carboxymethyl starch 2%, attapulgite complements to 100%.
Embodiment 14:75% fenoxanil phosethyl-Al water dispersible granules
Fenoxanil 6%, phosethyl-Al 69%, ammonium sulfate 1%, sodium alginate 2%, methyl naphthalene sulfonate formaldehyde condensate 1%, organic silicone 1%, bentonite complements to 100%.
(4) processing of oil-suspending agent and embodiment
The active component fenoxanil is mixed in the ratio of formula with each components such as S-Ethyl ethylthio sulfonate or phosethyl-Al, dispersant, stabilizing agent, defoamer and solvents, after putting into the grinding of sand milling still, send into the interior mixing of mixer for well-distribution and get product.
Embodiment 15:15% fenoxanil S-Ethyl ethylthio sulfonate oil-suspending agent
Fenoxanil 5%, S-Ethyl ethylthio sulfonate 10%, sodium lignin sulfonate 8%, bentonite 4%, xanthans 1%, silicone defoaming agent 2%, soybean oil complements to 100%.
Embodiment 16:28% fenoxanil S-Ethyl ethylthio sulfonate oil-suspending agent
Fenoxanil 24%, S-Ethyl ethylthio sulfonate 4% pulls open powder 8%, bentonite 5%, organic silicone 2%, machine oil complements to 100%.
Embodiment 17:30% fenoxanil phosethyl-Al oil-suspending agent
Fenoxanil 26%, phosethyl-Al 4%, naphthalene sulfonic acid-formaldehyde condensation product 8%, diatomite 5%, aluminium-magnesium silicate 2%, dichloroethane complements to 100%.
Embodiment 18:18% fenoxanil phosethyl-Al oil-suspending agent
Fenoxanil 5%, phosethyl-Al 13%, sodium lignin sulfonate 11%, aerosil 4%, aluminium-magnesium silicate 2%, castor oil complements to 100%.
(5) processing of aqueous emulsion and embodiment
In emulsifying kettle, fenoxanil and S-Ethyl ethylthio sulfonate or phosethyl-Al, solvent, auxiliary agent are mixed under mechanical agitation, then drop into emulsifier and stabilizing agent stirs, add at last entry, stirred 10-30 minute under the rotating speed of 100-12000 rev/min, make it to become the product of even emulsus.
Embodiment 19:30% fenoxanil S-Ethyl ethylthio sulfonate aqueous emulsion
Fenoxanil 18%, S-Ethyl ethylthio sulfonate 12%, N-repefral 4%, nonyl phenol benzene oxygen vinethene 3%, 2,6-di-tert-butyl-4-methy phenol 2%, ethylene glycol 3%, polyvinyl alcohol 1%, Sodium Benzoate 1%, silicone defoaming agent 0.8%, water complements to 100%.
Embodiment 20:45% fenoxanil S-Ethyl ethylthio sulfonate aqueous emulsion
Fenoxanil 8%, S-Ethyl ethylthio sulfonate 37%, butylated hydroxy anisole 4%, poly-isosuccinic acid acid anhydride-ethylene glycol copolymer 3%, propane diols 2%, xanthans 3%, polyvinyl alcohol 1%, silicone defoaming agent 1.2%, water complements to 100%.
Embodiment 21:25% fenoxanil phosethyl-Al aqueous emulsion
Fenoxanil 5%, phosethyl-Al 20%, polyoxyethylene block copolymer 3%, propane diols 1%, xanthans 2%, poly-isosuccinic acid acid anhydride-ethylene glycol copolymer 3%, silicone defoaming agent 1.2%, water complements to 100%.
Embodiment 22:28% fenoxanil phosethyl-Al aqueous emulsion
Fenoxanil 24%, phosethyl-Al 4%, N-dodecylpyrrolidone 2%, castor oil polyoxyethylene ether 1%, glycerine 3%, polyvinyl alcohol 1.2%, Sodium Benzoate 1%, isooctanol 2%, water complements to 100%.
(6) processing of microemulsion and embodiment
With fenoxanil and S-Ethyl ethylthio sulfonate or phosethyl-Al in solvent fully after dissolving, stir, add simultaneously emulsifier, builder and antifreeze, after above-mentioned system mixing, again water is slowly added in above-mentioned mixed liquor, can be made into the microemulsion of different content after fully stirring.
Embodiment 23:15% fenoxanil S-Ethyl ethylthio sulfonate microemulsion
Fenoxanil 3%, S-Ethyl ethylthio sulfonate 12%, acetone 18%, alkyl polyoxyethylene ether and polyoxyethylene nonylphenol ether 4%, propane diols 2%, glycerine 1%, azone 2%, water complements to 100%.
Embodiment 24:10% fenoxanil S-Ethyl ethylthio sulfonate microemulsion
Fenoxanil 8%, S-Ethyl ethylthio sulfonate 2%, methyl alcohol 14%, polyoxyethylene carboxylate and phenethyl phenol polyethenoxy ether 5%, compound sodium nitrophenolate 0.5%, urea 2%, water complements to 100%.
Embodiment 25:18% fenoxanil phosethyl-Al microemulsion
Fenoxanil 4%, phosethyl-Al 14%, ethyl acetate 18%, alkylbenzenesulfonate and alkylnaphthalene sulfonate 15%, thiophene ketone 0.8%, propane diols 2%, water complements to 100%.
Embodiment 26:15% fenoxanil phosethyl-Al microemulsion
Fenoxanil 12%, phosethyl-Al 3%, calcium dodecyl benzene sulfonate 9%, sorbic acid 15%, thiophene ketone 0.8%, polyethylene glycol 2%, water complements to 100%.
Two, drug effect demonstration test
(1) biologicall test embodiment
1, fenoxanil and S-Ethyl ethylthio sulfonate are composite tests the rice blast toxicity test
Subjects: rice blast fungus (pick up from the field and through separation and purification)
Test method: pot-culture method.Choose the consistent rice seedlings in tri-leaf period of growth potential, every basin 2 young plants, 5 basins are selected in each processing.Pyricularia oryzae is cultivated on tomato juice oat agar medium, wash spore with sterile water after producing spore, be made into the spore suspension of 1 * 105 spore/ml after double gauze filters, spray inoculation in for trying on rice seedling, puts black plastic sack moisturizing and cultivates 24h after inoculation equably.After inoculation 24h, carry out chemicals treatment, each medicament arranges under the condition of 25 ℃ of left and right, relative moisture 〉=90% and cultivates, after 7d according to the incidence of the whole strain blade of morbidity grade scale investigation of rice blast, as the standard medicament, calculate disease index and control efficiency with fenoxanil.
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, calculates concentration EC50 in virulence equation and inhibition with method of least squares, calculates the toxicity index level co-toxicity coefficient (CTC) of medicament according to the abundant method of Sun Yun.Toxicity test the results are shown in Table 1.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ reagent agent EC50) * 100
The percentage composition of B in the percentage composition of A+B medicament toxicity index * mixture in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/theoretical toxicity index (TTI) of mixture] * 100
CTC≤80, the composition performance is antagonism, 80＜CTC＜120, the composition performance is summation action, CTC 〉=120, the composition performance is synergistic effect.
Table 1 fenoxanil, S-Ethyl ethylthio sulfonate and different proportioning thereof are composite to the interpretation of result of rice blast toxicity test
| The medicament title | EC 50（μg/ml） | ATI | TTI | Co-toxicity coefficient (CTC) |
| Fenoxanil | 3.25 | 100.0 | / | / |
| S-Ethyl ethylthio sulfonate | 5.41 | 60.1 | / | / |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=50:1 | 2.37 | 137.1 | 99.93 | 137.196 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=30:1 | 1.91 | 170.1 | 98.71 | 172.322 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=10:1 | 1.58 | 205.7 | 96.36 | 213.470 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=1:1 | 2.08 | 156.2 | 80.05 | 195.128 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=1:10 | 2.26 | 143.8 | 63.6 | 226.101 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=1:30 | 2.81 | 115.7 | 61.4 | 188.436 |
| Proportioning fenoxanil: S-Ethyl ethylthio sulfonate=1:50 | 3.91 | 83.1 | 60.9 | 136.453 |
Measurement result (table 1) shows, fenoxanil and S-Ethyl ethylthio sulfonate are ratio 50～0.02 at proportioning 50:1～1:50() between, control to rice blast has synergistic effect, especially be ratio 30～0.03 at 30:1～1:30() between, synergistic effect is remarkable, and co-toxicity coefficient is all more than 170.
2, fenoxanil and phosethyl-Al are composite tests the rice blast toxicity test
Subjects: rice blast (pick up from the field and through separation and purification)
Test method: pot-culture method.Test, statistical method are with biologicall test embodiment 1.Toxicity test the results are shown in Table 2
Table 2 fenoxanil, phosethyl-Al and different proportioning thereof are composite to the interpretation of result of rice blast toxicity test
| The medicament title | EC 50（μg/ml） | ATI | TTI | Co-toxicity coefficient (CTC) |
| Fenoxanil | 3.25 | 100.0 | / | / |
| Phosethyl-Al | 3.85 | 84.4 | / | / |
| Proportioning fenoxanil: phosethyl-Al=50:1 | 2.51 | 129.4 | 99.6 | 129.91 |
| Proportioning fenoxanil: phosethyl-Al=30:1 | 1.76 | 184.4 | 98.7 | 186.82 |
| Proportioning fenoxanil: phosethyl-Al=10:1 | 1.29 | 251.9 | 98.5 | 255.73 |
| Proportioning fenoxanil: phosethyl-Al=1:1 | 1.14 | 285.3 | 92.2 | 309.43 |
| Proportioning fenoxanil: phosethyl-Al=1:10 | 1.20 | 270.1 | 85.2 | 317.01 |
| Proportioning fenoxanil: phosethyl-Al=1:30 | 1.43 | 226.7 | 84.9 | 267.7 |
| Proportioning fenoxanil: phosethyl-Al=1:50 | 2.07 | 157.0 | 84.7 | 185.36 |
Measurement result (table 1) shows, fenoxanil and phosethyl-Al are ratio 50～0.02 at proportioning 50:1～1:50() between, control to rice blast has synergistic effect, especially be ratio 30～0.03 at 30:1～1:30() between, synergistic effect is remarkable, and co-toxicity coefficient is all more than 180.
(2) field control effectiveness test
1, adopt the method for parallel test to verify fenoxanil and the composite field control effect to rice blast of S-Ethyl ethylthio sulfonate.
(1) test site: test arrangement is in abutment Farm Rice field, east, Dafeng City, and the plot is smooth, and rice blast is fallen ill heavier throughout the year, and rice seedling is in tillering stage;
(2) test method: at the initial stage of a disease, spray for the first time immediately, carry out dispenser for the second time after 7 days, each processes 4 residential quarters, each residential quarter 20 square meter.10 days investigation statistics incidences after medicine before medicine and for the second time, the random sampling of 5 of each residential quarters, every some investigation 5 strain paddy rice, the lesion area of investigate every blade on whole strain paddy rice accounts for percentage and the classification of blade area, calculating disease index and control efficiency.
Expect preventive effect (%)=X+Y-XY/100(wherein, X, Y are the single dose preventive effect)
Grade scale:
0 grade: without scab;
1 grade: leaf spot lesion is less than 5, and length is less than 1cm;
3 grades: leaf spot lesion 6-10, part scab length is greater than 1cm;
5 grades: leaf spot lesion 11-25, the part scab is linked to be sheet, and lesion area accounts for the 10-25% of leaf area;
7 grades: leaf spot lesion is more than 26, and scab is linked to be sheet, and lesion area accounts for the 26-50% of leaf area;
9 grades: scab is linked to be sheet, lesion area account for leaf area more than 50% or full leaf withered.
The composite field efficiency test result to rice blast of table 3 fenoxanil and S-Ethyl ethylthio sulfonate
Measurement result (table 3) shows, the composite preventive effect to the control rice blast of fenoxanil and S-Ethyl ethylthio sulfonate obviously improves, and illustrating both compositely has significant synergistic effect to rice blast.
The composite field efficiency test result to rice blast of table 4 fenoxanil and phosethyl-Al
Measurement result (table 3) shows, the composite preventive effect to the control rice blast of fenoxanil and phosethyl-Al obviously improves, and illustrating both compositely has significant synergistic effect to rice blast.
Claims (6)
1. microbicide compositions, it is characterized in that described composition is comprised of acceptable insecticides adjuvant on A and two kinds of active components of B and agricultural, wherein active component A is fenoxanil, active component B is selected from a kind of in S-Ethyl ethylthio sulfonate or phosethyl-Al, and the weight ratio between A and B two components is 50～0.02.
2. composition according to claim 1, is characterized in that the weight ratio between A and B two components is 35～0.05.
3. composition according to claim 1, is characterized in that described composition is comprised of the active component of 8～85% weight portions and the insecticides adjuvant of 92～15% weight portions.
4. composition according to claim 1, is characterized in that active component fenoxanil and active component S-Ethyl ethylthio sulfonate weight ratio are 30～0.03.
5. composition according to claim 1, is characterized in that active component fenoxanil and active component phosethyl-Al weight ratio are 0.06～35.
6. composition according to claim 1 is in the application that prevents and treats on rice disease.
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| CN103004814B (en) * | 2012-12-19 | 2014-07-23 | 青岛东生药业有限公司 | Thifluzamide-contained suspension emulsion and production method thereof |
| CN103098801B (en) * | 2013-01-17 | 2014-07-09 | 海南正业中农高科股份有限公司 | Sterilization composition containing tiadinil |
| CN103190402A (en) * | 2013-04-17 | 2013-07-10 | 江苏省绿盾植保农药实验有限公司 | Compound composition of 2-cyano-3-amino-3-phenyl ethyl acrylate and ethylicin and application thereof |
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| TW201008493A (en) * | 2009-10-19 | 2010-03-01 | Sheng-Hsu Zee | Allicin, ethylicin, and organically produced gem |
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| CN101198254A (en) * | 2005-06-21 | 2008-06-11 | 拜尔农科股份有限公司 | Fungicide composition comprising a phosphorous acid derivative, a mandelamide type compound and a further fungicide compound |
| TW201008493A (en) * | 2009-10-19 | 2010-03-01 | Sheng-Hsu Zee | Allicin, ethylicin, and organically produced gem |
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| 乔依.防治稻瘟病的新颖内吸杀菌剂-氰菌胺.《世界农药》.2004,第26卷(第2期),第46-48页. |
| 张一宾.新的稻瘟病防治药剂-氰菌胺(fenoxanil).《世界农药》.2002,第24卷(第1期),第50-51页. |
| 新的稻瘟病防治药剂-氰菌胺(fenoxanil);张一宾;《世界农药》;20021231;第24卷(第1期);第50-51页 * |
| 防治稻瘟病的新颖内吸杀菌剂-氰菌胺;乔依;《世界农药》;20041231;第26卷(第2期);第46-48页 * |
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| CN102318641A (en) | 2012-01-18 |
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