CN102266308A - Method for preparing odor masking sustained-release garlicin composite micro-capsules - Google Patents
Method for preparing odor masking sustained-release garlicin composite micro-capsules Download PDFInfo
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- CN102266308A CN102266308A CN2011102108996A CN201110210899A CN102266308A CN 102266308 A CN102266308 A CN 102266308A CN 2011102108996 A CN2011102108996 A CN 2011102108996A CN 201110210899 A CN201110210899 A CN 201110210899A CN 102266308 A CN102266308 A CN 102266308A
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Abstract
The invention discloses a method for preparing odor masking sustained-release garlicin composite micro-capsules. In the method, a garlicin/organic attapulgite complex serving as a capsule core is combined with sodium alginate to obtain a complex, and sodium alginate/chitosan micro-capsules are prepared from the obtained complex in a complex coacervation method. In the method, odor is masked and the medicine carrying capacity and envelop rate of the micro-capsules are improved by utilizing the adsorptive power and appetency of organic attapulgite on garlicin; gastric mucosae are protected against the irritation of the garlicin by utilizing the pH dependence of calcium alginate and the protective effect of attapulgite mucosae, and the micro-capsules become enteric medicine carrier materials under the synergistic action of the garlicin and the attapulgite on germs in intestinal tracts. In addition, the release of medicines in the micro-capsules is retarded by utilizing the detention effect of the attapulgite on the garlicin and the sustained-release performance of chitosan to improve the sustained-release performance of the micro-capsules. The preparation method is simple and environment-friendly, and can be used for sustained-release carrier materials of various medicines.
Description
Technical field
The present invention relates to microcapsule preparation method, be specifically related to the preparation method of the compound microcapsule of a kind of taste masking slow release garlicin.
Background technology
As everyone knows, garlicin is the main active in the Bulbus Allii, its chemical constitution is allicin (DATS), have that broad-spectrum is antibiotic, the effect of antiviral, blood pressure lowering, blood fat reducing, prevention and treatment person in middle and old age cardiovascular disease and coronary heart disease, and have anticancer and multiple efficacies such as fat-reducing, domestic can synthetic production.But the garlicin unstable chemcial property, chance heat, chance alkali easily decompose, and human intestines and stomach's mucous membrane spinosity is swashed property, intravenous injection inconvenience, intramuscular injection pain, biological half-life is shorter, and the patient must repeatedly take medicine every day, and the distinctive garlic odour of garlicin makes the patient be difficult for acceptance.Therefore develop its slow releasing preparation, alleviating medicine stimulates gastrointestinal, reduces and takes number of times, shelters its specific stink, is the effective way that improves garlicin curative effect and patient's compliance.Studies show that, adopt the microcapsule carrier technology, can improve medicine stability effectively, cover its abnormal smells from the patient, increase the intestines and stomach toleration, prolong the release time of oral administration and realize sustained release function etc.
In recent years, inorganic clay material has caused people's attention in the application of field of medicaments.Wherein, attapulgite clay (be called for short down attapulgite clay) is an a kind of layer of chain silicate clay, has bigger specific surface area, considerable pore structure and good heat stability.Because its good adsorptivity, ion exchangeable, swellability, outstanding adhesion, medicine carrying ability and nontoxic pollution-free have become the focus of preparation, pharmacology and aspect research such as clinical.Abroad, the attapulgite clay oral formulations is the very sophisticated OTC medicine that is used for digestive tract disease, multiple virus, antibacterial and toxin in the intestinal is had absorption and fixation, and can repair and protect the gastrointestinal mucosal barrier.
Summary of the invention
The objective of the invention is to: the preparation method that the compound microcapsule of a kind of taste masking slow release garlicin is provided; this preparation method is carried out attapulgite clay organically-modified to improve its compatibility and affinity to garlicin; and there are organic attapulgite clay of garlicin and sodium alginate to carry out compound the load; adopt complex coacervation to prepare the compound microcapsule of organic attapulgite clay/alginate; performance attapulgite clay and garlicin are removed and germ-resistant synergism pathogenic bacteria in the intestinal; shelter stink simultaneously; the protection gastrointestinal mucosal; improve the medicine carrying and the envelop rate of microcapsule, delay drug release.
Technical solution of the present invention is: at first attapulgite clay is carried out organically-modifiedly, carry out mixing and absorption with garlicin then, compound with sodium alginate again, last gained complex adopts complex coacervation to prepare the alginate microcapsule.
In the preparation method of the compound microcapsule of taste masking slow release garlicin of the present invention, said method comprising the steps of: at first, attapulgite clay is carried out with cetyl trimethyl ammonium bromide (CTAB) organically-modified, organic attapulgite clay; Then, garlicin is dissolved in the dehydrated alcohol, adds organic attapulgite clay mixing, volatilize, add sodium alginate soln again, get uniform suspension in the room temperature high speed dispersion; At last, this suspension is dripped to calcium chloride solution by orifice with 2.2 rpm flow velocitys with constant flow pump, the crosslinked gel microcapsule that gets, sucking filtration is cleaned gel microcapsule surface calcium ion, be transferred to overlay film in the certain density chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, vacuum drying gets the compound microcapsule of garlicin to constant weight.
In the preparation method of the compound microcapsule of taste masking slow release garlicin of the present invention, described attapulgite clay organically-modified is to be modifier with cetyl trimethyl ammonium bromide (CTAB), and the mass ratio of its addition and attapulgite clay is 1:10.
In the preparation method of the compound microcapsule of taste masking slow release garlicin of the present invention, the organically-modified of described attapulgite clay is that attapulgite clay is suspended in 0.1% ~ 1%(w/v) the CTAB aqueous solution according to mass volume ratio 1:100 ~ 3:100, sucking filtration, washing behind 60 ℃ ~ 80 ℃ stirring 6 h ~ 12 h, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves.
In the preparation method of the compound microcapsule of taste masking slow release garlicin of the present invention, the mass volume ratio of described garlicin and dehydrated alcohol is 1:5 ~ 1:10, the mass ratio of organic attapulgite clay and sodium alginate is 1:0.5 ~ 1:4, the mass ratio of garlicin and organic attapulgite clay is 1:1 ~ 1:4, sodium alginate concentration is 2%(w/v), calcium chloride concentration is 2%(w/v).
In the preparation method of the compound microcapsule of taste masking slow release garlicin of the present invention, the crosslinking time of described gel microcapsule is 10 min ~ 60 min, and the overlay film time is 1 h ~ 3 h, and used chitosan molecule amount is 500,000 ~ 700,000, and concentration is 0.5% ~ 2%(w/v).
The present invention has following advantage:
1. be the capsule heart with garlicin/organic attapulgite clay complex, utilize the bigger specific surface area of attapulgite clay, with absorption affinity and the affinity of its organically-modified back enhancing to garlicin, to shelter stink, improve the drug loading and the envelop rate of microcapsule, and utilize of the delay effect of organic attapulgite clay to garlicin, improve the sustained release performance of microcapsule.
2. because attapulgite clay itself has absorption and the fixedly effect of intestinal inner virus, antibacterial and toxin; and gastrointestinal mucosal had protective effect; garlicin is adsorbed in the attapulgite clay surface, both can have brought into play both synergism, can protect gastric mucosa not to be subjected to the stimulation of garlicin again pathogenic bacteria in the intestinal.
3. utilize the pH dependency of calcium alginate gel and the sustained release performance of chitosan, the sodium alginate microcapsule overlay film further to slow down the release of medicine, is made it to become the enteric solubility drug carrier material.
The specific embodiment
Below by embodiment in detail technical solution of the present invention is described in detail, but technical solution of the present invention is not limited to following embodiment.
Embodiment 1:
2 g attapulgite clay are suspended in 100 mL, 0.5 %(w/v) in the CTAB solution, in 70 ℃ stir 8 h after sucking filtration, washing, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves, organic attapulgite clay; 1.0 g garlicins are dissolved in the 8 mL dehydrated alcohol, add the organic attapulgite clay of 2.0 g in 250 mL round-bottomed flasks mixing, volatilize, add sodium alginate soln 100 mL of 2 % (w/v), 15 min get uniform suspension in the room temperature high speed dispersion; With constant flow pump with the flow velocity of 2.2 rpm with this suspendible drop to 2 %(w/v) calcium chloride solution in, crosslinked 30 min, get the gel microcapsule, sucking filtration is cleaned gel microcapsule surface calcium ion, the molecular weight that is transferred to 1% (w/v) is overlay film 2 h in 600,000 the chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, 40 ℃ of vacuum dryings get the compound microcapsule of garlicin to constant weight.
Embodiment 2:
1 g attapulgite clay is suspended in 100 mL, 0.1 %(w/v) in the CTAB solution, in 60 ℃ stir 12 h after sucking filtration, washing, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves, organic attapulgite clay; 1.0 g garlicins are dissolved in the 5 mL dehydrated alcohol, add the organic attapulgite clay of 1.0 g in the 100mL round-bottomed flask mixing, volatilize, add 2%(w/v) sodium alginate soln 25 mL, 15 min get even suspension in the room temperature high speed dispersion; With constant flow pump with the flow velocity of 2.2 rpm with this suspendible drop to 2 %(w/v) calcium chloride solution in, crosslinked 10 min, get the gel microcapsule, sucking filtration is cleaned gel microcapsule surface calcium ion, the molecular weight that is transferred to 2 % (v/v) is overlay film 1 h in 500,000 the chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, 40 ℃ of vacuum dryings get the compound microcapsule of garlicin to constant weight.
Embodiment 3:
6 g attapulgite clay are suspended in 200 mL, 1.0 %(w/v) in the CTAB solution, in 80 ℃ stir 6 h after sucking filtration, washing, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves, organic attapulgite clay; 1.0 g garlicins are dissolved in the 10 mL dehydrated alcohol, add the organic attapulgite clay of 4.0 g in round-bottomed flask mixing, volatilize, add 2 %(w/v) sodium alginate soln 800 mL, 15 min get even suspension in the room temperature high speed dispersion; With constant flow pump with the flow velocity of 2.2 rpm with this suspendible drop to 2 %(w/v) calcium chloride solution in, crosslinked 60 min, get the gel microcapsule, sucking filtration is cleaned gel microcapsule surface calcium ion, the molecular weight that is transferred to 0.5% (v/v) is overlay film 3 h in 700,000 the chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, 40 ℃ of vacuum dryings get the compound microcapsule of garlicin to constant weight.
Embodiment 4:
2 g attapulgite clay are suspended in 100 mL, 0.8 %(w/v) in the CTAB solution, in 75 ℃ stir 10 h after sucking filtration, washing, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves, organic attapulgite clay; 1.0 g garlicins are dissolved in the 6 mL dehydrated alcohol, add the organic attapulgite clay of 3.0 g in 1000 mL round-bottomed flasks mixing, volatilize, add sodium alginate soln 450 mL of 2% (w/v), 15 min get even suspension in the room temperature high speed dispersion; With constant flow pump with the flow velocity of 2.2 rpm with this suspendible drop to 2 %(w/v) calcium chloride solution in, crosslinked 50 min, get the gel microcapsule, sucking filtration is cleaned gel microcapsule surface calcium ion, the molecular weight that is transferred to 1.5 % (v/v) is overlay film 1.5 h in 600,000 the chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, 40 ℃ of vacuum dryings get the compound microcapsule of garlicin to constant weight.
Embodiment 5:
1.5 g attapulgite clay are suspended in 100 mL, 0.3 %(w/v) in the CTAB solution, in 65 ℃ stir 9 h after sucking filtration, washing, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves, organic attapulgite clay; 1.0 g garlicins are dissolved in the 7 mL dehydrated alcohol, add the organic attapulgite clay of 2.5 g in 500 mL round-bottomed flasks mixing, volatilize, add 2%(w/v) sodium alginate soln 300 mL, 15 min get even suspension in the room temperature high speed dispersion; With constant flow pump with the flow velocity of 2.2 rpm with this suspendible drop to 2 %(w/v) calcium chloride solution in, crosslinked 40 min, get the gel microcapsule, sucking filtration is cleaned gel microcapsule surface calcium ion, the molecular weight that is transferred to 1 % (w/v) is overlay film 2.5 h in 700,000 the chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, 40 ℃ of vacuum dryings get the compound microcapsule of garlicin to constant weight.
The compound microcapsule of garlicin that adds organic attapulgite clay is compared (reaction condition and step are with embodiment 1) with the alginate microcapsule, its envelop rate, drug loading and the cumulative release rate in the phosphate buffer of pH 6.8 are as shown in the table, the adding that organic attapulgite clay is described has improved envelop rate and the drug loading of complex microsphere to garlicin, and has delayed the rate of release of garlicin.
The comparison of the compound microcapsule drug loading of garlicin, envelop rate and cumulative in vitro release rate
Claims (6)
1. the preparation method of the compound microcapsule of taste masking slow release garlicin, it is characterized in that: at first carry out attapulgite clay organically-modified, carry out mixing and absorption with garlicin then, compound with sodium alginate again, last gained complex adopts complex coacervation to prepare the alginate microcapsule.
2. the preparation method of the compound microcapsule of taste masking slow release garlicin according to claim 1 is characterized in that said method comprising the steps of: at first, attapulgite clay is carried out with cetyl trimethyl ammonium bromide (CTAB) organically-modified, organic attapulgite clay; Then, garlicin is dissolved in the dehydrated alcohol, adds organic attapulgite clay mixing, volatilize, add sodium alginate soln again, get uniform suspension in the room temperature high speed dispersion; At last, this suspension is dripped to calcium chloride solution by orifice with 2.2 rpm flow velocitys with constant flow pump, the crosslinked gel microcapsule that gets, sucking filtration is cleaned gel microcapsule surface calcium ion, be transferred to overlay film in the certain density chitosan solution, filter, washing gets uniform and smooth spherical microcapsule, vacuum drying gets the compound microcapsule of garlicin to constant weight.
3. the preparation method of the compound microcapsule of taste masking slow release garlicin according to claim 2 is characterized in that: described attapulgite clay organically-modified is to be modifier with cetyl trimethyl ammonium bromide (CTAB), and the mass ratio of its addition and attapulgite clay is 1:10.
4. the preparation method of the compound microcapsule of taste masking slow release garlicin according to claim 3, it is characterized in that: the organically-modified of described attapulgite clay is that attapulgite clay is suspended in 0.1% ~ 1%(w/v) the CTAB aqueous solution according to mass volume ratio 1:100 ~ 3:100, sucking filtration, washing behind 60 ℃ ~ 80 ℃ stirring 6 h ~ 12 h, must not detect bromide ion in the cleaning mixture, in 105 ℃ of oven dry, ground 200 mesh sieves.
5. the preparation method of the compound microcapsule of taste masking slow release garlicin according to claim 2, it is characterized in that: the mass volume ratio of described garlicin and dehydrated alcohol is 1:5 ~ 1:10, the mass ratio of organic attapulgite clay and sodium alginate is 1:0.5 ~ 1:4, the mass ratio of garlicin and organic attapulgite clay is 1:1 ~ 1:4, sodium alginate concentration is 2%(w/v), calcium chloride concentration is 2%(w/v).
6. the preparation method of the compound microcapsule of taste masking slow release garlicin according to claim 2, it is characterized in that: the crosslinking time of described gel microcapsule is 10 min ~ 60 min, the overlay film time is 1 h ~ 3 h, and used chitosan molecule amount is 500,000 ~ 700,000, and concentration is 0.5% ~ 2%(w/v).
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Cited By (13)
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| CN102579398A (en) * | 2011-12-31 | 2012-07-18 | 沈阳药科大学 | Enteric microcapsule with function of balancing bad taste of medicament and preparation method of enteric microcapsule |
| CN102952792A (en) * | 2012-11-12 | 2013-03-06 | 淮阴工学院 | Preparation method of beta-glucosidase immobilized by sodium alginate loaded with attapulgite |
| CN104208710A (en) * | 2014-09-11 | 2014-12-17 | 广西大学 | Method for preparing modified konjac glucomannan sustained-release microcapsule |
| CN104630299A (en) * | 2015-03-03 | 2015-05-20 | 广东轻工职业技术学院 | Extraction method of odorless allicin |
| CN105078899A (en) * | 2015-08-26 | 2015-11-25 | 四川农业大学 | Enrofloxacin stratified high molecular taste mashing skeleton particle and preparation method thereof |
| CN105168179A (en) * | 2015-08-04 | 2015-12-23 | 浙江汇能动物药品有限公司 | Clopidol controlled-release microparticle preparation and preparation method thereof |
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| CN109430265A (en) * | 2018-11-23 | 2019-03-08 | 中国科学院兰州化学物理研究所 | The method for preparing carvacrol microcapsule anti-bacterial agent using attapulgite stabilized oil-in-water lotion |
| CN109498645A (en) * | 2018-11-28 | 2019-03-22 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Charge regulation cooperates with the high-pressure homogeneous method for preparing attapulgite cationic antibacterial agent |
| CN109731103A (en) * | 2019-01-20 | 2019-05-10 | 桂林理工大学 | P-zeolite-chitin-sodium alginate-potassium diformate sustained-release antibacterial agent preparation method |
| CN111870588A (en) * | 2020-08-24 | 2020-11-03 | 广州立达尔生物科技股份有限公司 | Method for preparing allicin microcapsule by coupling carrier adsorption and precipitation |
| CN112076155A (en) * | 2020-10-26 | 2020-12-15 | 临沂大学 | Allicin taste-masking nano suspension and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101239052A (en) * | 2008-03-06 | 2008-08-13 | 浙江中医药大学 | Method for preparing sodium alginate/ chitosan sustained-release microcapsule by external gelation |
| CN101716198A (en) * | 2010-01-25 | 2010-06-02 | 淮阴工学院 | Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite |
| CN101716158A (en) * | 2010-01-25 | 2010-06-02 | 淮阴工学院 | Method for preparing matrine slow-release tablet by applying attapulgite |
| CN101721449A (en) * | 2009-11-19 | 2010-06-09 | 淮阴工学院 | Method for preparing lindley eupatorium herb general flavone by using attapulgite adsorption method |
| CN101919879A (en) * | 2010-08-06 | 2010-12-22 | 淮阴工学院 | Method for preparing probiotics preparation by taking attapulgite as carrier |
-
2011
- 2011-07-27 CN CN201110210899A patent/CN102266308B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101239052A (en) * | 2008-03-06 | 2008-08-13 | 浙江中医药大学 | Method for preparing sodium alginate/ chitosan sustained-release microcapsule by external gelation |
| CN101721449A (en) * | 2009-11-19 | 2010-06-09 | 淮阴工学院 | Method for preparing lindley eupatorium herb general flavone by using attapulgite adsorption method |
| CN101716198A (en) * | 2010-01-25 | 2010-06-02 | 淮阴工学院 | Method for preparing total ginkgo flavone glycosides slow-release capsules by applying attapulgite |
| CN101716158A (en) * | 2010-01-25 | 2010-06-02 | 淮阴工学院 | Method for preparing matrine slow-release tablet by applying attapulgite |
| CN101919879A (en) * | 2010-08-06 | 2010-12-22 | 淮阴工学院 | Method for preparing probiotics preparation by taking attapulgite as carrier |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579398A (en) * | 2011-12-31 | 2012-07-18 | 沈阳药科大学 | Enteric microcapsule with function of balancing bad taste of medicament and preparation method of enteric microcapsule |
| CN102952792A (en) * | 2012-11-12 | 2013-03-06 | 淮阴工学院 | Preparation method of beta-glucosidase immobilized by sodium alginate loaded with attapulgite |
| CN104208710A (en) * | 2014-09-11 | 2014-12-17 | 广西大学 | Method for preparing modified konjac glucomannan sustained-release microcapsule |
| CN104630299A (en) * | 2015-03-03 | 2015-05-20 | 广东轻工职业技术学院 | Extraction method of odorless allicin |
| CN107846960A (en) * | 2015-06-03 | 2018-03-27 | 安纳生物科技有限公司 | Microcapsules containing stabilized liposome and preparation method thereof |
| CN105168179A (en) * | 2015-08-04 | 2015-12-23 | 浙江汇能动物药品有限公司 | Clopidol controlled-release microparticle preparation and preparation method thereof |
| CN105078899A (en) * | 2015-08-26 | 2015-11-25 | 四川农业大学 | Enrofloxacin stratified high molecular taste mashing skeleton particle and preparation method thereof |
| CN105078899B (en) * | 2015-08-26 | 2018-06-29 | 四川农业大学 | A kind of Enrofloxacin cladding macromolecule flavoring skeleton particle and preparation method thereof |
| CN109430265A (en) * | 2018-11-23 | 2019-03-08 | 中国科学院兰州化学物理研究所 | The method for preparing carvacrol microcapsule anti-bacterial agent using attapulgite stabilized oil-in-water lotion |
| CN109430265B (en) * | 2018-11-23 | 2021-03-26 | 中国科学院兰州化学物理研究所 | Method for preparing carvacrol microcapsule antibacterial agent by using attapulgite stable oil-in-water emulsion |
| CN109498645A (en) * | 2018-11-28 | 2019-03-22 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Charge regulation cooperates with the high-pressure homogeneous method for preparing attapulgite cationic antibacterial agent |
| CN109731103A (en) * | 2019-01-20 | 2019-05-10 | 桂林理工大学 | P-zeolite-chitin-sodium alginate-potassium diformate sustained-release antibacterial agent preparation method |
| WO2021134976A1 (en) * | 2019-12-31 | 2021-07-08 | 公牛集团股份有限公司 | Anti-biting agent, anti-biting material, anti-biting article and preparation method therefor |
| CN111870588A (en) * | 2020-08-24 | 2020-11-03 | 广州立达尔生物科技股份有限公司 | Method for preparing allicin microcapsule by coupling carrier adsorption and precipitation |
| CN112076155A (en) * | 2020-10-26 | 2020-12-15 | 临沂大学 | Allicin taste-masking nano suspension and preparation method thereof |
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