CN102266387B - Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease - Google Patents
Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease Download PDFInfo
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- CN102266387B CN102266387B CN 201110196520 CN201110196520A CN102266387B CN 102266387 B CN102266387 B CN 102266387B CN 201110196520 CN201110196520 CN 201110196520 CN 201110196520 A CN201110196520 A CN 201110196520A CN 102266387 B CN102266387 B CN 102266387B
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Abstract
The invention discloses a medicament for treating a foot-and-mouth disease and a method for producing the medicament for treating the foot-and-mouth disease. The medicament is prepared from the following raw materials in parts by volume: 450-550 parts of camphor spirit, 325-425 parts of azone and 100-150 parts of turpentine, wherein azone has a transdermal penetration assisting effect. Due to the adoption of a formula, the absorption of the medicament is greatly improved, disease symptoms are relieved quickly, the antimicrobial activities of camphor and turpentine are increased, optimal treatment opportunity is created for the treatment of quickly infective diseases such as the foot-and-mouth disease, the antivirus capability is facilitated fundamentally, the autoimmunity is excited and the effects of preventing and treating diseases are achieved.
Description
Technical field
The present invention relates to the veterinary drug technical field, relate in particular to the method for the medicament of a kind of medicament for the treatment of foot and mouth disease and production for treating foot and mouth disease.
Background technology
Foot and mouth disease is a kind of acute, hot, the height contagious disease that is caused by foot and mouth disease virus, it is beastly mainly to encroach on artiodactyl, and its morbidity is anxious, popular soon, propagation is wide, infectiousness is strong, sickness rate is high, and the epidemic-stricken area sickness rate can reach 50～100%, the poultry production capacity of catching an illness on average descends 30%, breeding stock is worth forfeiture, sometimes can be up to 100% to newborn young stock fatality rate, and the people also has infection by chance, hazardness is very big, easily identification of foot and mouth disease pathological changes typical case, cardinal symptom has: a large amount of sialorrheas are and draw the thread shape; Blister or erosion appear in the specific paries such as oral mucosa, hoof and skin of nipple; Visible tiger spot heart during pernicious foot and mouth disease, foot and mouth disease can cause that to suffer from poultry manic and uneasy, thereby cause loss of appetite, and treatment is mainly take antiviral and increase autoimmunity as main
Now use the compound camphor liniment to be the local excitation medicine, external curing arthritis, tendinitis, rheumatism of muscles disease, cellulitis, various contusion, sprain, chronic orchitis and chronic inflammatory myalgia and neuralgia etc.Its main curative mechanism is the anti-inflammatory of Camphora; Camphor ointment is dermerethistica, can promote local blood circulation with alleviation swelling, and pain relieving, itching-relieving action are arranged, and is used for chilblain and itching skin disease; The effect of Chloral Hydrate Tincture is used for the pain caused temporary transient pain relieving of dental caries; The effect of Comphor and phenol solution is used for pulpitis, dental caries nest and root canal sterilization; Camphora Herba Menthae willow ester emulsifiable paste is used for headache, giddy, insect bite, mosquito bite, detumescence, pain relieving; Compound recipe beclometasone Camphora emulsifiable paste has the effects such as antiinflammatory, analgesia, antipruritic, antibiotic, local anesthesia, is used for insect dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin pruritus etc.; There is now the application of document record that arthromyodynia, anal eczema, enterobiasis, Tinea Pedis, decubital ulcer and pain are arranged, utilize mainly in Traditional Chinese medicine historical preparation that its tool is refrigerant, the effect of fragrance and warming and odynolysis, often enter the dosage forms such as rubber-emplastrum, tincture, plaster, oil preparation, ointment, still be not used for the treatment of the record of foot and mouth disease.
Summary of the invention
Technical problem to be solved by this invention provides the medicament of the treatment foot and mouth disease that a kind of composition is simple, cure rate is high.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of medicament for the treatment of foot and mouth disease, described medicament are to be formed by the configuration of the raw material of following parts by volume:
Camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume.
As preferred technical scheme, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 450～550ml, azone 325～425ml, Oleum Terebinthinae 100～150ml.
As preferred technical scheme, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 500ml, azone 375ml, Oleum Terebinthinae 125ml.
As preferred technical scheme, described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
As to improvement of the technical scheme, in the liquid medicine of described treatment foot and mouth disease, add the propellant that accounts for described liquid medicine weight 15～30%, make the medicament aerosol for the treatment of foot and mouth disease.
As preferred technical scheme, described propellant is dichlorodifluoromethane or normal butane.
The effect of Camphora:
1) local action: Camphora is applied to skin gentle stimulation and antisepsis.Firmly embrocated and sent out effect red; Dab is similar Herba Menthae then, and refrigerant sense is arranged, and this is owing to stimulate the effect of Cold receptor.It also has slight local anesthesia effect.For gastrointestinal tract mucous, Camphora has stimulation, stomach is basked and comfortable, then can produce in a large number to feel sick and vomiting.With camphorated oil analgesia, itching-relieving action are arranged clinically.Oral have wind dispelling effect and a slight phlegm-dispelling functions.The effect that promotes that inflammatory absorbs is arranged;
2) to central nervous system's effect: the general action of Camphora mainly is the stimulating central nervous system system, and is particularly remarkable for high-level center, acts in a large number zona rolandica and brain stem, causes epileptiform convulsion.The Camphora of general dosage in extreme inhibition situation, can be seen the excitement of some breathings to breathing without obvious effect, mainly is because the caused reflex excitation of excitement receiver during subcutaneous injection;
3) to the effect of blood circulation: once once extensive use of camphor preparations is cardiac tonic, but that each is reported the result is very inconsistent, up to without final conclusion.It is without Folium Digitalis Purpureae or the effect of epinephrine sample.Without effect, high concentration is counter to suppress it to normal myocardium.On isolated heart, only when causing depletion, the side sees that excitation is arranged.To vasomotor center, only when its function was extremely low, the side saw that excitation is arranged, and visceral vessel shrinks and the skin heart diastole, increased blood pressure.So think effective to circulatory collapse or acute heart failure person; But also having the people that its curative effect is held suspects or negative attitude.Someone reports, a Camphora water soluble metabolites-vitacampher in animal body has obvious heart tonifying, boosts and excited effect of breathing the trade name Oxocamphor.
The effect of azone:
Dermal osmosis accelerator can change skin chromaticness layer lipid and protein structure, promotes the drug percutaneous skin to absorb, and can both strengthen its transdermal effect to hydrophilic and hydrophobic chemical compound, generally can work in low quality concentration 0.5～2%.To skin, mucosa nonirritant, in ointment, cream, liniment, add this product and all can bring into play the Transdermal absorption effect.Can be used as the adjuvant of the medicine for external use such as ointment, cream, liniment.
Terebinthine effect:
1) antibacterial action: Radix Pini massonianae extract asbolin In Vitro Bacteriostasis experiment and zoopery gonosome tinea, ringworm treatment observed and show: have stronger antifungic action, such as Candida albicans etc.; Staphylococcus aureus, escherichia coli etc. also there is certain bacteriostasis;
2) the external lithodialysis experiment of litholytic effect shows: 5% medical Oleum Terebinthinae Emulsion can make bile pigments type calculus entirely molten behind 60h; It is fragment that main component australene in the Oleum Terebinthinae, nopinene and both mixture also can make bile pigments type calculus molten.Experiment in vivo and vitro and clinical observation prove that australene and nopinene mixed emulsion all present obvious litholytic effect, and have the effect of certain antiinflammatory and inhibition various bacteria.
Another technical problem to be solved by this invention provides a kind of method of medicament of production for treating foot and mouth disease.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of method of medicament of production for treating foot and mouth disease, the camphor spirit of at first getting 450～550 parts by volume adds in the container, the azone that under stirring, adds afterwards 325～425 parts by volume, the Oleum Terebinthinae and the mix homogeneously that add at last 100～150 parts by volume can make the medicament of described treatment foot and mouth disease.
As preferred technical scheme, described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
As the improvement to above-mentioned technology, in the liquid medicine of described treatment foot and mouth disease, add the propellant that accounts for described liquid medicine weight 15～30%, make the medicament aerosol for the treatment of foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because pain causes, reduces the misery of suffering from poultry, the time of the consumption when having reduced a large amount of administration.
As preferred technical scheme, described propellant is dichlorodifluoromethane or normal butane.
The using method of the medicament aerosol of described treatment foot and mouth disease: use front jolting, from skin 30～50 centimeters: press shower nozzle to the affected part even spraying, be advisable not drop down medicinal liquid, every day 2～3 times; It is antibacterial antitoxin also to can be used for the breeding house space, and every tank can be used for 3000 cubic metres.
Owing to adopted technique scheme, the method of the medicament of a kind of medicament for the treatment of foot and mouth disease and production for treating foot and mouth disease, described medicament is to be formed by the configuration of the raw material of following parts by volume: camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume; Azone has transdermal and helps the effect of oozing, and this prescription has improved the absorption of medicine greatly, alleviates rapidly disease, the ability that the Camphora of enhancing and Oleum Terebinthinae are antibiotic, the treatment opportunity of the best of creating for the fast disease of this class infectiousness for the treatment of foot and mouth disease; Fundamentally promote himself anti-virus ability, excite autoimmunity, thereby play the effect of preventing and curing diseases.
Further set forth the present invention below in conjunction with concrete case:
1) the existing sow of certain plant is 100,400 of growing and fattening pigs, there are first growing and fattening pigs to infect doubtful hoof-and-mouth disease, just carry out the pig house sterilization, because the place reason is not isolated, only carry out disinfection, 200 bull pigs infect in succession after 5 days, and appearance limping, hoof vesicle, fervescence, sialorrhea, happiness are crouched and do not thought walking.Town's Disease Diagnosis of Veterinary is foot and mouth disease, with panic, begins the medication of breeding pig is treated.The medicine for treatment situation is as follows: 31 injections of Radix Isatidis injection that mix 10 milliliter of 5 gram of astragalin injection of 10 milliliter of 0.2 gram of every sow intramuscular injection, 2 injections of distillation aquation benzathine benzylpenicillin with 600,000 units, 5 grams, once a day, and with golden multidimensional drinking-water, be used in conjunction three days except a breeding pig situation is taken a favourable turn, all the other effects are not clearly.The sick hog snout dish of part, oral cavity, gums, tongue, also can see vesicle and speck, other has 3 pigs to develop complications---enteritis.
The medicament aerosol of rear usefulness treatment foot and mouth disease of the present invention is treated, due to illness the swine diseases journey is longer, we are divided into three groups according to the weight of symptom with sick pig, totally 137 of comparatively serious one groups, administration every day 3 times, simultaneously with this aerosol to the breeding house space every sterilization in 6 hours once, continuous use 10 days began in 2 days, and 134 swine diseases feelings are stable, without increasing the weight of sign, other has 3 aggravations, dies off in 3 days for myocarditis because infecting, and the state of an illness alleviated gradually after it did continuation medication to 4 day, medication is sick pig transference cure after 8 days, and it is normal that appetite is recovered.Continued administration 2, every day 1 time, cure rate reached 97.8% to prevent palindromia.
Another state of an illness is gentlier organized totally 86, administration every day 2 times, simultaneously with this aerosol to the breeding house space every sterilization in 6 hours once, continuous use 8 days begins stable disease in 1 day, without increasing the weight of sign, medication after 2 days the state of an illness alleviate gradually, medication is sick pig transference cure after 4 days, and it is normal that appetite is recovered, continue medication to 6 day after, ill pig transference cure, continued administration 2, every day 1 time, cure rate reached 100% to end palindromia.
For be divided into one group that symptom do not occur, administration every day 1 time, with this aerosol to sterilization every day of breeding house space once, continuous use 3 days is all without disease symptom simultaneously.
Pay a return visit after a few days, the equal appetite of sick pig is normal, and no case was recurrence.
The specific embodiment
Below in conjunction with embodiment, further set forth the present invention.Should be understood that these embodiment only to be used for explanation the present invention and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment one:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 450ml is that the alcoholic solution of 8% Camphora adds in the container, the azone that adds afterwards 325ml under stirring adds Oleum Terebinthinae and the mix homogeneously of 100ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant dichlorodifluoromethane that accounts for described liquid medicine weight 15%, make the medicament aerosol for the treatment of foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
Embodiment two:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 500ml is that the alcoholic solution of 10% Camphora adds in the container, the azone that adds afterwards 375ml under stirring adds Oleum Terebinthinae and the mix homogeneously of 125ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant normal butane that accounts for described liquid medicine weight 27%, make the medicament aerosol for the treatment of foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
Embodiment three:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 550ml is that the alcoholic solution of 12% Camphora adds in the container, the azone that adds afterwards 425ml under stirring adds Oleum Terebinthinae and the mix homogeneously of 150ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant dichlorodifluoromethane that accounts for described liquid medicine weight 30%, make the medicament aerosol for the treatment of foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in above-described embodiment and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof
All from the present invention is to devise, the reconfiguration of having done without creative work all drops within protection scope of the present invention.
Claims (10)
1. a medicament for the treatment of foot and mouth disease is characterized in that, described medicament is to be formed by the configuration of the raw material of following parts by volume:
Camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume.
2. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 1 is characterized in that, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 450～550ml, azone 325～425ml, Oleum Terebinthinae 100～150ml.
3. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 2 is characterized in that, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 500ml, azone 375ml, Oleum Terebinthinae 125ml.
4. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 3 is characterized in that: described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
5. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 1 is characterized in that: add the propellant that accounts for described liquid medicine weight 15～30% in the liquid medicine of described treatment foot and mouth disease, make the medicament aerosol for the treatment of foot and mouth disease.
6. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 5, it is characterized in that: described propellant is dichlorodifluoromethane or normal butane.
7. the method for the medicament of a production such as the described treatment foot and mouth disease of the arbitrary claim of claim 1 to 4, it is characterized in that: the camphor spirit of at first getting 450～550 parts by volume adds in the container, the azone that under stirring, adds afterwards 325～425 parts by volume, the Oleum Terebinthinae and the mix homogeneously that add at last 100～150 parts by volume can make the medicament of described treatment foot and mouth disease.
8. the method for the medicament of a kind of production for treating foot and mouth disease as claimed in claim 7 is characterized in that: described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
9. the method for the medicament of a production such as claim claim 5 or 6 described treatment foot and mouth disease, it is characterized in that: in the liquid medicine of described treatment foot and mouth disease, add the propellant that accounts for described liquid medicine weight 15～30%, make the medicament aerosol for the treatment of foot and mouth disease.
10. the method for the medicament of a kind of production for treating foot and mouth disease as claimed in claim 9, it is characterized in that: described propellant is dichlorodifluoromethane or normal butane.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110196520 CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110196520 CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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| Publication Number | Publication Date |
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| CN102266387A CN102266387A (en) | 2011-12-07 |
| CN102266387B true CN102266387B (en) | 2013-01-30 |
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| CN 201110196520 Expired - Fee Related CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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| CN107223628A (en) * | 2017-05-09 | 2017-10-03 | 安徽禾泉农庄生态农业有限公司 | A kind of cultural method for preventing and treating wild boar Schweineseuche disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049343A (en) * | 2006-12-25 | 2007-10-10 | 郭其现 | Powder for treating foot-and-mouth disease |
| CN101869601A (en) * | 2010-06-28 | 2010-10-27 | 潘冠军 | External veterinary medicament |
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2011
- 2011-07-14 CN CN 201110196520 patent/CN102266387B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049343A (en) * | 2006-12-25 | 2007-10-10 | 郭其现 | Powder for treating foot-and-mouth disease |
| CN101869601A (en) * | 2010-06-28 | 2010-10-27 | 潘冠军 | External veterinary medicament |
Non-Patent Citations (2)
| Title |
|---|
| 孙凌峰.植物精油及萜类成分的生物活性.《江西师范大学学报(自然科学版)》.2000,第24卷(第02期),159-163. * |
| 舒常永.奶牛蹄病的病因及防治.《河南畜牧兽医(综合版)》.2009,第30卷(第01期),24-25. * |
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