CN101716158A - Method for preparing matrine slow-release tablet by applying attapulgite - Google Patents
Method for preparing matrine slow-release tablet by applying attapulgite Download PDFInfo
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- CN101716158A CN101716158A CN201010100897A CN201010100897A CN101716158A CN 101716158 A CN101716158 A CN 101716158A CN 201010100897 A CN201010100897 A CN 201010100897A CN 201010100897 A CN201010100897 A CN 201010100897A CN 101716158 A CN101716158 A CN 101716158A
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Abstract
The invention discloses a method for preparing matrine slow-release tablets by applying attapulgite, which comprises the following steps of: dissolving matrine by using hydrochloric acid with the mass concentration of 0.1 percent to obtain 2-5mg/ml of matrine solution; adsorbing the matrine solution through modified attapulgite for 4-6 hours according to the proportion by weight of 1:2; filtering and drying to obtain the attapulgite loading the matrine; and adding 2 percent by weight of talcum powder into the attapulgite loading the matrine, granulating by a dry method, and tabletting to obtain the matrine slow-release tablets. A modifying method of the attapulgite comprises the following steps of: weighing 20g of attapulgite, placing the attapulgite into 1000ml of aqueous solution, stirring for 12 hours, settling, removing upper water, adding purified water, stirring for 12 hours, settling, taking an intermediate fine particle layer, adding concentrated hydrochloric acid, settling for 24 hours, filtering through suction, washing with water to be neutral, drying at the temperature of 105DEG C, finely grinding and screening with a 120-mesh screen to obtain acid modified attapulgite. The invention adopts the principle of adsorption separation and selects the modified attapulgite which can be taken as an adsorbent for adsorbing the matrine, the matrine slow-release tablets are slowly released under the desorption action of a body fluid, operation steps are simple, and the production period of traditional Chinese medicine preparations is shortened.
Description
Technical field
The present invention relates to the preparation method of oral sustained release sheet, be specifically related to a kind of method of preparing matrine slow-release tablet by applying attapulgite.
Background technology
Matrine is the tetracyclic quinolizidine kind alkaloid that comes out from separation such as leguminous plant Radix Sophorae Flavescentis Herba Sophorae alopecuroidis, root of subprostrate sophoras, has to suppress hepatitis B HbeAg and duplicate, improve pharmacological actions such as pathologic hepatitis symptom and sign, anticancer, arrhythmia, anti-hepatic fibrosis, immunosuppressant, antiinflammatory, resisting hypertension vascular remodeling.The matrine preparation of clinical use is based on injection, and it is short that it eliminates the half-life, if make ordinary tablet, need oral 3～4 times every day, and " peak valley " phenomenon can appear in the back blood drug level of taking medicine, and side effect is increased, curative effect reduces, and brings inconvenience for treatment and patient.The patent of Granted publication CN1235584C " matrine slow-release tablet and preparation method thereof ", publication number is the patent " matrine oral sustained release sheet and preparation method thereof " of CN1555797A, the preparation method of matrine slow-release tablet is all disclosed, method therefor all is the slow releasing preparation common method, adopt the rate of release of sustained-release matrix host material control active component commonly used, reach the slow release purpose, the used adjuvant complexity of this technology, cost height.
Attapulgite shows good adsorption because of having bigger specific surface area, can be used for multiple field.The modification of attapulgite can make structure charge and the surface charge of attapulgite in aqueous solution change, can improve its specific surface area even change its structure, improve the specific surface area of attapulgite, thereby absorption property improves greatly, is applicable to the separation of active component in the Chinese medicine extraction liquid.The research of attapulgite oral formulations has had very deep research, and applied research shows its safety non-toxic, is fit to be applied to pharmaceutical preparation.
Summary of the invention
The objective of the invention is to: a kind of method of preparing matrine slow-release tablet by applying attapulgite is provided, and this preparation method can shorten the production cycle, reduces production costs, and improves the added value of attapulgite, reaches the preparation slow release simultaneously, satisfies the requirement of clinical application.
Technical solution of the present invention is that this preparation method may further comprise the steps:
(1), gets the matrine solution of 2～5mg/ml with the dissolving with hydrochloric acid matrine of mass concentration 0.1%;
(2) matrine solution filters through attapulgite modified absorption 4～6h, dries, and obtains the attapulgite of load matrine;
(3) add pharmaceutic adjuvant in the attapulgite of load matrine, dry granulation, tabletting get matrine slow-release tablet.
Wherein, the attapulgite modified of (2) step employing is that acid is attapulgite modified, and the method for modifying of described attapulgite is: take by weighing attapulgite 20g and place the 1000ml aqueous solution, stir 12h, leave standstill, remove upper water, add pure water, stir 12h, leave standstill, the fine grained layer adds concentrated hydrochloric acid and leaves standstill 24h, sucking filtration in the middle of getting, be washed to neutrality, 105 ℃ of dryings, porphyrize, cross 120 mesh sieves, it is attapulgite modified to obtain acid.
Wherein, sour attapulgite modified and weight ratio matrine of (2) step employing is 2: 1.
Wherein, (3) step was added the Pulvis Talci of its weight 2% in the attapulgite of load matrine.
The present invention has the following advantages: 1, matrine slow-release tablet coating or adopt coating material coating, even, bright and clean, the invariant color of the product color of dry granulation tabletting gained not; 2, this method is attapulgite modified to the matrine selective absorption by acid, and the absorption back is the preparation tablet directly, oral entering in the body, and matrine can discharge from attapulgite under the desorption of body fluid slowly, thereby reaches the effect of slow release; 3, this preparation method is with short production cycle, and production cost is low, has improved the added value of attapulgite, and the preparation slow release satisfies the requirement of clinical application simultaneously.
Description of drawings
Fig. 1 is the release curve of the matrine slow-release tablet of embodiment 1
Fig. 2 is the release curve of the matrine slow-release tablet of embodiment 2
Fig. 3 is the release curve of the matrine slow-release tablet of embodiment 3
The specific embodiment
Below by specific embodiment technical scheme of the present invention is further described, can not be interpreted as that these embodiment are the restrictions to technical scheme.
Embodiment 1: take by weighing attapulgite 20g and place the 1000ml aqueous solution, stir 12h, leave standstill, remove upper water, add pure water, stir 12h, leave standstill, the fine grained layer adds concentrated hydrochloric acid and leaves standstill 24h in the middle of getting, sucking filtration, be washed to neutrality, 105 ℃ of dryings, porphyrize, cross 120 mesh sieves, it is attapulgite modified to obtain acid; Get matrine 20g, become the solution of 2mg/ml with the dissolving with hydrochloric acid of mass concentration 0.1%; With matrine solution through the attapulgite modified absorption 4h of 40g acid, filtration, 60 ℃ of vacuum dryings obtain the attapulgite of load matrine; In the attapulgite of load matrine, add the Pulvis Talci mix homogeneously of its weight 2%, dry granulation, the granulate that sieves, tabletting is made 100 altogether.
Embodiment 2: take by weighing attapulgite 20g and place the 1000ml aqueous solution, stir 12h, leave standstill, remove upper water, add pure water, stir 12h, leave standstill, the fine grained layer adds concentrated hydrochloric acid and leaves standstill 24h in the middle of getting, sucking filtration, be washed to neutrality, 105 ℃ of dryings, porphyrize, cross 120 mesh sieves, it is attapulgite modified to obtain acid; Get matrine 40g, become the solution of 3mg/ml with the dissolving with hydrochloric acid of mass concentration 0.1%; With matrine solution through the attapulgite modified absorption 5h of 80g acid, filtration, 60 ℃ of vacuum dryings obtain the attapulgite of load matrine; In the attapulgite of load matrine, add the Pulvis Talci mix homogeneously of its weight 2%, dry granulation, the granulate that sieves, tabletting is made 200 altogether.
Embodiment 3: take by weighing attapulgite 20g and place the 1000ml aqueous solution, stir 12h, leave standstill, remove upper water, add pure water, stir 12h, leave standstill, the fine grained layer adds concentrated hydrochloric acid and leaves standstill 24h in the middle of getting, sucking filtration, be washed to neutrality, 105 ℃ of dryings, porphyrize, cross 120 mesh sieves, it is attapulgite modified to obtain acid; Get matrine 40g, become the solution of 5mg/ml with the dissolving with hydrochloric acid of mass concentration 0.1%; With matrine solution through the attapulgite modified absorption 6h of 80g acid, filtration, 60 ℃ of vacuum dryings obtain the attapulgite of load matrine; In load matrine sour attapulgite modified, add the Pulvis Talci mix homogeneously of its weight 2%, dry granulation, the granulate that sieves, tabletting is made 200 altogether.
Assay: get slow releasing tablet a slice, grind, place to add 50ml methanol eddy extraction 2h in the boiling flask, extracting liquid filtering is collected filtrate, filters through 0.45 μ m microporous filter membrane, and employing is that the high performance liquid chromatography of reference substance is carried out assay with the matrine.
Drug release determination: according to " 2005 editions two appendix XD first methods of Chinese pharmacopoeia, the device of employing dissolution method first method carries out the mensuration of release; The release curve of embodiment 1-3 gained matrine slow-release tablet respectively as Figure 1-3.
Claims (4)
1. the method for a preparing matrine slow-release tablet by applying attapulgite is characterized in that this preparation method may further comprise the steps:
(1), gets the matrine solution of 2～5mg/ml with the dissolving with hydrochloric acid matrine of mass concentration 0.1%;
(2) matrine solution filters through attapulgite modified absorption 4～6h, dries, and obtains the attapulgite of load matrine;
(3) add pharmaceutic adjuvant in the attapulgite of load matrine, dry granulation, tabletting get matrine slow-release tablet.
2. the method for a kind of preparing matrine slow-release tablet by applying attapulgite according to claim 1, it is characterized in that: it is attapulgite modified for sour attapulgite modified that (2) step adopted, the method of modifying of described attapulgite is: take by weighing attapulgite 20g and place the 1000ml aqueous solution, stir 12h, leave standstill, remove upper water, add pure water, stir 12h, leave standstill, the fine grained layer adds concentrated hydrochloric acid and leaves standstill 24h in the middle of getting, sucking filtration, be washed to neutrality, 105 ℃ of dryings, porphyrize, cross 120 mesh sieves, it is attapulgite modified to obtain acid.
3. the method for a kind of preparing matrine slow-release tablet by applying attapulgite according to claim 2 is characterized in that: sour attapulgite modified and weight ratio matrine that (2) step adopted is 2: 1.
4. the method for a kind of preparing matrine slow-release tablet by applying attapulgite according to claim 1 is characterized in that: the Pulvis Talci of (3) step its weight 2% of interpolation in the attapulgite of load matrine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101008977A CN101716158B (en) | 2010-01-25 | 2010-01-25 | Method for preparing matrine slow-release tablet by applying attapulgite |
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| CN2010101008977A CN101716158B (en) | 2010-01-25 | 2010-01-25 | Method for preparing matrine slow-release tablet by applying attapulgite |
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| CN101716158B CN101716158B (en) | 2011-06-15 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266308A (en) * | 2011-07-27 | 2011-12-07 | 淮阴工学院 | Method for preparing odor masking sustained-release garlicin composite micro-capsules |
| CN102552925A (en) * | 2012-01-31 | 2012-07-11 | 淮阴工学院 | Method for preparing alginic acid/attapulgite composite for sustained or controlled release tablets of medicine |
| CN103251956A (en) * | 2013-04-19 | 2013-08-21 | 张彩云 | Matrine-montmorillonite nano composite and preparation method thereof |
| CN103749571A (en) * | 2013-12-23 | 2014-04-30 | 杨立新 | Attapulgite sterilization mite suppressor and preparation method thereof |
| CN106929031A (en) * | 2017-03-24 | 2017-07-07 | 孙志廷 | It is a kind of with broad spectrum disinfestation and the good Nutrition Soil of water retention property and preparation method thereof |
| CN109549967A (en) * | 2018-12-20 | 2019-04-02 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of sophora alapecuroides slow-releasing granules and preparation method thereof |
| CN113289024A (en) * | 2021-06-07 | 2021-08-24 | 明光市铭垚凹凸棒产业科技有限公司 | Medicine carrying nano-particles based on attapulgite |
-
2010
- 2010-01-25 CN CN2010101008977A patent/CN101716158B/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266308A (en) * | 2011-07-27 | 2011-12-07 | 淮阴工学院 | Method for preparing odor masking sustained-release garlicin composite micro-capsules |
| CN102266308B (en) * | 2011-07-27 | 2012-10-24 | 淮阴工学院 | Method for preparing odor masking sustained-release garlicin composite micro-capsules |
| CN102552925A (en) * | 2012-01-31 | 2012-07-11 | 淮阴工学院 | Method for preparing alginic acid/attapulgite composite for sustained or controlled release tablets of medicine |
| CN102552925B (en) * | 2012-01-31 | 2013-05-22 | 淮阴工学院 | Method for preparing alginic acid/attapulgite composite for sustained or controlled release tablets of medicine |
| CN103251956A (en) * | 2013-04-19 | 2013-08-21 | 张彩云 | Matrine-montmorillonite nano composite and preparation method thereof |
| CN103749571A (en) * | 2013-12-23 | 2014-04-30 | 杨立新 | Attapulgite sterilization mite suppressor and preparation method thereof |
| CN103749571B (en) * | 2013-12-23 | 2016-01-20 | 杨立新 | A kind of attapulgite sterilization mite suppressor and preparation method thereof |
| CN106929031A (en) * | 2017-03-24 | 2017-07-07 | 孙志廷 | It is a kind of with broad spectrum disinfestation and the good Nutrition Soil of water retention property and preparation method thereof |
| CN109549967A (en) * | 2018-12-20 | 2019-04-02 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of sophora alapecuroides slow-releasing granules and preparation method thereof |
| CN113289024A (en) * | 2021-06-07 | 2021-08-24 | 明光市铭垚凹凸棒产业科技有限公司 | Medicine carrying nano-particles based on attapulgite |
| CN113289024B (en) * | 2021-06-07 | 2024-02-09 | 明光市铭垚凹凸棒产业科技有限公司 | Medicine carrying nano-particle based on attapulgite |
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| Publication number | Publication date |
|---|---|
| CN101716158B (en) | 2011-06-15 |
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Granted publication date: 20110615 Termination date: 20120125 |