CN102266387A - Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease - Google Patents
Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease Download PDFInfo
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- CN102266387A CN102266387A CN 201110196520 CN201110196520A CN102266387A CN 102266387 A CN102266387 A CN 102266387A CN 201110196520 CN201110196520 CN 201110196520 CN 201110196520 A CN201110196520 A CN 201110196520A CN 102266387 A CN102266387 A CN 102266387A
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Abstract
The invention discloses a medicament for treating a foot-and-mouth disease and a method for producing the medicament for treating the foot-and-mouth disease. The medicament is prepared from the following raw materials in parts by volume: 450-550 parts of camphor spirit, 325-425 parts of azone and 100-150 parts of turpentine, wherein azone has a transdermal penetration assisting effect. Due to the adoption of a formula, the absorption of the medicament is greatly improved, disease symptoms are relieved quickly, the antimicrobial activities of camphor and turpentine are increased, optimal treatment opportunity is created for the treatment of quickly infective diseases such as the foot-and-mouth disease, the antivirus capability is facilitated fundamentally, the autoimmunity is excited and the effects of preventing and treating diseases are achieved.
Description
Technical field
The present invention relates to the veterinary drug technical field, relate in particular to the method for the medicament of a kind of medicament for the treatment of foot and mouth disease and production for treating foot and mouth disease.
Background technology
Foot and mouth disease is a kind of acute, hot, the height contagious disease that is caused by foot and mouth disease virus, main infringement artiodactyl beast, its morbidity anxious, popular fast, propagate wide, infectiousness is strong, sickness rate is high, the epidemic-stricken area sickness rate can reach 50～100%, the dirty swine production capacity of catching an illness power on average descends 30%, breeding stock is worth forfeiture, sometimes can be to newborn young stock fatality rate up to 100%, and the people also has infection by chance, hazardness is very big, easily identification of foot and mouth disease pathological changes typical case, cardinal symptom has: a large amount of sialorrheas are and draw the thread shape; Blister or erosion appear in specific paries such as oral mucosa, hoof and skin of nipple; Visible tiger spot heart during pernicious foot and mouth disease, foot and mouth disease can cause that to suffer from poultry manic and uneasy, thereby cause loss of appetite, and treatment is mainly based on antiviral and increase autoimmunity
Now use the compound camphor liniment to be the local excitation medicine, external curing arthritis, tendinitis, rheumatism of muscles disease, cellulitis, various contusion, sprain, chronic orchitis and chronic inflammatory myalgia and neuralgia etc.Its mechanism of mainly curing the disease is the anti-inflammatory of Camphora; Camphor ointment is a dermerethistica, can promote local blood circulation with alleviation swelling, and pain relieving, itching-relieving action are arranged, and is used for chilblain and itching skin disease; The effect of Camphora chloral hydrate tincture is used for the pain caused temporary transient pain relieving of dental caries; The effect of Comphor and phenol solution is used for pulpitis, dental caries nest and root canal sterilization; Camphora Herba Menthae willow ester emulsifiable paste is used for headache, giddy, insect bite, mosquito bite, detumescence, pain relieving; Compound recipe beclometasone Camphora emulsifiable paste has effects such as antiinflammatory, analgesia, antipruritic, antibiotic, local anesthesia, is used for insect dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin pruritus etc.; There is the application of document record that arthromyodynia, anal eczema, enterobiasis, tinea pedis infection, decubital ulcer and pain are arranged now, utilize mainly in the Chinese traditional patent formulation preparation that its tool is refrigerant, the effect of fragrance and warming and odynolysis, often go into dosage forms such as rubber-emplastrum, tincture, plaster, oil preparation, ointment, still be not used in the record of treatment foot and mouth disease.
Summary of the invention
Technical problem to be solved by this invention provides the medicament of the treatment foot and mouth disease that a kind of composition is simple, cure rate is high.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of medicament for the treatment of foot and mouth disease, described medicament are to be formed by the configuration of the raw material of following parts by volume:
Camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume.
As optimized technical scheme, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 450～550ml, azone 325～425ml, Oleum Terebinthinae 100～150ml.
As optimized technical scheme, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 500ml, azone 375ml, Oleum Terebinthinae 125ml.
As optimized technical scheme, described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
As to improvement of the technical scheme, in the liquid medicine of described treatment foot and mouth disease, add the propellant that accounts for described liquid medicine weight 15～30%, make the medicament aerosol of treatment foot and mouth disease.
As optimized technical scheme, described propellant is dichlorodifluoromethane or normal butane.
The effect of Camphora:
1) local action: Camphora is applied to skin gentle stimulation and antisepsis.Firmly embrocated and sent out effect red; The then similar Herba Menthae of dab has refrigerant sense, and this is owing to stimulate the effect of Cold receptor.It also has slight local anesthesia effect.For gastrointestinal tract mucous, Camphora has stimulation, stomach is basked and comfortable, then can produce in a large number to feel sick and vomiting.With camphorated oil analgesia, itching-relieving action are arranged clinically.Oral have wind dispelling effect and a slight phlegm-dispelling functions.The effect that promotes that inflammatory absorbs is arranged;
2) to central nervous system's effect: the general action of Camphora mainly is the stimulating central nervous system system, and is particularly remarkable for high-level center, acts on zona rolandica and brain stem in a large number, causes epileptiform convulsion.The Camphora of general dosage does not have obviously effect to breathing, and under extreme inhibition situation, can see the excitement of some breathings, mainly is because the caused reflex excitation of excitement receiver during subcutaneous injection;
3) to the effect of blood circulation: camphor preparations extensive use once once is a cardiac tonic, but that each family reports the result is very inconsistent, up to there not being final conclusion.Its no Folium Digitalis Purpureae or the effect of epinephrine sample.Normal myocardium is not had effect, and high concentration is counter to suppress it.On isolated heart, only when causing depletion, the side sees that excitation is arranged.To vasomotor center, only when its function was extremely low, the side saw that excitation is arranged, and visceral vessel shrinks and the skin heart diastole, increased blood pressure.So think effective to circulatory collapse or acute heart failure person; But also having the people that its curative effect is held suspects or negative attitude.Someone reports, a Camphora water soluble metabolites-vitacampher in animal body has tangible heart tonifying, boosts and excited effect of breathing the trade name Oxocamphor.
The effect of azone:
Dermal osmosis accelerator can change skin chromaticness layer lipid and protein structure, promotes that medicine absorbs through skin, can both strengthen its transdermal effect to hydrophilic and hydrophobic chemical compound, generally can work in low quality concentration 0.5～2%.To skin, mucosa nonirritant, in ointment, cream, liniment, add this product and all can bring into play the Transdermal absorption effect.The adjuvant that can be used as medicine for external use such as ointment, cream, liniment.
Terebinthine effect:
1) antibacterial action: the external bacteriostatic experiment of Radix Pini massonianae extract asbolin and to zoopery gonosome tinea, ringworm treatment observe and show: have stronger antifungic action, as Candida albicans etc.; Staphylococcus aureus, escherichia coli etc. also there is certain bacteriostasis;
2) the external lithodialysis experiment of litholytic effect shows: 5% medical Oleum Terebinthinae Emulsion can make bile pigments type calculus molten entirely behind 60h; It is fragment that main component australene in the Oleum Terebinthinae, nopinene and both mixture also can make bile pigments type calculus molten.Experiment in vivo and vitro and clinical observation prove that australene and nopinene mixed emulsion all present significantly litholytic effect, and have the effect of certain antiinflammatory and inhibition various bacteria.
Another technical problem to be solved by this invention provides a kind of method of medicament of production for treating foot and mouth disease.
For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of method of medicament of production for treating foot and mouth disease, the camphor spirit of at first getting 450～550 parts by volume adds in the container, the azone that under stirring, adds 325～425 parts by volume afterwards, the Oleum Terebinthinae and the mix homogeneously that add 100～150 parts by volume at last can make the medicament of described treatment foot and mouth disease.
As optimized technical scheme, described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
As improvement to above-mentioned technology, in the liquid medicine of described treatment foot and mouth disease, add the propellant that accounts for described liquid medicine weight 15～30%, make the medicament aerosol of treatment foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because of pain causes, reduces the misery of suffering from poultry, the time of the consumption when having reduced a large amount of administration.
As optimized technical scheme, described propellant is dichlorodifluoromethane or normal butane.
The using method of the medicament aerosol of described treatment foot and mouth disease: use preceding jolting, from skin 30～50 centimeters: push shower nozzle to the affected part even spraying, be advisable, every day 2～3 times not drop down medicinal liquid; It is antibacterial antitoxin also to can be used for raising the house space, and every jar can be used for 3000 cubic metres.
Owing to adopted technique scheme, the method of the medicament of a kind of medicament for the treatment of foot and mouth disease and production for treating foot and mouth disease, described medicament is to be formed by the configuration of the raw material of following parts by volume: camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume; Azone has transdermal and helps the effect of oozing, and this prescription has improved the absorption of medicine greatly, alleviates disease rapidly, the antimicrobial ability of enhanced Camphora and Oleum Terebinthinae, the treatment opportunity of the best of creating for the fast disease of this class infectiousness of treatment foot and mouth disease; Fundamentally promote himself anti-virus ability, excite autoimmunity, thereby play the effect of preventing and curing diseases.
Further set forth the present invention below in conjunction with concrete case:
1) the existing sow of certain plant is 100,400 of growing and fattening pigs, there are growing and fattening pigs to infect doubtful hoof-and-mouth disease earlier, just carry out the pig house sterilization, because of the place reason is not isolated, only carry out disinfection, 200 bull pigs infect in succession after 5 days, and appearance limping, hoof vesicle, fervescence, sialorrhea, happiness are crouched and do not thought walking.The town veterinary is diagnosed as foot and mouth disease, with panic, begins the medication of breeding pig is treated.The medicine for treatment situation is as follows: 31 injections of Radix Isatidis injection that mix 10 milliliter of 5 gram of astragalin injection of 10 milliliter of 0.2 gram of every sow intramuscular injection, 2 injections of distillation aquation benzathine benzylpenicillin with 600,000 units, 5 grams, once a day, and with golden multidimensional drinking-water, all the other effects were not clearly except that a breeding pig situation is taken a favourable turn in three days in logotype.The sick hog snout dish of part, oral cavity, gums, tongue, also can see vesicle and speck, other has 3 pigs to develop complications---enteritis.
Treat with the medicament aerosol of treatment foot and mouth disease of the present invention the back, due to illness the swine diseases journey is longer, we are divided into three groups according to the weight of symptom with sick pig, totally 137 of comparatively serious one groups, administration every day 3 times, sterilized once every 6 hours to raising the house space with this aerosol simultaneously, continuous use 10 days began in 2 days, and 134 swine diseases feelings are stable, do not have and increase the weight of sign, other has 3 state of an illness to increase the weight of, and dies off in 3 days for myocarditis because of infecting, and the state of an illness alleviated gradually after it did continuation medication to 4 day, medication is sick pig transference cure after 8 days, and it is normal that appetite is recovered.Continued administration 2, every day 1 time, cure rate reached 97.8% to prevent palindromia.
Another state of an illness is gentlier organized totally 86, and administration every day 2 times was sterilized once every 6 hours to raising the house space with this aerosol simultaneously, continuous use 8 days begins stable disease in 1 day, does not have and increases the weight of sign, medication after 2 days the state of an illness alleviate gradually, medication is sick pig transference cure after 4 days, and it is normal that appetite is recovered, continue medication to 6 day after, ill pig transference cure, continued administration 2, every day 1 time, cure rate reached 100% to end palindromia.
For be divided into one group that symptom do not occur, administration every day 1 time is sterilized once to raising the house space with this aerosol simultaneously every day, and continuous use 3 days does not all have disease symptom.
Pay a return visit after a few days, the equal appetite of sick pig is normal, and no case was recurrence.
The specific embodiment
Below in conjunction with embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment one:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 450ml is that the alcoholic solution of 8% Camphora adds in the container, the azone that adds 325ml afterwards under stirring adds Oleum Terebinthinae and the mix homogeneously of 100ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant dichlorodifluoromethane that accounts for described liquid medicine weight 15%, make the medicament aerosol of treatment foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because of pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
Embodiment two:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 500ml is that the alcoholic solution of 10% Camphora adds in the container, the azone that adds 375ml afterwards under stirring adds Oleum Terebinthinae and the mix homogeneously of 125ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant normal butane that accounts for described liquid medicine weight 27%, make the medicament aerosol of treatment foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because of pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
Embodiment three:
A kind of method of medicament of production for treating foot and mouth disease, the mass concentration of at first getting 550ml is that the alcoholic solution of 12% Camphora adds in the container, the azone that adds 425ml afterwards under stirring adds Oleum Terebinthinae and the mix homogeneously of 150ml at last, can make the medicament of described treatment foot and mouth disease.
In the liquid medicine of described treatment foot and mouth disease, add the propellant dichlorodifluoromethane that accounts for described liquid medicine weight 30%, make the medicament aerosol of treatment foot and mouth disease, the medicament aerosol of described treatment foot and mouth disease is getting final product administration at a distance, administration is used easy to carry, do not contact the affected part during medication, do not rub, and avoid causing artificial pain and cross infection.The propellant of dishing out in addition can absorb the heat of skin surface, reduces pain, avoids suffering from the alarmed, uneasy of poultry because of pain causes, reduces the misery of suffering from poultry, the time that has consumed when having reduced a large amount of administration.
More than show and described ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof
All from the present invention is to devise, the reconfiguration of having done without creative work all drops within protection scope of the present invention.
Claims (10)
1. a medicament for the treatment of foot and mouth disease is characterized in that, described medicament is to be formed by the configuration of the raw material of following parts by volume:
Camphor spirit 450～550 parts by volume, azone 325～425 parts by volume, Oleum Terebinthinae 100～150 parts by volume.
2. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 1 is characterized in that, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 450～550ml, azone 325～425ml, Oleum Terebinthinae 100～150ml.
3. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 2 is characterized in that, described medicament is to be formed by the configuration of the raw material of following volume:
Camphor spirit 500ml, azone 375ml, Oleum Terebinthinae 125ml.
4. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 3 is characterized in that: described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
5. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 1 is characterized in that: add the propellant that accounts for described liquid medicine weight 40～50% in the liquid medicine of described treatment foot and mouth disease, make the medicament aerosol of treatment foot and mouth disease.
6. a kind of medicament for the treatment of foot and mouth disease as claimed in claim 5 is characterized in that: described propellant is dichlorodifluoromethane or normal butane.
7. the method for the medicament of production such as the described treatment foot and mouth disease of the arbitrary claim of claim 1 to 6, it is characterized in that: the camphor spirit of at first getting 450～550 parts by volume adds in the container, the azone that under stirring, adds 325～425 parts by volume afterwards, the Oleum Terebinthinae and the mix homogeneously that add 100～150 parts by volume at last can make the medicament of described treatment foot and mouth disease.
8. the method for the medicament of a kind of production for treating foot and mouth disease as claimed in claim 7 is characterized in that: described camphor spirit is that mass concentration is the alcoholic solution of 8～12% Camphora.
9. the method for the medicament of a kind of production for treating foot and mouth disease as claimed in claim 7 is characterized in that: add the propellant that accounts for described liquid medicine weight 15～30% in the liquid medicine of described treatment foot and mouth disease, make the medicament aerosol of treatment foot and mouth disease.
10. the method for the medicament of a kind of production for treating foot and mouth disease as claimed in claim 9 is characterized in that: described propellant is dichlorodifluoromethane or normal butane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110196520 CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110196520 CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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| Publication Number | Publication Date |
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| CN102266387A true CN102266387A (en) | 2011-12-07 |
| CN102266387B CN102266387B (en) | 2013-01-30 |
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| CN 201110196520 Expired - Fee Related CN102266387B (en) | 2011-07-14 | 2011-07-14 | Medicament for treating foot-and-mouth disease and method for producing medicament for treating foot-and-mouth disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107223628A (en) * | 2017-05-09 | 2017-10-03 | 安徽禾泉农庄生态农业有限公司 | A kind of cultural method for preventing and treating wild boar Schweineseuche disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049343A (en) * | 2006-12-25 | 2007-10-10 | 郭其现 | Powder for treating foot-and-mouth disease |
| CN101869601A (en) * | 2010-06-28 | 2010-10-27 | 潘冠军 | External veterinary medicament |
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2011
- 2011-07-14 CN CN 201110196520 patent/CN102266387B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049343A (en) * | 2006-12-25 | 2007-10-10 | 郭其现 | Powder for treating foot-and-mouth disease |
| CN101869601A (en) * | 2010-06-28 | 2010-10-27 | 潘冠军 | External veterinary medicament |
Non-Patent Citations (2)
| Title |
|---|
| 《江西师范大学学报(自然科学版)》 20000630 孙凌峰 植物精油及萜类成分的生物活性 159-163 1-10 第24卷, 第02期 * |
| 《河南畜牧兽医(综合版)》 20090105 舒常永 奶牛蹄病的病因及防治 24-25 1-10 第30卷, 第01期 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107223628A (en) * | 2017-05-09 | 2017-10-03 | 安徽禾泉农庄生态农业有限公司 | A kind of cultural method for preventing and treating wild boar Schweineseuche disease |
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