CN102292638B - 可溶性icam-1作为生物标志物用于预测治疗性应答 - Google Patents
可溶性icam-1作为生物标志物用于预测治疗性应答 Download PDFInfo
- Publication number
- CN102292638B CN102292638B CN201080004940.8A CN201080004940A CN102292638B CN 102292638 B CN102292638 B CN 102292638B CN 201080004940 A CN201080004940 A CN 201080004940A CN 102292638 B CN102292638 B CN 102292638B
- Authority
- CN
- China
- Prior art keywords
- sicam
- purposes
- patient
- level
- immunogenic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305044.1 | 2009-01-20 | ||
| EP09305044 | 2009-01-20 | ||
| EP09305294 | 2009-04-07 | ||
| EP09305294.2 | 2009-04-07 | ||
| PCT/EP2010/050532 WO2010084100A1 (en) | 2009-01-20 | 2010-01-18 | Soluble icam-1 as biomarker for prediction of therapeutic response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102292638A CN102292638A (zh) | 2011-12-21 |
| CN102292638B true CN102292638B (zh) | 2014-05-28 |
Family
ID=42028081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080004940.8A Expired - Fee Related CN102292638B (zh) | 2009-01-20 | 2010-01-18 | 可溶性icam-1作为生物标志物用于预测治疗性应答 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20110312525A1 (https=) |
| EP (1) | EP2382474B1 (https=) |
| JP (1) | JP5379243B2 (https=) |
| KR (1) | KR20110116016A (https=) |
| CN (1) | CN102292638B (https=) |
| AU (1) | AU2010206195B2 (https=) |
| BR (1) | BRPI1006901A2 (https=) |
| CA (1) | CA2749192A1 (https=) |
| CO (1) | CO6390020A2 (https=) |
| CR (1) | CR20110438A (https=) |
| DK (1) | DK2382474T3 (https=) |
| ES (1) | ES2536747T3 (https=) |
| HR (1) | HRP20150470T1 (https=) |
| HU (1) | HUE025015T2 (https=) |
| IL (1) | IL213098A (https=) |
| MX (1) | MX2011007386A (https=) |
| NZ (1) | NZ593749A (https=) |
| PL (1) | PL2382474T3 (https=) |
| PT (1) | PT2382474E (https=) |
| SG (2) | SG196837A1 (https=) |
| TW (1) | TWI440854B (https=) |
| WO (1) | WO2010084100A1 (https=) |
| ZA (1) | ZA201105271B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103175959B (zh) * | 2013-02-28 | 2015-10-14 | 成都创宜生物科技有限公司 | 一种检测胎膜早破免疫层析试纸的制备方法 |
| CN103235134B (zh) * | 2013-05-08 | 2015-10-14 | 成都创宜生物科技有限公司 | 一种检测胎膜早破的免疫层析试纸及其制备方法 |
| CN103698537A (zh) * | 2014-01-06 | 2014-04-02 | 天津医科大学总医院 | 定量检测人血清可溶性细胞间粘附分子-1的化学发光免疫分析试剂盒及检测方法 |
| JP2021514678A (ja) * | 2018-03-06 | 2021-06-17 | ペップバックス・インコーポレイテッド | 核酸分子およびそれを使用する方法 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| FR2643817B1 (fr) | 1989-03-06 | 1993-12-17 | Transgene Sa | Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus |
| FR2602790B1 (fr) * | 1986-08-13 | 1990-06-01 | Transgene Sa | Expression d'un antigene specifique de tumeur par un virus vecteur recombinant et utilisation de celui-ci pour le traitement preventif ou curatif de la tumeur correspondante |
| DE3642912A1 (de) | 1986-12-16 | 1988-06-30 | Leybold Ag | Messeinrichtung fuer paramagnetische messgeraete mit einer messkammer |
| US6222020B1 (en) | 1987-01-07 | 2001-04-24 | Imperial Cancer Research Technology Limited | Antigens derived from the core protein of the human mammary epithelial mucin |
| ATE128727T1 (de) | 1987-05-04 | 1995-10-15 | Dana Farber Cancer Inst Inc | Interzellulare adhäsions-moleküle und deren bindungsliganden. |
| FR2632863B2 (fr) | 1987-10-29 | 1990-08-31 | Transgene Sa | Virus du fowlpox recombinant et vaccins derives de ces virus |
| CA2008368C (en) | 1989-01-24 | 2003-04-08 | Jeffrey Greve | Soluble molecule related to but distinct from icam-1 |
| US5100587A (en) | 1989-11-13 | 1992-03-31 | The United States Of America As Represented By The Department Of Energy | Solid-state radioluminescent zeolite-containing composition and light sources |
| FR2668064B1 (fr) | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US5756102A (en) | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| DE69233158T2 (de) | 1991-03-07 | 2004-05-13 | Connaught Technology Corp., Greenville | Gentechnologisch hergestellter stamm für impfstoffe |
| US5179993A (en) | 1991-03-26 | 1993-01-19 | Hughes Aircraft Company | Method of fabricating anisometric metal needles and birefringent suspension thereof in dielectric fluid |
| US6013638A (en) | 1991-10-02 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Adenovirus comprising deletions on the E1A, E1B and E3 regions for transfer of genes to the lung |
| US6133028A (en) | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US5698443A (en) | 1995-06-27 | 1997-12-16 | Calydon, Inc. | Tissue specific viral vectors |
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| US5998205A (en) | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| FR2727689A1 (fr) | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| SI0833934T2 (sl) | 1995-06-15 | 2013-04-30 | Crucell Holland B.V. | Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji |
| CA2261989C (en) | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| FR2751879B1 (fr) | 1996-07-30 | 1998-10-30 | Transgene Sa | Composition pharmaceutique contre les tumeurs et infections a papillomavirus |
| EP1012276A2 (en) | 1997-02-24 | 2000-06-28 | Therion Biologics Corporation | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| US6110929A (en) | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
| US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| US20020037274A1 (en) | 1998-10-26 | 2002-03-28 | Angelica Williams | Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants |
| FR2787465A1 (fr) | 1998-12-21 | 2000-06-23 | Transgene Sa | Procede d'inactivation des virus enveloppes dans une preparation virale de virus non enveloppes |
| CA2362367C (en) | 1999-02-04 | 2004-08-03 | Geron Corporation | Telomerase reverse transcriptase transcriptional regulatory sequences |
| EP1155120B1 (fr) | 1999-02-22 | 2006-07-05 | Transgene S.A. | Procede d'obtention d'une preparation virale purifiee |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| ES2288488T3 (es) | 1999-11-15 | 2008-01-16 | Onyx Pharmaceuticals, Inc. | Adenovirus oncoliticos. |
| AUPQ520800A0 (en) | 2000-01-21 | 2000-02-17 | Alfred Hospital | Prime-boost vaccination strategy |
| PL212047B1 (pl) | 2000-11-23 | 2012-08-31 | Bavarian Nordic As | Zmodyfikowany wirus krowianki szczepu Ankara MVA-BN i jego pochodna, genom i zawierające je kompozycja farmaceutyczna, zwłaszcza szczepionka oraz ich zastosowania |
| GB0118532D0 (en) | 2001-07-30 | 2001-09-19 | Isis Innovation | Materials and methods relating to improved vaccination strategies |
| PT2241325E (pt) | 2002-10-29 | 2012-04-12 | Coley Pharm Gmbh | Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c |
| FR2855758B1 (fr) | 2003-06-05 | 2005-07-22 | Biomerieux Sa | Composition comprenant la polyproteine ns3/ns4 et le polypeptide ns5b du vhc, vecteurs d'expression incluant les sequences nucleiques correspondantes et leur utilisation en therapeutique |
| FR2862648B1 (fr) | 2003-11-21 | 2006-02-03 | Biomerieux Sa | Nouveau peptide immunogene et nouveaux epitopes et utilisations notamment dans la preparation de compositions pharmaceutiques actives contre le virus de l 'hepatite c |
| US7381536B2 (en) | 2005-03-01 | 2008-06-03 | Gurbel Paul A | Assessment of cardiac health and thrombotic risk in a patient |
-
2010
- 2010-01-18 EP EP10704115.4A patent/EP2382474B1/en not_active Not-in-force
- 2010-01-18 PL PL10704115T patent/PL2382474T3/pl unknown
- 2010-01-18 JP JP2011545757A patent/JP5379243B2/ja not_active Expired - Fee Related
- 2010-01-18 MX MX2011007386A patent/MX2011007386A/es active IP Right Grant
- 2010-01-18 SG SG2014004030A patent/SG196837A1/en unknown
- 2010-01-18 DK DK10704115T patent/DK2382474T3/en active
- 2010-01-18 AU AU2010206195A patent/AU2010206195B2/en not_active Ceased
- 2010-01-18 HR HRP20150470TT patent/HRP20150470T1/hr unknown
- 2010-01-18 CN CN201080004940.8A patent/CN102292638B/zh not_active Expired - Fee Related
- 2010-01-18 BR BRPI1006901A patent/BRPI1006901A2/pt not_active Application Discontinuation
- 2010-01-18 SG SG2011052404A patent/SG173065A1/en unknown
- 2010-01-18 KR KR1020117016841A patent/KR20110116016A/ko not_active Abandoned
- 2010-01-18 ES ES10704115.4T patent/ES2536747T3/es active Active
- 2010-01-18 HU HUE10704115A patent/HUE025015T2/en unknown
- 2010-01-18 CA CA2749192A patent/CA2749192A1/en not_active Abandoned
- 2010-01-18 WO PCT/EP2010/050532 patent/WO2010084100A1/en not_active Ceased
- 2010-01-18 PT PT107041154T patent/PT2382474E/pt unknown
- 2010-01-18 US US13/145,336 patent/US20110312525A1/en not_active Abandoned
- 2010-01-18 NZ NZ593749A patent/NZ593749A/xx not_active IP Right Cessation
- 2010-01-20 TW TW099101520A patent/TWI440854B/zh not_active IP Right Cessation
-
2011
- 2011-05-24 IL IL213098A patent/IL213098A/en not_active IP Right Cessation
- 2011-07-18 ZA ZA2011/05271A patent/ZA201105271B/en unknown
- 2011-07-19 CO CO11090083A patent/CO6390020A2/es not_active Application Discontinuation
- 2011-08-17 CR CR20110438A patent/CR20110438A/es not_active Application Discontinuation
-
2013
- 2013-05-23 US US13/900,869 patent/US20140023686A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| Soluble intercellular adhesion molecule-1 (sICAM-1):an overview;Anna Maria Witkowska et al;《E ur.Cytokine Netw.》;20040630;第15卷(第2期);91-98 * |
| urinary ICAM-1 levels can predict response in superficial bladder cancer treated with intravesical immunotherapy;zoumpos I et al;《eur j cancer》;20051001;第3卷(第2期);250-251 * |
| 肝细胞肝癌患者血清和组织细胞间粘附因子-1及其mRNA的表达;梅铭惠等;《中华实验外科杂志》;20010531;第18卷(第3期);261-264 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG173065A1 (en) | 2011-08-29 |
| US20110312525A1 (en) | 2011-12-22 |
| AU2010206195B2 (en) | 2016-03-10 |
| TW201031917A (en) | 2010-09-01 |
| CA2749192A1 (en) | 2010-07-29 |
| NZ593749A (en) | 2012-05-25 |
| TWI440854B (zh) | 2014-06-11 |
| HK1161643A1 (en) | 2012-07-27 |
| CO6390020A2 (es) | 2012-02-29 |
| KR20110116016A (ko) | 2011-10-24 |
| ES2536747T3 (es) | 2015-05-28 |
| CN102292638A (zh) | 2011-12-21 |
| PL2382474T3 (pl) | 2015-08-31 |
| CR20110438A (es) | 2011-12-28 |
| IL213098A0 (en) | 2011-07-31 |
| ZA201105271B (en) | 2012-03-28 |
| HRP20150470T1 (hr) | 2015-06-05 |
| US20140023686A1 (en) | 2014-01-23 |
| IL213098A (en) | 2015-08-31 |
| AU2010206195A1 (en) | 2010-07-29 |
| EP2382474B1 (en) | 2015-03-04 |
| HUE025015T2 (en) | 2016-04-28 |
| RU2011134415A (ru) | 2013-02-27 |
| MX2011007386A (es) | 2011-08-03 |
| JP2012515893A (ja) | 2012-07-12 |
| BRPI1006901A2 (pt) | 2016-02-16 |
| DK2382474T3 (en) | 2015-04-07 |
| JP5379243B2 (ja) | 2013-12-25 |
| EP2382474A1 (en) | 2011-11-02 |
| WO2010084100A1 (en) | 2010-07-29 |
| PT2382474E (pt) | 2015-06-03 |
| SG196837A1 (en) | 2014-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5650212B2 (ja) | 患者を選択するためのバイオマーカーおよび関連方法 | |
| CN102292638B (zh) | 可溶性icam-1作为生物标志物用于预测治疗性应答 | |
| KR20110138354A (ko) | 환자를 모니터링하기 위한 바이오마커 | |
| US9207231B2 (en) | Biomarker for selecting patients and related methods | |
| RU2574984C2 (ru) | Растворимый icam-1 в качестве биомаркера для прогнозирования терапевтического ответа | |
| HK1161643B (en) | Soluble icam-1 as biomarker for prediction of therapeutic response |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140528 Termination date: 20180118 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |