CN102309933A - Liquid phase gradient mixer - Google Patents
Liquid phase gradient mixer Download PDFInfo
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- CN102309933A CN102309933A CN2010102284118A CN201010228411A CN102309933A CN 102309933 A CN102309933 A CN 102309933A CN 2010102284118 A CN2010102284118 A CN 2010102284118A CN 201010228411 A CN201010228411 A CN 201010228411A CN 102309933 A CN102309933 A CN 102309933A
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Abstract
The invention discloses a liquid phase gradient mixer, comprising a first mixing chamber and a second mixing cavity, wherein the cross sections of the two mixing cavities are square; the first mixing chamber and the second mixing cavity are filled with zirconia beads; one end of the first mixing chamber is provided with a flowing phase inlet; the other end is connected with one end of the second mixing chamber via a transmission pipe; and the other end of the second mixing chamber is provided with a flowing phase outlet. In the liquid phase gradient mixer disclosed by the invention, the two mixing chambers of which the cross sections are square are adopted to serve as the containers of mixed flowing phase, wherein the two mixing chambers are connected by the transmission pipe, the flowing phase can occupy most area of the mixer, and therefore the problem of larger dead volume of the traditional static mixer is solved.
Description
Technical field
The present invention relates to the liquid-phase chromatographic analysis technical field, more particularly, relate to a kind of liquid phase gradient mixer.
Background technology
In the binary gradient elution device, two kinds of different solvents mix at gradient mixer after two high pressure pump superchargings, and mixed flowing phase gets into sampling valve and chromatographic column again.
High pressure liquid phase gradient blender mainly contains two types of static mixer and dynamic mixers.Wherein: said dynamic mixer is meant the parts that in housing or pipeline, are provided with the high speed rotation, and fluid produces very big shearing force under the effect of high-speed rotary part, and different fluid realizes mixing under the effect of shearing force.Said static mixer is named with respect to the dynamic agitation blender, and its internals is motion not, but relies on the power of fluid itself, and each hybrid element in the blender of flowing through is to reach the purpose of mixing.Concrete, indissoluble or immiscible material receive constraints such as flow channel shape and changes of section, and motions such as stirring are sheared, are rotated at generation shunting cutting, interflow, reach good dispersion and mixed effect at last.
Existing static mixer is mainly rich cast blender, is a kind of circular stainless steel tube of having mercy on into, yet because it is a toroidal, dead volume is bigger.
Summary of the invention
In view of this, the present invention provides a kind of liquid phase gradient mixer, to solve the bigger problem of existing static mixer dead volume.
For addressing the above problem, the technical scheme of proposition is following:
A kind of liquid phase gradient mixer comprises: cross section is square first hybrid chamber and second hybrid chamber, wherein:
Be filled with zirconium oxide bead in said first hybrid chamber and second hybrid chamber; And an end of said first hybrid chamber is provided with the flowing phase import; The other end links to each other with said second hybrid chamber, one end through transfer tube, and the other end of said second hybrid chamber is provided with the flowing phase outlet.
Preferably, comprise that also cross section is square the 3rd hybrid chamber and the 4th hybrid chamber, wherein:
Be filled with zirconium oxide bead in said the 3rd hybrid chamber and the 4th hybrid chamber, and the outlet of the flowing phase of said the 3rd hybrid chamber one end and said second hybrid chamber links to each other, the other end passes through transfer tube and links to each other with said the 4th hybrid chamber one end;
The other end of said the 4th hybrid chamber is provided with the flowing phase outlet.
Preferably, also comprise: comprise that cross section is square the 5th hybrid chamber and the 6th hybrid chamber, wherein:
Be filled with zirconium oxide bead in said the 5th hybrid chamber and the 6th hybrid chamber, and the outlet of the flowing phase of said the 5th hybrid chamber one end and said the 4th hybrid chamber links to each other, the other end passes through transfer tube and links to each other with said the 6th hybrid chamber one end;
The other end of said the 6th hybrid chamber is provided with the flowing phase outlet.
Preferably, the said first hybrid chamber liquid is provided with 2 or 4 flowing phase imports.
Preferably, said first hybrid chamber and second hybrid chamber are cylinder or cuboid.
Preferably, said the 3rd hybrid chamber and the 4th hybrid chamber are cylinder or cuboid.
Preferably, said the 5th hybrid chamber and the 6th hybrid chamber are cylinder or cuboid.
Can find out from above-mentioned technical scheme; Liquid phase gradient mixer disclosed by the invention; Adopting cross section is the containers of two hybrid chambers square and that be connected through transfer tube as the mixed flow phase; Flowing phase can take most of volume of blender, has solved the bigger problem of existing static mixer dead volume.
And the hybrid chamber of this blender adopts zirconium oxide bead to fill, zirconium oxide bead have wholely spend, smooth surface, density height, intensity are good, inertia, hard, stability is good, and advantages such as anti-strong acid and highly basic can play good mixed effect.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art; To do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below; Obviously, the accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills; Under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the structural representation of the disclosed a kind of liquid phase gradient mixer of the embodiment of the invention;
Fig. 2 is the structural representation of the disclosed a kind of liquid phase gradient mixer of another embodiment of the present invention;
Fig. 3 is the structural representation of the disclosed a kind of liquid phase gradient mixer of yet another embodiment of the invention.
The specific embodiment
To combine the accompanying drawing in the embodiment of the invention below, the technical scheme in the embodiment of the invention is carried out clear, intactly description, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiment.Based on the embodiment among the present invention, those of ordinary skills are not making the every other embodiment that is obtained under the creative work prerequisite, all belong to the scope of the present invention's protection.
The embodiment of the invention discloses a kind of liquid phase gradient mixer, to solve the bigger problem of existing static mixer dead volume.
As shown in Figure 1, this liquid phase gradient mixer comprises: cross section is square first hybrid chamber 1 and second hybrid chamber 2, wherein:
Be filled with zirconium oxide bead 7 in first hybrid chamber 1 and second hybrid chamber 2, and an end of first hybrid chamber 1 is provided with the flowing phase import, the other end links to each other with second hybrid chamber, 2 one ends through transfer tube, and the other end of second hybrid chamber 2 is provided with flowing phase and exports 13.
And first hybrid chamber 1 and second hybrid chamber 2 can be cylinder or cuboid, and set inside is placed the cavity of zirconium oxide bead.
According to the difference of mixer mixing flowing phase quantity, can be divided into the gradient mixer that binary high pressure and quarternary low pressure mix, wherein: the binary high pressure is meant that two kinds of flowing phases carry out high pressure mixing according to the ratio of setting, and blender needs two flowing phase imports; Quarternary low pressure is meant that four kinds of flowing phases carry out low pressure according to the ratio of setting and mix, and blender needs four flowing phase imports.
For the ease of explanation, below all illustrate with the binary high voltage style.
Map 1, at this moment, the flowing phase import that is arranged on first hybrid chamber, one end of blender is divided into two, is respectively the first flowing phase import 11 and the second flowing phase import 12.Mobile phase A gets in first hybrid chamber, 1 body through the first flowing phase import 11; Mobile phase B gets in first hybrid chamber, 1 body through the second flowing phase import 12; Under the extruding of the zirconium oxide bead 7 in being arranged on first mixing chamber 1, the effect of shearing, mobile phase A and Mobile phase B are constantly mixed, and its mixed liquor flows in second hybrid chamber, 2 bodies through transfer tube; Equally; Under zirconium oxide bead extruding in being provided with second mixing chamber 2, the effect of shearing, mobile phase A and Mobile phase B continue to mix, and finally flow out through flowing phase outlet 13.
The mixing volume of the mixed liquor that flows out from flowing phase mouth 13 is less, in order to increase the mixing volume of flowing phase, improves the mixed effect of flowing phase; Another embodiment has been proposed earlier; As shown in Figure 2, the disclosed blender of present embodiment is compared with the disclosed blender of the foregoing description, also comprises: cross section is the 3rd square hybrid chamber 3 and the 4th hybrid chamber 4; It specifically can be cylinder or cuboid equally; Wherein: two hybrid chamber inside also are filled with zirconium oxide bead, and an end of the 3rd hybrid chamber 3 is provided with transfer tube 14, and this transfer tube links to each other with flowing phase outlet 13; The other end links to each other with an end of the 4th hybrid chamber 4 through transfer tube, and the other end of the 4th hybrid chamber 4 is provided with flowing phase outlet 15.
At this moment; Mobile phase A and Mobile phase B are through after the mixing of first, second hybrid chamber; Directly do not flow out, but flow into transfer tube 14, and then flow in the 3rd hybrid chamber 3 along the direction of arrow through flowing phase outlet 13; Flowing in the 4th hybrid chamber 4 through transfer tube, finally flowing out through flowing phase outlet 15.
Equally, the mixed liquor of the zirconium oxide bead of the 3rd hybrid chamber 3 and the 4th hybrid chamber 4 continuation shearing, extruding mobile phase A and Mobile phase B makes it continue to mix, and the formation mixability is higher, the bigger mixed liquor of mixing volume, and flows out through flowing phase outlet 15.
In order to continue to strengthen the mixability of flowing phase; As shown in Figure 3, another embodiment of the present invention also discloses a kind of liquid phase gradient mixer, also comprises: cross section is square the 5th hybrid chamber 5 and the 6th hybrid chamber 6; Wherein: be filled with zirconium oxide bead equally in two hybrid chambers; And an end of the 5th hybrid chamber 5 is provided with transfer tube 16, and this transfer tube links to each other with flowing phase outlet 15; The other end links to each other with an end of the 6th hybrid chamber 6 through transfer tube, and the other end of the 6th hybrid chamber is provided with flowing phase outlet 17.
After the mixing of mobile phase A and Mobile phase B through the first, second, third and the 4th hybrid chamber; Flow into transfer tube 16 along the direction of arrow again; And then flow in the 5th hybrid chamber 5, flowing in the 6th hybrid chamber 6 through transfer tube, finally flow out through flowing phase outlet 17.
Shear at the zirconium oxide bead of the 5th hybrid chamber 5 and the 6th hybrid chamber 6, under the squeezing action, mobile phase A and Mobile phase B can be formed and mix volume maximum mixed liquid, through flowing phase outlet 17 outflows by abundant mixing.
Identical with above-mentioned two embodiment, the 5th hybrid chamber 5 and the 6th hybrid chamber 6 can be cylinder or cuboid.
In above-mentioned three embodiment; What fill in the hybrid chamber of blender is zirconium oxide bead; Since its have whole spend, smooth surface, density height, intensity is good, inertia, hard, stability is good and advantages such as anti-strong acid and highly basic, can optimize the mixed effect of mobile phase A and Mobile phase B.
Each embodiment adopts the mode of going forward one by one to describe in this specification, and what each embodiment stressed all is and the difference of other embodiment that identical similar part is mutually referring to getting final product between each embodiment.
Need to prove; In this article; Relational terms such as first and second grades only is used for an entity or operation are made a distinction with another entity or operation, and not necessarily requires or hint relation or the order that has any this reality between these entities or the operation.
To the above-mentioned explanation of the disclosed embodiments, make this area professional and technical personnel can realize or use the present invention.Multiple modification to these embodiment will be conspicuous concerning those skilled in the art, and defined General Principle can realize under the situation that does not break away from the spirit or scope of the present invention in other embodiments among this paper.Therefore, the present invention will can not be restricted to these embodiment shown in this paper, but will meet and principle disclosed herein and features of novelty the wideest corresponding to scope.
Claims (7)
1. a liquid phase gradient mixer is characterized in that, comprising: cross section is square first hybrid chamber and second hybrid chamber, wherein:
Be filled with zirconium oxide bead in said first hybrid chamber and second hybrid chamber; And an end of said first hybrid chamber is provided with the flowing phase import; The other end links to each other with said second hybrid chamber, one end through transfer tube, and the other end of said second hybrid chamber is provided with the flowing phase outlet.
2. blender according to claim 1 is characterized in that, comprises that also cross section is square the 3rd hybrid chamber and the 4th hybrid chamber, wherein:
Be filled with zirconium oxide bead in said the 3rd hybrid chamber and the 4th hybrid chamber, and the outlet of the flowing phase of said the 3rd hybrid chamber one end and said second hybrid chamber links to each other, the other end passes through transfer tube and links to each other with said the 4th hybrid chamber one end;
The other end of said the 4th hybrid chamber is provided with the flowing phase outlet.
3. blender according to claim 2 is characterized in that, also comprises: comprise that cross section is square the 5th hybrid chamber and the 6th hybrid chamber, wherein:
Be filled with zirconium oxide bead in said the 5th hybrid chamber and the 6th hybrid chamber, and the outlet of the flowing phase of said the 5th hybrid chamber one end and said the 4th hybrid chamber links to each other, the other end passes through transfer tube and links to each other with said the 6th hybrid chamber one end;
The other end of said the 6th hybrid chamber is provided with the flowing phase outlet.
4. blender according to claim 1 is characterized in that, the said first hybrid chamber liquid is provided with 2 or 4 flowing phase imports.
5. blender according to claim 1 is characterized in that, said first hybrid chamber and second hybrid chamber are cylinder or cuboid.
6. blender according to claim 2 is characterized in that, said the 3rd hybrid chamber and the 4th hybrid chamber are cylinder or cuboid.
7. blender according to claim 3 is characterized in that, said the 5th hybrid chamber and the 6th hybrid chamber are cylinder or cuboid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010228411 CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010228411 CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
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| Publication Number | Publication Date |
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| CN102309933A true CN102309933A (en) | 2012-01-11 |
| CN102309933B CN102309933B (en) | 2013-09-04 |
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| CN 201010228411 Active CN102309933B (en) | 2010-07-08 | 2010-07-08 | Liquid phase gradient mixer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104280488A (en) * | 2014-10-24 | 2015-01-14 | 王峰 | Static mixer for liquid chromatographic analyzer |
| CN106855550A (en) * | 2015-12-08 | 2017-06-16 | 戴安公司 | For many tube chamber mixing arrangements of chromatogram |
| CN112740029A (en) * | 2018-11-14 | 2021-04-30 | 株式会社岛津制作所 | Low-pressure gradient liquid feeding system and liquid chromatograph |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176148A (en) * | 1997-06-24 | 1998-03-18 | 煤炭科学研究总院北京煤化学研究所 | Fluid mixer |
| CN201912899U (en) * | 2010-07-08 | 2011-08-03 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
-
2010
- 2010-07-08 CN CN 201010228411 patent/CN102309933B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1176148A (en) * | 1997-06-24 | 1998-03-18 | 煤炭科学研究总院北京煤化学研究所 | Fluid mixer |
| CN201912899U (en) * | 2010-07-08 | 2011-08-03 | 江苏天瑞仪器股份有限公司 | Liquid phase gradient mixer |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104280488A (en) * | 2014-10-24 | 2015-01-14 | 王峰 | Static mixer for liquid chromatographic analyzer |
| CN106855550A (en) * | 2015-12-08 | 2017-06-16 | 戴安公司 | For many tube chamber mixing arrangements of chromatogram |
| CN106855550B (en) * | 2015-12-08 | 2018-07-13 | 戴安公司 | Multitube chamber mixing arrangement for chromatography |
| US10295512B2 (en) | 2015-12-08 | 2019-05-21 | Dionex Corporation | Multi-lumen mixing device for chromatography |
| CN112740029A (en) * | 2018-11-14 | 2021-04-30 | 株式会社岛津制作所 | Low-pressure gradient liquid feeding system and liquid chromatograph |
| CN112740029B (en) * | 2018-11-14 | 2023-08-04 | 株式会社岛津制作所 | Low-pressure gradient liquid feeding system and liquid chromatograph |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102309933B (en) | 2013-09-04 |
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