CN102283912B - Chinese medicinal composition for treating chronic kidney failure and preparation method thereof - Google Patents
Chinese medicinal composition for treating chronic kidney failure and preparation method thereof Download PDFInfo
- Publication number
- CN102283912B CN102283912B CN 201110216895 CN201110216895A CN102283912B CN 102283912 B CN102283912 B CN 102283912B CN 201110216895 CN201110216895 CN 201110216895 CN 201110216895 A CN201110216895 A CN 201110216895A CN 102283912 B CN102283912 B CN 102283912B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- parts
- radix
- medicine composition
- hirudo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The invention discloses a Chinese medicinal composition for treating chronic kidney failure and a preparation method thereof, and provides a Chinese medicinal composition for treating chronic kidney failure. The Chinese medicinal composition comprises the following active ingredients in part by mass: 1 to 30 parts of rhubarb, 3 to 60 parts of prepared common monkshood daughter root, 1 to 90 parts of astragalus, 5 to 60 parts of root of red-rooted salvia, 1 to 12 parts of leech and 1 to 60 parts of common macrocarpium fruit. The Chinese medicinal composition for treating the chronic kidney failure has a stable and improvement effect on the endogenous creatinine clearance rate (Ccr) of patients who suffer from the chronic kidney failure, and plays a role in treating and delaying the development of the chronic kidney failure. In addition, the composition is prepared for discomfort primary symptom of the patients who suffer from the chronic kidney failure, and the right remedy is prescribed for illness to improve a curative effect.
Description
Technical field
The present invention relates to Chinese medicine composition for the treatment of chronic renal failure and preparation method thereof.
Background technology
Chronic renal failure, claim again chronic renal insufficiency, refer to the infringement of the chronic progressive external nephrolithotomy that caused by various factors, cause the obvious atrophy of kidney, the drainage of kidney, secretion, regulatory function decline, can not keep its basic function, with metabolite and poisonous substance retention, water, electrolyte and acid base imbalance are main manifestations.Its possible pathogenic factors has acute and chronic nephritis, systemic lupus erythematosus (sle), urinary tract obstruction, polycystic kidney, diabetes, gout, hypertension etc.And endogenous creatinine clearance rate (Ccr) test can reflect the quantity of detection of glomeruli filtration function and the effective nephron of rough estimate, so for measuring the quantitative test of renal damage, can be used for estimating the progress of kidney disease.The categories such as its ownership traditional Chinese medical science " the kidney-wind syndrome ", " impairment of the kidney caused by overstrain ", " obstruction and rejection ", " edema ".
Summary of the invention
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of nephropathy.
The Chinese medicine composition for the treatment of nephropathy provided by the present invention, its active component are to be made by the raw material of Chinese medicine of following mass parts:
1～60 part or 1 part or 30 parts or 60 parts of 1～12 part of 5～60 parts of 1～90 part of 3～60 parts of 1～30 part of Radix Et Rhizoma Rhei or 1 part or 6 parts or 30 parts, Radix Aconiti Lateralis Preparatas or 3 parts or 30 parts or 60 parts, the Radix Astragali or 1 part or 60 parts or 90 parts, Radix Salviae Miltiorrhizaes or 5 parts or 30 parts or 60 parts, Hirudo or 1 part or 3 parts or 12 parts and Fructus Corni.
The curative effect of the Chinese medicine composition of described treatment nephropathy is presented as stabilizes and increases nephrotic's endogenous creatinine clearance rate; Described nephropathy is chronic renal failure.
Described Chinese medicine composition is made by the raw material of Chinese medicine of following mass parts:
30 parts of 6 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Aconiti Lateralis Preparatas, 60 parts of the Radixs Astragali, 30 parts of Radix Salviae Miltiorrhizaes, 3 parts of Hirudos and Fructus Corni.
Described Chinese medicine composition is following 1)-4) shown in:
1) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～30 part or 1 part or 15 parts or 30 parts of 10～240 parts in 1～60 part of 1～12 part of 5～60 parts of 1～90 part of 3～60 parts of 1～30 part of Radix Et Rhizoma Rhei or 1 part or 6 parts or 30 parts, Radix Aconiti Lateralis Preparatas or 3 parts or 30 parts or 60 parts, the Radix Astragali or 1 part or 60 parts or 90 parts, Radix Salviae Miltiorrhizaes or 5 parts or 30 parts or 60 parts, Hirudo or 1 part or 3 parts or 12 parts and Fructus Corni or 1 part or 30 parts or 60 parts, Poria or 10 parts or 60 parts or 240 parts and Rhizoma Alismatis; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving edema; Described nephropathy is chronic renal failure;
2) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～180 part or 1 part or 60 parts or 180 parts of 1～60 part of 1～12 part of 5～60 parts of 1～90 part of 3～60 parts of 1～30 part of Radix Et Rhizoma Rhei or 1 part or 6 parts or 30 parts, Radix Aconiti Lateralis Preparatas or 3 parts or 30 parts or 60 parts, the Radix Astragali or 1 part or 60 parts or 90 parts, Radix Salviae Miltiorrhizaes or 5 parts or 30 parts or 60 parts, Hirudo or 1 part or 3 parts or 12 parts and Fructus Corni or 1 part or 30 parts or 60 parts and Semen Ziziphi Spinosae; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving insomnia; Described nephropathy is chronic renal failure;
3) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～30 part or 1 part or 15 parts or 30 parts of 1～30 part of 1～60 part of 1～12 part of 5～60 parts of 1～90 part of 3～60 parts of 1～30 part of Radix Et Rhizoma Rhei or 1 part or 6 parts or 30 parts, Radix Aconiti Lateralis Preparatas or 3 parts or 30 parts or 60 parts, the Radix Astragali or 1 part or 60 parts or 90 parts, Radix Salviae Miltiorrhizaes or 5 parts or 30 parts or 60 parts, Hirudo or 1 part or 3 parts or 12 parts and Fructus Corni or 1 part or 30 parts or 60 parts, Fructus Aurantii Immaturus or 1 part or 15 parts or 30 parts of magnolia obovata; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving constipation; Described nephropathy is chronic renal failure;
4) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～60 part of 1～12 part of 5～60 parts of 1～90 part of 3～60 parts of 1～30 part of Radix Et Rhizoma Rhei or 1 part or 6 parts or 30 parts, Radix Aconiti Lateralis Preparatas or 3 parts or 30 parts or 60 parts, the Radix Astragali or 1 part or 60 parts or 90 parts, Radix Salviae Miltiorrhizaes or 5 parts or 30 parts or 60 parts, Hirudo or 1 part or 3 parts or 12 parts and Fructus Corni or 1 part or 30 parts or 60 parts, 1～60 part or 1 part or 30 parts or 60 parts of Cortex Cinnamomi; The curative effect of described Chinese medicine composition is presented as stabilizes and increases nephrotic's endogenous creatinine clearance rate and improves the symptom that nocturia increases; Described nephropathy is chronic renal failure.
The dosage form of described Chinese medicine composition is pill, capsule, tablet, powder or granule.
Another object of the present invention provides the preparation method of described Chinese medicine composition.
The preparation method of described Chinese medicine composition provided by the present invention comprises the steps:
1) raw material of Chinese medicine except Hirudo in the described Chinese medicine composition is mixed, after soaking, decoct, collect decoction liquor;
2) Hirudo is pulverized, obtain Hirudo powder;
3) with step 1) described decoction liquor and step 2) described Hirudo powder merging, namely obtain described Chinese medicine composition; Wherein, step 1) and 2) in no particular order the order.
Step 1) amount of water that soaks described in is 4 times-16 times or 4 times or 8 times or 16 times of the raw material of Chinese medicine quality sum except Hirudo; The time of described immersion is 0.5 hour-2 hours or 0.5 hour or 1 hour or 2 hours; The temperature of described immersion is 20 ℃-40 ℃ or 20 ℃ or 30 ℃ or 40 ℃.
Described decoction is carried out once; Each time that decocts is 30 minutes-80 minutes or 30 minutes or 60 minutes or 80 minutes; The temperature of described decoction is 97 ℃-99 ℃ or 97 ℃ or 98 ℃ or 99 ℃.
Another purpose of the present invention provides a kind of medicine that is used for the treatment of nephropathy.
The medicine that is used for the treatment of nephropathy provided by the present invention contains described Chinese medicine composition, and pharmaceutically acceptable carrier; Described nephropathy is chronic renal failure.
The application in the medicine of preparation treatment nephropathy of described Chinese medicine composition or described medicine also belongs to protection scope of the present invention; Described nephropathy is chronic renal failure.
The invention provides a kind of Chinese medicine composition for the treatment of chronic renal failure, chronic kidney patient's endogenous creatinine clearance rate (Ccr) is had stable and raising effect, play the effect that treatment and postponing chronic kidney function failure develop.For the common uncomfortable primary symptom of patients of chronic renal failure, select to the ill medicine again, improve curative effect.
The invention is characterized in that it is based on the Coryza Treated by Syndrome Differentiation pattern of " disease-card-disease-modern pharmacological research combination ", take patient's Ccr and the targeting of uncomfortable primary symptom as treating.This is in the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of Chinese medicine again, analysis-by-synthesis patient's syndrome.With reference to void, the stasis of blood, the turbid pathological characteristic of Chronic renal failure, its middle kidney network stasis blocking is its main feature; Empty then show as gas, the blood in disease progression later stage, the deficiency of yin, yang, attach most importance to yang deficiency again; The while YANG not transforming the turbid pathogen, gas is transporting not, causes accumulateing in the turbid poison.Use again the modern pharmacological research achievement of plurality of Chinese.The present invention fully combines above 4 points, the comprehensive summary, and by clinical for many years repeatedly utilization, constantly screening has finally formed side's medicine of the present invention and has formed and proportioning.
Chinese medicine composition of the present invention has warming YANG and rushes down turbid, the enriching yin boost qi effect that nourishes blood.Radix Et Rhizoma Rhei is monarch in the side, rushes down turbid purging FU-organs, makes " turbid YIN being discharged from the lower orifices ", has again the merit of activating blood circulation to dissipate blood stasis and dredge the collateral.The Radix Aconiti Lateralis Preparata warming YANG is ministerial drug, is that master's syndrome is set up for the yang deficiency of chronic renal failure, and warming YANG is turbid to change; Hot temperature helps the network stasis of blood of rhubarb treatment chronic kidney to dredge network again.Radix Astragali activating qi and collateral, astringency inducing is precise and tiny with astringent therapy again.Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation collateral dredging, compatible with the Radix Astragali, benefiting QI and nourishing blood, the renal anemia that qi and blood tonifying causes with prevention and treatment renal failure.Hirudo removing blood stasis collateral dredging is the good medicine for the treatment of " pathogen usually intruding into collateral in protracted disease ".The Fructus Corni YIN nourishing is established for the network stasis of blood causes the network damage for a long time to support network.Full policy stagnates to the stasis of blood of kidney network and damage and choose different method for the treatment of, rush down turbid with clear network, the removing blood stasis of invigorating blood circulation with collateral dredging, warming YANG to dredge network, benefiting qi and nourishing yin nourishes blood to moisten network.Full side looks after the excess syndrome of accumulateing in patient's the turbid poison, considers again the deficiency syndrome of with the passing of time gas of chronic nephropathy, blood, yin, yang, and deficiency and excess is taken into account, make the kidney network must be logical, network decreases and repaired, the depletion of postponing chronic kidney function and called after kidney network is peaceful.
Increasing medicine according to primary symptom is: edema adds Poria, the detumescence of Rhizoma Alismatis removing water retention by purgation, invigorating spleen to remove dampness.Insomnia adds the Semen Ziziphi Spinosae nourishing blood to tranquillize the mind.Constipation adds Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, and with the Radix et Rhizoma Rhei (stir-fried with wine) compatibility, relieving distension by promoting circulation of QI, purging FU-organs rush down turbid.Nocturia increases and is the insufficiency of kidney-YANG performance, add Herba Cistanches, Herba Cynomorii with warming the kidney to activate YANG with the taste source.
Description of drawings
Fig. 1 is the therapeutic evaluation result of Chinese medicine composition take endogenous creatinine clearance rate as evaluation index of embodiment 1 preparation.
Fig. 2 is the therapeutic evaluation result of Chinese medicine composition take edema as evaluation index of embodiment 2 preparations.
Fig. 3 is the therapeutic evaluation result of Chinese medicine composition take insomnia as evaluation index of embodiment 3 preparations.
Fig. 4 is that the Chinese medicine composition of embodiment 4 preparation increases therapeutic evaluation result as evaluation index take nocturia.
Fig. 5 is the therapeutic evaluation result of Chinese medicine composition take constipation as evaluation index of embodiment 5 preparations.
The specific embodiment
Employed experimental technique is conventional method if no special instructions among the following embodiment.
Used material, reagent etc. if no special instructions, all can obtain from commercial channels among the following embodiment.
Used Radix Et Rhizoma Rhei, Radix Aconiti Lateralis Preparata, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni, Poria, Rhizoma Alismatis, Semen Ziziphi Spinosae, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Herba Cistanches and Herba Cynomorii all meets the pertinent regulations under each medical material item of text of Chinese Pharmacopoeia version in 2010 among the following embodiment.Before feeding intake, be tested and appraised, ingredients is in kind to conform to the quality conformance with standard with title.
Embodiment 1, for the preparation of the treatment chronic renal failure Chinese medicine composition
Method I
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 6 grams, Radix Aconiti Lateralis Preparata 30 grams, the Radix Astragali 60 grams, Radix Salviae Miltiorrhizae 30 grams, Hirudo 3 grams and Fructus Corni 30 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 97 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae and Fructus Corni are mixed, then with after above-mentioned medicine juice and medicinal residues mix, soak with the water of 8 times of quality, the temperature of immersion is 30 ℃, and the time of immersion is 1 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 60 minutes at 97 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method II
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 1 gram, Radix Aconiti Lateralis Preparata 3 grams, the Radix Astragali 1 gram, Radix Salviae Miltiorrhizae 5 grams, Hirudo 1 gram and Fructus Corni 1 gram.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 98 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae and Fructus Corni are mixed, then with after above-mentioned medicine juice and medicinal residues mix, soak with the water of 4 times of quality, the temperature of immersion is 20 ℃, and the time of immersion is 0.5 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 30 minutes at 98 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method III
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 30 grams, Radix Aconiti Lateralis Preparata 60 grams, the Radix Astragali 90 grams, Radix Salviae Miltiorrhizae 60 grams, Hirudo 12 grams and Fructus Corni 60 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 99 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae and Fructus Corni are mixed, then with after above-mentioned medicine juice and medicinal residues mix, soak with the water of 8 times of quality, the temperature of immersion is 40 ℃, and the time of immersion is 2 hours; Decocted 2 minutes at 100 ℃ afterwards, after boiling, decocted 80 minutes at 99 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Embodiment 2, for the preparation of the treatment chronic renal failure Chinese medicine composition
Method I
Primary symptom for chronic renal failure is edema, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 6 grams, Radix Aconiti Lateralis Preparata 30 grams, the Radix Astragali 30 grams, Radix Salviae Miltiorrhizae 30 grams, Hirudo 3 grams, Fructus Corni 30 grams, Poria 60 grams and Rhizoma Alismatis 30 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 97 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni, Poria and Rhizoma Alismatis are mixed, the water with 8 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 30 ℃, and the time of immersion is 1 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 60 minutes at 97 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method II
Primary symptom for chronic renal failure is edema, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 1 gram, Radix Aconiti Lateralis Preparata 3 grams, the Radix Astragali 1 gram, Radix Salviae Miltiorrhizae 5 grams, Hirudo 1 gram, Fructus Corni 1 gram, Poria 10 grams and Rhizoma Alismatis 1 gram.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 98 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Corni, Poria and Rhizoma Alismatis are mixed, then with after above-mentioned medicine juice and medicinal residues mix, soak with the water of 4 times of quality, the temperature of immersion is 20 ℃, and the time of immersion is 0.5 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 30 minutes at 98 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method III
Primary symptom for chronic renal failure is edema, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 30 grams, Radix Aconiti Lateralis Preparata 60 grams, the Radix Astragali 90 grams, Radix Salviae Miltiorrhizae 60 grams, Hirudo 12 grams, Fructus Corni 60 grams, Poria 240 grams and Rhizoma Alismatis 15 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 99 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Corni, Poria and Rhizoma Alismatis are mixed, then with after above-mentioned medicine juice and medicinal residues mix, soak with the water of 8 times of quality, the temperature of immersion is 40 ℃, and the time of immersion is 2 hours; Decocted 2 minutes at 100 ℃ afterwards, after boiling, decocted 80 minutes at 99 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Embodiment 3, for the preparation of the treatment chronic renal failure Chinese medicine composition
Method I
Primary symptom for chronic renal failure is insomnia, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 6 grams, Radix Aconiti Lateralis Preparata 30 grams, the Radix Astragali 30 grams, Radix Salviae Miltiorrhizae 30 grams, Hirudo 3 grams, Fructus Corni 30 grams and Semen Ziziphi Spinosae 60 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 97 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Semen Ziziphi Spinosae are mixed, the water with 8 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 30 ℃, and the time of immersion is 1 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 60 minutes at 97 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method II
Primary symptom for chronic renal failure is insomnia, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 1 gram, Radix Aconiti Lateralis Preparata 3 grams, the Radix Astragali 1 gram, Radix Salviae Miltiorrhizae 5 grams, Hirudo 1 gram, Fructus Corni 1 gram and Semen Ziziphi Spinosae 1 gram.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 98 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Semen Ziziphi Spinosae are mixed, the water with 4 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 20 ℃, and the time of immersion is 0.5 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 30 minutes at 98 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method III
Primary symptom for chronic renal failure is insomnia, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 30 grams, Radix Aconiti Lateralis Preparata 60 grams, the Radix Astragali 90 grams, Radix Salviae Miltiorrhizae 60 grams, Hirudo 12 grams, Fructus Corni 60 grams and Semen Ziziphi Spinosae 180 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 99 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Semen Ziziphi Spinosae are mixed, the water with 8 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 40 ℃, and the time of immersion is 2 hours; Decocted 2 minutes at 100 ℃ afterwards, after boiling, decocted 80 minutes at 99 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Embodiment 4, for the preparation of the treatment chronic renal failure Chinese medicine composition
Method I
Primary symptom for chronic renal failure is constipation, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 12 grams, Radix Aconiti Lateralis Preparata 30 grams, the Radix Astragali 30 grams, Radix Salviae Miltiorrhizae 30 grams, Hirudo 3 grams, Fructus Corni 30 grams, Fructus Aurantii Immaturus 15 gram magnolia obovatas 15 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 97 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni, Fructus Aurantii Immaturus magnolia obovata are mixed, the water with 8 times of quality after then mixing with above-mentioned medicinal residues soaks, and the temperature of immersion is 30 ℃, and the time of immersion is 1 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 60 minutes at 97 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method II
Primary symptom for chronic renal failure is constipation, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 1 gram, Radix Aconiti Lateralis Preparata 3 grams, the Radix Astragali 1 gram, Radix Salviae Miltiorrhizae 5 grams, Hirudo 1 gram, Fructus Corni 1 gram, Fructus Aurantii Immaturus 1 gram magnolia obovata 1 gram.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 98 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni, Fructus Aurantii Immaturus magnolia obovata are mixed, the water with 4 times of quality after then mixing with above-mentioned medicinal residues soaks, and the temperature of immersion is 20 ℃, and the time of immersion is 0.5 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 30 minutes at 98 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method III
Primary symptom for chronic renal failure is constipation, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 30 grams, Radix Aconiti Lateralis Preparata 60 grams, the Radix Astragali 90 grams, Radix Salviae Miltiorrhizae 60 grams, Hirudo 12 grams, Fructus Corni 60 grams, Fructus Aurantii Immaturus 30 gram magnolia obovatas 30 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 99 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni, Fructus Aurantii Immaturus magnolia obovata are mixed, the water with 16 times of quality after then mixing with above-mentioned medicinal residues soaks, and the temperature of immersion is 40 ℃, and the time of immersion is 2 hours; Decocted 2 minutes at 100 ℃ afterwards, after boiling, decocted 60 minutes at 99 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Embodiment 5, for the preparation of the treatment chronic renal failure Chinese medicine composition
Method I
Primary symptom for chronic renal failure is that nocturia increases, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 6 grams, Radix Aconiti Lateralis Preparata 30 grams, the Radix Astragali 30 grams, Radix Salviae Miltiorrhizae 30 grams, Hirudo 3 grams, Fructus Corni 30 grams, Cortex Cinnamomi 30 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 97 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Cortex Cinnamomi are mixed, the water with 8 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 30 ℃, and the time of immersion is 1 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 60 minutes at 97 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method II
Primary symptom for chronic renal failure is that nocturia increases, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 1 gram, Radix Aconiti Lateralis Preparata 3 grams, the Radix Astragali 1 gram, Radix Salviae Miltiorrhizae 5 grams, Hirudo 1 gram, Fructus Corni 1 gram, Cortex Cinnamomi 1 gram.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 98 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Cortex Cinnamomi are mixed, the water with 4 times of quality after then mixing with above-mentioned medicine juice and medicinal residues soaks, and the temperature of immersion is 20 ℃, and the time of immersion is 0.5 hour; Decocted 2 minutes at 99 ℃ afterwards, after boiling, decocted 30 minutes at 98 ℃.Decoct once, get decoction liquor;
(3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
Method III
Primary symptom for chronic renal failure is that nocturia increases, and is for the preparation of the Chinese medicine composition for the treatment of chronic renal failure, specific as follows:
1, the composition of raw material of Chinese medicine and consumption
Radix Et Rhizoma Rhei 30 grams, Radix Aconiti Lateralis Preparata 60 grams, the Radix Astragali 90 grams, Radix Salviae Miltiorrhizae 60 grams, Hirudo 12 grams, Fructus Corni 60 grams, Cortex Cinnamomi 60 grams.
2, the raw material of Chinese medicine with above-mentioned consumption is prepared into Chinese medicine
(1) Radix Aconiti Lateralis Preparata is added the water of 16 times of quality in 99 ℃ of decoctions 2 hours; Collect medicine juice and medicinal residues;
(2) Radix Et Rhizoma Rhei, the Radix Astragali, Radix Salviae Miltiorrhizae, Hirudo, Fructus Corni and Cortex Cinnamomi are mixed, the water with 16 times of quality after then mixing with above-mentioned medicinal residues soaks, and the temperature of immersion is 40 ℃, and the time of immersion is 2 hours; Decocted 2 minutes at 100 ℃ afterwards, after boiling, decocted 60 minutes at 99 ℃.Decoct once, get decoction liquor; (3) Hirudo was ground to form the fine powder of 100～200 mesh sieves, namely obtained Hirudo powder;
(4) get decoction liquor 300～400ml that step (2) obtains and mix with the Hirudo powder that step (3) obtains, namely obtain being used for the treatment of the Chinese medicine of chronic renal failure; One daily dose, oral.
The clinical effectiveness test of the Chinese medicine composition of embodiment 6, embodiment 1 preparation
Method I
1, object of study
Chronic renal failure take serum creatinine continue 3 months greater than 133 μ mol/L as diagnostic criteria.
Be selected in altogether 56 routine patients of chronic renal failures, women 26 examples, male 30 examples according to above-mentioned standard.
2, research method and result
2.1 test medication
The Chinese medicine composition of embodiment 1 preparation.
2.1 therapeutic evaluation
Reference " new Chinese medicine guideline of clinical investigations " formulation evaluation index is endogenous creatinine clearance rate.
Endogenous creatinine clearance rate is measured (ml/min), uses the serum creatinine computing method, considers serum creatinine concentration (umol/L), age, body weight, sex.The endogenous creatinine clearance rate formula is the Ccr=[(140-age) * body weight (kg)]/[0.818 * Scr (umol/L)].Women's endogenous creatinine clearance rate is by the result of calculation of above formula * 0.85.In the formula, Ccr is endogenous creatinine clearance rate, and Scr is serum creatinine concentration.
Chronic renal failure therapeutic evaluation time point is chosen treatment front (0 month), treatment 3 months, 6 months and 12 months;
Endogenous creatinine clearance rate (Ccr) changes (produce effects, effective, steady, invalid) computational methods: (Ccr before Ccr-treats after treating)/Ccr before treating.
Curative effect is divided into: produce effects, effective, stable and invalid, specific as follows:
Produce effects: endogenous creatinine clearance rate (Ccr) increases 〉=20%;
Effectively: endogenous creatinine clearance rate (Ccr) increases 〉=10%;
Steadily: endogenous creatinine clearance rate (Ccr) is without reducing or increasing＜10%;
Invalid: endogenous creatinine clearance rate (Ccr) reduces.
Efficacy result sees Table 1 and Fig. 1.
The therapeutic evaluation result of table 1 take endogenous creatinine clearance rate as evaluation index
Treated effect=the produce effects of chronic renal failure+effectively+steadily.Draw from table 1,3 months effective percentage are that 92.31%, 6 month effective percentage is that 83.33%, 12 effective percentage is 72.73%.
Method II
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method II preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Method III
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method III preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
The clinical effectiveness test of the Chinese medicine composition of embodiment 7, embodiment 2 preparations
Method I
1, object of study
Chronic renal failure take serum creatinine continue 3 months greater than 133 μ mol/L as diagnosis.
The judgement of chronic renal failure edema primary symptom: take the lower limb pitting edema as main manifestations.
According to above-mentioned standard, among the embodiment 6 among the 56 routine patients take edema as primary symptom person selected 35 examples altogether, women 17 examples, male 18 examples.
2, research method and result
2.1 test medication
The Chinese medicine composition of embodiment 2 preparations.
2.1 therapeutic evaluation
The edema symptom of examining take patient head and patient main suit's edema degree take patient's readme as evaluation principle, are estimated the situation of change of edema symptom every month as baseline.According to patient's readme, record the increasing the weight of of edema, constant, alleviate and disappear four grades and percentage ratio thereof.Efficacy result sees Table 2 and Fig. 2.
The therapeutic evaluation result of table 2 take edema as evaluation index
The effective percentage of edema=constant+alleviate+disappear.Draw from table 2,1 month effective percentage is that 90.0%, 2 month effective percentage is that 90.0%, 3 effective percentage is 100.0%.
Method II
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method II preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Method III
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method III preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
The clinical effectiveness test of the Chinese medicine composition of embodiment 8, embodiment 3 preparations
Method I
1, object of study
Chronic renal failure take serum creatinine continue 3 months greater than 133 μ mol/L as diagnosis.
The judgement of chronic renal failure insomnia primary symptom: refer to the patient without obvious inducement and the dissatisfied state of sleeping, comprise can't fall asleep, the length of one's sleep deficiency, poor sleeping quality, awake etc. easily.
According to above-mentioned standard, among the embodiment 6 among the 56 routine patients take insomnia as primary symptom person selected 21 examples altogether, women 14 examples, male 7 examples.
2, research method and result
2.1 test medication
The Chinese medicine composition of embodiment 3 preparations.
2.1 therapeutic evaluation
The insomnia of examining take patient head and patient main suit's insomnia degree take patient's readme as evaluation principle, are estimated the situation of change of insomnia every month as baseline.According to patient's readme, the increasing the weight of of record insomnia, constant, alleviate and disappear four grades and percentage ratio thereof.Efficacy result sees Table 3 and Fig. 3.
The therapeutic evaluation result of table 3 take insomnia as evaluation index
The effective percentage of insomnia=constant+alleviate+disappear.Draw from table 3,1 month effective percentage is that 100.0%, 2 month effective percentage is that 100.0%, 3 effective percentage is 100.0%.
Method II
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method II preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Method III
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method III preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
The clinical effectiveness test of the Chinese medicine composition of embodiment 9, embodiment 4 preparations
Method I
1, object of study
Chronic renal failure take serum creatinine continue 3 months greater than 133 μ mol/L as diagnosis.
The chronic renal failure nocturia increases the judgement of primary symptom: increase without the front drinking-water of obviously sleeping, and the nocturia number of times is more than or equal to 2 times.
According to above-mentioned standard, increase selected 31 examples altogether as primary symptom person, women 14 examples, male 17 examples take nocturia among the 56 routine patients among the embodiment 6.
2, research method and result
2.1 test medication
The Chinese medicine composition of embodiment 4 preparations.
2.1 therapeutic evaluation
The nycturia shape of examining take patient head and patient main suit's nocturia increase degree as baseline, take patient's readme as evaluation principle, estimate the situation of change of nycturia shape every month.According to patient's readme, increasing the weight of of increasing of record nocturia, constant, alleviate and disappear four grades and percentage ratio thereof.Efficacy result sees Table 4 and Fig. 4.
Table 4 increases therapeutic evaluation result as evaluation index take nocturia
The effective percentage that nocturia increases=constant+alleviate+disappear.Draw from table 4,1 month effective percentage is that 96.15%, 2 month effective percentage is that 100.0%, 3 effective percentage is 92.86%.
Method II
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method II preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Method III
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method III preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
The clinical effectiveness test of the Chinese medicine composition of embodiment 10, embodiment 5 preparations
Method I
1, object of study
Chronic renal failure take serum creatinine continue 3 months greater than 133 μ mol/L as diagnosis.
The judgement of chronic renal failure constipation primary symptom: defecation frequency obviously reduces, per 2～3 days or the longer time once, irregular, excrement matter is stiff, often with the difficult defecation sense.
According to above-mentioned standard, among the embodiment 6 among the 56 routine patients take constipation as primary symptom person selected 25 examples altogether, women 11 examples, male 14 examples.
2, research method and result
2.1 test medication
The Chinese medicine composition of embodiment 5 preparations.
2.1 therapeutic evaluation
The constipation symptom of examining take patient head and patient main suit's constipation degree take patient's readme as evaluation principle, are estimated the situation of change of constipation every month symptom as baseline.According to patient's readme, record the increasing the weight of of constipation, constant, alleviate and disappear four grades and percentage ratio thereof.Efficacy result sees Table 5 and Fig. 5.
The therapeutic evaluation result of table 5 take constipation as evaluation index
The effective percentage of constipation=constant+alleviate+disappear.Draw from table 5,1 month effective percentage is that 95.0%, 2 month effective percentage is that 100.0%, 3 effective percentage is 100.0%.
Method II
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method II preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Method III
1, object of study
I is identical with method.
2, research method and result
2.1 test medication
The Chinese medicine composition of method III preparation among the embodiment 1.
2.1 therapeutic evaluation
Evaluation methodology is identical with method I.
Result and method I are without significant difference.
Claims (9)
1. Chinese medicine composition for the treatment of nephropathy, its active component is to be made by the raw material of Chinese medicine of following mass parts:
1～60 part of 1～30 part of Radix Et Rhizoma Rhei, 3～60 parts of Radix Aconiti Lateralis Preparatas, 1～90 part of the Radix Astragali, 5～60 parts of Radix Salviae Miltiorrhizaes, 1～12 part of Hirudo and Fructus Corni.
2. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition is made by the raw material of Chinese medicine of following mass parts:
30 parts of 6 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Aconiti Lateralis Preparatas, 60 parts of the Radixs Astragali, 30 parts of Radix Salviae Miltiorrhizaes, 3 parts of Hirudos and Fructus Corni.
3. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition is following 1)-4) one of shown in:
1) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～30 part of 1～30 part of Radix Et Rhizoma Rhei, 3～60 parts of Radix Aconiti Lateralis Preparatas, 1～90 part of the Radix Astragali, 5～60 parts of Radix Salviae Miltiorrhizaes, 1～12 part of Hirudo, 1～60 part of Fructus Corni, 10～240 parts in Poria and Rhizoma Alismatis; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving edema; Described nephropathy is chronic renal failure;
2) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～180 part of 1～30 part of Radix Et Rhizoma Rhei, 3～60 parts of Radix Aconiti Lateralis Preparatas, 1～90 part of the Radix Astragali, 5～60 parts of Radix Salviae Miltiorrhizaes, 1～12 part of Hirudo, 1～60 part of Fructus Corni and Semen Ziziphi Spinosae; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving insomnia; Described nephropathy is chronic renal failure;
3) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～30 part of Radix Et Rhizoma Rhei, 3～60 parts of Radix Aconiti Lateralis Preparatas, 1～90 part of the Radix Astragali, 5～60 parts of Radix Salviae Miltiorrhizaes, 1～12 part of Hirudo, 1～60 part of Fructus Corni, 1～30 part of 1～30 part of magnolia obovata of Fructus Aurantii Immaturus; The curative effect of described Chinese medicine composition is presented as the symptom of stabilizing and increasing nephrotic's endogenous creatinine clearance rate and improving constipation; Described nephropathy is chronic renal failure;
4) described Chinese medicine composition, its active component are to be made by the raw material of Chinese medicine of following mass parts: 1～30 part of Radix Et Rhizoma Rhei, 3～60 parts of Radix Aconiti Lateralis Preparatas, 1～90 part of the Radix Astragali, 5～60 parts of Radix Salviae Miltiorrhizaes, 1～12 part of Hirudo, 1～60 part of Fructus Corni, 1～60 part of Cortex Cinnamomi; The curative effect of described Chinese medicine composition is presented as stabilizes and increases nephrotic's endogenous creatinine clearance rate and improves the symptom that nocturia increases; Described nephropathy is chronic renal failure.
4. arbitrary described Chinese medicine composition according to claim 1-3 is characterized in that: the dosage form of described Chinese medicine composition is pill, capsule, tablet, powder or granule.
5. the preparation method of arbitrary described Chinese medicine composition among the claim 1-4 comprises the steps:
1) raw material of Chinese medicine except Hirudo in arbitrary described Chinese medicine composition among the claim 1-4 is mixed, after soaking, decoct, collect decoction liquor;
2) Hirudo is pulverized, obtain Hirudo powder;
3) with the described decoction liquor of step 1) and step 2) described Hirudo powder merging, namely obtain described Chinese medicine composition; Wherein, step 1) and 2) in no particular order sequentially.
6. method according to claim 5 is characterized in that:
The amount of water that soaks described in the step 1) is 4 times-16 times of the raw material of Chinese medicine quality sum except Hirudo; The time of described immersion is 0.5 hour-2 hours; The temperature of described immersion is 20 ℃-40 ℃.
7. it is characterized in that according to claim 5 or 6 described methods:
Described decoction is carried out once; Each time that decocts is 30 minutes-80 minutes; The temperature of described decoction is 97 ℃-99 ℃.
8. a medicine that is used for the treatment of nephropathy contains arbitrary described Chinese medicine composition among the claim 1-4, and pharmaceutically acceptable carrier; Described nephropathy is chronic renal failure.
9. arbitrary described Chinese medicine composition or medicine claimed in claim 8 application in the medicine of preparation treatment nephropathy among the claim 1-4; Described nephropathy is chronic renal failure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110216895 CN102283912B (en) | 2011-07-29 | 2011-07-29 | Chinese medicinal composition for treating chronic kidney failure and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110216895 CN102283912B (en) | 2011-07-29 | 2011-07-29 | Chinese medicinal composition for treating chronic kidney failure and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102283912A CN102283912A (en) | 2011-12-21 |
| CN102283912B true CN102283912B (en) | 2013-03-20 |
Family
ID=45330848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110216895 Active CN102283912B (en) | 2011-07-29 | 2011-07-29 | Chinese medicinal composition for treating chronic kidney failure and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102283912B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103830466A (en) * | 2012-11-27 | 2014-06-04 | 包桂荣 | Medicine for treating early kidney failure |
| CN104758727A (en) * | 2015-04-03 | 2015-07-08 | 吴扬华 | Miao medicine composition for treating nephropathy |
| CN106138494B (en) * | 2015-04-07 | 2021-06-08 | 何世东 | Kidney nourishing composition and production method thereof |
| CN106236857B (en) * | 2015-06-04 | 2020-01-10 | 张宁 | Traditional Chinese medicine composition for treating chronic renal failure and preparation method, preparation and application thereof |
| CN105250588A (en) * | 2015-10-19 | 2016-01-20 | 陈立爱 | Chinese herbal preparation for treating kidney failure and preparation method of Chinese herbal preparation |
| CN105168664A (en) * | 2015-10-19 | 2015-12-23 | 管遵信 | Traditional Chinese medicine for treating chronic renal failure |
| CN105582139B (en) * | 2016-03-03 | 2020-07-03 | 上海市浦东新区人民医院 | Traditional Chinese medicine composition for treating spleen and kidney qi deficiency and qi and yin deficiency type chronic renal failure and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204481A (en) * | 2007-12-17 | 2008-06-25 | 牟培超 | Chinese traditional medicine for chronic nephritis |
-
2011
- 2011-07-29 CN CN 201110216895 patent/CN102283912B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204481A (en) * | 2007-12-17 | 2008-06-25 | 牟培超 | Chinese traditional medicine for chronic nephritis |
Non-Patent Citations (1)
| Title |
|---|
| 吴瑞萍.中医药治疗慢性肾功能衰竭概况.《河北中医》.2007,第29卷(第12期),1138-1140. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102283912A (en) | 2011-12-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102283912B (en) | Chinese medicinal composition for treating chronic kidney failure and preparation method thereof | |
| CN104435692A (en) | Prescription for treating nerve headache and preparation method thereof | |
| CN103083505A (en) | Liver-soothing and qi-regulating traditional Chinese medicine composition used for treating depression, and preparation method thereof | |
| CN100460008C (en) | Chinese medicine composition for treating cancer | |
| CN102266472B (en) | Chinese medicinal composition for preventing and/or treating diabetic nephropathy and preparation method thereof | |
| CN102423423B (en) | Traditional Chinese medicine for treating urinary tract infection | |
| CN104524416A (en) | Pharmaceutical composition, and use and preparation method of pharmaceutical composition as well as medicine, food and/or health food prepared from pharmaceutical composition | |
| CN102028842A (en) | Medicament for treating dysmenorrhea and preparation method thereof | |
| CN103330868B (en) | Intestinal tract replenishing liquid for chronic renal failure | |
| CN101744965A (en) | Traditional Chinese herb composition for treating sub-health and preparation method thereof | |
| CN103127472A (en) | Traditional Chinese medicine compound for refractory insomnia | |
| CN102370727A (en) | Compound Chinese medicinal preparation for treating depression and preparation method thereof | |
| CN101181383A (en) | Medicine composition for treating apoplexy as well as preparation method | |
| CN102764337B (en) | Traditional Chinese medicine composition for curing hepatitis B | |
| CN105194301A (en) | Traditional Chinese medicine preparation for treating chronic cardiac failure | |
| CN101229292B (en) | Chinese traditional medicine preparation for treating nephropathy, preparation method and applications thereof | |
| CN104435614A (en) | Pharmaceutical composition for treating infantile enuresis | |
| CN103341095B (en) | Clysis liquid used for chronic renal failure | |
| CN103191303B (en) | Traditional Chinese medicine for treating night sweat | |
| CN102579678B (en) | Medicinal composition for treating vitligo | |
| CN105770748A (en) | Traditional Chinese medicine composition for treating gouts | |
| CN104288579A (en) | Traditional Chinese medicine for treating chronic nephritis and preparation method thereof | |
| CN104606650A (en) | Traditional Chinese medicine composition treating insomnia | |
| CN102670983B (en) | Medicine for treating nephropathy | |
| CN103656516A (en) | Chinese herbal preparation for treating diabetic nephropathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20171227 Address after: 100083 Jinhui Business Hotel 2, 2741 room, Beijing four, Beijing, Haidian District, Haidian District, Beijing Patentee after: Beijing Zhong Yi Medical Technology Co., Ltd. Address before: 100053 Guanganmen Hospital of Chinese Academy of traditional Chinese medicine, 5 north line Pavilion, Beijing, Xicheng District Patentee before: Tong Xiaolin |
|
| TR01 | Transfer of patent right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: Room 2741, 2f, Beijing sidaokou Jinhui Business Hotel, 48 Xueyuan Road, Haidian District, Beijing 100083 Patentee after: Beijing zhongyitang Technology Co.,Ltd. Address before: Room 2741, 2f, Beijing sidaokou Jinhui Business Hotel, 48 Xueyuan Road, Haidian District, Beijing 100083 Patentee before: BEIJING ZHONGYITANG MEDICAL TECHNOLOGY CO.,LTD. |
|
| CP01 | Change in the name or title of a patent holder | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220303 Address after: 100073 floor 2-3, building 1, No. 15, Xizhan South Road, Fengtai District, Beijing Patentee after: Beijing Nord Kangze Hospital Management Co.,Ltd. Address before: Room 2741, 2f, Beijing sidaokou Jinhui Business Hotel, 48 Xueyuan Road, Haidian District, Beijing 100083 Patentee before: Beijing zhongyitang Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right |