CN201612864U - Chitosan coated medicine controller-release micro-sphere - Google Patents
Chitosan coated medicine controller-release micro-sphere Download PDFInfo
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- CN201612864U CN201612864U CN2009201042538U CN200920104253U CN201612864U CN 201612864 U CN201612864 U CN 201612864U CN 2009201042538 U CN2009201042538 U CN 2009201042538U CN 200920104253 U CN200920104253 U CN 200920104253U CN 201612864 U CN201612864 U CN 201612864U
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- resveratrol
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Abstract
The utility model relates to a chitosan coated medicine controller-release micro-sphere, which comprises a condensation compound bag casing of chitosan and glutaraldehyde, resveratrol, oxidation resveratrol, red sandalwood stilbene or piceatannol, wherein the resveratrol, the oxidation resveratrol, the red sandalwood stilbene or the piceatannol are coated in the bag casing. The micro-sphere has fine rounding and scattering performances, improves steadiness of original medicines, and achieves the purpose of medicine sustained release. In addition, the micro-sphere facilitates compatibility with other medicines. The micro-sphere is applicable to controlled-release formulations of medicines such as the resveratrol, the oxidation resveratrol, the red sandalwood stilbene and the piceatannol.
Description
Technical field
This utility model belongs to the slow release formulation of health product, medicine, specifically a kind of sustained-release micro-spheres with chitosan coating medicine.
Background technology
Resveratrol (3 as drug use, 4 ', 5-trihydroxy stilbene), oxidized resveratrol (2,4,3 ', 5 '-tetrahydroxystilbene), pterostilbene (3, the 5-dimethoxy-4 ' '-hydroxy stibene), Rhizoma Euonymus China fir alcohol (3,4,3 ', 5 '-tetrahydroxystilbene), belong to active non-flavone polyphenol substance, extensively be present in natural food or the plant, they have significant antiinflammatory in a large amount of studies show that, antioxidation, antibiotic, free radical resisting and anticoagulant, antithrombotic, the effect of lipidemia can be used for arteriosclerosis, coronary heart disease, viral hepatitis, acquired immune deficiency syndrome (AIDS), the prevention of diseases such as cancer and treatment.
Because resveratrol, oxidized resveratrol, pterostilbene contains the phenolic hydroxyl group of different numbers respectively in the Rhizoma Euonymus China fir alcohol molecule, easily oxidized in air, causes the color of product and performance to change; And the existence of phenolic hydroxyl group makes above-mentioned several chemical compound be subject to the influence of pH, as medicine or health product and other chemical compounds are composite may produce complicated variation, influences itself and brings into play curative effect effectively.
(chitosan is that it is good that it has excellent biological compatibility by the poly-aminopolysaccharide of a kind of natural polymer that obtains behind the chitin deacetylase base CS) to chitosan; Can be absorbed fully by organism in vivo by the plurality of enzymes biodegradation; Increase medicine to biomembranous permeability, help medicine and in cell, bring into play drug effect.As a kind of good biological organic carrier, free amine group is arranged on 2 of the molecule of chitosan own, can make it to form key bridge solidified microsphere by the aldehyde ammonia condensation reaction, also can utilize this character to be applied to the research of slow releasing preparation.Sustained-release micro-spheres is a kind of novel form in the medicine, and its ultimate principle is to utilize technique for packing that pharmaceutical pack is overlayed on the small cryptomere preparation of formation in the capsule material, increases stability of drug, is convenient to take, and reaches the purpose of slow controlled release simultaneously.
The utility model content
The technical problems to be solved in the utility model provides a kind of chitosan coating medicine slow release microsphere, and softgel shell is a chitosan, and coating medicine is a kind of in resveratrol, oxidized resveratrol, Lignum pterocarpi indici Stilbene or the Rhizoma Euonymus China fir alcohol.This sustained-release micro-spheres structure has increased stability of drug, can realize the purpose of slow controlled release.Chitosan itself also has good biocompatibility, and toxicity is low, and characteristics such as haemolysis do not help medicine performance curative effect.
This utility model will solve above-mentioned technical problem, and the technical scheme that is adopted is:
A kind of chitosan coating medicine slow release microsphere comprises softgel shell, is coated on the medicine in the softgel shell, and this microsphere is the sphere of rounding, has hole on the shell wall.
The technique scheme that this utility model adopted is to utilize the natural macromolecule amylose chitosan, is softgel shell with the condensation substance of itself and glutaraldehyde, and coating medicine resveratrol, oxidized resveratrol, Lignum pterocarpi indici Stilbene or Rhizoma Euonymus China fir alcohol form microsphere rounding, good dispersion.Because the advantage that had of chitosan itself, make the microsphere dosage form medicine not only the stability of former medicine be improved, and realized the purpose of medicine sustained and controlled release; Also make things convenient for and the other drug compatibility in addition.This utility model is suitable for the slow release formulation of making medicine resveratrol, oxidized resveratrol, Lignum pterocarpi indici Stilbene or Rhizoma Euonymus China fir alcohol.
This utility model is described in further detail below in conjunction with Figure of description and specific embodiment.
Description of drawings
Fig. 1 is this utility model overall structure sketch map;
Fig. 2 is the vertical profile profile of Fig. 1.
Among the figure: 1, drug powder-veratryl alcohol, oxidized resveratrol, Lignum pterocarpi indici Stilbene or Rhizoma Euonymus China fir alcohol;
2, the condensation layer of shell-chitosan and glutaraldehyde.
3, hole;
4, gauffer.
The specific embodiment
Embodiment
Fig. 1, Figure 2 shows that a kind of chitosan coating medicine slow release microsphere.This microsphere comprises spherical softgel shell 2, is coated on powdery medicine resveratrol, oxidized resveratrol, pterostilbene or Rhizoma Euonymus China fir alcohol in the softgel shell 2, and described softgel shell is the condensation substance for chitosan and glutaraldehyde.
Microspherulite diameter is the 2-100 micron.
Described microsphere is the sphere of rounding, and is rough, has gauffer 4, has hole 3 on the shell wall.
Claims (1)
1. a chitosan coating medicine slow release microsphere comprises softgel shell, is coated on the medicine in the softgel shell, and it is characterized in that: this microsphere is the sphere of rounding, has hole on the shell wall.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201042538U CN201612864U (en) | 2009-08-12 | 2009-08-12 | Chitosan coated medicine controller-release micro-sphere |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009201042538U CN201612864U (en) | 2009-08-12 | 2009-08-12 | Chitosan coated medicine controller-release micro-sphere |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201612864U true CN201612864U (en) | 2010-10-27 |
Family
ID=42999236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009201042538U Expired - Fee Related CN201612864U (en) | 2009-08-12 | 2009-08-12 | Chitosan coated medicine controller-release micro-sphere |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201612864U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101871A (en) * | 2019-05-30 | 2019-08-09 | 广东工业大学 | A kind of preparation method embedding resveratrol |
-
2009
- 2009-08-12 CN CN2009201042538U patent/CN201612864U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110101871A (en) * | 2019-05-30 | 2019-08-09 | 广东工业大学 | A kind of preparation method embedding resveratrol |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101027 Termination date: 20110812 |