CN104280488A - Static mixer for liquid chromatographic analyzer - Google Patents
Static mixer for liquid chromatographic analyzer Download PDFInfo
- Publication number
- CN104280488A CN104280488A CN201410576826.2A CN201410576826A CN104280488A CN 104280488 A CN104280488 A CN 104280488A CN 201410576826 A CN201410576826 A CN 201410576826A CN 104280488 A CN104280488 A CN 104280488A
- Authority
- CN
- China
- Prior art keywords
- static mixer
- liquid phase
- chromatographic analyzer
- phase static
- adsorption stuffing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention belongs to the field of static mixers, and particularly relates to a static mixer for liquid chromatographic analyzer. The static mixer comprises an outer pipe (1) and a plurality of turbulent flow unit plates (3) which are arranged in the outer pipe (1), wherein sieve plates (5) are arranged between the adjacent turbulent flow unit plates (3); cavities between the turbulent flow unit plates (3) and the wall of the outer pipe (1) are filled with adsorption fillings (6); and the particle sizes of the adsorption fillings (6) are greater than the pore diameters of the sieve plates (5). According to the static mixer, the dead volume of the mixer can be decreased, the performance of gradient elution can be improved, the mobile phases can be purified on line and the blockage and the pollution of chromatographic columns and detectors can be prevented.
Description
Technical field
The invention belongs to static mixer field, be specifically related to a kind of chromatographic analyzer of liquid phase static mixer.
Background technology
Usually need in chromatographic applications to use two or more different solution, between pump and chromatographic column, therefore add the Blending Efficiency of Blending that static mixer increases fluid.Static mixer of the prior art as shown in Figure 1, comprises outer tube (1), the flange (2) being arranged on outer tube two ends and the multiple flow-disturbing cell boards (3) arranged within the outer tube; Or as shown in Figure 2, comprise outer tube (1) and multiple flow-disturbing cell boards (3) of passing through connecting link (4) within the outer tube and being connected are set.This type of static mixer cavity volume (dead volume) is large, in order to reach good analytical effect, generally should reduce the dead volume in static mixer as far as possible.
The siphunculus Lu Zhongchang of mobile phase or mobile phase contains the impurity such as unwanted organism, ion in addition, therefore between pump and chromatographic column, add clarifier in chromatographic applications carry out mobile phase pre-service, usually particle organism, ion being had to adsorptive power is filled with in described clarifier, but the cavity volume of static vortex mixer and clarifier (dead volume) all can affect the time delay of chromatogram gradient elution, thus impact analysis performance; When tandem static vortex mixer and clarifier use, need more joint to be connected with pipeline, therefore dead volume is larger; And series connection uses the failure rate that also can increase instrument; And manufacturing cost is high.Also have described clarifier to be filled by particulate matter, not quite identical due to grain size, after therefore using a period of time, granule is reset gradually, and the gap inside clarifier is blocked, thus cause clarifier hypertonia and cannot use.
Summary of the invention
For deficiency of the prior art, the present invention aims to provide a kind of chromatographic analyzer of liquid phase static mixer, and filling material occupies the segment space of mixer, thus minimizing dead volume, improve the performance of gradient elution, simultaneously can in-line purification mobile phase, the blocking of prevention chromatographic column and pollution.
For achieving the above object, technical scheme of the present invention is:
A kind of chromatographic analyzer of liquid phase static mixer, comprise outer tube and be placed in the multiple flow-disturbing cell boards in outer tube, the both sides of flow-disturbing cell board are provided with sieve plate, and be filled with adsorption stuffing in cavity between flow-disturbing cell board and outer tube wall, and the particle diameter of described adsorption stuffing is greater than the aperture of described sieve plate.
The mean grain size of described adsorption stuffing is 1 μm-500 μm, more preferably 3 microns-300 microns.
Described adsorption stuffing is preferably selected from one or more in silica gel and silica gel bonded group particle, zirconium dioxide particle, high molecular polymerization composition granule, graphitized carbon particle and zirconium dioxide binding groups particle, ion-exchange resin particles.
The material of sieve plate be preferably selected from sintered stainless steel, glass filter paper, large molecular porous material any one.
The connecting link for connecting flow-disturbing cell board is preferably provided with between described multiple flow-disturbing cell board.
The thickness of described sieve plate is less than 5mm.
The present invention will be further explained below:
The present invention's adsorption stuffing closely fills the gap between flow spoiler and tube wall because in the filler that fills occupy space in pipe, thus make vortex mixer internal volume less than conventional vortex mixer; Between flow-disturbing cell board, add sieve plate, make adsorption stuffing also be divided into several layers, the adsorption stuffing particle between different layers can not occur to reset and pile up, and avoids the gap between filler blocked, thus makes interior casting resin keep unimpeded, prevents line clogging; When fluid flows through flow spoiler, shear, eddy current, the effect such as convolution, realize mixing object; Fine and close adsorption stuffing can stop the insoluble particle in fluid, and adsorption stuffing according to the impurity such as organism, ion in filling adsorption performance adsorption fluid, therefore can form clean-up effect simultaneously.
The structure of flow-disturbing cell board can be varied, circular, semicircle, spiral fashion or other is irregularly shaped, as illustrated in figures 4-5.
Outer tube cross sectional shape can make circle, square or other is irregularly shaped.
The particle of adsorption stuffing can be spherical or other shape.
Compared with prior art, advantage of the present invention is:
1, static mixer of the present invention possesses mixing and purification function at same device simultaneously, reduces and installs complexity and mounting material.
2, in static mixer of the present invention, adsorption stuffing occupies the space of flow spoiler and tube wall, effective minimizing cavity dead volume, improve chromatographic system performance, for the static mixer that the vortex mixer cavity volume of Shimadzu Corporation is 2.7mL, if after filling adsorption stuffing, dead volume can drop to below 0.6mL.
3, static mixer of the present invention has sandwich construction, fills rearrangement and the accumulation of adsorption stuffing in can preventing, thus makes interior casting resin keep unimpeded, prevents line clogging.
4, in static mixer of the present invention, thin footpath adsorption stuffing can increase the contact surface area of fluid, contributes to improving Blending Efficiency of Blending.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of static mixer in prior art;
Fig. 2 is the inner structure schematic diagram of another kind of static mixer in prior art;
Fig. 3 is the inner structure schematic diagram of a kind of chromatographic analyzer of liquid phase static mixer of the present invention;
Fig. 4 is a kind of structural representation of flow-disturbing cell board;
Fig. 5 is the another kind of structural representation of flow-disturbing cell board;
Wherein, 1 is outer tube, and 2 is flanges, and 3 is flow-disturbing cell boards, and 4 is connecting links, and 5 is sieve plates, and 6 is adsorption stuffings.
Embodiment
Below in conjunction with drawings and Examples, the present invention is described further.
As shown in Figure 3, a kind of chromatographic analyzer of liquid phase static mixer, comprise outer tube 1 and the multiple flow-disturbing cell boards 3 be connected by connecting link 4 be placed in outer tube, between adjacent two flow-disturbing cell boards 3 or in the both sides of flow-disturbing cell board 3, be provided with sieve plate 5, and use the cationic exchange resin adsorption filler 6 of particle mean size 10 μm to fill cavity in outer tube 1.The particle diameter of described adsorption stuffing is greater than the aperture of described sieve plate.
Described adsorption stuffing 6 also can be one or more in silica gel, ion exchange resin, graphitized carbon, macromolecule polymer material.
The material of described sieve plate 5 be selected from sintered stainless steel, glass filter paper, large molecular porous material any one.
Effect data:
Choose the conventional static mixer of 3 kinds of different inner volumes, use nitrogen purge internal solution, weigh to obtain weight W1, after inner injection distilled water solution, weigh to obtain weight W2 after being full of, and static mixer internal volume calculates by V=(W2-W1)/ρ (ρ is the density of distilled water).
Adopt the principle of the invention, fill in above-mentioned static mixer ODP ?4H adsorption stuffing, in like manner measure internal volume, the results are shown in Table 1, illustrate that the present invention can effectively reduce static mixer internal dead volumes.
| ? | Conventional static mixer 1 | Conventional static mixer 2 | Conventional static mixer 3 |
| Dead volume | 2.75ml | 1.5ml | 0.5ml |
| ? | Interior casting resin static mixer 1 | Interior casting resin static mixer 2 | Interior casting resin static mixer 3 |
| Dead volume | 0.42ml | 0.29ml | 0.09ml |
Claims (7)
1. a chromatographic analyzer of liquid phase static mixer, comprise outer tube (1) and be placed in the multiple flow-disturbing cell boards (3) in outer tube, it is characterized in that, sieve plate (5) is provided with between adjacent two flow-disturbing cell boards (3), and be filled with adsorption stuffing (6) in cavity between flow-disturbing cell board (3) and outer tube (1) tube wall, and the particle diameter of described adsorption stuffing (6) is greater than the aperture of described sieve plate (5).
2. chromatographic analyzer of liquid phase static mixer according to claim 1, it is characterized in that, the mean grain size of described adsorption stuffing (6) is 1 μm-500 μm.
3. chromatographic analyzer of liquid phase static mixer according to claim 1 or 2, is characterized in that, the mean grain size of described adsorption stuffing (6) is 3 μm-300 μm.
4. chromatographic analyzer of liquid phase static mixer according to claim 1 or 2, it is characterized in that, described adsorption stuffing (6) is selected from silica gel and silica gel bonded group particle, zirconium dioxide particle, high molecular polymerization composition granule, graphitized carbon particle and zirconium dioxide binding groups particle, ion-exchange resin particles.
5. chromatographic analyzer of liquid phase static mixer according to claim 1 or 2, is characterized in that, the material of sieve plate (5) be selected from sintered stainless steel, glass filter paper, large molecular porous material any one.
6. chromatographic analyzer of liquid phase static mixer according to claim 1 or 2, is characterized in that, is provided with the connecting link (4) for connecting flow-disturbing cell board (3) between described multiple flow-disturbing cell board (3).
7. chromatographic analyzer of liquid phase static mixer according to claim 1 or 2, is characterized in that, the thickness of described sieve plate (5) is less than 5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410576826.2A CN104280488A (en) | 2014-10-24 | 2014-10-24 | Static mixer for liquid chromatographic analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410576826.2A CN104280488A (en) | 2014-10-24 | 2014-10-24 | Static mixer for liquid chromatographic analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104280488A true CN104280488A (en) | 2015-01-14 |
Family
ID=52255576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410576826.2A Pending CN104280488A (en) | 2014-10-24 | 2014-10-24 | Static mixer for liquid chromatographic analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104280488A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106855550A (en) * | 2015-12-08 | 2017-06-16 | 戴安公司 | For many tube chamber mixing arrangements of chromatogram |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3861652A (en) * | 1972-11-15 | 1975-01-21 | Du Pont | Mixing device |
| US4686089A (en) * | 1985-02-26 | 1987-08-11 | Wiederaufarbeitungsanlage Karlsruhe Betriebsgesellschaft Mbh | Sieve-plate column for counterflow extraction |
| US5032156A (en) * | 1988-11-01 | 1991-07-16 | Sulzer Brothers Limited | Device for performing a sorption process |
| EP0289755B1 (en) * | 1987-05-04 | 1991-09-04 | GebràDer Sulzer Aktiengesellschaft | Absorption column for the chromatographic separation of mixtures of substances |
| CN1669626A (en) * | 2004-02-23 | 2005-09-21 | 希尔蒂股份公司 | Static mixer and application thereof |
| JP2010247348A (en) * | 2009-04-10 | 2010-11-04 | Atect Corp | Method of manufacturing static mixer |
| CN202052482U (en) * | 2011-03-03 | 2011-11-30 | 北京清博华科技有限公司 | Static mixer |
| CN102309933A (en) * | 2010-07-08 | 2012-01-11 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
| CN203385703U (en) * | 2013-07-19 | 2014-01-08 | 安徽皖仪科技股份有限公司 | Ion chromatography gradient static mixer |
| CN204116295U (en) * | 2014-10-24 | 2015-01-21 | 王峰 | A kind of chromatographic analyzer of liquid phase static mixer |
-
2014
- 2014-10-24 CN CN201410576826.2A patent/CN104280488A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3861652A (en) * | 1972-11-15 | 1975-01-21 | Du Pont | Mixing device |
| US4686089A (en) * | 1985-02-26 | 1987-08-11 | Wiederaufarbeitungsanlage Karlsruhe Betriebsgesellschaft Mbh | Sieve-plate column for counterflow extraction |
| EP0289755B1 (en) * | 1987-05-04 | 1991-09-04 | GebràDer Sulzer Aktiengesellschaft | Absorption column for the chromatographic separation of mixtures of substances |
| US5032156A (en) * | 1988-11-01 | 1991-07-16 | Sulzer Brothers Limited | Device for performing a sorption process |
| CN1669626A (en) * | 2004-02-23 | 2005-09-21 | 希尔蒂股份公司 | Static mixer and application thereof |
| JP2010247348A (en) * | 2009-04-10 | 2010-11-04 | Atect Corp | Method of manufacturing static mixer |
| CN102309933A (en) * | 2010-07-08 | 2012-01-11 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
| CN202052482U (en) * | 2011-03-03 | 2011-11-30 | 北京清博华科技有限公司 | Static mixer |
| CN203385703U (en) * | 2013-07-19 | 2014-01-08 | 安徽皖仪科技股份有限公司 | Ion chromatography gradient static mixer |
| CN204116295U (en) * | 2014-10-24 | 2015-01-21 | 王峰 | A kind of chromatographic analyzer of liquid phase static mixer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106855550A (en) * | 2015-12-08 | 2017-06-16 | 戴安公司 | For many tube chamber mixing arrangements of chromatogram |
| CN106855550B (en) * | 2015-12-08 | 2018-07-13 | 戴安公司 | Multitube chamber mixing arrangement for chromatography |
| US10295512B2 (en) | 2015-12-08 | 2019-05-21 | Dionex Corporation | Multi-lumen mixing device for chromatography |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204116295U (en) | A kind of chromatographic analyzer of liquid phase static mixer | |
| KR100862940B1 (en) | Fluid distribution apparatus | |
| Petro et al. | Molded monolithic rod of macroporous poly (styrene-co-divinylbenzene) as a separation medium for HPLC of synthetic polymers:“On-Column” precipitation− redissolution chromatography as an alternative to size exclusion chromatography of styrene oligomers and polymers | |
| Gu et al. | Efficient polymer monolith for strong cation-exchange capillary liquid chromatography of peptides | |
| CN104254376A (en) | Composite ion exchange media for liquid filtration sytems | |
| JP2010008410A (en) | Chromatographic apparatus | |
| US20040129641A1 (en) | Distributing or collecting device | |
| Li et al. | Preparation of polymer monoliths that exhibit size exclusion properties for proteins and peptides | |
| Rozenbrand et al. | Silica‐based and organic monolithic capillary columns for LC: Recent trends in proteomics | |
| Wang et al. | Enhanced adsorption capacity of cryogel bed by incorporating polymeric resin particles | |
| Ghose et al. | Characterization and modeling of monolithic stationary phases: application to preparative chromatography | |
| CN104280488A (en) | Static mixer for liquid chromatographic analyzer | |
| Masini | Semi‐micro reversed‐phase liquid chromatography for the separation of alkyl benzenes and proteins exploiting methacrylate‐and polystyrene‐based monolithic columns | |
| Li et al. | Poly [hydroxyethyl acrylate-co-poly (ethylene glycol) diacrylate] Monolithic Column for Efficient Hydrophobic Interaction Chromatography of Proteins | |
| Lin et al. | Methacrylate‐based monolithic column with mixed‐mode hydrophilic interaction/strong cation‐exchange stationary phase for capillary liquid chromatography and pressure‐assisted CEC | |
| CN110108809B (en) | Method for measuring fine sesame drugs | |
| CN102659859B (en) | Application of monodispersed polymethacrylate ion exchange chromatography medium in column chromatography purification of fondaparinux sodium | |
| Podgornik | Pressure drop in liquid chromatography | |
| Inglezakis et al. | Liquid holdup and flow dispersion in zeolite packed beds | |
| US9897578B2 (en) | Chromatography columns | |
| Nordborg et al. | Extending the array of crosslinkers suitable for the preparation of polymethacrylate‐based monoliths | |
| CN112924604B (en) | Ion pair purifying column | |
| Zhu et al. | Zeolitic imidazolate framework‐8 as a dispersive solid phase extraction sorbent for simultaneous determination of 145 pesticide residues in polyphenol‐rich plants | |
| Podgornik | Characterization of a convection‐based support microstructure through a flow resistance parameter | |
| Da’na et al. | Modeling adsorption of copper on amine-functionalized SBA-15: predicting breakthrough curves |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150114 |