CN102240308A - Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament - Google Patents
Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament Download PDFInfo
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- CN102240308A CN102240308A CN2010101698120A CN201010169812A CN102240308A CN 102240308 A CN102240308 A CN 102240308A CN 2010101698120 A CN2010101698120 A CN 2010101698120A CN 201010169812 A CN201010169812 A CN 201010169812A CN 102240308 A CN102240308 A CN 102240308A
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Abstract
The invention relates to application of valeriana jatamansi jones to preparation of an anti-canine parvovirus medicament. An oral preparation, prepared from the Chinese medicament valeriana jatamansi jones serving as a medicinal ingredient and medicinal auxiliary materials, is taken orally by a dog infected with the parvovirus, so that the canine parvovirus antigen is detected to be negative, and symptoms such as decreased appetite, fever, irregular bowel movement and the like caused by the canine parvovirus are treated. Compared with the traditional method for performing treatment by using antibiotic, the application of valeriana jatamansi jones has the characteristics of high pertinence, high safety, remarkable curative effect and the like.
Description
Technical field
The present invention relates to the application of Rhizoma valerianae latifoliae in preparation anti-dog parvovirus medicine, belong to field of veterinary.
Background technology
The Canine Parvovirus enteritis is that a kind of acute with vomiting, dysentery etc. clinically, gastroenteritis haemorrhagica that is caused by Canine Parvovirus is the infectious disease of cardinal symptom.Its sickness rate height, infectiousness is strong, and the mortality rate height is one of the most serious infectious disease of foster dog industry of harm China and fur-bearing animal aquaculture, and the economic loss that therefore cause every year is serious.
Can not determine under the situation of cause of disease clinically at present, mainly the way that prevents secondary infection and energize mixture maintenance homergy by broad-spectrum antiviral medicament treatment, antibiotic.These methods lack specific aim and curative effect is very little, and a large amount of uses of what is more important antibiotic and antiviral drugs also can cause the appearance of drug resistance strain, so are badly in need of wanting a kind of medicine of safety and environmental protection in clinical and the production practices.
Rhizoma valerianae latifoliae (Valeriana jatamansi Jones) has another name called Herba Asari, tiger seven, Indian Rhizoma et radix valerianae etc., is the Valerianaceae valerian.The name beginning of Rhizoma valerianae latifoliae is stated from Compendium of Material Medica, and it is said: " suffering, temperature, nontoxic "." Rhizoma valerianae latifoliae goes out in the another name for Sichuan Province Xi Maozhou pine fence mountain.Grass roots also, black has thick palpus, shape such as Aranea and Rhizoma Ligustici, Rhizoma Chuanxiong, fragrant odour ".It can " ward off pestilence, attacked by pestiferous factors be evil smart, terrible gas consumptive disease with protracted syncope." version Chinese Pharmacopoeia (an one) was once recorded 1977 years.Among the peoplely ache, and can be calm, pleasant, help digestion, control dermexanthesis, sealing and let out etc. with its treatment trusted subordinate pain, rheumatic numbness and muscles, a plurality of nationalitys such as the Dong nationality, Miao ethnic group and Naxi with it as treatment diarrheal good medicine.Yet there is not the people to be used for dog as medicine as yet and infects the parvovirus treatment with it.
Summary of the invention
The present invention is crude drug with the Rhizoma valerianae latifoliae, make granule after the pulverizing and directly take or be equipped with acceptable accessories to dog, take to dog as starch, PEG6000, magnesium stearate, dextrin, Polyethylene Glycol and/or corresponding correctives etc., can make parvovirus Detection of antigen feminine gender, thereby treatment is because of infecting symptom that parvovirus causes.Good effect of the present invention is to have evident in efficacy, high safety, characteristics such as easy and simple to handle.
Those skilled in the art can expect, use the organic or inorganic solvent to extract to the Rhizoma valerianae latifoliae medical material, and extract also may be obtained better antiviral curative effect.As make methods such as water, ethanol, petroleum ether, carbon dioxide supercritical fluid extraction extract resulting extract.
Following examples are not for qualification of the present invention only as the explanation of effect of the present invention.
Embodiment 1: the capsular preparation of Rhizoma valerianae latifoliae:
1, will check medical material up to specification to select, remove impurity such as silt and dis-medicinal part, drain away the water after cleaning.
2, be cut into 2～3cm section, put in the baking oven 55～60 ℃ of dryings 4 hours, take out, pulverize the cooling back.
3, cross 65～80 mesh sieves, in the hermetic container of packing into, detect moisture, should be less than 10%, qualified back is standby.
4, recipe quantity starch is made 10% starch slurry after, join in the above-mentioned medicinal powder, mix thoroughly, the system soft material makes wet granular with the screen cloth about 14 orders.
5, the wet granular that makes is tiled in immediately in the oven dry pallet, thickness is dried 55～60 ℃ of humidity less than 2.5cm, and drying time is that moisture Control is 3～5% about 3.5～4 hours.
6, detect moisture qualified after, dried granule is sieved the granulate that sieves with 12 orders～16 purpose medicines.To be sub-packed in 0～No. 2 hungry area softgel shell through the Aranea smoked bean curd granule of arrangement.
Embodiment 2: the preparation of Rhizoma valerianae latifoliae tablet
1, will check Rhizoma valerianae latifoliae up to specification to select, remove impurity such as silt, drain away the water after cleaning.
2, be cut into 2～3cm section, put in the baking oven 55～60 ℃ of dryings 4 hours, take out, pulverize the cooling back.
3, cross 65～80 mesh sieves, in the hermetic container of packing into, detect moisture, should be less than 10%, qualified back is standby.
4, recipe quantity starch is made 10% starch slurry after, in the Aranea XIANGFEN: starch=0.7～0.9: 0.3～0.1 ratio joins in the Rhizoma valerianae latifoliae powder, mixes thoroughly, and the system soft material makes wet granular with the screen cloth about 14 orders.
5, the wet granular that makes is tiled in immediately in the oven dry pallet, thickness is dried 55～60 ℃ of humidity less than 2.5cm, and drying time is that moisture Control is 3～5% about 3.5～4 hours.
6, detect moisture qualified after, tabletting is promptly.
Embodiment 3 Rhizoma valerianae latifoliae capsules are to the observation of curative effect of canine parvovirus disease
1, the negative dog of 2～3 monthly age of animal grouping parvovirus antibody is 30, buys back 1 week of breeding observing, is divided into 3 groups at random, 10 every group, is respectively the treatment group, keeps to treat and shine and the counteracting toxic substances matched group.
2, the counteracting toxic substances method is pressed the 1ml/kg body weight with the strong venom of Canine Parvovirus and is given experimental dog oral.
3, medication counteracting toxic substances observation experiment every day dog clinical manifestation, disease symptom appears and after, according to the form below carries out administration.
The grouping of table 1 dosage
| Grouping | Dosage | Administration number of times |
| The treatment group | 50mg·kg -1·d -1 | 3-7 days continuously |
| Keep the treatment group | Celebrate big toxin 2.5～4.5mgkg -1·d -1Sodium bicarbonate 1g 5% sugar-salt-water 100ml | 3-7 days continuously |
| The counteracting toxic substances matched group | Do not have | Do not have |
4, after observation index counteracting toxic substances and the administration, every day observation/determination experiment dog appetite, drinking-water, defecation, body temperature, body weight and feces toxin expelling situation.
5, availability deciding standard
Cure: 5-7 days appetite, body temperature, defecation are normal continuously, Canine Parvovirus Detection of antigen feminine gender.
Take a turn for the better: 3-5 days appetite, body temperature, defecation are normal continuously, and body weight is stable or increase.
Invalid: the experimental dog clinical symptoms worsens, and body weight continues to descend, and anorexia or do not eat is thin and weak or dead.
6, evaluating drug effect
Medicine effective percentage=(curing number+good revolution)/morbidity number * 100%.
7, result of the test
The grouping of table 1 dosage
| Grouping | Cure number | Good revolution | Morbidity/death toll | Effective percentage |
| The treatment group | 8 | 2 | 0/0 | 100％ |
| Positive drug group (gentamycin) | 2 | 3 | 5/0 | 50％ |
| The counteracting toxic substances matched group | - | - | 6/4 | - |
Experimental result shows that this capsule can effectively treat canine parvovirus disease, and therapeutic effect is better than conventional maintenance therapy.
Claims (2)
1. the application of Rhizoma valerianae latifoliae in preparation anti-dog parvovirus medicine.
2. medicine according to claim 1, it is characterized in that be by Rhizoma valerianae latifoliae can give separately or and acceptable accessories be prepared from oral formulations and give dog.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101698120A CN102240308A (en) | 2010-05-12 | 2010-05-12 | Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101698120A CN102240308A (en) | 2010-05-12 | 2010-05-12 | Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament |
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| Publication Number | Publication Date |
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| CN102240308A true CN102240308A (en) | 2011-11-16 |
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| CN2010101698120A Pending CN102240308A (en) | 2010-05-12 | 2010-05-12 | Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634370A (en) * | 2004-11-03 | 2005-07-06 | 车维新 | Spider aroma preparation for treating diarrhea and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1634370A (en) * | 2004-11-03 | 2005-07-06 | 车维新 | Spider aroma preparation for treating diarrhea and preparation method thereof |
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Application publication date: 20111116 |