CN102240280A - Aromatic essential oil medicinal composition for preventing and treating hypertension and adjusting functions of internal organs through olfactory path in a brain targeted mode - Google Patents
Aromatic essential oil medicinal composition for preventing and treating hypertension and adjusting functions of internal organs through olfactory path in a brain targeted mode Download PDFInfo
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- CN102240280A CN102240280A CN 201110109563 CN201110109563A CN102240280A CN 102240280 A CN102240280 A CN 102240280A CN 201110109563 CN201110109563 CN 201110109563 CN 201110109563 A CN201110109563 A CN 201110109563A CN 102240280 A CN102240280 A CN 102240280A
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Abstract
The invention discloses an aromatic essential oil medicinal composition for preventing and treating hypertension and adjusting functions of internal organs through an olfactory path in a brain targeted mode. The composition comprises lavandula burnatii and highland lavender and also comprises the following pharmacological active ingredients of lavender ester, acetic lavender ester and any mixture of an isomer thereof, or lavender essential oil which can be directly used, wherein other natural flavors can also be added. In the aromatic essential oil medicinal composition, the plant essential oil and the active ingredients thereof stimulate olfactory neurons through a nose and an oral cavity, regulate and control a brain olfactory center and hypothalamus through the olfactory path, directly perform brain targeting, aim at a hypertension action mechanism, and can be used for preventing and treating hypertension, remitting mental pressure and eliminating nervous and mental tension.
Description
Technical field
The invention belongs to medicines and health protection and aromatotherapy quintessence oil effect field, be specifically related to Herba Lysimachiae foenum-graeci quintessence oil, lavandula angustifolia ester, acetyl lavandula angustifolia ester and form prescription or prevent and treat hypertension in preparation, alleviate stress and improve the medicine of brain function and the application in the novel form thereof for the prescription of main component.
Background technology
Hypertension is present the most common cardiovascular disease, and it can cause a series of serious pathological changes such as coronary heart disease, apoplexy, congestive heart failure and renal failure.Cardiovascular and cerebrovascular disease causes 1,200 ten thousand people's death in the whole world every year, and human beings'health in serious threat, has become one of important public health problem.Whole world disease burden survey result shows that 50% cardiovascular disease is caused that by hypertension hypertension accounts for 4.5% in present global disease burden, and the patients with hypertension sum reaches 9.72 hundred million people.China's investigation in 2004 shows that China now has 1.6 hundred million patients with hypertension, annual newly-increased patient about 3,000 ten thousand.And the treatment present situation of China's hypertension is very severe, and control rate only is 6.1%.Because the change of The development in society and economy and people life style, China's hypertension prevalence is sustainable growth trend, has become one of key of China's cardiovascular disease prevention.At present, 6 big hypotensor things commonly used in the Western medicine all pass through oral administration, main through the Liver and kidney metabolism, thereby the bigger weak points of side effect such as blood-fat and blood sugar Developmental and Metabolic Disorder, hyperuricemia, cough, bradycardia and electrolyte disturbance are subject to people's attention.Therefore, oral drug therapy hypertension has certain limitation, and various countries all are devoted to seek new depressor substance and route of administration at present.
The cardiovascular diseases is normally asymptomatic in early days, slowly takes place, and the patient is everlasting just to go to seek medical advice when occurring than serious symptoms and has little time the sudden death of seeking medical advice even.Therefore cardiovascular diseases's sickness rate and prevalence statistics is very difficult and is difficult for doing accurately.Mortality rate is the index of the popular state of the most frequently used cardiovascular diseases of description.Because cardiovascular death is-and individual clear and definite, objectively reflect the index of CR Critical cardiovascular disease event, easily understanding, record easily.Most of developed countries and part developing country all have the disease death register system of complete or part and system-the classification of diseases principle, its data is credible, and can compare between country variant.Therefore, normally cardiovascular diseases's distribution situation between the different crowd is described in the world with cardiovascular diseases's mortality rate.The branch sex of all countries that the disease death registration arranged since nineteen fifty that the annual world health statistics annual report of publishing of WHO and data base's tape provide and the necrology data at age are also for observing and the Regional Distribution and the long-term trend of comparative study various disease have been created condition, the epidemiological study result also shows apoplexy between the different crowd, and the M ﹠ M of coronary event is a significant correlation.
As everyone knows, the sex difference of cardiovascular death rate significant difference between different crowd does not draw attention as yet.In arbitrary crowd, masculinity and femininity is lived in the essentially identical natural environment, geographical position for example, environmental pollution.Economic condition.Provand.Medical condition etc. since heredity or biology the aspect difference due to the sex difference of mortality rate should be close between different crowd.But discover true really not so.France male cardiovascular death rate is 2.7 times of women, is 2.0 times in Japan.And this ratio is 1.3 times in the Chinese city resident, is 1.4 times in Cuba, and people's constellation variance of cardiovascular death rate sex ratio is different with the age because of kinds of Diseases.And in the past 40 years, the sex ratio of cardiovascular death rate generally continues the influence that inherited genetic factors has also been got rid of in rising in various countries, the whole world, because significant variation can not take place in 40 years crowd's hereditary property.Crowd's differences of mortality rate sex ratio has reflected that the difference of both sexes cardiovascular risk factors exposure level (for example smoking, the sex difference of the rate of drinking) and men and women's both sexes are to the difference of identical risk factor reaction in the different crowd.Life style, particularly smoking, drink and meals in the ratio of Animal fat may be the partly cause of these differences.Only be male 1/10 China in the women's smoking rate and the rate of drinking, the sex ratio of cardiovascular death rate is minimum in the whole world then need further be explored.
Aromatotherapy is a kind of ancient method, be with the material of aromatic odor by for oral administration or external, the aromatic substance of plant is inhaled in the body, bring into play the effect of its physiology that has and psychological aspects, reach disease preventing and treating and salubrious purpose.The Egyptian just used aromatic spice before 5000.Ancient Times in China is also early on the books, and the Classic of Mountains and Rivers before more than 2000 year carries " preventable disease of Herba Lysimachiae foenum-graeci pendant "; The magnificent top of the period of Three Kingdoms was once made sachet with Flos Caryophylli, Lignum Santali Albi etc., wore with oneself, in case infections such as consumptive diseases; Qing Dynasty's " herbal book series " record: " Rhizoma Cyperi, gas fragrance suffering can be controlled cholera and vomit and diarrhoea ".The current treatment that generally is used for chronic pain, depression, anxiety, cognitive disorder, insomnia and stress-related disorder of aromatotherapy.
Quintessence oil treatment is exactly " aroma-therapeutic " that we often say, methods such as it can be smelt by suction, massages, smears, shower, champignon play a role.In addition since volatile oil have high osmosis, metabolism soon, be not detained, characteristics such as toxicity is little, be easy to see through skin and mucosa, reach that having one's ideas straightened out is turbid, the therapeutic purposes of blood circulation promoting and blood stasis dispelling, quintessence oil can also be by olfactory sensation path mediator's the emotion and the function of brain simultaneously, thereby reach the pressure of releiving, loosen emotion etc. blood pressure is played regulating action.Different quintessence oils have specific effect, as effects such as anthelmintic, antiinflammatory sterilization, calmness, hypnosis, anxiety reduction depressions.Also find that quintessence oil has regulating action to blood pressure, as the grapefruit quintessence oil blood pressure that can raise, Flos Rosae Rugosae, Herba Pogostemonis essential oil then have the function that brings high blood pressure down.The curative effect that quintessence oil sucks is all from the flavor molecule of quintessence oil, and it may play a role by olfactory sensation, but the concrete action pathway of quintessence oil it be unclear that.
Summary of the invention
The invention provides a kind of pharmaceutical composition of preventing and treating hypertension and adjusting viscera function volatile oil class through olfactory sensation path brain targeting in order to address the above problem.
The present invention adopts following technical scheme to achieve these goals:
Prevent and treat hypertension and regulate the pharmaceutical composition of viscera function volatile oil class through olfactory sensation path brain targeting, it is characterized in that containing in the described compositions the following pharmacological component that is had in eye-catching lavandula angustifolia or the highland lavandula angustifolia: a kind of or any mixture in lavandula angustifolia ester, acetic acid lavandula angustifolia ester or its isomer; Or contain Herba Lysimachiae foenum-graeci quintessence oil in the described compositions.
Described pharmaceutical composition is characterized in that containing natural perfume material in the described compositions in addition, and contains natural drug penetration enhancer, the Natural antioxidant or natural antiseptic agent.
Described pharmaceutical composition is characterized in that described compositions contains one or more in the following penetration enhancer: 1. synthetic surfactant: polyoxyethylene-9-Laurel ether, sulfo-Laurel sodium alkoxide; 2. chlolic acid derivatives: Bile Salts, glucose sodium cholate, NaTDC and deoxidation Bile Salts; 3. the beta-schardinger dextrin-class that replaces of alkyl; 4. cyclic peptide class: bacitracin; 5. other: ethylene diamine tetra acetic acid disodium, citric acid and polyacrylic acid.
Described pharmaceutical composition, it is characterized in that also containing in the described compositions following pharmacological component: australene, camphene, beta-myrcene, linalyl acetate, acetic acid lavandula angustifolia ester, neryl acetate, acetic acid geranyl alcohol ester, β-sentence farnesol is present in Folium Eriobotryae, Rhizoma Zingiberis Recens, reaches in the volatile oil of Flos Matricariae chamomillae).5-ethylidene-1-methyl-cycloheptene.Borneolum Syntheticum, Mang geraniol, Mang cattle ester, lavandula angustifolia ester, linalool, Fructus Citri Limoniae are rare, caryophyllene, coumarin, firpene, 2-nopinene, δ-carene, 1-methyl-4-(1-isopropyl) benzene, 1, the 8-eucalyptole, 3,7-dimethyl-1,3,6-sarohornene, 3,7-dimethyl-1,3,7-sarohornene, linalool, 2,2-dimethyl-dicyclo (4,2,0) suffering-1-alkene, (-)-elemi-1,3,11 (13)-triolefins-12-alcohol, Camphora, linalyl propionate, 3,7-dimethyl-1,5-octadiene-3,7-glycol.
Described pharmaceutical composition is characterized in that said composition is capsule, tablet, oral liquid, electuary, powder dosage form.
The purposes of described pharmaceutical composition is characterized in that it prevents and treats application in the medicine in the hypertension in preparation.
Beneficial effect of the present invention:
Because it is natural that the fragrant matter of the present invention all is derived from, make the patient use the sensation that a kind of security and back to nature are arranged simultaneously; Simultaneously, stimulate olfactory receptor cell with natural fragrance, influence corticocerebral excitement and inhibition activity by specific receptor, improve patient's mental status, the balance vegetative nerve function, recover neurotransmitter in the brain of body, nurse one's health hormonal system and improve immune ability, cooperate medicine to reach the purpose of system's adjustment, treating both the principal and the secondary aspects of a disease at the same time from macroscopic view; Plants essential oil of the present invention and active component per nasal thereof and oral stimulation olfactory nerves unit, by olfactory sensation path regulation and control brain olfactory center and hypothalamus, directly the brain targeting reaches at the hypertension mechanism of action, can be used for preventing and treating hypertension, alleviates stress, eliminates nervous mental strain.
The specific embodiment
Embodiment one:
This experiment finds also that Herba Lysimachiae foenum-graeci quintessence oil brings high blood pressure down acts on to suck and finishes back 15min and begin to have downward trend gradually, and suck when finishing back 80-100min the most obvious, and in observation period 100min, be not returned to intervene before level.Show that this hypotensive effect takes place comparatively fast and the persistent period is longer.This experiment finds, blank group after sucking distilled water in the 100min SP, DP, MAP do not have significant change, difference does not have significance (P＞0.05).Compare with the blank group, Herba Lysimachiae foenum-graeci quintessence oil group, sham-operation+Herba Lysimachiae foenum-graeci quintessence oil group SP, DP, MAP all reduce, and SP, DP, MAP begin to descend when sucking quintessence oil end back 15min, and 80-100min difference has significance after the suction quintessence oil finishes; And model+Herba Lysimachiae foenum-graeci quintessence oil group SP, DP, MAP do not have obvious reduction, and difference does not have significance.Compare with model+Herba Lysimachiae foenum-graeci quintessence oil group, sham-operation+Herba Lysimachiae foenum-graeci quintessence oil group SP, DP, MAP reduce, and 80-100min difference has significance after sucking the quintessence oil end.Showing that action pathway that Herba Lysimachiae foenum-graeci quintessence oil brings high blood pressure down should be enters the central nervous system by olfactory epithelium to the olfactory sensation approach of olfactory bulb and brings into play effect.So the research of olfactory system will provide new thinking and route of administration for hypertensive treatment.
Embodiment two:
Herba Lysimachiae foenum-graeci quintessence oil brings high blood pressure down by the olfactory sensation path and has breed difference
This research has been carried out the comparative study of four kinds of lavandula angustifoliaes and found that there is difference in its antihypertensive effect: better with eye-catching lavandula angustifolia and highland lavandula angustifolia, the more weak head lavandula angustifolia of Honoka lavandula angustifolia does not then almost have antihypertensive effect.Wherein eye-catching lavandula angustifolia antihypertensive effect is greater than the highland lavandula angustifolia.SP, the DP, the MAP that find eye-catching lavandula angustifolia and highland Herba Lysimachiae foenum-graeci quintessence oil group rat all are lower than blank group, and Herba Rosmarini Officinalis and clove oil group SP, DP, MAP and blank group relatively do not have significant change.Show that eye-catching lavandula angustifolia and highland Herba Lysimachiae foenum-graeci quintessence oil can reduce rat blood pressure, infer that its possible mechanism is lavandula angustifolia and combines with ORs on the specificity OSNs film, activate the specific olfactory glomerulus of lavandula angustifolia by its aixs cylinder, project specific brain district through the olfactory sensation pathway, the final specific recognition that produces the lavandula angustifolia abnormal smells from the patient; And Herba Rosmarini Officinalis, clove oil activates its specific olfactory glomerulus respectively after sucking, and fails to be delivered to the brain district of regulation and control blood pressure thereby the effect that does not bring high blood pressure down after sucking through the olfactory sensation path.But being still waiting further experiment, concrete mechanism proves.
Embodiment three:
Blood pressure lowering realizes by the olfactory sensation path, illustrates the scientific basis of champignon blood pressure lowering.The rat olfactory epithelium is damaged the back suction and is smelt the experimental result prompting of variety classes Herba Lysimachiae foenum-graeci quintessence oil to the blood pressure influence: the effect that the rat after the variety classes Herba Lysimachiae foenum-graeci quintessence oil is damaged for olfactory epithelium does not bring high blood pressure down.For explaining above-mentioned variation, this experiment is inhaled the variation of smelling peripheral blood catecholamine behind the variety classes Herba Lysimachiae foenum-graeci quintessence oil by measuring; And the employing immunohistochemical method, the variation of different brains district neurotransmitteies such as rat hypothalamus, corpus amygdaloideum, brain stem is analyzed, inquire into the possibility mechanism that Herba Lysimachiae foenum-graeci quintessence oil brings high blood pressure down.
Embodiment four:
The mechanism of olfactory sensation path blood pressure lowering is to realize by the neurotransmitter and the path at positions such as adjusting hypothalamus, at present about neurotransmitter in olfactory sensation conduction really cutter system still be not very clear but have some evidences to show that neurotransmitter has participated in the formation and the conduction of olfactory sensation really.As inhibitory nerve mediator important in the brain, the release of mediators such as adjusting glutamic acid (Glu), DA, NE and 5-HT is arranged, can cause serious function of cortex obstacle after the damage.GABA expresses at olfactory bulb, olfactory tubercle, corpus amygdaloideum and septal area.In addition, dopamine and some neuropeptides (as SS, NPY, VP, VIP) also affect the transmission of olfactory system.Other neurotransmitter relevant with the olfactory sensation conduction also comprises: norepinephrine, 5-hydroxy tryptamine, cyclic adenosine monophosphate (cAMP) and carnosine etc.Olfactory bulb is mainly by olfactory glomerulus, ball pericyte, granular cell, mistral cell/bunch shape cellularity, form the synapse transmission between the cell in the olfactory bulb and between olfactory bulb cell and nervi olfactory and the olfactory cortex, the neurotransmitter of transmission information has Ach, GABA, Glu and 5-HT etc., participate in the cognitive identification and the scent-memorizing of olfactory sensation, and comprise that with the important brain district of blood pressure regulating limbic forebrain, corpus amygdaloideum, Hippocampus, brain stem etc. form nerve connections.
Embodiment five:
May also there be the critical function of other brain in lavandula angustifolia, and lavandula angustifolia is a kind of famous and precious and important natural perfume plant, is widely used in the daily cosmetics as the main component of odorant, aspect medical certain purposes is arranged also.As far back as the ancient Rome and Greece epoch, promptly with medicinal and famous.Herba Lysimachiae foenum-graeci quintessence oil is the volatile oil that extracts from lavandula angustifolia spica, strain and flower, is the complex mixture that multiple aromatic compound is formed, and its main component is linalool and linalyl acetate.The pharmacological action of its active component has become the focus of domestic and international research at present.Many researchs prove that all Herba Lysimachiae foenum-graeci quintessence oil has effects such as sterilization, antifungal, anxiety reduction depression, relaxing smooth muscle, in addition the central nervous system are also had calm, syngignoscism.Hwang JH is by allowing the hyperpietic continuous 4 weeks suck lavandula angustifolia, fragrant cananga and the blended quintessence oil of Fructus Citri Sarcodactylis three, the level of finding their blood pressure, pulse, subjective pressure sensation, anxiety and blood hydrocortisone all has obvious variation, show and adopt olfactory sensation to suck the method for quintessence oil, can alleviate the psychological stress reaction effectively and reduce level of plasma cortisol, and can reduce essential hypertension patient's blood pressure.
Claims (6)
1. prevent and treat hypertension and regulate the pharmaceutical composition of viscera function volatile oil class through olfactory sensation path brain targeting for one kind, it is characterized in that containing in the described compositions the following pharmacological component that is had in eye-catching lavandula angustifolia or the highland lavandula angustifolia: a kind of or any mixture in lavandula angustifolia ester, acetic acid lavandula angustifolia ester or its isomer; Or contain Herba Lysimachiae foenum-graeci quintessence oil in the described compositions.
2. pharmaceutical composition according to claim 1 is characterized in that containing natural perfume material in the described compositions in addition, and contains natural drug penetration enhancer, the Natural antioxidant or natural antiseptic agent.
3. pharmaceutical composition according to claim 1 is characterized in that described compositions contains one or more in the following penetration enhancer: 1. synthetic surfactant: polyoxyethylene-9-Laurel ether, sulfo-Laurel sodium alkoxide; 2. chlolic acid derivatives: Bile Salts, glucose sodium cholate, NaTDC and deoxidation Bile Salts; 3. the beta-schardinger dextrin-class that replaces of alkyl; 4. cyclic peptide class: bacitracin; 5. other: ethylene diamine tetra acetic acid disodium, citric acid and polyacrylic acid.
4. pharmaceutical composition according to claim 1, it is characterized in that also containing in the described compositions following pharmacological component: australene, camphene, beta-myrcene, linalyl acetate, acetic acid lavandula angustifolia ester, neryl acetate, acetic acid geranyl alcohol ester, β-sentence farnesol is present in Folium Eriobotryae, Rhizoma Zingiberis Recens, reaches in the volatile oil of Flos Matricariae chamomillae).5-ethylidene-1-methyl-cycloheptene.Borneolum Syntheticum, Mang geraniol, Mang cattle ester, lavandula angustifolia ester, linalool, Fructus Citri Limoniae are rare, caryophyllene, coumarin, firpene, 2-nopinene, δ-carene, 1-methyl-4-(1-isopropyl) benzene, 1, the 8-eucalyptole, 3,7-dimethyl-1,3,6-sarohornene, 3,7-dimethyl-1,3,7-sarohornene, linalool, 2,2-dimethyl-dicyclo (4,2,0) suffering-1-alkene, (-)-elemi-1,3,11 (13)-triolefins-12-alcohol, Camphora, linalyl propionate, 3,7-dimethyl-1,5-octadiene-3,7-glycol.
5. pharmaceutical composition according to claim 1 is characterized in that said composition is capsule, tablet, oral liquid, electuary, powder dosage form.
6. the purposes of the described pharmaceutical composition of claim 1 is characterized in that it prevents and treats application in the medicine in the hypertension in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127394A (en) * | 2014-07-15 | 2014-11-05 | 沈祥春 | Application of above one of alpha-pinene, beta-pinene, 1,8-eudesmol and camphene in preparation of human blood vessel endothelial cell damage treatment medicines |
| CN105713725A (en) * | 2016-03-17 | 2016-06-29 | 南京大塘金药用与芳香植物研究所 | Space capsule and plant compound essential oil for lowering blood pressure and application method thereof |
| CN110151766A (en) * | 2013-05-24 | 2019-08-23 | 雀巢产品有限公司 | Use the method for menthol, linalool and/or ice extract for treating or prevention autism obstacle |
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2011
- 2011-04-29 CN CN 201110109563 patent/CN102240280A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 《中华高血压杂志》 20100930 杨莹等 《薰衣草精油对大鼠血压的影响》 845-850 1-4,6 第18卷, 第9期 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110151766A (en) * | 2013-05-24 | 2019-08-23 | 雀巢产品有限公司 | Use the method for menthol, linalool and/or ice extract for treating or prevention autism obstacle |
| US11241433B2 (en) | 2013-05-24 | 2022-02-08 | Societe Des Produits Nestle S.A. | Treatment or prevention of autism disorders using menthol, linalool and/or icilin |
| CN110151766B (en) * | 2013-05-24 | 2022-08-16 | 雀巢产品有限公司 | Methods of treating or preventing autism disorders using menthol, linalool, and/or icilin |
| CN104127394A (en) * | 2014-07-15 | 2014-11-05 | 沈祥春 | Application of above one of alpha-pinene, beta-pinene, 1,8-eudesmol and camphene in preparation of human blood vessel endothelial cell damage treatment medicines |
| CN105713725A (en) * | 2016-03-17 | 2016-06-29 | 南京大塘金药用与芳香植物研究所 | Space capsule and plant compound essential oil for lowering blood pressure and application method thereof |
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Application publication date: 20111116 |