CN102293331A - Feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes - Google Patents
Feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes Download PDFInfo
- Publication number
- CN102293331A CN102293331A CN2011101613150A CN201110161315A CN102293331A CN 102293331 A CN102293331 A CN 102293331A CN 2011101613150 A CN2011101613150 A CN 2011101613150A CN 201110161315 A CN201110161315 A CN 201110161315A CN 102293331 A CN102293331 A CN 102293331A
- Authority
- CN
- China
- Prior art keywords
- feed
- vitamin
- liver
- marine fish
- gall syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 36
- 210000004185 liver Anatomy 0.000 title claims abstract description 21
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 21
- 235000016709 nutrition Nutrition 0.000 title abstract description 5
- 239000003674 animal food additive Substances 0.000 title abstract 3
- 239000002994 raw material Substances 0.000 claims abstract description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 8
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 7
- 235000009566 rice Nutrition 0.000 claims abstract description 7
- 230000002265 prevention Effects 0.000 claims abstract description 5
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims abstract description 4
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims abstract description 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 4
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 4
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 4
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 4
- 239000003613 bile acid Substances 0.000 claims abstract description 4
- 229960000304 folic acid Drugs 0.000 claims abstract description 4
- 235000019152 folic acid Nutrition 0.000 claims abstract description 4
- 239000011724 folic acid Substances 0.000 claims abstract description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229960000367 inositol Drugs 0.000 claims abstract description 4
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims abstract description 4
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 4
- 239000011709 vitamin E Substances 0.000 claims abstract description 4
- 229940046009 vitamin E Drugs 0.000 claims abstract description 4
- 241000209094 Oryza Species 0.000 claims description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 3
- 229930003451 Vitamin B1 Natural products 0.000 claims description 3
- 229930003471 Vitamin B2 Natural products 0.000 claims description 3
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 3
- 235000010374 vitamin B1 Nutrition 0.000 claims description 3
- 239000011691 vitamin B1 Substances 0.000 claims description 3
- 235000019164 vitamin B2 Nutrition 0.000 claims description 3
- 239000011716 vitamin B2 Substances 0.000 claims description 3
- 235000019158 vitamin B6 Nutrition 0.000 claims description 3
- 239000011726 vitamin B6 Substances 0.000 claims description 3
- 229940011671 vitamin b6 Drugs 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 241001596950 Larimichthys crocea Species 0.000 abstract description 2
- 241001417495 Serranidae Species 0.000 abstract description 2
- 229930003270 Vitamin B Natural products 0.000 abstract 3
- 235000019156 vitamin B Nutrition 0.000 abstract 3
- 239000011720 vitamin B Substances 0.000 abstract 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- 240000007594 Oryza sativa Species 0.000 abstract 1
- 241000269810 Pagrus Species 0.000 abstract 1
- 241001290266 Sciaenops ocellatus Species 0.000 abstract 1
- 241000719209 Trachinotus ovatus Species 0.000 abstract 1
- 235000012041 food component Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000009360 aquaculture Methods 0.000 description 5
- 244000144974 aquaculture Species 0.000 description 5
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 239000013535 sea water Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 241000276694 Carangidae Species 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 241001417534 Lutjanidae Species 0.000 description 1
- 241000269799 Perca fluviatilis Species 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
A feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes is prepared from the following raw materials in percentage by weight, based on the addition of each ton of feed, in terms of pure product: 800-1500 g of vitamin E; 400-1000 g of L-carnitine; 600-2000 g of bile acid; 110-30 g of vitamin B; 215-30 g of vitamin B; 615-30 g of vitamin B; 2-10 g of folic acid; 120-800 g of inositol; 10-50 g of antioxidant; 2000-8000 g of defatted rice bran with 80-mesh fineness. The long-term culture test of marine fishes such as weever, large yellow croaker, American red fish, Pagrus fish, trachinotus ovatus, grouper and the like proves that the feed additive has good treatment or prevention effect on the nutritional liver and gall syndrome of various high-density cultured marine fishes; the main components of the feed are nutritional components required by the culture of the marine fishes, and the feed is safe and efficient to use for a long time, has no toxic or side effect, and has strong vitality of cultured objects, rapid growth, high feed conversion rate and good culture benefit.
Description
Technical field
The present invention relates to a kind of feed addictive, particularly a kind of feed addictive of preventing and treating marine fish auxotype liver and gall syndrome.
Background technology
China is the No.1 big country of world's aquaculture, also is the country that unique in the world cultured output surpasses fishery output, and aquaculture occupies considerable status in national economy.In recent years, China's aquaculture cause is flourish, especially is that the 4th aquaculture tide of representative is in the ascendant with the marine fish culture.Yet because at present international abundant inadequately with the research of domestic relevant seawater fish nutrition, its feed formula and additive are mostly with reference to other close aquaculture kind or decide by rule of thumb; Simultaneously, because the incorrect raising of culturist and the mode of throwing something and feeding, cause present marine fish feed coefficient generally higher, disease ubiquity and frequent outbursts such as marine fish liver and gall syndrome greatly reduce survival rate and the economic benefit of breeding seawater fish.This kind situation has seriously hindered further developing of marine fish culture industry.
Summary of the invention
The objective of the invention is provides a kind of feed addictive of preventing and treating marine fish auxotype liver and gall syndrome in order to remedy the above-mentioned deficiency of prior art.
To achieve these goals, the technical scheme that the present invention takes is: the feed addictive of this control marine fish auxotype liver and gall syndrome is to be made by the raw material of following weight ratio, is benchmark with the addition of feed per ton, in pure product:
The feed addictive of described control marine fish auxotype liver and gall syndrome, interpolation weight in marine fish feed per ton is 5-10kg, charging sequence is that every kind of raw material fully mix respectively with the partially skimmed rice bran earlier, and then all premixed raw material unifications are mixed and prevent classification, finally promptly obtain the feed addictive of control marine fish auxotype liver and gall syndrome of the present invention.
The feed addictive of described control marine fish auxotype liver and gall syndrome, the weight ratio of each raw material be, is its standard with the addition of feed per ton, in pure product:
Vitamin E 1200g l-cn 800g bile acid 1000g vitamin B1 16g
Vitamin B2 25g vitamin B6 30g folic acid 8g inositol 600g
Antioxidant 10g 80 order fineness defatted rice bran 6311g;
The feed addictive of described control marine fish auxotype liver and gall syndrome, the addition in marine fish feed per ton is: treatment stage adds 10 kilograms, and the prevention stage is added 5 kilograms.
Advantage of the present invention: (1) this additive raw material steady sources, at marine fish auxotype fatty liver, short-term is used can play therapeutic action; Reduce by half for a long time to use and to play prevention effect.(2) this additive long-term safe in utilization efficient, have no side effect, it is energetic to culture object, growth rapidly, the feed conversion rate height, culture benefit is good.
The specific embodiment
The feed addictive of this control marine fish auxotype liver and gall syndrome is formulated as follows, and it is that addition in feed per ton is benchmark (with pure product): accurately take by weighing vitamin E 1200g; L-cn 800g; Bile acid 1000g; Vitamin B1 16g: vitamin B2 25g; Vitamin B6 30g; Folic acid 8g; Inositol 600 g; Antioxidant 10g; 80 order fineness defatted rice bran 6311g.Charging sequence is that every kind of raw material fully mix respectively with the partially skimmed rice bran earlier, and then all premixed raw material unifications are mixed and prevent classification, finally promptly obtain the feed addictive of control marine fish auxotype liver and gall syndrome of the present invention.The addition of this product in marine fish feed per ton is: treatment stage adds 10 kilograms, and the prevention stage is added 5 kilograms.
Through proving at long-term culture experiments of seawater fish such as perch, large yellow croaker, U.S. snapper, sparid class, egg-shaped pompano and groupers, the feed addictive of control marine fish auxotype liver and gall syndrome of the present invention all has good curing or preventive effect to the auxotype liver and gall syndrome of multiple high-density breeding seawater fish; This additive main component is marine fish culture desired nutritional composition, long-term safe in utilization efficient, have no side effect, it is energetic to culture object, growth rapidly, the feed conversion rate height, culture benefit is good.
Claims (2)
1. feed addictive of preventing and treating marine fish auxotype liver and gall syndrome, it is characterized in that: it is to be made by the raw material of following weight ratio, is benchmark with the addition of feed per ton, in pure product:
The feed addictive of described control marine fish auxotype liver and gall syndrome, interpolation weight in marine fish feed per ton is 5-10kg, charging sequence is that every kind of raw material fully mix respectively with the partially skimmed rice bran earlier, and then all premixed raw material unifications are mixed and prevent classification, finally promptly obtain the feed addictive of control marine fish auxotype liver and gall syndrome of the present invention.
2. the feed addictive of control marine fish auxotype liver and gall syndrome according to claim 1 is characterized in that: the weight ratio of each raw material is, is its standard with the addition of feed per ton, in pure product:
Vitamin E 1200g l-cn 800g bile acid 1000g vitamin B1 16g
Vitamin B2 25g vitamin B6 30g folic acid 8g inositol 600g
Antioxidant 10g 80 order fineness defatted rice bran 6311g;
The feed addictive of described control marine fish auxotype liver and gall syndrome, the addition in marine fish feed per ton is: treatment stage adds 10 kilograms, and the prevention stage is added 5 kilograms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101613150A CN102293331B (en) | 2011-06-10 | 2011-06-10 | Feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101613150A CN102293331B (en) | 2011-06-10 | 2011-06-10 | Feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293331A true CN102293331A (en) | 2011-12-28 |
| CN102293331B CN102293331B (en) | 2012-12-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101613150A Active CN102293331B (en) | 2011-06-10 | 2011-06-10 | Feed additive for preventing and treating nutritional liver and gall syndrome of marine cultured fishes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102293331B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104431368A (en) * | 2014-12-15 | 2015-03-25 | 中国水产科学研究院长江水产研究所 | Compound feed additive for promoting healthy growth of fishes and preparation method |
| CN106923082A (en) * | 2017-03-15 | 2017-07-07 | 苏州大学 | A kind of feed for preventing and treating liver and gall syndrome of fish |
| CN112890048A (en) * | 2021-01-25 | 2021-06-04 | 重庆斯特佳生物科技有限公司 | Initial feed for improving survival rate of sturgeon fries |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018147A (en) * | 2010-12-16 | 2011-04-20 | 广东现代农业集团研究院有限公司 | Compound feed for reducing intestinal fat of tilapia mossambica |
-
2011
- 2011-06-10 CN CN2011101613150A patent/CN102293331B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018147A (en) * | 2010-12-16 | 2011-04-20 | 广东现代农业集团研究院有限公司 | Compound feed for reducing intestinal fat of tilapia mossambica |
Non-Patent Citations (1)
| Title |
|---|
| 汪军涛 等: "饲粮中添加DL_肉碱复合物和复合胆汁酸对斑点叉尾鮰生长性能的影响", 《中国饲料》, no. 22, 31 December 2009 (2009-12-31), pages 28 - 30 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104431368A (en) * | 2014-12-15 | 2015-03-25 | 中国水产科学研究院长江水产研究所 | Compound feed additive for promoting healthy growth of fishes and preparation method |
| CN106923082A (en) * | 2017-03-15 | 2017-07-07 | 苏州大学 | A kind of feed for preventing and treating liver and gall syndrome of fish |
| CN112890048A (en) * | 2021-01-25 | 2021-06-04 | 重庆斯特佳生物科技有限公司 | Initial feed for improving survival rate of sturgeon fries |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102293331B (en) | 2012-12-26 |
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| C14 | Grant of patent or utility model | ||
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