CN102309933B - Liquid phase gradient mixer - Google Patents
Liquid phase gradient mixer Download PDFInfo
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- CN102309933B CN102309933B CN 201010228411 CN201010228411A CN102309933B CN 102309933 B CN102309933 B CN 102309933B CN 201010228411 CN201010228411 CN 201010228411 CN 201010228411 A CN201010228411 A CN 201010228411A CN 102309933 B CN102309933 B CN 102309933B
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Abstract
The invention discloses a liquid phase gradient mixer, comprising a first mixing chamber and a second mixing cavity, wherein the cross sections of the two mixing cavities are square; the first mixing chamber and the second mixing cavity are filled with zirconia beads; one end of the first mixing chamber is provided with a flowing phase inlet; the other end is connected with one end of the second mixing chamber via a transmission pipe; and the other end of the second mixing chamber is provided with a flowing phase outlet. In the liquid phase gradient mixer disclosed by the invention, the two mixing chambers of which the cross sections are square are adopted to serve as the containers of mixed flowing phase, wherein the two mixing chambers are connected by the transmission pipe, the flowingphase can occupy most area of the mixer, and therefore the problem of larger dead volume of the traditional static mixer is solved.
Description
Technical field
The present invention relates to the liquid-phase chromatographic analysis technical field, more particularly, relate to a kind of liquid phase gradient mixer.
Background technology
In the binary gradient elution device, two kinds of different solvents mix at gradient mixer after two high pressure pump superchargings, and mixed mobile phase enters sampling valve and chromatographic column again.
High pressure liquid phase gradient blender mainly contains two types of static mixer and dynamic mixers.Wherein: described dynamic mixer refers to be provided with the parts of rotation at a high speed in housing or pipeline, fluid produces very big shearing force under the effect of high-speed rotary part, and different fluid realizes mixing under the effect of shearing force.Described static mixer is named with respect to the dynamic agitation blender, and its internals is motion not, but relies on the power of fluid itself, and each hybrid element in the blender of flowing through is to reach the purpose of mixing.Concrete, indissoluble or immiscible material are subjected to constraints such as flow channel shape and changes of section, and motions such as stirring are sheared, are rotated at generation shunting cutting, interflow, reach good dispersion and mixed effect at last.
Existing static mixer is mainly rich cast blender, is a kind of circular stainless steel tube of having mercy on into, yet because it is toroidal, dead volume is bigger.
Summary of the invention
In view of this, the invention provides a kind of liquid phase gradient mixer, to solve the bigger problem of existing static mixer dead volume.
For addressing the above problem, the technical scheme of proposition is as follows:
A kind of liquid phase gradient mixer comprises: cross section is square first hybrid chamber and second hybrid chamber, wherein:
Be filled with zirconium oxide bead in described first hybrid chamber and second hybrid chamber, and an end of described first hybrid chamber is provided with the phase import of flowing, the other end links to each other with described second hybrid chamber, one end by transfer tube, and the other end of described second hybrid chamber is provided with the outlet mutually of flowing.
Preferably, comprise that also cross section is square the 3rd hybrid chamber and the 4th hybrid chamber, wherein:
Be filled with zirconium oxide bead in described the 3rd hybrid chamber and the 4th hybrid chamber, and described the 3rd hybrid chamber one end and described second hybrid chamber flow mutually that outlet links to each other, the other end links to each other with described the 4th hybrid chamber one end by transfer tube;
The other end of described the 4th hybrid chamber is provided with the outlet mutually of flowing.
Preferably, also comprise: comprise that cross section is square the 5th hybrid chamber and the 6th hybrid chamber, wherein:
Be filled with zirconium oxide bead in described the 5th hybrid chamber and the 6th hybrid chamber, and described the 5th hybrid chamber one end and described the 4th hybrid chamber flow mutually that outlet links to each other, the other end links to each other with described the 6th hybrid chamber one end by transfer tube;
The other end of described the 6th hybrid chamber is provided with the outlet mutually of flowing.
Preferably, the described first hybrid chamber liquid is provided with 2 or 4 mobile phase imports.
Preferably, described first hybrid chamber and second hybrid chamber are cylinder or cuboid.
Preferably, described the 3rd hybrid chamber and the 4th hybrid chamber are cylinder or cuboid.
Preferably, described the 5th hybrid chamber and the 6th hybrid chamber are cylinder or cuboid.
From above-mentioned technical scheme as can be seen, liquid phase gradient mixer disclosed by the invention, adopting cross section is that two hybrid chambers square and that be connected by transfer tube are as the container of mixed flow phase, mobile phase can take most of volume of blender, has solved the bigger problem of existing static mixer dead volume.
And the hybrid chamber of this blender adopts zirconium oxide bead to fill, zirconium oxide bead have wholely spend, smooth surface, density height, intensity are good, inertia, hard, stability is good, and advantages such as anti-strong acid and highly basic can play good mixed effect.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art, to do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below, apparently, accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills, under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the structural representation of the disclosed a kind of liquid phase gradient mixer of the embodiment of the invention;
Fig. 2 is the structural representation of the disclosed a kind of liquid phase gradient mixer of another embodiment of the present invention;
Fig. 3 is the structural representation of the disclosed a kind of liquid phase gradient mixer of yet another embodiment of the invention.
The specific embodiment
Below in conjunction with the accompanying drawing in the embodiment of the invention, the technical scheme in the embodiment of the invention is clearly and completely described, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiment.Based on the embodiment among the present invention, those of ordinary skills belong to the scope of protection of the invention not making the every other embodiment that obtains under the creative work prerequisite.
The embodiment of the invention discloses a kind of liquid phase gradient mixer, to solve the bigger problem of existing static mixer dead volume.
As shown in Figure 1, this liquid phase gradient mixer comprises: cross section is square first hybrid chamber 1 and second hybrid chamber 2, wherein:
Be filled with zirconium oxide bead 7 in first hybrid chamber 1 and second hybrid chamber 2, and an end of first hybrid chamber 1 is provided with the phase import of flowing, the other end links to each other with second hybrid chamber, 2 one ends by transfer tube, and the other end of second hybrid chamber 2 is provided with and mobilely exports 13 mutually.
And first hybrid chamber 1 and second hybrid chamber 2 can be cylinder or cuboid, and inside arranges the cavity of placing zirconium oxide bead.
According to the difference of blender mixed flow phase amount, can be divided into the gradient mixer that binary high pressure and quarternary low pressure mix, wherein: the binary high pressure refers to that two kinds flow and carry out high pressure mixing according to the ratios of setting, two mobile phase imports of blender needs; Quarternary low pressure refers to that four kinds flow and to carry out low pressure according to the ratios of setting and mix four mobile phase imports of blender needs.
For convenience of explanation, all illustrate with the binary high voltage style below.
Contrast Fig. 1, at this moment, the mobile phase import that is arranged on first hybrid chamber, one end of blender is divided into two, is respectively the first mobile phase import 11 and the second mobile import 12 mutually.Mobile phase A enters in first hybrid chamber, 1 body by the first mobile phase import 11, Mobile phase B enters in first hybrid chamber, 1 body by the second mobile phase import 12, under the extruding of the zirconium oxide bead 7 in being arranged on first mixing chamber 1, the effect of shearing, mobile phase A and Mobile phase B are constantly mixed, its mixed liquor flows in second hybrid chamber, 2 bodies by transfer tube, equally, under zirconium oxide bead extruding in being provided with second mixing chamber 2, the effect of shearing, mobile phase A and Mobile phase B continue to mix, and finally export 13 mutually by flowing and flow out.
Less from the mixing volume of phase mouthful 13 mixed liquors that flow out that flow, in order to increase the mixing volume of the phase that flows, improve the mixed effect of the phase that flows, another embodiment has been proposed earlier, as shown in Figure 2, the disclosed blender of present embodiment is compared with the disclosed blender of above-described embodiment, also comprise: cross section is the 3rd square hybrid chamber 3 and the 4th hybrid chamber 4, it specifically can be cylinder or cuboid equally, wherein: two hybrid chamber inside also are filled with zirconium oxide bead, one end of the 3rd hybrid chamber 3 is provided with transfer tube 14, this transfer tube exports 13 mutually and links to each other with flowing, the other end links to each other by the end of transfer tube with the 4th hybrid chamber 4, and the other end of the 4th hybrid chamber 4 is provided with to flow and exports 15 mutually.
At this moment, mobile phase A and Mobile phase B are through after the mixing of first, second hybrid chamber, directly not exporting 13 mutually by flowing flows out, but flow into transfer tube 14 along the direction of arrow, and then flow in the 3rd hybrid chamber 3, flowing in the 4th hybrid chamber 4 through transfer tube, finally exporting 15 mutually by flowing and flow out.
Equally, the mixed liquor of the zirconium oxide bead of the 3rd hybrid chamber 3 and the 4th hybrid chamber 4 continuation shearing, extruding mobile phase A and Mobile phase B mixes its continuation, and the formation mixability is higher, the bigger mixed liquor of mixing volume, and exports 15 outflows mutually by flowing.
In order to continue to strengthen the mixability of mobile phase, as shown in Figure 3, another embodiment of the present invention also discloses a kind of liquid phase gradient mixer, also comprise: cross section is square the 5th hybrid chamber 5 and the 6th hybrid chamber 6, wherein: be filled with zirconium oxide bead equally in two hybrid chambers, and, one end of the 5th hybrid chamber 5 is provided with transfer tube 16, this transfer tube exports 15 mutually and links to each other with flowing, the other end links to each other by the end of transfer tube with the 6th hybrid chamber 6, and the other end of the 6th hybrid chamber is provided with to flow and exports 17 mutually.
After the mixing through the first, second, third and the 4th hybrid chamber of mobile phase A and Mobile phase B, flow into transfer tube 16 along the direction of arrow again, and then flow in the 5th hybrid chamber 5, flowing in the 6th hybrid chamber 6 through transfer tube, finally export 17 mutually by flowing and flow out.
Shear at the zirconium oxide bead of the 5th hybrid chamber 5 and the 6th hybrid chamber 6, under the squeezing action, mobile phase A and Mobile phase B can fully be mixed, and form the mixed liquor that mixes the volume maximum, export 17 mutually by flowing and flow out.
Identical with above-mentioned two embodiment, the 5th hybrid chamber 5 and the 6th hybrid chamber 6 can be cylinder or cuboid.
In above-mentioned three embodiment, what fill in the hybrid chamber of blender is zirconium oxide bead, since its have whole spend, smooth surface, density height, intensity is good, inertia, hard, stability is good and advantages such as anti-strong acid and highly basic, can optimize the mixed effect of mobile phase A and Mobile phase B.
Each embodiment adopts the mode of going forward one by one to describe in this specification, and what each embodiment stressed is and the difference of other embodiment that identical similar part is mutually referring to getting final product between each embodiment.
Need to prove, in this article, relational terms such as first and second grades only is used for an entity or operation are made a distinction with another entity or operation, and not necessarily requires or hint and have the relation of any this reality or in proper order between these entities or the operation.
To the above-mentioned explanation of the disclosed embodiments, make this area professional and technical personnel can realize or use the present invention.Multiple modification to these embodiment will be apparent concerning those skilled in the art, and defined General Principle can realize under the situation that does not break away from the spirit or scope of the present invention in other embodiments herein.Therefore, the present invention will can not be restricted to these embodiment shown in this article, but will meet the wideest scope consistent with principle disclosed herein and features of novelty.
Claims (4)
1. a liquid phase gradient mixer is characterized in that, comprising: cross section is square first hybrid chamber and second hybrid chamber, wherein:
Be filled with zirconium oxide bead in described first hybrid chamber and second hybrid chamber, and an end of described first hybrid chamber is provided with the phase import of flowing, the other end links to each other with described second hybrid chamber, one end by transfer tube, and the other end of described second hybrid chamber is provided with the outlet mutually of flowing.
2. blender according to claim 1 is characterized in that, comprises that also cross section is square the 3rd hybrid chamber and the 4th hybrid chamber, wherein:
Be filled with zirconium oxide bead in described the 3rd hybrid chamber and the 4th hybrid chamber, and described the 3rd hybrid chamber one end and described second hybrid chamber flow mutually that outlet links to each other, the other end links to each other with described the 4th hybrid chamber one end by transfer tube;
The other end of described the 4th hybrid chamber is provided with the outlet mutually of flowing.
3. blender according to claim 2 is characterized in that, also comprises: comprise that cross section is square the 5th hybrid chamber and the 6th hybrid chamber, wherein:
Be filled with zirconium oxide bead in described the 5th hybrid chamber and the 6th hybrid chamber, and described the 5th hybrid chamber one end and described the 4th hybrid chamber flow mutually that outlet links to each other, the other end links to each other with described the 6th hybrid chamber one end by transfer tube;
The other end of described the 6th hybrid chamber is provided with the outlet mutually of flowing.
4. blender according to claim 1 is characterized in that, the described first hybrid chamber liquid is provided with 2 or 4 mobile phase imports.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010228411 CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010228411 CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
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| Publication Number | Publication Date |
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| CN102309933A CN102309933A (en) | 2012-01-11 |
| CN102309933B true CN102309933B (en) | 2013-09-04 |
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| CN 201010228411 Active CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104280488A (en) * | 2014-10-24 | 2015-01-14 | 王峰 | Static mixer for liquid chromatographic analyzer |
| US10295512B2 (en) | 2015-12-08 | 2019-05-21 | Dionex Corporation | Multi-lumen mixing device for chromatography |
| CN112740029B (en) * | 2018-11-14 | 2023-08-04 | 株式会社岛津制作所 | Low-pressure gradient liquid feeding system and liquid chromatograph |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176148A (en) * | 1997-06-24 | 1998-03-18 | 煤炭科学研究总院北京煤化学研究所 | Fluid mixer |
| CN201912899U (en) * | 2010-07-08 | 2011-08-03 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
-
2010
- 2010-07-08 CN CN 201010228411 patent/CN102309933B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176148A (en) * | 1997-06-24 | 1998-03-18 | 煤炭科学研究总院北京煤化学研究所 | Fluid mixer |
| CN201912899U (en) * | 2010-07-08 | 2011-08-03 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
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| Publication number | Publication date |
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| CN102309933A (en) | 2012-01-11 |
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