CN1304022C - Medicine for treating depression - Google Patents
Medicine for treating depression Download PDFInfo
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- CN1304022C CN1304022C CNB021368074A CN02136807A CN1304022C CN 1304022 C CN1304022 C CN 1304022C CN B021368074 A CNB021368074 A CN B021368074A CN 02136807 A CN02136807 A CN 02136807A CN 1304022 C CN1304022 C CN 1304022C
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Abstract
The present invention relates to medicine for treating depression, which adopts natural Chinese herbal medicine as raw materials and is formed by extracting and preparing. The present invention is characterized in that the medicine contains hypericum perforatum (yanri red) extracts, and the components of raw materials contain red sange root extracts. The components contains various raw materials of the following proportion by weight: 80 to 120 of hypericum perforatum and 20 to 60 of red sage root. Clinical researches and experimental results indicate that the present invention has a function of depression and anxiety resistance, has a curative effect which is equivalent to amitriptyline, and has a certain functions for improving emotion of patients, increasing activity, increasing appetite and improving sleep. The present invention is safe and effective medicine of which the anti-appetite reaction degree is light, is accepted by patients, and has an obviously better safety than traditional antidepressant medicine. The present invention is especially suitable for the treatment of light and moderate depression patients. The present invention has low medical care cost because the daily treating cost is 0.9 to 1.2 yuan RMB according to the existing coat, and can largely reduce the economic burden to patients who have a long course of treatment and a large dosage.
Description
Technical field: the invention belongs to a kind of medicine that is used for the treatment of depression, specifically a kind of a kind of medicine (compositions) for the treatment of depression of making by Chinese herbal medicine extract.
Background technology: depressive psychosis is a kind of commonly encountered diseases clinically, and according to World Health Organization's statistics, current various types of other patients with depression has occupied the 3-5% of global population.That the common clinical symptoms of this disease is in a bad mood is low, pessimistic and worldweary, lost in a reverie, sentimentality, nose heave cardiopalmus, weak-eyed, nervous fear etc.Modern society's life is nervous, and competitive pressure is big, and mental sickness such as depression obviously rise, and its sickness rate is also raising year by year.This mattoid of treatment is still based on Drug therapy at present, medicine commonly used has tricyclic antidepressant (TCAS), Fourth Ring class antidepressants, monoamine oxidase, MAO, inhibitor (MAOL) and selectivity 5-hydroxy tryptamine (5-HT) and reclaims down etc., these drug side effectes are big, lack specific aim, some costs an arm and a leg, and patient takes for a long time and is difficult to accept.Because it is long that depressive psychosis has the course of disease, the characteristics of easy recurrence, the clinical principle that the time must adhere to taking medicine for a long time control again in treatment, restriction because of erious adverse reactions such as toxic and side effects and price endurance, make patient be difficult to adhere to carrying on the treatment, so but press for a kind of patients energy novel drugs that the long period takes, curative effect is good, price is suitable, toxic and side effects is little at present clinically.
Summary of the invention
The purpose of this invention is to provide a kind of determined curative effect, effect is obvious, and toxic and side effects is little, the medicine of the treatment depression that price is lower than import medicine (its decoction can claim to forget the pharmaceutical preparation of melancholy grass Chinese medicine composition)
The realization of the object of the invention is based on modern pharmacological research, and in conjunction with motherland's medical science to the treatment depressive psychosis understanding and Therapeutic Principle: will have dispersing the stagnated live-QI to relieve the stagnation of QI, go turbid reducing phlegm, the mind calming of regulating the flow of vital energy, the extract of the vegetable Chinese herbal medicine of resuscitation inducing and mind tranquilizing " Herba Hyperici perforati " (it is red to have another name called wild goose day) is that one of main component is formed this medicine, this medicine can be reduced even avoid using chemical synthetic drug, not only reduce its toxic and side effects, can alleviate the treatment cost again, feedstock composition of the present invention is except Herba Hyperici perforati extract, also comprise Radix Salviae Miltiorrhizae extract, according to the above, the present invention is that the employing natural Chinese medicinal herb is that raw material forms through extracting preparation, it is characterized in that this medicine is that employing Herba Hyperici perforati (it is red to have another name called wild goose day) and Radix Salviae Miltiorrhizae are that raw material is made, the ratio of the weight portion of described various raw materials is: Herba Hyperici perforati 80～120, Radix Salviae Miltiorrhizae 20～60.
Why adopting said herbal medicine among the side of the present invention is raw material, is that the flavor efficacy because of Herba Hyperici perforati is: bitter in the mouth, puckery, property put down, return Liver Channel, can clearing heat and relieving fidgetness, dispersing the stagnated live-QI to relieve the stagnation of QI, blood-arresting catamenia-regulating.Contain Quercetin (guercetin), methylhesperidin, hyperin, phenylpropyl alcohol alkane, flavonol derivant, flavone compound in its extract, also contain the Herba Hyperici perforati element, compositions such as caffeic acid.Its pharmacological action: have antitumor, anti HIV-1 virus, antidepressant effect; To the central nervous system to influence the aspect similar to most of antidepressant drugs, can strengthen mice runner mobility, continuous use can reduce the aggressive behavior of male mice; To the cardiovascular effect: the reinforcement cardiomotility is arranged, the effect of vasoconstrictive and rising blood pressure.The Radix Salviae Miltiorrhizae that the present invention is used, its flavor efficacy is: bitter, be slightly cold, GUIXIN, Liver Channel, calm the nerves, mind calming, blood circulation promoting and blood stasis dispelling, evacuation of pus pain relieving.Its extract chemical analysis contains: furo phenanthrenequione class pigment Tanshinone I, tanshinone, IIB, cryptotanshinone, multiple TANSHINONES such as iso tanshinone.Its pharmacological action: to central nervous system's effect: Radix Salviae Miltiorrhizae or FUFANG DANSHEN ZHUSHEYE show tangible sedation to white mice, and can prolong the length of one's sleep of cyclic ethylene barbital; To cardiovascular influence: the coronary artery dilating effect is arranged.
The present invention with Herba Hyperici perforati and Radix Salviae Miltiorrhizae make to forget melancholy decoction thing (forgetting melancholy soup) Western medicine amitriptyline in treatment light, moderate depressive patients clinical control result of study is as follows: adopt a Chinese honey that depression scale (HAMD), Manifest Anxiety Scale (HAMA), clinical global impression scale (CGT) and side reaction scale, to 156 patients, wherein forget 83 of melancholy soup groups, 73 of amitriptyline groups are carried out six all clinical observations, result: forget melancholy soup group effective percentage 79.7%, amitriptyline group effective percentage 77.8%, do not see statistical significant difference between two treatment groups, curative effect has significant difference (P＜0.05) before and after two groups of treatments, the result of study prompting, the present invention has antidepressant and angst resistance effect, and curative effect and amitriptyline are suitable, to improving patient's emotion, increase activity stimulating appetite improves sleep and has tangible curative effect.Side reaction (untoward reaction) is analyzed: forgetting melancholy soup group has 32 (37%), amitriptyline group to have patient's report of 50 (64%) that untoward reaction (P＜0.05) is arranged, main adverse reaction of the present invention is slight headache, the amitriptyline group is xerostomia, dizziness, sleepy, xerostomia and sleepy, dizzy aspect, untoward reaction degree of the present invention is lighter, difference between two groups is that significance is arranged, and forgets melancholy soup group and is better than the amitriptyline group.
Above-mentioned clinical research and experimental result can show that the present invention has antidepressant and angst resistance effect, curative effect and amitriptyline are suitable, to improving patient's emotion, increase activity, stimulating appetite, improving the sleep tool has certain effect, its untoward reaction degree is lighter, and the patient can both tolerate, and is a kind of safe and effective medicine, safety is particularly useful for treatment light, moderate depressive patients patient significantly better than traditional antidepressants.In medical treatment cost in price, of the present invention to forget melancholy soup consumption be each 20ml, and 2-3 time on the one, by existing price, 0.9-1.2 yuan of day treatment valency to the big patient of the long consumption course of treatment, can significantly alleviate its financial burden.
Below be a kind of embodiment of the present invention (concrete processing instance).
The present invention can adopt conventional water extraction, its technological process is as follows: Herba Hyperici perforati and Radix Salviae Miltiorrhizae are taken by weighing by the prescription proportional quantity, raw material is eliminated impurity, it is standby to be cut into segment, two kinds of crude drug of ormal weight are added drinking water immersion a period of time, heating is boiled and is carried 1 hour then, filtered while hot, filtrate place settling box overnight staticly settle standby.Medicinal residues are extracting in water twice again, and every all over 40 minutes, the water extract is with aforementioned step process.The supernatant of above-mentioned two extracting solution put in the uncovered jacketed pan concentrate, be concentrated into normal concentration and add an amount of Buddhist nun's platinum ethyl ester (antiseptic) and stir, the fill rear pressing cover, sterilization is decoction (forgetting melancholy soup finished product).The also available conventional decoction and alcohol sedimentation technique of the present invention is made capsule (or tablet).Preparation process slightly.
Claims (2)
1, a kind of medicine for the treatment of depression is characterized in that this medicine is is that raw material is made by natural Chinese medicinal herb Herba Hyperici perforati and Radix Salviae Miltiorrhizae, and the ratio of the weight portion of each raw material is: Herba Hyperici perforati 80～120, Radix Salviae Miltiorrhizae 20～60.
2, the medicine of treatment depression according to claim 1 is characterized in that this medicine is to adopt the common process method to make the decoction of oral type, or the capsule or the tablet that adopt the common process method to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021368074A CN1304022C (en) | 2002-09-01 | 2002-09-01 | Medicine for treating depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021368074A CN1304022C (en) | 2002-09-01 | 2002-09-01 | Medicine for treating depression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1478506A CN1478506A (en) | 2004-03-03 |
| CN1304022C true CN1304022C (en) | 2007-03-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021368074A Expired - Fee Related CN1304022C (en) | 2002-09-01 | 2002-09-01 | Medicine for treating depression |
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| Country | Link |
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| CN (1) | CN1304022C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212019A (en) * | 2012-12-10 | 2013-07-24 | 宋爱民 | Chinese materia medica preparation for treating depression |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1925302A1 (en) | 2006-11-24 | 2008-05-28 | DSMIP Assets B.V. | Dietary or pharmaceutical compositions containing tricyclic diterpenes and derivatives thereof for the treatment of depression |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129569A (en) * | 1995-02-23 | 1996-08-28 | 颜建邦 | Medicament for removing blood stasis and resolving depression |
| CN1217929A (en) * | 1997-11-20 | 1999-06-02 | 张志刚 | Chinese medicine for AlDs and preparing process therefor |
| CN1251999A (en) * | 1997-04-08 | 2000-05-03 | 威廉施瓦布博士有限公司 | Stable extract of hypericum perforatum L.,method for producing same and corresponding pharmaceutical preparations |
-
2002
- 2002-09-01 CN CNB021368074A patent/CN1304022C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129569A (en) * | 1995-02-23 | 1996-08-28 | 颜建邦 | Medicament for removing blood stasis and resolving depression |
| CN1251999A (en) * | 1997-04-08 | 2000-05-03 | 威廉施瓦布博士有限公司 | Stable extract of hypericum perforatum L.,method for producing same and corresponding pharmaceutical preparations |
| CN1217929A (en) * | 1997-11-20 | 1999-06-02 | 张志刚 | Chinese medicine for AlDs and preparing process therefor |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212019A (en) * | 2012-12-10 | 2013-07-24 | 宋爱民 | Chinese materia medica preparation for treating depression |
| CN103212019B (en) * | 2012-12-10 | 2014-10-22 | 宋爱民 | Chinese materia medica preparation for treating depression |
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| Publication number | Publication date |
|---|---|
| CN1478506A (en) | 2004-03-03 |
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Granted publication date: 20070314 Termination date: 20100901 |